Sandra Mary Lima Vasconcelos | UFAL - Universidade Federal de Alagoas (original) (raw)
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Papers by Sandra Mary Lima Vasconcelos
International Journal of Cardiovascular Sciences, 2015
Revista de Nutrição, 2010
Ciência & saúde coletiva, 2014
The scope of this study was to review the literature on the methods used to assess the completene... more The scope of this study was to review the literature on the methods used to assess the completeness of the data in health information systems. Searches were conducted in the Medline, SciELO and Lilacs databases using the key words "quality," "data quality," "quality of information" and "information systems." It included articles, dissertations and theses that assessed the fulfillment of variables. In the 19 studies reviewed, the epidemiological rationality systems were the most evaluated (90.5%). Studies on completeness are still scarce (one per year on average). Methods vary from isolated analysis to the evaluation of more than one dimension of quality. The term completeness is the word most used to characterize the fulfillment of variables. The Romero and Cunha score is the most frequent. The SIS databases and Datasus site were the sources and means of access to the most common data. Studies with data from the Southeast of Brazil were predom...
International Journal of Molecular Sciences, 2013
The high prevalence of diabetes mellitus and its increasing incidence worldwide, coupled with sev... more The high prevalence of diabetes mellitus and its increasing incidence worldwide, coupled with several complications observed in its carriers, have become a public health issue of great relevance. Chronic hyperglycemia is the main feature of such a disease, being considered the responsible for the establishment of micro and macrovascular complications observed in diabetes. Several efforts have been directed in order to better OPEN ACCESS Int. J. Mol. Sci. 2013, 14 3266 comprehend the pathophysiological mechanisms involved in the course of this endocrine disease. Recently, numerous authors have suggested that excess generation of highly reactive oxygen and nitrogen species is a key component in the development of complications invoked by hyperglycemia. Overproduction and/or insufficient removal of these reactive species result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids, leading different research groups to search for biomarkers which would be capable of a proper and accurate measurement of the oxidative stress (OS) in diabetic patients, especially in the presence of chronic complications. In the face of this scenario, the present review briefly addresses the role of hyperglycemia in OS, considering basic mechanisms and their effects in diabetes mellitus, describes some of the more commonly used biomarkers of oxidative/nitrosative damage and includes selected examples of studies which evaluated OS biomarkers in patients with diabetes, pointing to the relevance of such biological components in general oxidative stress status of diabetes mellitus carriers.
Revista de Nutrição, 2012
Arquivos brasileiros de cardiologia, 2011
Recent studies describe the participation of reactive oxygen and nitrogen species in hypertension... more Recent studies describe the participation of reactive oxygen and nitrogen species in hypertension. To identify the redox imbalance in the blood of hypertensive. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), vitamin C, transferrin, ceruloplasmin, malondialdehyde (MDA) and carbonyl group were quantified in the blood of 20 hypertensives and 21 controls. The individuals had a Body Mass Index of ≥ 18.5 and ≤ 30 kg/m(2), glycemia ≤ 100 mg/dL, serum cholesterol ≤ 200 mg/dL, and were nonsmokers, non-pregnant and non-lactating women, non-users of alopurinol and probucol, with hypertensives on antihypertensive medication. All individuals underwent a preparatory period of 4 weeks without alcohol, vitamin supplements, dexamethasone and paracetamol. Reduced levels of CAT (p 0.013), GSH (p 0.003) and MDA (p 0.014), and high levels of GPx (p 0.001) and ceruloplasmin (p 0.015) were obtained in the hypertensive group compared with controls. A positive c...
Química Nova, 2007
Recebido em 1/2/06; aceito em 9/1/07; publicado na web em 2/7/07 REACTIVE OXYGEN AND NITROGEN SPE... more Recebido em 1/2/06; aceito em 9/1/07; publicado na web em 2/7/07 REACTIVE OXYGEN AND NITROGEN SPECIES, ANTIOXIDANTS AND MARKERS OF OXIDATIVE DAMAGE IN HUMAN BLOOD: MAIN ANALYTICAL METHODS FOR THEIR DETERMINATION. We review here the chemistry of reactive oxygen and nitrogen species, their biological sources and targets; particularly, biomolecules implicated in the redox balance of the human blood, and appraise the analytical methods available for their detection and quantification. Those biomolecules are represented by the enzymatic antioxidant defense machinery, whereas coadjutant reducing protection is provided by several low molecular weight molecules. Biomolecules can be injured by RONS yielding a large repertoire of oxidized products, some of which can be taken as biomarkers of oxidative damage. Their reliable determination is of utmost interest for their potentiality in diagnosis, prevention and treatment of maladies.
Revista de Nutrição, 2010
RESUMO O café é a bebida mais consumida no Brasil e no mundo ocidental. O fato de ser uma bebida ... more RESUMO O café é a bebida mais consumida no Brasil e no mundo ocidental. O fato de ser uma bebida tão popular, aliado à sua importância econômica, explica o interesse por estudos sobre o café, desde a sua composição até seus efeitos na saúde humana. Dentre ...
Systemic Arterial Hypertension (HAS) is a condition charac- terized by endothelial dysfunction, w... more Systemic Arterial Hypertension (HAS) is a condition charac- terized by endothelial dysfunction, which main role consists on stopping the vase-relaxation caused by the decreased bioactivity of the nitric oxide (NO•) in the vascular wall, due, equally, to the oxidative stress, which represents the oxidative hypothesis of hypertension. Conceptually, the oxidative stress results in an unbalance between the antioxidant and pro-oxidant
International Journal of Cardiovascular Sciences, 2015
Revista de Nutrição, 2010
Ciência & saúde coletiva, 2014
The scope of this study was to review the literature on the methods used to assess the completene... more The scope of this study was to review the literature on the methods used to assess the completeness of the data in health information systems. Searches were conducted in the Medline, SciELO and Lilacs databases using the key words "quality," "data quality," "quality of information" and "information systems." It included articles, dissertations and theses that assessed the fulfillment of variables. In the 19 studies reviewed, the epidemiological rationality systems were the most evaluated (90.5%). Studies on completeness are still scarce (one per year on average). Methods vary from isolated analysis to the evaluation of more than one dimension of quality. The term completeness is the word most used to characterize the fulfillment of variables. The Romero and Cunha score is the most frequent. The SIS databases and Datasus site were the sources and means of access to the most common data. Studies with data from the Southeast of Brazil were predom...
International Journal of Molecular Sciences, 2013
The high prevalence of diabetes mellitus and its increasing incidence worldwide, coupled with sev... more The high prevalence of diabetes mellitus and its increasing incidence worldwide, coupled with several complications observed in its carriers, have become a public health issue of great relevance. Chronic hyperglycemia is the main feature of such a disease, being considered the responsible for the establishment of micro and macrovascular complications observed in diabetes. Several efforts have been directed in order to better OPEN ACCESS Int. J. Mol. Sci. 2013, 14 3266 comprehend the pathophysiological mechanisms involved in the course of this endocrine disease. Recently, numerous authors have suggested that excess generation of highly reactive oxygen and nitrogen species is a key component in the development of complications invoked by hyperglycemia. Overproduction and/or insufficient removal of these reactive species result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids, leading different research groups to search for biomarkers which would be capable of a proper and accurate measurement of the oxidative stress (OS) in diabetic patients, especially in the presence of chronic complications. In the face of this scenario, the present review briefly addresses the role of hyperglycemia in OS, considering basic mechanisms and their effects in diabetes mellitus, describes some of the more commonly used biomarkers of oxidative/nitrosative damage and includes selected examples of studies which evaluated OS biomarkers in patients with diabetes, pointing to the relevance of such biological components in general oxidative stress status of diabetes mellitus carriers.
Revista de Nutrição, 2012
Arquivos brasileiros de cardiologia, 2011
Recent studies describe the participation of reactive oxygen and nitrogen species in hypertension... more Recent studies describe the participation of reactive oxygen and nitrogen species in hypertension. To identify the redox imbalance in the blood of hypertensive. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), vitamin C, transferrin, ceruloplasmin, malondialdehyde (MDA) and carbonyl group were quantified in the blood of 20 hypertensives and 21 controls. The individuals had a Body Mass Index of ≥ 18.5 and ≤ 30 kg/m(2), glycemia ≤ 100 mg/dL, serum cholesterol ≤ 200 mg/dL, and were nonsmokers, non-pregnant and non-lactating women, non-users of alopurinol and probucol, with hypertensives on antihypertensive medication. All individuals underwent a preparatory period of 4 weeks without alcohol, vitamin supplements, dexamethasone and paracetamol. Reduced levels of CAT (p 0.013), GSH (p 0.003) and MDA (p 0.014), and high levels of GPx (p 0.001) and ceruloplasmin (p 0.015) were obtained in the hypertensive group compared with controls. A positive c...
Química Nova, 2007
Recebido em 1/2/06; aceito em 9/1/07; publicado na web em 2/7/07 REACTIVE OXYGEN AND NITROGEN SPE... more Recebido em 1/2/06; aceito em 9/1/07; publicado na web em 2/7/07 REACTIVE OXYGEN AND NITROGEN SPECIES, ANTIOXIDANTS AND MARKERS OF OXIDATIVE DAMAGE IN HUMAN BLOOD: MAIN ANALYTICAL METHODS FOR THEIR DETERMINATION. We review here the chemistry of reactive oxygen and nitrogen species, their biological sources and targets; particularly, biomolecules implicated in the redox balance of the human blood, and appraise the analytical methods available for their detection and quantification. Those biomolecules are represented by the enzymatic antioxidant defense machinery, whereas coadjutant reducing protection is provided by several low molecular weight molecules. Biomolecules can be injured by RONS yielding a large repertoire of oxidized products, some of which can be taken as biomarkers of oxidative damage. Their reliable determination is of utmost interest for their potentiality in diagnosis, prevention and treatment of maladies.
Revista de Nutrição, 2010
RESUMO O café é a bebida mais consumida no Brasil e no mundo ocidental. O fato de ser uma bebida ... more RESUMO O café é a bebida mais consumida no Brasil e no mundo ocidental. O fato de ser uma bebida tão popular, aliado à sua importância econômica, explica o interesse por estudos sobre o café, desde a sua composição até seus efeitos na saúde humana. Dentre ...
Systemic Arterial Hypertension (HAS) is a condition charac- terized by endothelial dysfunction, w... more Systemic Arterial Hypertension (HAS) is a condition charac- terized by endothelial dysfunction, which main role consists on stopping the vase-relaxation caused by the decreased bioactivity of the nitric oxide (NO•) in the vascular wall, due, equally, to the oxidative stress, which represents the oxidative hypothesis of hypertension. Conceptually, the oxidative stress results in an unbalance between the antioxidant and pro-oxidant