Marta Monteiro | UFPA - Federal University of Pará (original) (raw)

Papers by Marta Monteiro

Revista de Ciências Médicas e Biológicas, 2013

Introdução: Extratos de ervas que são largamente empregadas na culinária têm se tornado comum em... more Introdução: Extratos de ervas que são largamente empregadas na culinária têm se tornado comum em meio à população como opção de cura para as mais diversas doenças. Infusos das partes aéreas, sementes e raízes da Petroselinum crispum (Mill.) Fuss, da família das Apiáceas, mais conhecida como salsa ou salsinha, tem sido utilizado popularmente nos últimos tempos comopotente diurético, laxativo e agente antiinfeccioso das vias urinárias. Objetivos: Os objetivos deste estudo foram determinar, por screening fitoquímico, os principais metabólitos presentes nos extratos aquoso e hidroalcoólico de raízes de P. crispum, determinar o teor de fenólicos totais presentes nesses extratos e avaliar a concentração inibitória mínima dos mesmos frente a Escherichia coli e Staphylococcus aureus por meio de método in vitro. Metodologia: Para tal fim foram utilizadas raízes obtidas na cidade deGuarapuava– PR, coletadas na época do outono, provenientes de sementes de Petroselinum crispum (Mill.) Fuss. Re...

Frontiers in Microbiology, 2019

Translational research : the journal of laboratory and clinical medicine, Jan 15, 2018

Aflatoxin B1 (AFB1) is currently the most commonly studied mycotoxin due to its great toxicity, i... more Aflatoxin B1 (AFB1) is currently the most commonly studied mycotoxin due to its great toxicity, its distribution in a wide variety of foods such as grains and cereals and its involvement in the development of + (hepatocellular carcinoma; HCC). HCC is one of the main types of liver cancer, and has become a serious public health problem, due to its high incidence mainly in Southeast Asia and Africa. Studies show that AFB1 acts in synergy with other risk factors such as hepatitis B and C virus leading to the development of HCC through genetic and epigenetic modifications. The genetic modifications begin in the liver through the biomorphic AFB1, the AFB1-exo-8.9-Epoxy active, which interacts with DNA to form adducts of AFB1-DNA. These adducts induce mutation in codon 249, mediated by a transversion of G-T in the p53 tumor suppressor gene, causing HCC. Thus, this review provides an overview of the evidence for AFB1-induced epigenetic alterations and the potential mechanisms involved in t...

Chemical biology & drug design, Jan 25, 2018

The Penicillin Binding Proteins (PBPs) are important biological target for new antibacterial drug... more The Penicillin Binding Proteins (PBPs) are important biological target for new antibacterial drugs development. This study focused on molecular interaction between cefoxitin and the Escherichia coli PBP5 by molecular dynamics (MD) by using hybrid quantum mechanics/molecular mechanics (QM/MM) simulations approach, searching to develop a computational simulations prototype method on antimicrobial susceptibility of gram-negative bacteria against antibiotics. E. coli ATCC 8739 strain susceptibility for the drugs used in the antimicrobial susceptibility testing and selection of bioactive molecules against resistant strain. The protonation revealed a deprotonate state for His146, His151, His216 and His320 residues. The complex was stabilized after 0.6 ns of MD simulation. The global interaction means for inhibition zone diameters of E. coli ATCC8739 strain and cefoxitin was 24.33 mm no showing significant difference between computational and experimental methods. Our computational simulat...

Journal of translational medicine, Feb 15, 2017

Macrophages and neutrophils are key components involved in the regulation of numerous chronic inf... more Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, and especially certain autoimmune disease. However, little is known regarding the contribution of these cells to the pathogenesis of autoimmune disorders. Recent studies have aimed to clarify certain important factors affecting the immunogenicity of these cells, including the type and dose of antigen, the microenvironment of the cell-antigen encounter, and the number, subset, and phenotype of these cells, which can prevent or induce autoimmune responses. This review highlights the role of macrophage subsets and neutrophils in injured tissues, supporting their cooperation during the pathogenesis of certain autoimmune diseases.

Oxidative Medicine and Cellular Longevity, 2016

Propolis is a resin produced by bees from raw material collected from plants, salivary secretions... more Propolis is a resin produced by bees from raw material collected from plants, salivary secretions, and beeswax. New therapeutic properties for the Central Nervous System have emerged. We explored the neurobehavioral and antioxidant effects of an ethanolic extract of yellow propolis (EEYP) rich in triterpenoids, primarily lupeol andβ-amyrin. Male Wistar rats, 3 months old, were intraperitoneally treated with Tween 5% (control), EEYP (1, 3, 10, and 30 mg/kg), or diazepam, fluoxetine, and caffeine (positive controls) 30 min before the assays. Animals were submitted to open field, elevated plus maze, forced swimming, and inhibitory avoidance tests. After behavioral tasks, blood samples were collected through intracardiac pathway, to evaluate the oxidative balance. The results obtained in the open field and in the elevated plus maze assay showed spontaneous locomotion preserved and anxiolytic-like activity. In the forced swimming test, EEYP demonstrated antidepressant-like activity. In t...

Journal of ethnopharmacology, 2016

Petiveria alliacea L. commonly grows in the tropical regions of the Americas such as the Amazon f... more Petiveria alliacea L. commonly grows in the tropical regions of the Americas such as the Amazon forest, Central America, Caribbean islands and Mexico, as well as specific regions of Africa. Popularly known by several different names including 'mucuracaá', 'guiné' and 'pipi', P. alliacea has been used in traditional medicine for the treatment of various central nervous system (CNS) disorders, such as anxiety, pain, memory deficits and seizures, as well as for its anaesthetic and sedative properties. Furthermore, the use of this species for religious…

Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, Dec 13, 2014

El objetivo del estudio fue evaluar la actividad bactericida de los aceites esenciales y dillapio... more El objetivo del estudio fue evaluar la actividad bactericida de los aceites esenciales y dillapiole de P. aduncum contra cepas estandar y multirresistentes de Staphylococcus spp . El aceite mostro accion antimicrobiana frente a estas cepas, pero se obtuvo mejores resultados para las cepas de S. epidermidis y S. aureus , con MIC de 250 y 500 μg/ml, respectivamente. Dillapiolle fue menos eficaz que el aceite contra cepas estandar y multirresistentes (MIC = 1000 μg/ml). Sin embargo, cuando dillapiolle fue probado en combinacion con la miristicina, otro componente del aceite, que aumento su actividad bactericida y mostro una accion sinergica.

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

The study aimed to evaluate the bactericidal activity of oil essential and dillapiole from P. adu... more The study aimed to evaluate the bactericidal activity of oil essential and dillapiole from P. aduncum against standard and multidrug-resistant strains of Staphylococcus spp. The oil showed antimicrobial action against these strains, but better results were obtained for the standards strains of S. epidermidis and S. aureus, with MIC of 250 and 500 μg/mL, respectively. Dillapiolle was less effective than the oil against the same standard and multi-drug resistant strains (MIC =1000 μg/mL). However, when dillapiolle was tested in combination with myristicin, another component of the oil, it increased its bactericidal activity and showed a synergistic action.

Journal of Molecular Modeling, 2015

An electronic study of nimesulide was performed by using density functional theory calculations. ... more An electronic study of nimesulide was performed by using density functional theory calculations. The activities of the six different derivatives were related with electron donating or accepting capacities. All compounds which had nitro moiety had low electron donating and high electron accepting capacities. However, the reduced derivative of nimesulide have more electron donating capacity than other compounds. The highest spin density contribution in nitro and lowest spin density contribution on phenoxyl moieties can be related with preferential metabolism by reduction when compared with the oxidation. The redox behavior between nitro and amino groups can be related with anti-inflammatory mechanism of nimesulide. These results explain the redox influence of nitro moiety on biological metabolism and mechanism of nimesulide.

Advances in Life Sciences, 2012

The purpose of this work was to assess the antimicrobial activity of ext racts from Urera baccife... more The purpose of this work was to assess the antimicrobial activity of ext racts from Urera baccifera. Aqueous, ethanol and methanol extracts made fro m the leaves, bark and roots of U. baccifera were tested, at different concentrations using the disk diffusion method, against the bacteria Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). Inoculated plates were incubated at 35º C ± 1 C for 24 hours and the inhibition halos were assessed and interpreted. The methanol ext racts fro m the leaves (ML) and roots (MR) had greatest antimicrobial activity against the three bacteria tested. The MICs of the ML and MR extracts against E. coli were 6.25 and 0.19 mg/L, respectively, and against P. aeruginosa and S. aureus they were 3.12 and 0.19 mg/ L (for both species). The results show that the methanol ext racts of the leaves and roots of U. baccifera are antimicrobially active against E. coli, P. aeruginosa and S. aureus.

Revista da Sociedade Brasileira de Medicina Tropical, 2007

Este trabalho teve como objetivo detectar os casos novos de hanseníase do período de 1998 a 2005 ... more Este trabalho teve como objetivo detectar os casos novos de hanseníase do período de 1998 a 2005 no município de Prudentópolis, PR. Assim como, verificar a faixa etária e a forma clínica predominante entre os casos de hanseníase. Os dados foram obtidos através das fichas clínico-epidemiológicas de casos com diagnóstico definitivo de hanseníase notificado no Sistema de Informação sobre Agravos de Notificação, de 1998 a 2005. Neste período, foram relatados 222 casos de hanseníase, dos quais 63% apresentavam a forma multibacilar, com predominância da forma clínica virchowiana, indicando um processo de intensa transmissão da doença. Dos casos de hanseníase, 35% dos pacientes se encontravam na faixa economicamente ativa, 31 a 45 anos. Esses indicadores apontam para uma elevada circulação do bacilo na comunidade, já que um fator de risco para infecção pelo bacilo Mycobacterium Leprae é o contato com pacientes com a forma multibacilar, sem tratamento, embora nas duas últimas décadas, tenha...

Journal of the Brazilian Chemical Society, 2014

Dapsona é uma sulfona sintética que é utilizada como um antibiótico em seres humanos e animais pa... more Dapsona é uma sulfona sintética que é utilizada como um antibiótico em seres humanos e animais para prevenir e tratar doenças, incluindo hanseníase, tuberculose, malária, e pneumonia por Pneumocystis carinii e encefalites por Toxoplasma gondii em pacientes com síndrome da imunodeficiência adquirida (AIDS), bem como em doenças anti-inflamatórias como dermatite herpetiforme. No entanto, este fármaco também está associado com vários efeitos adversos, incluindo a hemólise relacionada com a dose, metemoglobinemia, psicose, neuropatia periférica, agranulocitose, anemia aplástica, síndrome de hipersensibilidade, síndrome de sulfona, e outros. Destes efeitos, a metemoglobinemia é o mais comum efeito adverso da dapsona, que leva a anemia funcional e hipóxia celular com sintomas de cianose, dores de cabeça, fadiga, taquicardia, fraqueza e tonturas. Assim, esta revisão sumariza informações relevantes sobre a estrutura, mecanismo de ação, indicação clínica, e reações adversas de dapsona. Dapsone is a synthetic sulfone that is used as an antibiotic in humans and animals to prevent and treat diseases including leprosy, tuberculosis, malaria, and Pneumocystis carinii pneumonia and Toxoplasma gondii encephalitis in acquired immune deficiency syndrome (AIDS) patients as well as in anti-inflammatory conditions, such as dermatitis herpetiformis. However, this drug is also associated with several adverse effects, including dose-related hemolysis, methemoglobinemia, psychosis, peripheral neuropathy, agranulocytosis, aplastic anemia, hypersensitivity syndrome, sulfone syndrome, and others. Of these effects, methemoglobinemia is the most common side effect of dapsone, which leads to functional anemia and cellular hypoxia with symptoms of cyanosis, headache, fatigue, tachycardia, weakness, and dizziness. Thus, this review summarizes relevant information on the structure, mechanism of action, clinical indication, and adverse reactions of dapsone.

Journal of Food Quality, 2013

Journal of Computational and Theoretical Nanoscience, 2013

Quantum chemical calculations at the B3LYP level of theory, together with the 6-31G ∗ basis sets,... more Quantum chemical calculations at the B3LYP level of theory, together with the 6-31G ∗ basis sets, were employed to obtain electronic properties of the dapsone and related derivatives in order to study their methemoglobinemia mechanism. The electronic properties such as HOMO, LUMO, ionization potential, MEPs, and spin densities were correlated to redox properties of the compounds studied. The results show that the amine linked to the aniline moiety at the para-position is the main contributor to methemoglobin property. The sulfone moiety is responsible for the electron transition between both aniline rings. The lowest ionization potential is related with the increase of methemoglobinemia.

Journal of Computational and Theoretical Nanoscience, 2011

Quantum mechanical calculations at the B3LYP theory level, together with the 6-31G * basis set, w... more Quantum mechanical calculations at the B3LYP theory level, together with the 6-31G * basis set, were employed to obtain the energy, HOMO, LUMO, MEPs, and charge of dapsone is compared with others derivatives. Conformational analysis using density functional calculations show that symmetric conformational isomer has low energy than asymmetric conformational isomer. The symmetry level was observed by molecular charge analysis. Its redox properties by electrons transfer are dependent of amine and sulphone moieties. Our results explain the oxidation mechanism of dapsone by electron transfer.

Chemical Biology & Drug Design, 2013

This theoretical and experimental study describes the design and evaluation of the free-radical s... more This theoretical and experimental study describes the design and evaluation of the free-radical scavenging effect for the molecular association of 4-aminophenol and salicylate derivatives. For this purpose, we employed theoretical methods for the selection of antioxidant drugs and the rapid methods of evaluation: the 1,1-diphenyl-2-picrylhydrazyl radical and the thiobarbituric acid reactive substances in the lipid peroxidation initiated by Fe(2+) and ascorbic acid in human erythrocytes. The associate derivatives exhibited a more potent inhibition than the salicylic acid, while the benzoyl compound exhibited a more potent inhibition than paracetamol. The molecular parameters related to the electron distribution and structure (ionization potential and energy of the highest occupied molecular orbital) correlated very well with the antioxidant action of the compounds studied here in different tests.

Biochemistry, 1986

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Revista de Ciências Médicas e Biológicas, 2013

Introdução: Extratos de ervas que são largamente empregadas na culinária têm se tornado comum em... more Introdução: Extratos de ervas que são largamente empregadas na culinária têm se tornado comum em meio à população como opção de cura para as mais diversas doenças. Infusos das partes aéreas, sementes e raízes da Petroselinum crispum (Mill.) Fuss, da família das Apiáceas, mais conhecida como salsa ou salsinha, tem sido utilizado popularmente nos últimos tempos comopotente diurético, laxativo e agente antiinfeccioso das vias urinárias. Objetivos: Os objetivos deste estudo foram determinar, por screening fitoquímico, os principais metabólitos presentes nos extratos aquoso e hidroalcoólico de raízes de P. crispum, determinar o teor de fenólicos totais presentes nesses extratos e avaliar a concentração inibitória mínima dos mesmos frente a Escherichia coli e Staphylococcus aureus por meio de método in vitro. Metodologia: Para tal fim foram utilizadas raízes obtidas na cidade deGuarapuava– PR, coletadas na época do outono, provenientes de sementes de Petroselinum crispum (Mill.) Fuss. Re...

Frontiers in Microbiology, 2019

Translational research : the journal of laboratory and clinical medicine, Jan 15, 2018

Aflatoxin B1 (AFB1) is currently the most commonly studied mycotoxin due to its great toxicity, i... more Aflatoxin B1 (AFB1) is currently the most commonly studied mycotoxin due to its great toxicity, its distribution in a wide variety of foods such as grains and cereals and its involvement in the development of + (hepatocellular carcinoma; HCC). HCC is one of the main types of liver cancer, and has become a serious public health problem, due to its high incidence mainly in Southeast Asia and Africa. Studies show that AFB1 acts in synergy with other risk factors such as hepatitis B and C virus leading to the development of HCC through genetic and epigenetic modifications. The genetic modifications begin in the liver through the biomorphic AFB1, the AFB1-exo-8.9-Epoxy active, which interacts with DNA to form adducts of AFB1-DNA. These adducts induce mutation in codon 249, mediated by a transversion of G-T in the p53 tumor suppressor gene, causing HCC. Thus, this review provides an overview of the evidence for AFB1-induced epigenetic alterations and the potential mechanisms involved in t...

Chemical biology & drug design, Jan 25, 2018

The Penicillin Binding Proteins (PBPs) are important biological target for new antibacterial drug... more The Penicillin Binding Proteins (PBPs) are important biological target for new antibacterial drugs development. This study focused on molecular interaction between cefoxitin and the Escherichia coli PBP5 by molecular dynamics (MD) by using hybrid quantum mechanics/molecular mechanics (QM/MM) simulations approach, searching to develop a computational simulations prototype method on antimicrobial susceptibility of gram-negative bacteria against antibiotics. E. coli ATCC 8739 strain susceptibility for the drugs used in the antimicrobial susceptibility testing and selection of bioactive molecules against resistant strain. The protonation revealed a deprotonate state for His146, His151, His216 and His320 residues. The complex was stabilized after 0.6 ns of MD simulation. The global interaction means for inhibition zone diameters of E. coli ATCC8739 strain and cefoxitin was 24.33 mm no showing significant difference between computational and experimental methods. Our computational simulat...

Journal of translational medicine, Feb 15, 2017

Macrophages and neutrophils are key components involved in the regulation of numerous chronic inf... more Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, and especially certain autoimmune disease. However, little is known regarding the contribution of these cells to the pathogenesis of autoimmune disorders. Recent studies have aimed to clarify certain important factors affecting the immunogenicity of these cells, including the type and dose of antigen, the microenvironment of the cell-antigen encounter, and the number, subset, and phenotype of these cells, which can prevent or induce autoimmune responses. This review highlights the role of macrophage subsets and neutrophils in injured tissues, supporting their cooperation during the pathogenesis of certain autoimmune diseases.

Oxidative Medicine and Cellular Longevity, 2016

Propolis is a resin produced by bees from raw material collected from plants, salivary secretions... more Propolis is a resin produced by bees from raw material collected from plants, salivary secretions, and beeswax. New therapeutic properties for the Central Nervous System have emerged. We explored the neurobehavioral and antioxidant effects of an ethanolic extract of yellow propolis (EEYP) rich in triterpenoids, primarily lupeol andβ-amyrin. Male Wistar rats, 3 months old, were intraperitoneally treated with Tween 5% (control), EEYP (1, 3, 10, and 30 mg/kg), or diazepam, fluoxetine, and caffeine (positive controls) 30 min before the assays. Animals were submitted to open field, elevated plus maze, forced swimming, and inhibitory avoidance tests. After behavioral tasks, blood samples were collected through intracardiac pathway, to evaluate the oxidative balance. The results obtained in the open field and in the elevated plus maze assay showed spontaneous locomotion preserved and anxiolytic-like activity. In the forced swimming test, EEYP demonstrated antidepressant-like activity. In t...

Journal of ethnopharmacology, 2016

Petiveria alliacea L. commonly grows in the tropical regions of the Americas such as the Amazon f... more Petiveria alliacea L. commonly grows in the tropical regions of the Americas such as the Amazon forest, Central America, Caribbean islands and Mexico, as well as specific regions of Africa. Popularly known by several different names including 'mucuracaá', 'guiné' and 'pipi', P. alliacea has been used in traditional medicine for the treatment of various central nervous system (CNS) disorders, such as anxiety, pain, memory deficits and seizures, as well as for its anaesthetic and sedative properties. Furthermore, the use of this species for religious…

Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, Dec 13, 2014

El objetivo del estudio fue evaluar la actividad bactericida de los aceites esenciales y dillapio... more El objetivo del estudio fue evaluar la actividad bactericida de los aceites esenciales y dillapiole de P. aduncum contra cepas estandar y multirresistentes de Staphylococcus spp . El aceite mostro accion antimicrobiana frente a estas cepas, pero se obtuvo mejores resultados para las cepas de S. epidermidis y S. aureus , con MIC de 250 y 500 μg/ml, respectivamente. Dillapiolle fue menos eficaz que el aceite contra cepas estandar y multirresistentes (MIC = 1000 μg/ml). Sin embargo, cuando dillapiolle fue probado en combinacion con la miristicina, otro componente del aceite, que aumento su actividad bactericida y mostro una accion sinergica.

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

The study aimed to evaluate the bactericidal activity of oil essential and dillapiole from P. adu... more The study aimed to evaluate the bactericidal activity of oil essential and dillapiole from P. aduncum against standard and multidrug-resistant strains of Staphylococcus spp. The oil showed antimicrobial action against these strains, but better results were obtained for the standards strains of S. epidermidis and S. aureus, with MIC of 250 and 500 μg/mL, respectively. Dillapiolle was less effective than the oil against the same standard and multi-drug resistant strains (MIC =1000 μg/mL). However, when dillapiolle was tested in combination with myristicin, another component of the oil, it increased its bactericidal activity and showed a synergistic action.

Journal of Molecular Modeling, 2015

An electronic study of nimesulide was performed by using density functional theory calculations. ... more An electronic study of nimesulide was performed by using density functional theory calculations. The activities of the six different derivatives were related with electron donating or accepting capacities. All compounds which had nitro moiety had low electron donating and high electron accepting capacities. However, the reduced derivative of nimesulide have more electron donating capacity than other compounds. The highest spin density contribution in nitro and lowest spin density contribution on phenoxyl moieties can be related with preferential metabolism by reduction when compared with the oxidation. The redox behavior between nitro and amino groups can be related with anti-inflammatory mechanism of nimesulide. These results explain the redox influence of nitro moiety on biological metabolism and mechanism of nimesulide.

Advances in Life Sciences, 2012

The purpose of this work was to assess the antimicrobial activity of ext racts from Urera baccife... more The purpose of this work was to assess the antimicrobial activity of ext racts from Urera baccifera. Aqueous, ethanol and methanol extracts made fro m the leaves, bark and roots of U. baccifera were tested, at different concentrations using the disk diffusion method, against the bacteria Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). Inoculated plates were incubated at 35º C ± 1 C for 24 hours and the inhibition halos were assessed and interpreted. The methanol ext racts fro m the leaves (ML) and roots (MR) had greatest antimicrobial activity against the three bacteria tested. The MICs of the ML and MR extracts against E. coli were 6.25 and 0.19 mg/L, respectively, and against P. aeruginosa and S. aureus they were 3.12 and 0.19 mg/ L (for both species). The results show that the methanol ext racts of the leaves and roots of U. baccifera are antimicrobially active against E. coli, P. aeruginosa and S. aureus.

Revista da Sociedade Brasileira de Medicina Tropical, 2007

Este trabalho teve como objetivo detectar os casos novos de hanseníase do período de 1998 a 2005 ... more Este trabalho teve como objetivo detectar os casos novos de hanseníase do período de 1998 a 2005 no município de Prudentópolis, PR. Assim como, verificar a faixa etária e a forma clínica predominante entre os casos de hanseníase. Os dados foram obtidos através das fichas clínico-epidemiológicas de casos com diagnóstico definitivo de hanseníase notificado no Sistema de Informação sobre Agravos de Notificação, de 1998 a 2005. Neste período, foram relatados 222 casos de hanseníase, dos quais 63% apresentavam a forma multibacilar, com predominância da forma clínica virchowiana, indicando um processo de intensa transmissão da doença. Dos casos de hanseníase, 35% dos pacientes se encontravam na faixa economicamente ativa, 31 a 45 anos. Esses indicadores apontam para uma elevada circulação do bacilo na comunidade, já que um fator de risco para infecção pelo bacilo Mycobacterium Leprae é o contato com pacientes com a forma multibacilar, sem tratamento, embora nas duas últimas décadas, tenha...

Journal of the Brazilian Chemical Society, 2014

Dapsona é uma sulfona sintética que é utilizada como um antibiótico em seres humanos e animais pa... more Dapsona é uma sulfona sintética que é utilizada como um antibiótico em seres humanos e animais para prevenir e tratar doenças, incluindo hanseníase, tuberculose, malária, e pneumonia por Pneumocystis carinii e encefalites por Toxoplasma gondii em pacientes com síndrome da imunodeficiência adquirida (AIDS), bem como em doenças anti-inflamatórias como dermatite herpetiforme. No entanto, este fármaco também está associado com vários efeitos adversos, incluindo a hemólise relacionada com a dose, metemoglobinemia, psicose, neuropatia periférica, agranulocitose, anemia aplástica, síndrome de hipersensibilidade, síndrome de sulfona, e outros. Destes efeitos, a metemoglobinemia é o mais comum efeito adverso da dapsona, que leva a anemia funcional e hipóxia celular com sintomas de cianose, dores de cabeça, fadiga, taquicardia, fraqueza e tonturas. Assim, esta revisão sumariza informações relevantes sobre a estrutura, mecanismo de ação, indicação clínica, e reações adversas de dapsona. Dapsone is a synthetic sulfone that is used as an antibiotic in humans and animals to prevent and treat diseases including leprosy, tuberculosis, malaria, and Pneumocystis carinii pneumonia and Toxoplasma gondii encephalitis in acquired immune deficiency syndrome (AIDS) patients as well as in anti-inflammatory conditions, such as dermatitis herpetiformis. However, this drug is also associated with several adverse effects, including dose-related hemolysis, methemoglobinemia, psychosis, peripheral neuropathy, agranulocytosis, aplastic anemia, hypersensitivity syndrome, sulfone syndrome, and others. Of these effects, methemoglobinemia is the most common side effect of dapsone, which leads to functional anemia and cellular hypoxia with symptoms of cyanosis, headache, fatigue, tachycardia, weakness, and dizziness. Thus, this review summarizes relevant information on the structure, mechanism of action, clinical indication, and adverse reactions of dapsone.

Journal of Food Quality, 2013

Journal of Computational and Theoretical Nanoscience, 2013

Quantum chemical calculations at the B3LYP level of theory, together with the 6-31G ∗ basis sets,... more Quantum chemical calculations at the B3LYP level of theory, together with the 6-31G ∗ basis sets, were employed to obtain electronic properties of the dapsone and related derivatives in order to study their methemoglobinemia mechanism. The electronic properties such as HOMO, LUMO, ionization potential, MEPs, and spin densities were correlated to redox properties of the compounds studied. The results show that the amine linked to the aniline moiety at the para-position is the main contributor to methemoglobin property. The sulfone moiety is responsible for the electron transition between both aniline rings. The lowest ionization potential is related with the increase of methemoglobinemia.

Journal of Computational and Theoretical Nanoscience, 2011

Quantum mechanical calculations at the B3LYP theory level, together with the 6-31G * basis set, w... more Quantum mechanical calculations at the B3LYP theory level, together with the 6-31G * basis set, were employed to obtain the energy, HOMO, LUMO, MEPs, and charge of dapsone is compared with others derivatives. Conformational analysis using density functional calculations show that symmetric conformational isomer has low energy than asymmetric conformational isomer. The symmetry level was observed by molecular charge analysis. Its redox properties by electrons transfer are dependent of amine and sulphone moieties. Our results explain the oxidation mechanism of dapsone by electron transfer.

Chemical Biology & Drug Design, 2013

This theoretical and experimental study describes the design and evaluation of the free-radical s... more This theoretical and experimental study describes the design and evaluation of the free-radical scavenging effect for the molecular association of 4-aminophenol and salicylate derivatives. For this purpose, we employed theoretical methods for the selection of antioxidant drugs and the rapid methods of evaluation: the 1,1-diphenyl-2-picrylhydrazyl radical and the thiobarbituric acid reactive substances in the lipid peroxidation initiated by Fe(2+) and ascorbic acid in human erythrocytes. The associate derivatives exhibited a more potent inhibition than the salicylic acid, while the benzoyl compound exhibited a more potent inhibition than paracetamol. The molecular parameters related to the electron distribution and structure (ionization potential and energy of the highest occupied molecular orbital) correlated very well with the antioxidant action of the compounds studied here in different tests.

Biochemistry, 1986

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Sepsis is one of the main causes of ICU hospitalization worldwide, with a high mortality rate, an... more Sepsis is one of the main causes of ICU hospitalization worldwide, with a high mortality rate, and is associated with a large number of comorbidities. One of the main comorbidities associated with sepsis is septic cardiomyopathy. This process occurs mainly due to mechanisms of damage in the cardiovascular system that will lead to changes in cardiovascular physiology, such as decreased Ca2+ response, mitochondrial dysfunction and decreased β-adrenergic receptor response. Within this process the exosomes play an important role in the pathophysiology of this disease, in which the exosomal content is related to mechanisms that will trigger its development. After platelet activation through ROS exposition, exosomes containing high concentrations of NADPH are released in heart blood vessels, those exosomes will be internalized in endothelial cells leading to cell death and cardiac dysfunction. On the opposite, exosomes derived from mesenchymal stem cells contain miR-223, that have anti-inflammatory properties, are released in less quantities in septic patients causing an imbalance that leads to cardiac dysfunction.

Alcohol-induced brain disorders have been reported for many decades. Ethanol (EtOH) presents amph... more Alcohol-induced brain disorders have been reported for many decades. Ethanol (EtOH) presents amphiphilicity properties that permit the fluidibility across the biological barriers. The EtOH kinetics depends on the gender and age that elicit different brain susceptibility damage. The exact mechanisms that underlie such central nervous system (CNS) disruption due to EtOH is not well understood; however, neuroinflammation, oxidative stress, and neurotransmitter system disorder processes may play a role. Therefore, the principal CNS effects described are anxiety, depression, motor disorder, and cognitive impairment after chronic ethanol exposure. This chapter summarizes many of the alcohol kinetics differences, the possible mechanisms of CNS damage, the main behavioral/CNS function, and the structures affected by chronic alcohol exposure.