Gabriel Escudeiro | UFF - Universidade Federal Fluminense (original) (raw)

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Papers by Gabriel Escudeiro

Research paper thumbnail of Emerging Treatments for Neuropathic Pain

Neuropathic pain is a series of well-known conditions caused by diseases or lesions to the somato... more Neuropathic pain is a series of well-known conditions caused by diseases or lesions to the somato-sensory system. Due to the better understanding of the pathophysiology of neuropathic pain, previously unex-plored therapies have been used with encouraging results. As such, Acetyl-L-carnitine (ALC), Alpha-lipoic-acid (ALA), cannabinoids, Clonidine, EMA401, Botuli-num Toxin type A, and new voltage-gated sodium channel blockers, can be cited. Furthermore, new modalities in neuromodulation such as high-frequency spinal cord stimulation, burst stimulation, dorsal root ganglion stimulation , transcranial direct current stimulation, and many others have been showing exciting results. Besides, changing paradigms may occur with the advent of optogenetics and a better understanding of epigenetic regulation. This article reviews the published literature on the treatment of NP. Despite the interesting results, randomized controlled trials are demanded for the majority of the therapies previously mentioned.

Research paper thumbnail of Emerging Treatments for Neuropathic Pain

Neuropathic pain is a series of well-known conditions caused by diseases or lesions to the somato... more Neuropathic pain is a series of well-known conditions caused by diseases or lesions to the somato-sensory system. Due to the better understanding of the pathophysiology of neuropathic pain, previously unex-plored therapies have been used with encouraging results. As such, Acetyl-L-carnitine (ALC), Alpha-lipoic-acid (ALA), cannabinoids, Clonidine, EMA401, Botuli-num Toxin type A, and new voltage-gated sodium channel blockers, can be cited. Furthermore, new modalities in neuromodulation such as high-frequency spinal cord stimulation, burst stimulation, dorsal root ganglion stimulation , transcranial direct current stimulation, and many others have been showing exciting results. Besides, changing paradigms may occur with the advent of optogenetics and a better understanding of epigenetic regulation. This article reviews the published literature on the treatment of NP. Despite the interesting results, randomized controlled trials are demanded for the majority of the therapies previously mentioned.

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