Justo G Alonso | Universidad de la República (Uruguay) (original) (raw)

Papers by Justo G Alonso

Research paper thumbnail of Tratamiento conservador en la hemorragia posparto refractaria al tratamiento médico

DOAJ (DOAJ: Directory of Open Access Journals), Sep 1, 2010

Research paper thumbnail of W071 Procalcitonin and Routine Biomarkers in the Diagnosis of Maternal and Fetal Inflammatory Response in Pregnant Women with Pprom

International journal of gynaecology and obstetrics, Oct 1, 2012

Research paper thumbnail of Embarazo sin control

Revista Médica del Uruguay, 2012

Introducción: dada la frecuente consulta de pacientes en el Centro Hospitalario Pereira Rossell (... more Introducción: dada la frecuente consulta de pacientes en el Centro Hospitalario Pereira Rossell (CHPR) cursando embarazos no controlados, surge la necesidad de contar con información sobre las razones por las cuales dichas mujeres no se controlan. Objetivo: analizar las características sociales y culturales de las pacientes que llegan al CHPR en trabajo de parto o puerperio inmediato, y que no han controlado sus embarazos, con el fin de determinar las causas que llevan a estas mujeres a no controlarse. Material y método: estudio descriptivo, observacional, analizándose los datos en forma cuantitativa. Se recolectaron datos del total de embarazos sin control entre los días 1º de mayo al 10 de julio de 2009 en el CHPR o referidas al mismo. La muestra fue de 135 pacientes, en un total de 1.576 nacimientos registrados en dicho período, lo que corresponde a 8,6%. Resultados: se analizaron las características sociales y culturales de la población estudiada. Con respecto al análisis de ...

Research paper thumbnail of Importancia de la monitorización electrónica de la frecuencia cardiaca fetal intraparto como predictor de los resultados neonatales

Revista Médica del …, 2008

Research paper thumbnail of W071 Procalcitonin and Routine Biomarkers in the Diagnosis of Maternal and Fetal Inflammatory Response in Pregnant Women with Pprom

International Journal of Gynecology & Obstetrics, 2012

Research paper thumbnail of Carotid-radial pulse wave velocity as an alternative tool for the evaluation of endothelial function during pregnancy: Potential role in identifying hypertensive disorders of pregnancy

Preeclampsia/eclampsia syndrome, a major cause of maternal mortality and morbidity, has been reco... more Preeclampsia/eclampsia syndrome, a major cause of maternal mortality and morbidity, has been recognized as a condition with a globally impaired endothelial function (EF). The possibility of identifying early subclinical endothelial damage during pregnancy could be of value in classifying the different hypertensive states of pregnancy, and have a positive impact in the understanding of this syndrome, as well as on the appropriate treatment of these patients. Reactive hyperemia-related changes in carotid-radial pulse wave velocity (PWVcr) were proposed as an alternative tool for the evaluation of EF in patients with cardiovascular risk factors. If impaired EF, which follows hypertensive disorders of pregnancy can be assessed using PWVcr changes remains still unknown. To assess and compare reactive hyperemia-related changes in PWVcr and FMD in pregnant women (healthy and with hypertensive disorders) and non pregnant women. Healthy pregnant (HP; n=13), preeclamptic (PE; n=7), non-proteinuric hypertensive (NPH; n=6) and non-pregnant (NP; n=32) women were included. Left PWVcr (strain gauge mechano-transducers), left brachial arterial diameter (B-Mode ultrasound) and blood flow velocity (Doppler ultrasound) were measured before (baseline) and after the transient ischemia of the left forearm were determined. One minute after the cuff deflation, PWVcr decreased in HP (6.9 ± 1.5 to 6.0 ± 0.9 m/s, p<0.001) and in NP (8.1 ± 0.9 to 7.4 ± 0.9 m/s; p<0.001). NPH showed a blunted hyperemic PWVcr response (6.6 ± 1.4 to 6.7 ± 1.0 m/s; p=0.91), whereas PE showed a tendency to increase (6.0 ± 0.7 to 6.4 ± 0.8 m/s; p=0.10). Reactive hyperemia PWVcr response (ΔPWVcr in %) differed comparing HP with NPH (-12% vs. +2%; p<0.01) and with PE (-12 vs. +6%; p <0.01), whereas no differences were found between NHP and PE (p=1.00). HP showed an enhanced PWVcr reduction, whereas PE and NPH showed a blunted hyperemic PWVcr response. Carotid-radial PWVcr analysis could have a potential role in the assessment of pregnancy to study EF with a potential clinical application in predicting pregnancy induced hypertension and preeclampsia.

Research paper thumbnail of O603 Carotid-Radial Pulse Wave Velocity as an Alternative Tool for the Evaluation of Endothelial Function: Potential Role in Predicting and Classifying Hypertensive Disorders of Pregnancy

International Journal of Gynecology & Obstetrics, 2012

Research paper thumbnail of Opinion on a new and Challenging Tool in Prenatal Counseling: Non invasive Prenatal Testing by Fetal Cell-Free DNA in Maternal Blood

Journal of Health & Medical Informatics

Research paper thumbnail of Comparison between vaginal and sublingual misoprostol 50 µg for cervical ripening prior to induction of labor: randomized clinical trial

Archives of gynecology and obstetrics, Jan 16, 2017

To compare the effectiveness and safety of sublingual versus vaginal misoprostol on improving the... more To compare the effectiveness and safety of sublingual versus vaginal misoprostol on improving the Bishop score after 6 h of administration. Randomized clinical trial which includes pregnant women in gestational ages from 32/0 to 41/6, with indication of induction of labor with misoprostol. Bishop score was assessed at the time of induction and 6 h after administration of 50 µg misoprostol. Analysis was made over difference in mean Bishop score of 2 points, using a standard deviation of 2, with 90% power, reaching a 95% confidence interval. 102 patients were studied, 51 received sublingual misoprostol, and 51 received vaginal misoprostol. There was a statistically significant difference in cervical modifications in global terms regardless of the administration route at 6 h (P < 0.05). When analyzing each group, there was no significant difference for the mean and standard deviation for Bishop score for sublingual and vaginal route (P = 0.761). There was no significant difference i...

Research paper thumbnail of Tratamiento conservador en la hemorragia posparto refractaria al tratamiento médico. Sutura de B-Lynch

Revista Medica Del Uruguay, Sep 1, 2010

Research paper thumbnail of Embarazo sin control: Análisis epidemiológico

Revista Medica Del Uruguay, Jul 1, 2012

Research paper thumbnail of Prevalencia de altas concentraciones de lipoproteína (a) en embarazos complicados con restricción del crecimiento fetal intrauterino

Revista Medica Del Uruguay, Oct 1, 2005

... Ricardo Pou§, Eduardo Storch§, Enrique Pons¶, Justo Alonso¶, Daniela Lens††, Lics. Datevig At... more ... Ricardo Pou§, Eduardo Storch§, Enrique Pons¶, Justo Alonso¶, Daniela Lens††, Lics. Datevig Attarian‡‡, Nora Mota‡‡, Blanca Ceria‡‡, Alicia Ferrari‡‡. ... Blood 2001; 97(4): 981-6. [ Links ]. 32. Caplice NM, Panetta C, Peterson TE, Kleppe LS, Mueske CS, Kostner GM, et al. ...

Research paper thumbnail of Función endotelial y estados hipertensivos del embarazo: Velocidad de la onda del pulso carótido-radial como método alternativo para detectar disfunción endotelial en embarazadas

Revista Uruguaya De Cardiologia, Aug 1, 2013

Research paper thumbnail of Thrombophilia and pregnancy: Guidelines for diagnostic and treatment

Archivos De Medicina Interna, Jul 1, 2011

Research paper thumbnail of Effect of whole-body pH changes on thoracic duct lymph flow in anesthetized sheep

American Journal of Obstetrics and Gynecology, Dec 31, 1989

Research paper thumbnail of Trombofilia y embarazo: Pautas de diagnóstico y tratamiento Trombofilia hereditaria: asociación con etev y complicaciones obstétricas

Archivos De Medicina Interna, Jul 1, 2011

La trombofilia se relaciona con morbimortalidad materno-fetal, fundamentalmente en relación a eve... more La trombofilia se relaciona con morbimortalidad materno-fetal, fundamentalmente en relación a eventos tromboembólicos venosos (ETEV) y arteriales en el período grávido puerperal, así como también con alteraciones obstétricas como PRE, restricción del ...

Research paper thumbnail of Lawrence D. Longo: from chronic fetal hypoxia to proteomic predictors of fetal distress syndrome - a life devoted to research and mentoring based on virtue-ethics

Advances in experimental medicine and biology, 2014

The present chapter presents the experience of the author during his fellowship granted by the Fo... more The present chapter presents the experience of the author during his fellowship granted by the Fogarty Foundation of the NIH in the Division of Perinatal Biology, Loma Linda University, from 1989 to 1991. Experiments on maternal and fetal responses to long-term hypoxemia (including high-altitude) were performed successfully in pregnant sheep and their fetuses.Cardiovascular, hormonal and blood flow distribution responses were studied under a strict experimental protocol. As result of this research, four papers were accepted for publication in major scientific journals, and have served as basis for further research.Most of all, the leadership, virtue-based ethics, perseverance and continuous stimulus of Lawrence D. Longo is presented as an example to follow for future generations.

Research paper thumbnail of Toll receptor 4 Asp299Gly polymorphism and its association with preterm birth and premature rupture of membranes in a South American population

Molecular Human Reproduction, 2008

Research paper thumbnail of Comparison of placental alpha microglobulin-1 in vaginal fluid with intra-amniotic injection of indigo carmine for the diagnosis of rupture of membranes

Journal of Perinatal Medicine, 2000

The purpose of this study was to compare the diagnostic performance of an immunoassay for placent... more The purpose of this study was to compare the diagnostic performance of an immunoassay for placental alpha microglobulin-1 (PAMG-1) in vaginal fluid with the intra-amniotic instillation of indigo carmine for the diagnosis of membrane rupture in patients with an equivocal status.A prospective multi-site study was performed involving women reporting signs, symptoms, or complaints suggestive of rupture of membrane (ROM) between 21 and 42 weeks of gestation without obvious leakage of fluid from the cervical os during sterile speculum examination and without confirmation of ROM by traditional methods.A total of 140 patients were recruited with a prevalence of ROM of 19.3%. The PAMG-1 test had a sensitivity of 100.0% [confidence interval (CI) 0.87–1.0], specificity of 99.1% [(CI) 0.95–0.99], positive predictive value of 96.3% [(CI) 0.82–0.99], negative predictive value of 100.0% [(CI) 0.97–1.0], and ± likelihood ratios of 74.6 [(CI) 20.31–274.51] and 0.0 [(CI) 0.00–0.98].The PAMG-1 immunoa...

Research paper thumbnail of Repeated direct fetal intravascular high-dose immunoglobulin therapy for the treatment of Rh hemolytic disease

Journal of Perinatal Medicine, 1994

Recently, administration of high-dose intravenous immunoglobulin (HDivIG) either to the mother or... more Recently, administration of high-dose intravenous immunoglobulin (HDivIG) either to the mother or the neonate has been proposed in an effort to prevent progressive hemolysis in Rh(D) perinatal disease, but no cases have been published with direct fetal HDivIG administration. We report a case in which HDivIG was repeatedly administered by cordocentesis to a fetus affected by Rh(D) disease from 28 to 36 weeks gestation, at doses of approximately 450 mg/kg. The fetus required no transfusions, and the neonatal evolution was satisfactory. The treatment, performed at three weeks intervals, seemed to be useful in preventing fetal hemolysis. No fetal complications were present. Recurrent administration of HDivIG therapy to the fetus in cases of severe Rh(D) disease, appears to be feasible and free of serious complications to the fetus or the mother.

Research paper thumbnail of Tratamiento conservador en la hemorragia posparto refractaria al tratamiento médico

DOAJ (DOAJ: Directory of Open Access Journals), Sep 1, 2010

Research paper thumbnail of W071 Procalcitonin and Routine Biomarkers in the Diagnosis of Maternal and Fetal Inflammatory Response in Pregnant Women with Pprom

International journal of gynaecology and obstetrics, Oct 1, 2012

Research paper thumbnail of Embarazo sin control

Revista Médica del Uruguay, 2012

Introducción: dada la frecuente consulta de pacientes en el Centro Hospitalario Pereira Rossell (... more Introducción: dada la frecuente consulta de pacientes en el Centro Hospitalario Pereira Rossell (CHPR) cursando embarazos no controlados, surge la necesidad de contar con información sobre las razones por las cuales dichas mujeres no se controlan. Objetivo: analizar las características sociales y culturales de las pacientes que llegan al CHPR en trabajo de parto o puerperio inmediato, y que no han controlado sus embarazos, con el fin de determinar las causas que llevan a estas mujeres a no controlarse. Material y método: estudio descriptivo, observacional, analizándose los datos en forma cuantitativa. Se recolectaron datos del total de embarazos sin control entre los días 1º de mayo al 10 de julio de 2009 en el CHPR o referidas al mismo. La muestra fue de 135 pacientes, en un total de 1.576 nacimientos registrados en dicho período, lo que corresponde a 8,6%. Resultados: se analizaron las características sociales y culturales de la población estudiada. Con respecto al análisis de ...

Research paper thumbnail of Importancia de la monitorización electrónica de la frecuencia cardiaca fetal intraparto como predictor de los resultados neonatales

Revista Médica del …, 2008

Research paper thumbnail of W071 Procalcitonin and Routine Biomarkers in the Diagnosis of Maternal and Fetal Inflammatory Response in Pregnant Women with Pprom

International Journal of Gynecology & Obstetrics, 2012

Research paper thumbnail of Carotid-radial pulse wave velocity as an alternative tool for the evaluation of endothelial function during pregnancy: Potential role in identifying hypertensive disorders of pregnancy

Preeclampsia/eclampsia syndrome, a major cause of maternal mortality and morbidity, has been reco... more Preeclampsia/eclampsia syndrome, a major cause of maternal mortality and morbidity, has been recognized as a condition with a globally impaired endothelial function (EF). The possibility of identifying early subclinical endothelial damage during pregnancy could be of value in classifying the different hypertensive states of pregnancy, and have a positive impact in the understanding of this syndrome, as well as on the appropriate treatment of these patients. Reactive hyperemia-related changes in carotid-radial pulse wave velocity (PWVcr) were proposed as an alternative tool for the evaluation of EF in patients with cardiovascular risk factors. If impaired EF, which follows hypertensive disorders of pregnancy can be assessed using PWVcr changes remains still unknown. To assess and compare reactive hyperemia-related changes in PWVcr and FMD in pregnant women (healthy and with hypertensive disorders) and non pregnant women. Healthy pregnant (HP; n=13), preeclamptic (PE; n=7), non-proteinuric hypertensive (NPH; n=6) and non-pregnant (NP; n=32) women were included. Left PWVcr (strain gauge mechano-transducers), left brachial arterial diameter (B-Mode ultrasound) and blood flow velocity (Doppler ultrasound) were measured before (baseline) and after the transient ischemia of the left forearm were determined. One minute after the cuff deflation, PWVcr decreased in HP (6.9 ± 1.5 to 6.0 ± 0.9 m/s, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#60;0.001) and in NP (8.1 ± 0.9 to 7.4 ± 0.9 m/s; p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#60;0.001). NPH showed a blunted hyperemic PWVcr response (6.6 ± 1.4 to 6.7 ± 1.0 m/s; p=0.91), whereas PE showed a tendency to increase (6.0 ± 0.7 to 6.4 ± 0.8 m/s; p=0.10). Reactive hyperemia PWVcr response (ΔPWVcr in %) differed comparing HP with NPH (-12% vs. +2%; p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#60;0.01) and with PE (-12 vs. +6%; p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#60;0.01), whereas no differences were found between NHP and PE (p=1.00). HP showed an enhanced PWVcr reduction, whereas PE and NPH showed a blunted hyperemic PWVcr response. Carotid-radial PWVcr analysis could have a potential role in the assessment of pregnancy to study EF with a potential clinical application in predicting pregnancy induced hypertension and preeclampsia.

Research paper thumbnail of O603 Carotid-Radial Pulse Wave Velocity as an Alternative Tool for the Evaluation of Endothelial Function: Potential Role in Predicting and Classifying Hypertensive Disorders of Pregnancy

International Journal of Gynecology & Obstetrics, 2012

Research paper thumbnail of Opinion on a new and Challenging Tool in Prenatal Counseling: Non invasive Prenatal Testing by Fetal Cell-Free DNA in Maternal Blood

Journal of Health & Medical Informatics

Research paper thumbnail of Comparison between vaginal and sublingual misoprostol 50 µg for cervical ripening prior to induction of labor: randomized clinical trial

Archives of gynecology and obstetrics, Jan 16, 2017

To compare the effectiveness and safety of sublingual versus vaginal misoprostol on improving the... more To compare the effectiveness and safety of sublingual versus vaginal misoprostol on improving the Bishop score after 6 h of administration. Randomized clinical trial which includes pregnant women in gestational ages from 32/0 to 41/6, with indication of induction of labor with misoprostol. Bishop score was assessed at the time of induction and 6 h after administration of 50 µg misoprostol. Analysis was made over difference in mean Bishop score of 2 points, using a standard deviation of 2, with 90% power, reaching a 95% confidence interval. 102 patients were studied, 51 received sublingual misoprostol, and 51 received vaginal misoprostol. There was a statistically significant difference in cervical modifications in global terms regardless of the administration route at 6 h (P < 0.05). When analyzing each group, there was no significant difference for the mean and standard deviation for Bishop score for sublingual and vaginal route (P = 0.761). There was no significant difference i...

Research paper thumbnail of Tratamiento conservador en la hemorragia posparto refractaria al tratamiento médico. Sutura de B-Lynch

Revista Medica Del Uruguay, Sep 1, 2010

Research paper thumbnail of Embarazo sin control: Análisis epidemiológico

Revista Medica Del Uruguay, Jul 1, 2012

Research paper thumbnail of Prevalencia de altas concentraciones de lipoproteína (a) en embarazos complicados con restricción del crecimiento fetal intrauterino

Revista Medica Del Uruguay, Oct 1, 2005

... Ricardo Pou§, Eduardo Storch§, Enrique Pons¶, Justo Alonso¶, Daniela Lens††, Lics. Datevig At... more ... Ricardo Pou§, Eduardo Storch§, Enrique Pons¶, Justo Alonso¶, Daniela Lens††, Lics. Datevig Attarian‡‡, Nora Mota‡‡, Blanca Ceria‡‡, Alicia Ferrari‡‡. ... Blood 2001; 97(4): 981-6. [ Links ]. 32. Caplice NM, Panetta C, Peterson TE, Kleppe LS, Mueske CS, Kostner GM, et al. ...

Research paper thumbnail of Función endotelial y estados hipertensivos del embarazo: Velocidad de la onda del pulso carótido-radial como método alternativo para detectar disfunción endotelial en embarazadas

Revista Uruguaya De Cardiologia, Aug 1, 2013

Research paper thumbnail of Thrombophilia and pregnancy: Guidelines for diagnostic and treatment

Archivos De Medicina Interna, Jul 1, 2011

Research paper thumbnail of Effect of whole-body pH changes on thoracic duct lymph flow in anesthetized sheep

American Journal of Obstetrics and Gynecology, Dec 31, 1989

Research paper thumbnail of Trombofilia y embarazo: Pautas de diagnóstico y tratamiento Trombofilia hereditaria: asociación con etev y complicaciones obstétricas

Archivos De Medicina Interna, Jul 1, 2011

La trombofilia se relaciona con morbimortalidad materno-fetal, fundamentalmente en relación a eve... more La trombofilia se relaciona con morbimortalidad materno-fetal, fundamentalmente en relación a eventos tromboembólicos venosos (ETEV) y arteriales en el período grávido puerperal, así como también con alteraciones obstétricas como PRE, restricción del ...

Research paper thumbnail of Lawrence D. Longo: from chronic fetal hypoxia to proteomic predictors of fetal distress syndrome - a life devoted to research and mentoring based on virtue-ethics

Advances in experimental medicine and biology, 2014

The present chapter presents the experience of the author during his fellowship granted by the Fo... more The present chapter presents the experience of the author during his fellowship granted by the Fogarty Foundation of the NIH in the Division of Perinatal Biology, Loma Linda University, from 1989 to 1991. Experiments on maternal and fetal responses to long-term hypoxemia (including high-altitude) were performed successfully in pregnant sheep and their fetuses.Cardiovascular, hormonal and blood flow distribution responses were studied under a strict experimental protocol. As result of this research, four papers were accepted for publication in major scientific journals, and have served as basis for further research.Most of all, the leadership, virtue-based ethics, perseverance and continuous stimulus of Lawrence D. Longo is presented as an example to follow for future generations.

Research paper thumbnail of Toll receptor 4 Asp299Gly polymorphism and its association with preterm birth and premature rupture of membranes in a South American population

Molecular Human Reproduction, 2008

Research paper thumbnail of Comparison of placental alpha microglobulin-1 in vaginal fluid with intra-amniotic injection of indigo carmine for the diagnosis of rupture of membranes

Journal of Perinatal Medicine, 2000

The purpose of this study was to compare the diagnostic performance of an immunoassay for placent... more The purpose of this study was to compare the diagnostic performance of an immunoassay for placental alpha microglobulin-1 (PAMG-1) in vaginal fluid with the intra-amniotic instillation of indigo carmine for the diagnosis of membrane rupture in patients with an equivocal status.A prospective multi-site study was performed involving women reporting signs, symptoms, or complaints suggestive of rupture of membrane (ROM) between 21 and 42 weeks of gestation without obvious leakage of fluid from the cervical os during sterile speculum examination and without confirmation of ROM by traditional methods.A total of 140 patients were recruited with a prevalence of ROM of 19.3%. The PAMG-1 test had a sensitivity of 100.0% [confidence interval (CI) 0.87–1.0], specificity of 99.1% [(CI) 0.95–0.99], positive predictive value of 96.3% [(CI) 0.82–0.99], negative predictive value of 100.0% [(CI) 0.97–1.0], and ± likelihood ratios of 74.6 [(CI) 20.31–274.51] and 0.0 [(CI) 0.00–0.98].The PAMG-1 immunoa...

Research paper thumbnail of Repeated direct fetal intravascular high-dose immunoglobulin therapy for the treatment of Rh hemolytic disease

Journal of Perinatal Medicine, 1994

Recently, administration of high-dose intravenous immunoglobulin (HDivIG) either to the mother or... more Recently, administration of high-dose intravenous immunoglobulin (HDivIG) either to the mother or the neonate has been proposed in an effort to prevent progressive hemolysis in Rh(D) perinatal disease, but no cases have been published with direct fetal HDivIG administration. We report a case in which HDivIG was repeatedly administered by cordocentesis to a fetus affected by Rh(D) disease from 28 to 36 weeks gestation, at doses of approximately 450 mg/kg. The fetus required no transfusions, and the neonatal evolution was satisfactory. The treatment, performed at three weeks intervals, seemed to be useful in preventing fetal hemolysis. No fetal complications were present. Recurrent administration of HDivIG therapy to the fetus in cases of severe Rh(D) disease, appears to be feasible and free of serious complications to the fetus or the mother.