Marcos Dias | UFPB - Universidade Federal da Paraíba (original) (raw)
Papers by Marcos Dias
PloS one, 2015
A class of small non-coding RNAs, the microRNAs (miRNAs), has been shown to be essential for the ... more A class of small non-coding RNAs, the microRNAs (miRNAs), has been shown to be essential for the regulation of specific cell pathways, including skeletal muscle development, maintenance and homeostasis in vertebrates. However, the relative contribution of miRNAs for determining the red and white muscle cell phenotypes is far from being fully comprehended. To better characterize the role of miRNA in skeletal muscle cell biology, we investigated muscle-specific miRNA (myomiR) signatures in Nile tilapia fish. Quantitative (RT-qPCR) and spatial (FISH) expression analyses revealed a highly differential expression (forty-four-fold) of miR-499 in red skeletal muscle compared to white skeletal muscle, whereas the remaining known myomiRs were equally expressed in both muscle cell types. Detailed examination of the miR-499 targets through bioinformatics led us to the sox6 and rod1 genes, which had low expression in red muscle cells according to RT-qPCR, FISH, and protein immunofluorescence pr...
BMC Evolutionary Biology, 2014
Background: MicroRNAs (miRNAs) are small non-coding RNA molecules with an important role upon pos... more Background: MicroRNAs (miRNAs) are small non-coding RNA molecules with an important role upon post-transcriptional regulation. These molecules have been shown essential for several cellular processes in vertebrates, including muscle biology. Many miRNAs were described as exclusively or highly expressed in skeletal and/or cardiac muscle. However, knowledge on the genomic organization and evolution of muscle miRNAs has been unveiled in a reduced number of vertebrates and mostly only reflects their organization in mammals, whereas fish genomes remain largely uncharted. The main goal of this study was to elucidate particular features in the genomic organization and the putative evolutionary history of muscle miRNAs through a genome-wide comparative analysis of cartilaginous and bony fish genomes.
Reproductive Health, 2016
Cesarean section (CS) rates are increasing worldwide but there is some concern with this trend be... more Cesarean section (CS) rates are increasing worldwide but there is some concern with this trend because of potential maternal and perinatal risks. The Robson classification is the standard method to monitor and compare CS rates. Our objective was to analyze CS rates in Brazil according to source of payment for childbirth (public or private) using the Robson classification. Data are from the 2011-2012 "Birth in Brazil" study, which used a national hospital-based sample of 23,940 women. We categorized all women into Robson groups and reported the relative size of each Robson group, the CS rate in each group and the absolute and relative contributions made by each to the overall CS rate. Differences were analyzed through chi-square and Z-test with a significance level of < 0.05. The overall CS rate in Brazil was 51.9 % (42.9 % in the public and 87.9 % in the private health sector). The Robson groups with the highest impact on Brazil's CS rate in both public and private sectors were group 2 (nulliparous, term, cephalic with induced or cesarean delivery before labor), group 5 (multiparous, term, cephalic presentation and previous cesarean section) and group 10 (cephalic preterm pregnancies), which accounted for more than 70 % of CS carried out in the country. High-risk women had significantly greater CS rates compared with low-risk women in almost all Robson groups in the public sector only. Public policies should be directed at reducing CS in nulliparous women, particularly by reducing the number of elective CS in these women, and encouraging vaginal birth after cesarean to reduce repeat CS in multiparous women.
Reproductive Health, 2016
The rate of preterm birth has been increasing worldwide, including in Brazil. This constitutes a ... more The rate of preterm birth has been increasing worldwide, including in Brazil. This constitutes a significant public health challenge because of the higher levels of morbidity and mortality and long-term health effects associated with preterm birth. This study describes and quantifies factors affecting spontaneous and provider-initiated preterm birth in Brazil. Data are from the 2011-2012 "Birth in Brazil" study, which used a national population-based sample of 23,940 women. We analyzed the variables following a three-level hierarchical methodology. For each level, we performed non-conditional multiple logistic regression for both spontaneous and provider-initiated preterm birth. The rate of preterm birth was 11.5 % , (95 % confidence 10.3 % to 12.9 %) 60.7 % spontaneous - with spontaneous onset of labor or premature preterm rupture of membranes - and 39.3 % provider-initiated, with more than 90 % of the last group being pre-labor cesarean deliveries. Socio-demographic factors associated with spontaneous preterm birth were adolescent pregnancy, low total years of schooling, and inadequate prenatal care. Other risk factors were previous preterm birth (OR 3.74; 95 % CI 2.92-4.79), multiple pregnancy (OR 16.42; 95 % CI 10.56-25.53), abruptio placentae (OR 2.38; 95 % CI 1.27-4.47) and infections (OR 4.89; 95 % CI 1.72-13.88). In contrast, provider-initiated preterm birth was associated with private childbirth healthcare (OR 1.47; 95 % CI 1.09-1.97), advanced-age pregnancy (OR 1.27; 95 % CI 1.01-1.59), two or more prior cesarean deliveries (OR 1.64; 95 % CI 1.19-2.26), multiple pregnancy (OR 20.29; 95 % CI 12.58-32.72) and any maternal or fetal pathology (OR 6.84; 95 % CI 5.56-8.42). The high proportion of provider-initiated preterm birth and its association with prior cesarean deliveries and all of the studied maternal/fetal pathologies suggest that a reduction of this type of prematurity may be possible. The association of spontaneous preterm birth with socially-disadvantaged groups reaffirms that the reduction of social and health inequalities should continue to be a national priority.
Obstetricia Y Ginecologia Espanola, 1991
Cadernos De Saude Publica, 2014
Polymers Polymer Composites, 2003
International Journal of Polymer Analysis and Characterization, Jan 16, 2009
Blends of the commercial biodegradable polymer poly(hydroxybutyrate) (PHB) with an oligomeric pol... more Blends of the commercial biodegradable polymer poly(hydroxybutyrate) (PHB) with an oligomeric polyester such as poly(ethylene isophythalate) (PEIP) were prepared in the molten state. PEIP was synthesized by bulk condensation polymerization using two types of catalysts. The occurrence of transesterification reaction during the blend processing using samarium acetilacetonate as catalyst was evaluated. The behavior of the blends was investigated by hydrogen nuclear magnetic resonance (H NMR), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC). The results show that PHB/PEIP blends are immiscible under the applied conditions, but a significant degradation of PHB occurs by the effects of time and temperature of processing.
Nutrients, 2016
Yacon (Smallanthus sonchifolius), a perennial plant of the family Asteraceae native to the Andean... more Yacon (Smallanthus sonchifolius), a perennial plant of the family Asteraceae native to the Andean regions of South America, is an abundant source of fructooligosaccharides (FOS). This comprehensive review of the literature addressed the role of yacon supplementation in promoting health and reducing the risk of chronic diseases. According to several preclinical and clinical trials, FOS intake favors the growth of health-promoting bacteria while reducing pathogenic bacteria populations. Moreover, the endproducts of FOS fermentation by the intestinal microbiota, short chain fatty acids (SCFA), act as substrates or signaling molecules in the regulation of the immune response, glucose homeostasis and lipid metabolism. As a result, glycemic levels, body weight and colon cancer risk can be reduced. Based on these findings, most studies reviewed concluded that due to their functional properties, yacon roots may be effectively used as a dietary supplement to prevent and treat chronic diseases.
Polimeros, 2006
Resumo: A aplicação de estruturas tridimensionais bio-reabsorvíveis como suporte temporário na en... more Resumo: A aplicação de estruturas tridimensionais bio-reabsorvíveis como suporte temporário na engenharia de tecidos tem crescido nos últimos anos. Neste estudo, estruturas porosas de poli(3-hidroxibutirato) (P(3HB)) foram preparadas pelo método de vazamento e lixiviação de partículas. As amostras foram obtidas pela adição de cloreto de sódio em concentrações de 50, 60, 70, 80 e 90% p/p, a uma solução de
Zeitschrift Fur Naturforschung B a Journal of Chemical Sciences, 2003
Revista Brasileira De Epidemiologia, Dec 1, 2013
Revista Brasileira De Sementes, 2010
Materials Research Innovations, Apr 30, 2001
Page 1. Mat Res Innovat (2001) 4:360364 © Springer-Verlag 2001 Abstract Blends of polypropylene ... more Page 1. Mat Res Innovat (2001) 4:360364 © Springer-Verlag 2001 Abstract Blends of polypropylene (PP) and β-oligo-pinene, a synthetic low molar mass resin, were prepared by melt mixing in a Haake Rheocord at 473 K, 30 ...
Acta Scientiarum Biological Sciences, 2009
Polymer Bulletin, 1996
The abnormal behavior of acrylonitrile polymers shown by size exclusion chromatography (SEC) in N... more The abnormal behavior of acrylonitrile polymers shown by size exclusion chromatography (SEC) in N,N-dimethylformamide (DMF) was investigated by using model polymers having variable degrees of sulfonated moieties as electric charged groups. The unexpected small retention volume and very high UV absorption at 280 um were observed in the case of the samples with ionic sulfonate groups even in very small amounts, as chain ends. The abnormal behavior was confirmed to be due to impurities of DMF decomposition which interact with charged groups in the polymers.
Materials Research Innovations, 2005
Microporous and Mesoporous Materials, May 1, 2014
In this report we attempt to synthesize materials resistant to dehydration by exploiting the inte... more In this report we attempt to synthesize materials resistant to dehydration by exploiting the interaction of sulfonate groups with the hydrophilic surfaces of the inner pore walls of mesoporous titanium oxides to form channels for proton conduction. Thus, six mesoporous titanium oxide composites of naphthalene sulfonate formaldehyde (NSF) were synthesised, fully characterised and formed into pellets for potentiostatic impedance measurements. The most promising sample, a NSF composite of mesoporous TiO 2 (mTiO 2 ), displays a proton conductivity of 1.837 mS cm À1 at 100°C surpassing that of a pellet of Nafion 117 constructed as a reference under the same conditions (1.143 mS cm À1 ). This material also has greater conductivity than pure hydrated NSF (0.122 mS cm À1 ), confirming a synergistic interaction between the NSF and the oxide mesostructure in the proton conductivity mechanism. Both 1 H and 13 C solid state NMR studies of the NSF material and the mTiO 2 -NSF composites demonstrate that the oligomeric nature of the NSF is preserved while in contact with the mTiO 2 surface, thus facilitating conductivity.
PloS one, 2015
A class of small non-coding RNAs, the microRNAs (miRNAs), has been shown to be essential for the ... more A class of small non-coding RNAs, the microRNAs (miRNAs), has been shown to be essential for the regulation of specific cell pathways, including skeletal muscle development, maintenance and homeostasis in vertebrates. However, the relative contribution of miRNAs for determining the red and white muscle cell phenotypes is far from being fully comprehended. To better characterize the role of miRNA in skeletal muscle cell biology, we investigated muscle-specific miRNA (myomiR) signatures in Nile tilapia fish. Quantitative (RT-qPCR) and spatial (FISH) expression analyses revealed a highly differential expression (forty-four-fold) of miR-499 in red skeletal muscle compared to white skeletal muscle, whereas the remaining known myomiRs were equally expressed in both muscle cell types. Detailed examination of the miR-499 targets through bioinformatics led us to the sox6 and rod1 genes, which had low expression in red muscle cells according to RT-qPCR, FISH, and protein immunofluorescence pr...
BMC Evolutionary Biology, 2014
Background: MicroRNAs (miRNAs) are small non-coding RNA molecules with an important role upon pos... more Background: MicroRNAs (miRNAs) are small non-coding RNA molecules with an important role upon post-transcriptional regulation. These molecules have been shown essential for several cellular processes in vertebrates, including muscle biology. Many miRNAs were described as exclusively or highly expressed in skeletal and/or cardiac muscle. However, knowledge on the genomic organization and evolution of muscle miRNAs has been unveiled in a reduced number of vertebrates and mostly only reflects their organization in mammals, whereas fish genomes remain largely uncharted. The main goal of this study was to elucidate particular features in the genomic organization and the putative evolutionary history of muscle miRNAs through a genome-wide comparative analysis of cartilaginous and bony fish genomes.
Reproductive Health, 2016
Cesarean section (CS) rates are increasing worldwide but there is some concern with this trend be... more Cesarean section (CS) rates are increasing worldwide but there is some concern with this trend because of potential maternal and perinatal risks. The Robson classification is the standard method to monitor and compare CS rates. Our objective was to analyze CS rates in Brazil according to source of payment for childbirth (public or private) using the Robson classification. Data are from the 2011-2012 "Birth in Brazil" study, which used a national hospital-based sample of 23,940 women. We categorized all women into Robson groups and reported the relative size of each Robson group, the CS rate in each group and the absolute and relative contributions made by each to the overall CS rate. Differences were analyzed through chi-square and Z-test with a significance level of < 0.05. The overall CS rate in Brazil was 51.9 % (42.9 % in the public and 87.9 % in the private health sector). The Robson groups with the highest impact on Brazil's CS rate in both public and private sectors were group 2 (nulliparous, term, cephalic with induced or cesarean delivery before labor), group 5 (multiparous, term, cephalic presentation and previous cesarean section) and group 10 (cephalic preterm pregnancies), which accounted for more than 70 % of CS carried out in the country. High-risk women had significantly greater CS rates compared with low-risk women in almost all Robson groups in the public sector only. Public policies should be directed at reducing CS in nulliparous women, particularly by reducing the number of elective CS in these women, and encouraging vaginal birth after cesarean to reduce repeat CS in multiparous women.
Reproductive Health, 2016
The rate of preterm birth has been increasing worldwide, including in Brazil. This constitutes a ... more The rate of preterm birth has been increasing worldwide, including in Brazil. This constitutes a significant public health challenge because of the higher levels of morbidity and mortality and long-term health effects associated with preterm birth. This study describes and quantifies factors affecting spontaneous and provider-initiated preterm birth in Brazil. Data are from the 2011-2012 "Birth in Brazil" study, which used a national population-based sample of 23,940 women. We analyzed the variables following a three-level hierarchical methodology. For each level, we performed non-conditional multiple logistic regression for both spontaneous and provider-initiated preterm birth. The rate of preterm birth was 11.5 % , (95 % confidence 10.3 % to 12.9 %) 60.7 % spontaneous - with spontaneous onset of labor or premature preterm rupture of membranes - and 39.3 % provider-initiated, with more than 90 % of the last group being pre-labor cesarean deliveries. Socio-demographic factors associated with spontaneous preterm birth were adolescent pregnancy, low total years of schooling, and inadequate prenatal care. Other risk factors were previous preterm birth (OR 3.74; 95 % CI 2.92-4.79), multiple pregnancy (OR 16.42; 95 % CI 10.56-25.53), abruptio placentae (OR 2.38; 95 % CI 1.27-4.47) and infections (OR 4.89; 95 % CI 1.72-13.88). In contrast, provider-initiated preterm birth was associated with private childbirth healthcare (OR 1.47; 95 % CI 1.09-1.97), advanced-age pregnancy (OR 1.27; 95 % CI 1.01-1.59), two or more prior cesarean deliveries (OR 1.64; 95 % CI 1.19-2.26), multiple pregnancy (OR 20.29; 95 % CI 12.58-32.72) and any maternal or fetal pathology (OR 6.84; 95 % CI 5.56-8.42). The high proportion of provider-initiated preterm birth and its association with prior cesarean deliveries and all of the studied maternal/fetal pathologies suggest that a reduction of this type of prematurity may be possible. The association of spontaneous preterm birth with socially-disadvantaged groups reaffirms that the reduction of social and health inequalities should continue to be a national priority.
Obstetricia Y Ginecologia Espanola, 1991
Cadernos De Saude Publica, 2014
Polymers Polymer Composites, 2003
International Journal of Polymer Analysis and Characterization, Jan 16, 2009
Blends of the commercial biodegradable polymer poly(hydroxybutyrate) (PHB) with an oligomeric pol... more Blends of the commercial biodegradable polymer poly(hydroxybutyrate) (PHB) with an oligomeric polyester such as poly(ethylene isophythalate) (PEIP) were prepared in the molten state. PEIP was synthesized by bulk condensation polymerization using two types of catalysts. The occurrence of transesterification reaction during the blend processing using samarium acetilacetonate as catalyst was evaluated. The behavior of the blends was investigated by hydrogen nuclear magnetic resonance (H NMR), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC). The results show that PHB/PEIP blends are immiscible under the applied conditions, but a significant degradation of PHB occurs by the effects of time and temperature of processing.
Nutrients, 2016
Yacon (Smallanthus sonchifolius), a perennial plant of the family Asteraceae native to the Andean... more Yacon (Smallanthus sonchifolius), a perennial plant of the family Asteraceae native to the Andean regions of South America, is an abundant source of fructooligosaccharides (FOS). This comprehensive review of the literature addressed the role of yacon supplementation in promoting health and reducing the risk of chronic diseases. According to several preclinical and clinical trials, FOS intake favors the growth of health-promoting bacteria while reducing pathogenic bacteria populations. Moreover, the endproducts of FOS fermentation by the intestinal microbiota, short chain fatty acids (SCFA), act as substrates or signaling molecules in the regulation of the immune response, glucose homeostasis and lipid metabolism. As a result, glycemic levels, body weight and colon cancer risk can be reduced. Based on these findings, most studies reviewed concluded that due to their functional properties, yacon roots may be effectively used as a dietary supplement to prevent and treat chronic diseases.
Polimeros, 2006
Resumo: A aplicação de estruturas tridimensionais bio-reabsorvíveis como suporte temporário na en... more Resumo: A aplicação de estruturas tridimensionais bio-reabsorvíveis como suporte temporário na engenharia de tecidos tem crescido nos últimos anos. Neste estudo, estruturas porosas de poli(3-hidroxibutirato) (P(3HB)) foram preparadas pelo método de vazamento e lixiviação de partículas. As amostras foram obtidas pela adição de cloreto de sódio em concentrações de 50, 60, 70, 80 e 90% p/p, a uma solução de
Zeitschrift Fur Naturforschung B a Journal of Chemical Sciences, 2003
Revista Brasileira De Epidemiologia, Dec 1, 2013
Revista Brasileira De Sementes, 2010
Materials Research Innovations, Apr 30, 2001
Page 1. Mat Res Innovat (2001) 4:360364 © Springer-Verlag 2001 Abstract Blends of polypropylene ... more Page 1. Mat Res Innovat (2001) 4:360364 © Springer-Verlag 2001 Abstract Blends of polypropylene (PP) and β-oligo-pinene, a synthetic low molar mass resin, were prepared by melt mixing in a Haake Rheocord at 473 K, 30 ...
Acta Scientiarum Biological Sciences, 2009
Polymer Bulletin, 1996
The abnormal behavior of acrylonitrile polymers shown by size exclusion chromatography (SEC) in N... more The abnormal behavior of acrylonitrile polymers shown by size exclusion chromatography (SEC) in N,N-dimethylformamide (DMF) was investigated by using model polymers having variable degrees of sulfonated moieties as electric charged groups. The unexpected small retention volume and very high UV absorption at 280 um were observed in the case of the samples with ionic sulfonate groups even in very small amounts, as chain ends. The abnormal behavior was confirmed to be due to impurities of DMF decomposition which interact with charged groups in the polymers.
Materials Research Innovations, 2005
Microporous and Mesoporous Materials, May 1, 2014
In this report we attempt to synthesize materials resistant to dehydration by exploiting the inte... more In this report we attempt to synthesize materials resistant to dehydration by exploiting the interaction of sulfonate groups with the hydrophilic surfaces of the inner pore walls of mesoporous titanium oxides to form channels for proton conduction. Thus, six mesoporous titanium oxide composites of naphthalene sulfonate formaldehyde (NSF) were synthesised, fully characterised and formed into pellets for potentiostatic impedance measurements. The most promising sample, a NSF composite of mesoporous TiO 2 (mTiO 2 ), displays a proton conductivity of 1.837 mS cm À1 at 100°C surpassing that of a pellet of Nafion 117 constructed as a reference under the same conditions (1.143 mS cm À1 ). This material also has greater conductivity than pure hydrated NSF (0.122 mS cm À1 ), confirming a synergistic interaction between the NSF and the oxide mesostructure in the proton conductivity mechanism. Both 1 H and 13 C solid state NMR studies of the NSF material and the mTiO 2 -NSF composites demonstrate that the oligomeric nature of the NSF is preserved while in contact with the mTiO 2 surface, thus facilitating conductivity.