Blessing Aderibigbe | University of Fort Hare (original) (raw)

Papers by Blessing Aderibigbe

Pharmaceutics, Nov 24, 2023

Polymers, Sep 12, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Handbook of Graphene, Jun 17, 2019

Over the years, many different materials, e.g., titanium (Ti) and its alloys, have been used in b... more Over the years, many different materials, e.g., titanium (Ti) and its alloys, have been used in biomedicine for several purposes. A common application of such materials is seen in their usage as implants. However, quite a number of graphene-based materials have emerged and developed from a two dimensional single atomic thick block of a carbon allotrope, known as graphene. Since the discovery and isolation of graphene from graphite in the year 2004, there has been tremendous positive improvement in health conditions which require treatments that involves the use of implants. Worldwide , this has led to significant attention and appreciation of this versatile material, in biomedicine and obviously, in all fields of science and engineering. Examples of some of the graphene-based materials to be discussed, include: reduced graphene oxide (rGO) and graphite oxide (GO). Although, graphene-based materials are distinguishable by their individual and unique properties, nevertheless, they still have certain characteristics in common. Owing to these properties, possessed by different graphene-based materials, they are able to serve in the biomedical field as implants in order to combat a wide range of diseases that have been a challenge, previously. This chapter elaborates on some different graphenebased materials, in respect to their: structures, synthesis, properties, advantages and disadvantages and the applications of these materials as implants in biomedicine.

Recent Patents on Anti-infective Drug Discovery, Jan 22, 2019

BACKGROUND Carvacrol is the major constituent of essential oils derived from plants. It exhibits ... more BACKGROUND Carvacrol is the major constituent of essential oils derived from plants. It exhibits antimicrobial, antioxidant, anticancer, anti-inflammatory, and anticholinesterase activity. The analogues of carvacrol can be prepared via selected synthetic routes, resulting in potent compounds. OBJECTIVE Modifying carvacrol by the introduction of selected functionalities has the potential to enhance the biological activity of carvacrol. The functionalities on carvacrol such as the hydroxyl group, benzene ring and alkyl groups can be modified or used for hybridization with important pharmaceutical scaffolds. RESULTS In one of the patents cited, EP1053744B1, the modification of the hydroxyl group and the introduction of allyl groups into the benzene ring resulted in carvacrol analogues with antibacterial activity. Modifying the hydroxyl group influenced the hydrophobicity of the analogues and the size of the ring substituent. The hydrophobicity and the size of the ring substituent influence the analogues interactions with bacterial cells. The analogues of carvacrol with anticancer activity were influenced by the position of the substituted groups on the benzene ring. Substituent introduced at the ortho and para- positions resulted in better antitumor activity when compared to the ones with substituents on the meta-position. CONCLUSION Based on several reports on cavarcrol analogues, more research on the development of carvacrol analogues will result in potent compounds that can overcome drug resistance which is currently a challenge in the treatment of diseases, such as bacterial infections, cancer, fungal infections etc. However, more biological evaluation is required in order to fully understand the mode of action of these analogues on selected pathogens.

The Royal Society of Chemistry eBooks, May 22, 2023

Apple Academic Press eBooks, Feb 27, 2022

Journal of Microencapsulation, Jan 2, 2023

Apple Academic Press eBooks, Feb 27, 2022

Pharmaceutics, Feb 25, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Polymer-plastics technology and materials, Jan 25, 2022

ABSTRACT The combination of dopamine with anticancer drugs can result in enhanced anticancer acti... more ABSTRACT The combination of dopamine with anticancer drugs can result in enhanced anticancer activity. Polymer-drug conjugates (PDCs) containing anticancer drugs, such as platinum-based drugs, and doxorubicin together with dopamine were prepared. PDCs were characterized followed by in vitro cytotoxicity studies using pheochromocytoma (PC12) cell lines. The particle size analysis revealed the particles sizes of the PDCs in the range of 15.68–179.8 nm with PDI in the range of 0.373–0.687. T3 and T6 displayed promising cytotoxic effects with IC50 values of 5.25 and 11.56 μg/mL when compared to the free drugs (29.65 μg/mL for K2PtCl4 and 14.96 μg/mL for procaine). The findings revealed that combining dopamine with anticancer drugs is a promising approach to develop effective therapeutics for the treatment of cancer. GRAPHICAL ABSTRACT

Gels horizons: from science to smart materials, 2018

Injectable gels offer several advantages such as minimally invasive, targeted delivery, regenerat... more Injectable gels offer several advantages such as minimally invasive, targeted delivery, regenerate damaged tissues and organs, support cell proliferation and differentiation, and facilitate tissue growth. They are prepared from carbon-based biomaterials such as carbon nanotubes and graphene oxide, natural and synthetic polymers. In the design of injectable gels, the properties of the material used influence their application. Injectable gels have been investigated for delivery of bioactive agents such as anticancer, antimalarials, antihyperglycemic, antiviral, anti-inflammatory, antimicrobial. They are also used for wound dressing and regenerative medicine such as bone regeneration. This chapter will focus on the design and therapeutic efficacy of the currently developed injectable gels.

Polymers

Several factors, such as bacterial infections, underlying conditions, malnutrition, obesity, agei... more Several factors, such as bacterial infections, underlying conditions, malnutrition, obesity, ageing, and smoking are the most common issues that cause a delayed process of wound healing. Developing wound dressings that promote an accelerated wound healing process and skin regeneration is crucial. The properties of wound dressings that make them suitable for the acceleration of the wound healing process include good antibacterial efficacy, excellent biocompatibility, and non-toxicity, the ability to provide a moist environment, stimulating cell migration and adhesion, and providing gaseous permeation. Biopolymers have demonstrated features appropriate for the development of effective wound dressing scaffolds. Gellan gum is one of the biopolymers that has attracted great attention in biomedical applications. The wound dressing materials fabricated from gellan gum possess outstanding properties when compared to traditional dressings, such as good biocompatibility, biodegradability, non...

Antibiotic Materials in Healthcare

Polymeric Biomaterials for Healthcare Applications

Polymeric Biomaterials for Healthcare Applications

Pharmaceutics, Nov 24, 2023

Polymers, Sep 12, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Handbook of Graphene, Jun 17, 2019

Over the years, many different materials, e.g., titanium (Ti) and its alloys, have been used in b... more Over the years, many different materials, e.g., titanium (Ti) and its alloys, have been used in biomedicine for several purposes. A common application of such materials is seen in their usage as implants. However, quite a number of graphene-based materials have emerged and developed from a two dimensional single atomic thick block of a carbon allotrope, known as graphene. Since the discovery and isolation of graphene from graphite in the year 2004, there has been tremendous positive improvement in health conditions which require treatments that involves the use of implants. Worldwide , this has led to significant attention and appreciation of this versatile material, in biomedicine and obviously, in all fields of science and engineering. Examples of some of the graphene-based materials to be discussed, include: reduced graphene oxide (rGO) and graphite oxide (GO). Although, graphene-based materials are distinguishable by their individual and unique properties, nevertheless, they still have certain characteristics in common. Owing to these properties, possessed by different graphene-based materials, they are able to serve in the biomedical field as implants in order to combat a wide range of diseases that have been a challenge, previously. This chapter elaborates on some different graphenebased materials, in respect to their: structures, synthesis, properties, advantages and disadvantages and the applications of these materials as implants in biomedicine.

Recent Patents on Anti-infective Drug Discovery, Jan 22, 2019

BACKGROUND Carvacrol is the major constituent of essential oils derived from plants. It exhibits ... more BACKGROUND Carvacrol is the major constituent of essential oils derived from plants. It exhibits antimicrobial, antioxidant, anticancer, anti-inflammatory, and anticholinesterase activity. The analogues of carvacrol can be prepared via selected synthetic routes, resulting in potent compounds. OBJECTIVE Modifying carvacrol by the introduction of selected functionalities has the potential to enhance the biological activity of carvacrol. The functionalities on carvacrol such as the hydroxyl group, benzene ring and alkyl groups can be modified or used for hybridization with important pharmaceutical scaffolds. RESULTS In one of the patents cited, EP1053744B1, the modification of the hydroxyl group and the introduction of allyl groups into the benzene ring resulted in carvacrol analogues with antibacterial activity. Modifying the hydroxyl group influenced the hydrophobicity of the analogues and the size of the ring substituent. The hydrophobicity and the size of the ring substituent influence the analogues interactions with bacterial cells. The analogues of carvacrol with anticancer activity were influenced by the position of the substituted groups on the benzene ring. Substituent introduced at the ortho and para- positions resulted in better antitumor activity when compared to the ones with substituents on the meta-position. CONCLUSION Based on several reports on cavarcrol analogues, more research on the development of carvacrol analogues will result in potent compounds that can overcome drug resistance which is currently a challenge in the treatment of diseases, such as bacterial infections, cancer, fungal infections etc. However, more biological evaluation is required in order to fully understand the mode of action of these analogues on selected pathogens.

The Royal Society of Chemistry eBooks, May 22, 2023

Apple Academic Press eBooks, Feb 27, 2022

Journal of Microencapsulation, Jan 2, 2023

Apple Academic Press eBooks, Feb 27, 2022

Pharmaceutics, Feb 25, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Polymer-plastics technology and materials, Jan 25, 2022

ABSTRACT The combination of dopamine with anticancer drugs can result in enhanced anticancer acti... more ABSTRACT The combination of dopamine with anticancer drugs can result in enhanced anticancer activity. Polymer-drug conjugates (PDCs) containing anticancer drugs, such as platinum-based drugs, and doxorubicin together with dopamine were prepared. PDCs were characterized followed by in vitro cytotoxicity studies using pheochromocytoma (PC12) cell lines. The particle size analysis revealed the particles sizes of the PDCs in the range of 15.68–179.8 nm with PDI in the range of 0.373–0.687. T3 and T6 displayed promising cytotoxic effects with IC50 values of 5.25 and 11.56 μg/mL when compared to the free drugs (29.65 μg/mL for K2PtCl4 and 14.96 μg/mL for procaine). The findings revealed that combining dopamine with anticancer drugs is a promising approach to develop effective therapeutics for the treatment of cancer. GRAPHICAL ABSTRACT

Gels horizons: from science to smart materials, 2018

Injectable gels offer several advantages such as minimally invasive, targeted delivery, regenerat... more Injectable gels offer several advantages such as minimally invasive, targeted delivery, regenerate damaged tissues and organs, support cell proliferation and differentiation, and facilitate tissue growth. They are prepared from carbon-based biomaterials such as carbon nanotubes and graphene oxide, natural and synthetic polymers. In the design of injectable gels, the properties of the material used influence their application. Injectable gels have been investigated for delivery of bioactive agents such as anticancer, antimalarials, antihyperglycemic, antiviral, anti-inflammatory, antimicrobial. They are also used for wound dressing and regenerative medicine such as bone regeneration. This chapter will focus on the design and therapeutic efficacy of the currently developed injectable gels.

Polymers

Several factors, such as bacterial infections, underlying conditions, malnutrition, obesity, agei... more Several factors, such as bacterial infections, underlying conditions, malnutrition, obesity, ageing, and smoking are the most common issues that cause a delayed process of wound healing. Developing wound dressings that promote an accelerated wound healing process and skin regeneration is crucial. The properties of wound dressings that make them suitable for the acceleration of the wound healing process include good antibacterial efficacy, excellent biocompatibility, and non-toxicity, the ability to provide a moist environment, stimulating cell migration and adhesion, and providing gaseous permeation. Biopolymers have demonstrated features appropriate for the development of effective wound dressing scaffolds. Gellan gum is one of the biopolymers that has attracted great attention in biomedical applications. The wound dressing materials fabricated from gellan gum possess outstanding properties when compared to traditional dressings, such as good biocompatibility, biodegradability, non...

Antibiotic Materials in Healthcare

Polymeric Biomaterials for Healthcare Applications

Polymeric Biomaterials for Healthcare Applications