William Sanchez | Universidad de Costa Rica (original) (raw)
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Papers by William Sanchez
Liver international : official journal of the International Association for the Study of the Liver, Jan 9, 2015
Patients who achieve sustained virological response (SVR) following treatment of post-liver trans... more Patients who achieve sustained virological response (SVR) following treatment of post-liver transplant (LT) recurrence of hepatitis C virus (HCV) infection have improved outcomes. The full impact of eradication of HCV on allograft histology is, however, not clearly known. We studied allograft histology in protocol-based paired liver biopsies in consecutive LT recipients who underwent post-LT treatment of recurrence of HCV. A total 116 patients were treated with interferon-based therapy for recurrent HCV. Paired pre-treatment baseline biopsies and post-treatment biopsies were available in 83.2% of patients. SVR was achieved in 37.9% of patients. Among patients who achieved SVR 20.5% had progression of fibrosis on post treatment biopsies vs. 65.5% of patients with non-response/relapse (p<0.001). The impact of virologic response on fibrosis progression was sustained and similar outcome was observed in the subset of patients who had 4-5 year post treatment biopsies available. In the ...
Liver international : official journal of the International Association for the Study of the Liver, Jan 9, 2015
Patients who achieve sustained virological response (SVR) following treatment of post-liver trans... more Patients who achieve sustained virological response (SVR) following treatment of post-liver transplant (LT) recurrence of hepatitis C virus (HCV) infection have improved outcomes. The full impact of eradication of HCV on allograft histology is, however, not clearly known. We studied allograft histology in protocol-based paired liver biopsies in consecutive LT recipients who underwent post-LT treatment of recurrence of HCV. A total 116 patients were treated with interferon-based therapy for recurrent HCV. Paired pre-treatment baseline biopsies and post-treatment biopsies were available in 83.2% of patients. SVR was achieved in 37.9% of patients. Among patients who achieved SVR 20.5% had progression of fibrosis on post treatment biopsies vs. 65.5% of patients with non-response/relapse (p<0.001). The impact of virologic response on fibrosis progression was sustained and similar outcome was observed in the subset of patients who had 4-5 year post treatment biopsies available. In the ...