Evan Merkhofer | University of California, San Diego (original) (raw)
Address: San Diego, California, United States
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Papers by Evan Merkhofer
PLOS One, 2010
Background: Activation of the transcription factor NF-kB by cytokines is rapid, mediated through ... more Background: Activation of the transcription factor NF-kB by cytokines is rapid, mediated through the activation of the IKK complex with subsequent phosphorylation and degradation of the inhibitory IkB proteins. The IKK complex is comprised of two catalytic subunits, IKKa and IKKb, and a regulatory protein known as NEMO. Using cells from mice that are genetically deficient in IKKb or IKKa, or using a kinase inactive mutant of IKKb, it has been proposed that IKKb is critical for TNF-induced IkB phosphorylation/degradation through the canonical pathway while IKKa has been shown to be involved in the noncanonical pathway for NF-kB activation. These conclusions have led to a focus on development of IKKb inhibitors for potential use in inflammatory disorders and cancer.
PLOS One, 2010
Background: Activation of the transcription factor NF-kB by cytokines is rapid, mediated through ... more Background: Activation of the transcription factor NF-kB by cytokines is rapid, mediated through the activation of the IKK complex with subsequent phosphorylation and degradation of the inhibitory IkB proteins. The IKK complex is comprised of two catalytic subunits, IKKa and IKKb, and a regulatory protein known as NEMO. Using cells from mice that are genetically deficient in IKKb or IKKa, or using a kinase inactive mutant of IKKb, it has been proposed that IKKb is critical for TNF-induced IkB phosphorylation/degradation through the canonical pathway while IKKa has been shown to be involved in the noncanonical pathway for NF-kB activation. These conclusions have led to a focus on development of IKKb inhibitors for potential use in inflammatory disorders and cancer.