Matthew Farajzadeh | University of California, Los Angeles (original) (raw)
Papers by Matthew Farajzadeh
American Journal of Ophthalmology, 2016
To investigate whether lamellar macular holes can be divided into different subgroups. Retrospect... more To investigate whether lamellar macular holes can be divided into different subgroups. Retrospective observational case series. In this institutional study, clinical charts and Spectral-Domain Optical Coherence Tomography (OCT) images of 102 eyes of 90 consecutive patients diagnosed with lamellar macular hole were reviewed. In OCT imaging, the presence of lamellar macular hole was defined according to the following findings: presence of irregular foveal contour, separation of the layers of the neurosensory retina, and the absence of full thickness macular defect. Mean outcome was the morphological and functional characterization of different subtypes of macular hole. Two different subtypes of lamellar macular hole were identified: tractional and degenerative. The first type, tractional, was diagnosed in 43 eyes, and was characterized by the schitic separation of neurosensory retina between outer plexiform and outer nuclear layers. It often presented with an intact ellipsoid layer and was associated with tractional epiretinal membranes and/or vitreo-macular traction. The second type, degenerative, was diagnosed in 48 eyes, and its distinctive traits included the presence of intra-retinal cavitation that could affect all retinal layers. It was often associated with non-tractional epiretinal proliferation and a retinal "bump". Moreover, it often presented with early ellipsoidal zone defect and its pathogenesis, although chronic, and progressive remains poorly understood. Eleven eyes shared common features with both tractional and degenerative lamellar macular holes and were classified as mixed lesions. Degenerative and tractional lamellar macular holes may be two distinct clinical entities. A revision of the current concept of lamellar macular holes is needed.
Endocrinology, Jan 10, 2015
Bisphenol A (BPA) is a well-known environmental endocrine-disrupting chemical and bisphenol S (BP... more Bisphenol A (BPA) is a well-known environmental endocrine-disrupting chemical and bisphenol S (BPS) has been considered a "safer" alternative for BPA-free products. The present study aims to evaluate the impact of BPA and BPS on the reproductive neuroendocrine system during zebrafish embryonic and larval development, and to explore potential mechanisms of action associated with estrogen receptor (ER), thyroid hormone receptor (THRs) and enzyme aromatase (AROM) pathways. Environmentally relevant, low levels of BPA exposure during development led to advanced hatching time, increased numbers of Gonadotropin-Releasing Hormone 3 (GnRH3) neurons in both terminal nerve and hypothalamus, increased expression of reproduction-related genes (kiss1, kiss1r, gnrh3, lhβ, fshβ, and erα) and a marker for synaptic transmission (sv2). Low levels of BPS exposure led to similar effects: increased numbers of hypothalamic GnRH3 neurons and increased expression of kiss1, gnrh3, and erα. Antagoni...
Frontiers in Endocrinology, 2013
American Journal of Ophthalmology, 2016
To investigate whether lamellar macular holes can be divided into different subgroups. Retrospect... more To investigate whether lamellar macular holes can be divided into different subgroups. Retrospective observational case series. In this institutional study, clinical charts and Spectral-Domain Optical Coherence Tomography (OCT) images of 102 eyes of 90 consecutive patients diagnosed with lamellar macular hole were reviewed. In OCT imaging, the presence of lamellar macular hole was defined according to the following findings: presence of irregular foveal contour, separation of the layers of the neurosensory retina, and the absence of full thickness macular defect. Mean outcome was the morphological and functional characterization of different subtypes of macular hole. Two different subtypes of lamellar macular hole were identified: tractional and degenerative. The first type, tractional, was diagnosed in 43 eyes, and was characterized by the schitic separation of neurosensory retina between outer plexiform and outer nuclear layers. It often presented with an intact ellipsoid layer and was associated with tractional epiretinal membranes and/or vitreo-macular traction. The second type, degenerative, was diagnosed in 48 eyes, and its distinctive traits included the presence of intra-retinal cavitation that could affect all retinal layers. It was often associated with non-tractional epiretinal proliferation and a retinal "bump". Moreover, it often presented with early ellipsoidal zone defect and its pathogenesis, although chronic, and progressive remains poorly understood. Eleven eyes shared common features with both tractional and degenerative lamellar macular holes and were classified as mixed lesions. Degenerative and tractional lamellar macular holes may be two distinct clinical entities. A revision of the current concept of lamellar macular holes is needed.
Endocrinology, Jan 10, 2015
Bisphenol A (BPA) is a well-known environmental endocrine-disrupting chemical and bisphenol S (BP... more Bisphenol A (BPA) is a well-known environmental endocrine-disrupting chemical and bisphenol S (BPS) has been considered a "safer" alternative for BPA-free products. The present study aims to evaluate the impact of BPA and BPS on the reproductive neuroendocrine system during zebrafish embryonic and larval development, and to explore potential mechanisms of action associated with estrogen receptor (ER), thyroid hormone receptor (THRs) and enzyme aromatase (AROM) pathways. Environmentally relevant, low levels of BPA exposure during development led to advanced hatching time, increased numbers of Gonadotropin-Releasing Hormone 3 (GnRH3) neurons in both terminal nerve and hypothalamus, increased expression of reproduction-related genes (kiss1, kiss1r, gnrh3, lhβ, fshβ, and erα) and a marker for synaptic transmission (sv2). Low levels of BPS exposure led to similar effects: increased numbers of hypothalamic GnRH3 neurons and increased expression of kiss1, gnrh3, and erα. Antagoni...
Frontiers in Endocrinology, 2013