Isolda Mendes | UFMG - The Federal University of Minas Gerais (original) (raw)

Papers by Isolda Mendes

Journal of Inorganic Biochemistry, Jul 1, 1993

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Polyhedron, 2007

... The crystal structure of N(4)-meta-tolyl-2-acetylpyridine thiosemicarbazone (H2Ac4mT) was det... more ... The crystal structure of N(4)-meta-tolyl-2-acetylpyridine thiosemicarbazone (H2Ac4mT) was determined, as well as that of its copper(II) complex [Cu(2Ac4mT)Cl], which contains an anionic ligand and a chloride in the coordination sphere of the metal. ...

Polyhedron, 2007

N(4)-Methyl-4-nitroacetophenone thiosemicarbazone (H4NO2Ac4M, 1) and its nickel(II) complex ([Ni(... more N(4)-Methyl-4-nitroacetophenone thiosemicarbazone (H4NO2Ac4M, 1) and its nickel(II) complex ([Ni(4NO2Ac4M)2], 2) were obtained and fully characterized. Compound 1 crystallizes in the triclinic P1¯ space group and adopts the 1-E,E configuration in relation to the imino and thioamide groups, respectively. NMR data along with HF/6-31G∗ and DFT/BLYP/6-31G∗ theoretical calculations of energies and of 1H and 13C NMR chemical shifts for the optimized

Microbiological Research, 2010

Memórias do Instituto Oswaldo Cruz, 2013

Journal of the Brazilian Chemical Society, 2006

Journal of Molecular Structure, 2001

... of the formyl thiosemicarbazones are lower than found for the corresponding acetyl analogues,... more ... of the formyl thiosemicarbazones are lower than found for the corresponding acetyl analogues, probably due to a smaller angle between the ... 8. IC Mendes, LR Teixeira, R. Lima, TG Carneiro and H. Beraldo. ... Corresponding Author Contact Information Corresponding author. ...

Journal of Molecular Structure, 2008

... Angelica E. Graminha a , Alzir A. Batista a , Javier Ellena b , Eduardo E. Castellano b , Let... more ... Angelica E. Graminha a , Alzir A. Batista a , Javier Ellena b , Eduardo E. Castellano b , Letícia R. Teixeira c , Corresponding Author Contact Information , E-mail The Corresponding Author , Isolda C. Mendes d and Heloisa Beraldo d. ...

Journal of Molecular Structure, 2012

ABSTRACT In the present work N(3)-meta-chlorophenyl-(HAc3mCl, 1) and N(3)-meta-fluorphenyl-(HAc3m... more ABSTRACT In the present work N(3)-meta-chlorophenyl-(HAc3mCl, 1) and N(3)-meta-fluorphenyl-(HAc3mF, 2) acetophenone thiosemicarbazone, and N(3)-meta-chlorophenyl-(HBz3mCl, 3) and N(3)-meta-fluorphenyl-(HBz3mF, 4) benzophenone thiosemicarbazone were obtained, as well as their zinc(II) complexes [Zn(Ac3mCl)2] (5), [Zn(Ac3mF)2] (6), [Zn(Bz3mCl)2] (7) and [Zn(Bz3mF)2] (8). Upon re-crystallization in DMSO:acetone conversion of 8 into [Zn(Bz3mF)2]·(DMSO) (8a) occurred. The crystal structures of 2, 5 and 8a were determined.

Journal of Inorganic Biochemistry, 2011

Complexes [Au(H2Ac4DH)Cl]∙MeOH (1) [Au(H(2)2Ac4Me)Cl]Cl (2) [Au(H(2)2Ac4Ph)Cl]Cl∙2H(2)O (3) and [... more Complexes [Au(H2Ac4DH)Cl]∙MeOH (1) [Au(H(2)2Ac4Me)Cl]Cl (2) [Au(H(2)2Ac4Ph)Cl]Cl∙2H(2)O (3) and [Au(H(2)2Bz4Ph)Cl]Cl (4) were obtained with 2-acetylpyridine thiosemicarbazone (H2Ac4DH), its N(4)-methyl (H2Ac4Me) and N(4)-phenyl (H2Ac4Ph) derivatives, as well as with N(4)-phenyl 2-benzoylpyridine thiosemicarbazone (H2Bz4Ph). The compounds were cytotoxic to Jurkat (immortalized line of T lymphocyte), HL-60 (acute myeloid leukemia), MCF-7 (human breast adenocarcinoma) and HCT-116 (colorectal carcinoma) tumor cell lines. Jurkat and HL-60 cells were more sensitive than MCF-7 and HCT-116 cells. Upon coordinating to the gold(I) metal centers in complexes (2) and (4), the cytotoxic activity of the H2Ac4Me and H2Bz4Ph ligands increased against the HL-60 and Jurkat tumor cell lines. 2 was more active than auranofin against both leukemia cells. Most of the studied compounds were less toxic than auranofin to peripheral blood mononuclear cells (PBMC). All compounds induced DNA fragmentation in HL-60 and Jurkat cells indicating their pro-apoptotic potential. Complex (2) strongly inhibited the activity of thioredoxin reductase (TrxR), which suggests inhibition of TrxR to be part of its mechanism of action.

Journal of Inorganic Biochemistry, 2009

Inorganica Chimica Acta, 2009

... like activity. Isolda C. Mendes a , Leida M. Botion b , Adaliene VM Ferreira b , Eduardo E. C... more ... like activity. Isolda C. Mendes a , Leida M. Botion b , Adaliene VM Ferreira b , Eduardo E. Castellano c and Heloisa Beraldo a , Corresponding Author Contact Information , E-mail The Corresponding Author. a Departamento de ...