Dr. Supratim Biswas | University of Cape Town (original) (raw)

Papers by Dr. Supratim Biswas

Research paper thumbnail of In vitro & in vivo correlation of release behavior of andrographolide from silica and PEG assisted silica gel matrix

Colloids and Surfaces A: Physicochemical and Engineering Aspects, Aug 5, 2014

Silica xerogel and its PEG assisted derivatives were prepared by sol–gel method for controlled re... more Silica xerogel and its PEG assisted derivatives were prepared by sol–gel method for controlled release of andrographolide. In vitro and in vivo release of andrographolide from the nano porous silica as well as PEG modified silica matrix were studied. Drug release from the matrix increased with increasing percentage of PEG and followed a biphasic pattern. The in vitro release profile followed zero order kinetics with erosion of the matrix for the first six hours and higuchi model with the diffusion mechanism for rest of the time period. Pharmacokinetic data revealed sustained release of the drug from silica–drug composite with higher elimination t1/2 than the pure drug. For all the formulations Level A in vitro-in vivo correlation (IVIVC) was established with (R2) > 0.98. Histology of different organs was carried out following in vivo administration of the drug-carrier composite. The histological examination demonstrated absence of any inflammatory or degenerative response with the formulations. Fourier transform infrared (FTIR) data revealed the coexistence of andrographolide in the silica matrix. Transmission electron microscope (TEM) images also unfold the repose matrix structure in PEG assisted derivatives than the pure matrix. This study discloses that silica gel and PEG assisted derivatives could be used as a biocompatible and sustained release device for andrographolide.

Research paper thumbnail of Bioleaching of Nickel and Cobalt from Lateritic Chromite Overburden Using the Culture Filtrate of Aspergillus niger

Research paper thumbnail of Microbial leaching of chromite overburden from Sukinda mines, Orissa, India using Aspergillus niger

Research paper thumbnail of Sustained Release of Silica Gel Entrapped Methanol Extract of Andrographis paniculata and Its Retention of Antimicrobial Property

Research paper thumbnail of Microbial Extraction of Cobalt and Nickel from Lateritic Chromite Overburden using Aspergillus wentii

Research paper thumbnail of Optimization of process parameters and dissolution kinetics of nickel and cobalt from lateritic chromite overburden using organic acids

Research paper thumbnail of ‘Green’ Synthesis of Silver Nanoparticles by Using Grape (Vitis vinifera) Fruit Extract Characterization of the Particles and Study of Antibacterial Activity

Research paper thumbnail of Sol-gel derived silica-gel as a controlled delivery system of Andrographis paniculata extract and its anti-microbial efficacy

Research paper thumbnail of Recent scenario on the genetic abnormalities in patients suffering from Haemophilia A: A review

Research paper thumbnail of In vitro & in vivo correlation of release behavior of andrographolide from silica and PEG assisted silica gel matrix

Colloids and Surfaces A: Physicochemical and Engineering Aspects, Aug 5, 2014

Silica xerogel and its PEG assisted derivatives were prepared by sol–gel method for controlled re... more Silica xerogel and its PEG assisted derivatives were prepared by sol–gel method for controlled release of andrographolide. In vitro and in vivo release of andrographolide from the nano porous silica as well as PEG modified silica matrix were studied. Drug release from the matrix increased with increasing percentage of PEG and followed a biphasic pattern. The in vitro release profile followed zero order kinetics with erosion of the matrix for the first six hours and higuchi model with the diffusion mechanism for rest of the time period. Pharmacokinetic data revealed sustained release of the drug from silica–drug composite with higher elimination t1/2 than the pure drug. For all the formulations Level A in vitro-in vivo correlation (IVIVC) was established with (R2) > 0.98. Histology of different organs was carried out following in vivo administration of the drug-carrier composite. The histological examination demonstrated absence of any inflammatory or degenerative response with the formulations. Fourier transform infrared (FTIR) data revealed the coexistence of andrographolide in the silica matrix. Transmission electron microscope (TEM) images also unfold the repose matrix structure in PEG assisted derivatives than the pure matrix. This study discloses that silica gel and PEG assisted derivatives could be used as a biocompatible and sustained release device for andrographolide.

Research paper thumbnail of Bioleaching of Nickel and Cobalt from Lateritic Chromite Overburden Using the Culture Filtrate of Aspergillus niger

Research paper thumbnail of Microbial leaching of chromite overburden from Sukinda mines, Orissa, India using Aspergillus niger

Research paper thumbnail of Sustained Release of Silica Gel Entrapped Methanol Extract of Andrographis paniculata and Its Retention of Antimicrobial Property

Research paper thumbnail of Microbial Extraction of Cobalt and Nickel from Lateritic Chromite Overburden using Aspergillus wentii

Research paper thumbnail of Optimization of process parameters and dissolution kinetics of nickel and cobalt from lateritic chromite overburden using organic acids

Research paper thumbnail of ‘Green’ Synthesis of Silver Nanoparticles by Using Grape (Vitis vinifera) Fruit Extract Characterization of the Particles and Study of Antibacterial Activity

Research paper thumbnail of Sol-gel derived silica-gel as a controlled delivery system of Andrographis paniculata extract and its anti-microbial efficacy

Research paper thumbnail of Recent scenario on the genetic abnormalities in patients suffering from Haemophilia A: A review