Iury Nunes | Universidade Federal do Ceará (original) (raw)

Papers by Iury Nunes

O (-)-mirtenol (MIRT) e um alcool monoterpenico com atividade anti-inflamatoria, antinociceptiva ... more O (-)-mirtenol (MIRT) e um alcool monoterpenico com atividade anti-inflamatoria, antinociceptiva e sedativa. Este estudo avaliou o efeito gastroprotetor do MIRT (25, 50 e 100 mg/kg, v.o.) em modelo de lesoes gastricas induzidas por etanol absoluto (0,2ml/animal, v.o.) e ibuprofeno (400 mg/kg, v.o.) em camundongos Swiss, machos, 25-30g. N-acetilcisteina (NAC, 200 mg/kg, v.o.) ou misoprostol (MISP, 50 µg/kg, v.o.) foram usados como controles positivos. Para elucidar os mecanismos gastroprotetores do MIRT foi investigada a participacao dos canais de KATP, oxido nitrico (NO), malondialdeido (MDA), grupamentos sulfidrilas nao-proteicos (NP-SH), atividade da catalase e da superoxido dismutase (SOD). Um grupo de animais que recebeu o veiculo (2% Tween 80 em agua destilada, 10ml/kg) foi incluido no estudo. Os resultados foram expressos como media ± e.p.m e analisados por ANOVA e teste de Tukey. Projeto aprovado pelo Comite de Etica em Pesquisa Animal (CEPA-UFC) sob o no 18/15. MIRT 25, 50 e...

REVISTA INTERDISCIPLINAR EM CIÊNCIAS DA SAÚDE E BIOLÓGICAS – RICSB, Jan 8, 2020

RESUMO O sono é um estado fisiológico inato e recorrente do ser humano, sendo indispensável para ... more RESUMO O sono é um estado fisiológico inato e recorrente do ser humano, sendo indispensável para garantir a sua qualidade de vida. Disfunções do sono podem afetar o ritmo biológico do indivíduo, implicando em vários agravos a saúde. Nesse contexto, surgem conceitos como a medicalização, buscando sanar este e outros problemas em nossa sociedade contemporânea, atribuindo caráter clínico e/ou medicamentoso aos problemas em questão. Objetivou-se neste estudo investigar na literatura científica fontes e evidências confiáveis, acerca do fenômeno da medicalização dos distúrbios do sono, realizando-se, assim, um apanhado destas informações. Para a elaboração deste estudo incluiu-se as palavras "Distúrbios", "Medicamentos", "Medicalização" e "Sono" nas bases de dados científicos PubMed, ScienceDirect, SciELO e Web of Science. Diante do exposto, foi possível concluir uma investigação na literatura científica, reunindo-se fontes e evidências confiáveis, acerca do fenômeno da medicalização dos distúrbios do sono, realizando-se, assim, um apanhado satisfatório dessas informações.

Journal of Applied Pharmaceutical Science

This study aimed to investigate the antioxidant and immunomodulating activities of ethanolic extr... more This study aimed to investigate the antioxidant and immunomodulating activities of ethanolic extract from the sapwood of Astronium fraxinifolium (EEAF) on Lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The constituents of the EEAF were analyzed by high-performance liquid chromatography (HPLC). Antioxidant activity of EEAF was evaluated by its capacity of inhibiting the production of free radical 2,2'-diphenyl-1-picrylhydrazyl and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid. For the analysis of its immunomodulatory properties, Nitric oxide (NO), tumor necrosis factor alpha (TNF-α), and transforming growth factor beta (TGF-β) levels were determined in supernatants from LPS-stimulated RAW 264.7 cells after treatment with the EEAF at different concentrations. Expression for mRNA of Cyclooxygenase-2 (COX-2) and Inducible nitric oxide synthase (iNOS), and detection of COX-2 protein were also analyzed. Caffeic acid, quercetin, followed by orientin and ρ-coumaric acid, were identified in the extract by the HPLC technique. The EEAF showed poor antioxidant activity when compared to the reference standard. NO, expression of COX-2 mRNA and COX-2 protein were found in high levels when LPS-stimulated cells were treated with the EEAF. Moreover, increased levels of TNF-α and low secretion of TGF-β were demonstrated in supernatants from LPS-stimulated cells treated with EEAF at different concentrations. In opposition to many different types of medicinal plants, the EEAF demonstrated a powerful pro-inflammatory capacity.

The Location Based Social Networks (LBSN) are systems where the user can share the locations he/s... more The Location Based Social Networks (LBSN) are systems where the user can share the locations he/she has visited with his/her friends. These systems have become very popular because of the increasing number of users with smartphones equipped with GPS, which allow them to be connected to the internet wherever they are and geotag their current locations. In this context, the task to recommend new places for the user to visit is very important in order to improve the user experience while using the system. Several recommendation models have been proposed to solve this problem. In all these works, the nal model is a combination of several specialized recommender algorithms, being the most recurrent ones based on social networks, collaborative ltering, and geographic information. Although geographic information is a key dimension in LBSNs, there is no work so far providing an empirical comparison between the existing recommendation algorithms solely based on geographic information. In this paper, besides providing this comparison, we propose a new geographic-aware recommendation algorithm based on a gaussian kernel to infer the regions more likely to be visited by the user. We conduct experiments on real world datasets of two popular LBSNs: Gowalla and Foursquare. Our experiments show that our approach outperforms the state-of-the-art geographic-aware recommenders proposed by the literature.

O (-)-mirtenol (MIRT) e um alcool monoterpenico com atividade anti-inflamatoria, antinociceptiva ... more O (-)-mirtenol (MIRT) e um alcool monoterpenico com atividade anti-inflamatoria, antinociceptiva e sedativa. Este estudo avaliou o efeito gastroprotetor do MIRT (25, 50 e 100 mg/kg, v.o.) em modelo de lesoes gastricas induzidas por etanol absoluto (0,2ml/animal, v.o.) e ibuprofeno (400 mg/kg, v.o.) em camundongos Swiss, machos, 25-30g. N-acetilcisteina (NAC, 200 mg/kg, v.o.) ou misoprostol (MISP, 50 µg/kg, v.o.) foram usados como controles positivos. Para elucidar os mecanismos gastroprotetores do MIRT foi investigada a participacao dos canais de KATP, oxido nitrico (NO), malondialdeido (MDA), grupamentos sulfidrilas nao-proteicos (NP-SH), atividade da catalase e da superoxido dismutase (SOD). Um grupo de animais que recebeu o veiculo (2% Tween 80 em agua destilada, 10ml/kg) foi incluido no estudo. Os resultados foram expressos como media ± e.p.m e analisados por ANOVA e teste de Tukey. Projeto aprovado pelo Comite de Etica em Pesquisa Animal (CEPA-UFC) sob o no 18/15. MIRT 25, 50 e...

REVISTA INTERDISCIPLINAR EM CIÊNCIAS DA SAÚDE E BIOLÓGICAS – RICSB, Jan 8, 2020

RESUMO O sono é um estado fisiológico inato e recorrente do ser humano, sendo indispensável para ... more RESUMO O sono é um estado fisiológico inato e recorrente do ser humano, sendo indispensável para garantir a sua qualidade de vida. Disfunções do sono podem afetar o ritmo biológico do indivíduo, implicando em vários agravos a saúde. Nesse contexto, surgem conceitos como a medicalização, buscando sanar este e outros problemas em nossa sociedade contemporânea, atribuindo caráter clínico e/ou medicamentoso aos problemas em questão. Objetivou-se neste estudo investigar na literatura científica fontes e evidências confiáveis, acerca do fenômeno da medicalização dos distúrbios do sono, realizando-se, assim, um apanhado destas informações. Para a elaboração deste estudo incluiu-se as palavras "Distúrbios", "Medicamentos", "Medicalização" e "Sono" nas bases de dados científicos PubMed, ScienceDirect, SciELO e Web of Science. Diante do exposto, foi possível concluir uma investigação na literatura científica, reunindo-se fontes e evidências confiáveis, acerca do fenômeno da medicalização dos distúrbios do sono, realizando-se, assim, um apanhado satisfatório dessas informações.

Journal of Applied Pharmaceutical Science

This study aimed to investigate the antioxidant and immunomodulating activities of ethanolic extr... more This study aimed to investigate the antioxidant and immunomodulating activities of ethanolic extract from the sapwood of Astronium fraxinifolium (EEAF) on Lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The constituents of the EEAF were analyzed by high-performance liquid chromatography (HPLC). Antioxidant activity of EEAF was evaluated by its capacity of inhibiting the production of free radical 2,2'-diphenyl-1-picrylhydrazyl and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid. For the analysis of its immunomodulatory properties, Nitric oxide (NO), tumor necrosis factor alpha (TNF-α), and transforming growth factor beta (TGF-β) levels were determined in supernatants from LPS-stimulated RAW 264.7 cells after treatment with the EEAF at different concentrations. Expression for mRNA of Cyclooxygenase-2 (COX-2) and Inducible nitric oxide synthase (iNOS), and detection of COX-2 protein were also analyzed. Caffeic acid, quercetin, followed by orientin and ρ-coumaric acid, were identified in the extract by the HPLC technique. The EEAF showed poor antioxidant activity when compared to the reference standard. NO, expression of COX-2 mRNA and COX-2 protein were found in high levels when LPS-stimulated cells were treated with the EEAF. Moreover, increased levels of TNF-α and low secretion of TGF-β were demonstrated in supernatants from LPS-stimulated cells treated with EEAF at different concentrations. In opposition to many different types of medicinal plants, the EEAF demonstrated a powerful pro-inflammatory capacity.

The Location Based Social Networks (LBSN) are systems where the user can share the locations he/s... more The Location Based Social Networks (LBSN) are systems where the user can share the locations he/she has visited with his/her friends. These systems have become very popular because of the increasing number of users with smartphones equipped with GPS, which allow them to be connected to the internet wherever they are and geotag their current locations. In this context, the task to recommend new places for the user to visit is very important in order to improve the user experience while using the system. Several recommendation models have been proposed to solve this problem. In all these works, the nal model is a combination of several specialized recommender algorithms, being the most recurrent ones based on social networks, collaborative ltering, and geographic information. Although geographic information is a key dimension in LBSNs, there is no work so far providing an empirical comparison between the existing recommendation algorithms solely based on geographic information. In this paper, besides providing this comparison, we propose a new geographic-aware recommendation algorithm based on a gaussian kernel to infer the regions more likely to be visited by the user. We conduct experiments on real world datasets of two popular LBSNs: Gowalla and Foursquare. Our experiments show that our approach outperforms the state-of-the-art geographic-aware recommenders proposed by the literature.