Paulo Belmonte-de-Abreu | Universidade Federal do Rio Grande do Sul (original) (raw)

Papers by Paulo Belmonte-de-Abreu

Revista Brasileira de Terapia Comportamental e Cognitiva, 1969

O Transtorno de Ansiedade Obsessivo-Compulsivo (TOC) e o Transtorno da Personalidade Obsessivo-Co... more O Transtorno de Ansiedade Obsessivo-Compulsivo (TOC) e o Transtorno da Personalidade Obsessivo-Compulsiva (TPOC) mostram congruências conceituais que historicamente têm confundido o diagnóstico de muitos pesquisadores e clínicos. Em parte, as ambigüidades provavelmente ocorrem devido aos equívocos muitas vezes apresentados pelos instrumentos diagnósticos e também pelo despreparo profissional. A outra fração de erros certamente acontece devido à grande semelhança entre os fenômenos comportamentais. Pela pertinência clínica que o questionamento traz, faz-se mister um aprofundamento teórico. O objetivo deste ensaio foi analisar, sob os pressupostos do behaviorismo radical, o caso de uma cliente atendida durante o estágio clínico. A partir da análise, lançou-se a hipótese sobre a existência de uma semelhança entre as variáveis operantes nos comportamentos obsessivo-compulsivos de ambos os transtornos. Concluiu-se que a semelhança fenomenológica ocorre não pelas topografias comportamenta...

Molecular Psychiatry, 2006

Revista de Psiquiatria do Rio Grande do Sul, 2009

Não há confl itos de interesse associados à publicação desta carta.

Revista De Psiquiatria Do Rio Grande Do Sul, 2006

Estudos têm evidenciado o alto risco de osteoporose em pacientes esquizofrênicos. Alguns estudos ... more Estudos têm evidenciado o alto risco de osteoporose em pacientes esquizofrênicos. Alguns estudos têm demonstrado que os neurolépticos típicos e a risperidona podem induzir a osteoporose ou reduzir a densidade mineral óssea. Isso pode ser atribuído ao fato de estas drogas, em uso prolongado, induzirem a hiperprolactinemia a níveis acima do normal, em ambos os sexos, e a baixa dos níveis de estrogênio e de testosterona, aumentando o risco para osteopenia/osteoporose. Neste relato, será apresentado um caso de osteopenia em uma paciente mulher de 53 anos, em uso de antipsicóticos há 30 anos, sendo comentados os procedimentos recomendados para detecção dessa ocorrência e as diretrizes existentes para seu manejo.

International Clinical Psychopharmacology

The present study sought to assess biomarkers of inflammation in stable patients with schizophren... more The present study sought to assess biomarkers of inflammation in stable patients with schizophrenia (SZ) on clozapine therapy. We recruited 60 outpatients with SZ and 60 healthy controls, matched for sex and age. Compared with controls, patients had significantly increased concentrations of interleukin-6 and tumor necrosis factor-α. Interestingly, patients on simvastatin had lower interleukin-6 levels compared with patients not on simvastatin and controls. This study corroborated previous evidence for increased inflammatory biomarkers in SZ and detected a potential anti-inflammatory action of simvastatin in patients with a clinical diagnosis of SZ on clozapine therapy.

International Journal of Psychiatry in Clinical Practice, 2016

To assess the relationship between posture and inflammatory response markers (C-reactive protein ... more To assess the relationship between posture and inflammatory response markers (C-reactive protein [CRP] and von Willebrand factor [vWF]) in schizophrenics. Forty patients with stable schizophrenia were divided into early-stage (&amp;amp;amp;lt;10 years since first episode, n = 15) and late-stage (≥10 years since first episode, n = 25) groups. Both groups were compared to controls (n = 26). All participants underwent postural assessment by biophotogrammetry. Cases alone underwent blood collection. The significance level was set at 5%, and analyses were carried out in SPSS 18.0. In the early-stage group, 15 postural angles were significantly different from their reference ranges, whereas in the late-stage group, only seven angles were significantly different. In comparison with the control group, only six angles were significantly different. There was no difference in inflammation markers between the early- and late-stage groups. However, CRP levels were higher in cases with greater disease severity, and vWF was associated with forward head posture. Pain correlated with five postural angles, and late-stage patients reported more pain than early-stage cases. CRP was associated with disease severity, while vWF and pain were associated with forward head posture, hyperlordosis and scoliosis, suggesting an association between vascular inflammation and pain, with an influence on posture.

Frontiers in psychiatry, 2016

Schizophrenia (SZ) is associated with psychotic experiences and cognitive deficits. Therefore, co... more Schizophrenia (SZ) is associated with psychotic experiences and cognitive deficits. Therefore, cognitive function is one of the most critical determinants of quality of life in this pathology. Resveratrol has been related to neuroprotective action, but there are no studies evaluating resveratrol in SZ. The objective of this study was to determine the efficacy of resveratrol supplementation on cognition in individuals with SZ. This is a 1-month randomized, double-blind, and controlled trial (NCT 02062190), in which 19 men with diagnosis of SZ, aged 18-65 years, were assigned to a resveratrol supplementation group (200 mg) or placebo group (200 mg), with a 1-month follow-up. Applying a series of cognitive tests assessed neuropsychology performance (Hopkins Verbal Learning Test, Stroop Color and Word Test, and Weschler Adult Intelligence Scale) and Brief Psychiatric Rating Scale assessed psychopathology severity. There were no significant improvement in neuropsychology performance (epi...

Frontiers in Psychiatry, 2016

Rev Abp Apal, Jun 1, 1988

Revista Brasileira de Psiquiatria, 2016

Objective: To evaluate trends in psychiatric bed occupancy by elderly inpatients in the Brazilian... more Objective: To evaluate trends in psychiatric bed occupancy by elderly inpatients in the Brazilian public health care system between 2000 and 2010 and to determine the leading psychiatric diagnosis for hospital admissions. Methods: Data from all 895,476 elderly psychiatric admissions recorded in the Brazilian Public Health Care Database (DATASUS) between January 2000 and February 2010 were analyzed. Polynomial regression models with estimated curve models were used to determine the trends. The number of inpatient days was calculated for the overall psychiatric admissions and according to specific diagnoses. Results: A moderate decreasing trend (p o 0.001) in the number of inpatient days was observed in all geriatric psychiatric admissions (R 2 = 0.768) and in admissions for organic mental disorders (R 2 = 0.823), disorders due to psychoactive substance use (R 2 = 0.767), schizophrenia (R 2 = 0.680), and other diagnoses (R 2 = 0.770), but not for mood disorders (R 2 = 0.472). Most admissions (60 to 65%) were due to schizophrenia. Conclusion: There was a decreasing trend in inpatient days for elderly psychiatric patients between 2000 and 2010. The highest bed occupancy was due to schizophrenia, schizotypal, and delusional disorders.

Psychiatry research, Aug 24, 2016

In patients with schizophrenia, obsessive-compulsive symptoms (OCS) are associated with lower rat... more In patients with schizophrenia, obsessive-compulsive symptoms (OCS) are associated with lower rates of quality of life and polypharmacy. No previous controlled studies have tested the efficacy of repetitive transcranial magnetic stimulation (rTMS) on the treatment of OCS in this population. The present study examined the therapeutic effects of rTMS applied to the supplementary motor area (1Hz, 20min, 20 sessions) on OCS and general symptoms in patients with schizophrenia or schizoaffective disorder, and whether this intervention can produce changes in plasma levels of brain derived neurotrophic factor (BDNF). A double-blind randomized controlled trial was conducted. Active and sham rTMS were delivered to 12 patients (6 on each group). Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and Brief Psychiatric Rating Scale (BPRS) scores, as well as BDNF levels, were assessed before, after, and 4 weeks after treatment. rTMS did not significantly change the outcomes after treatment and on the...

Trends in psychiatry and psychotherapy, 2016

Objective To describe the case of a patient with schizophrenia on clozapine treatment who had an ... more Objective To describe the case of a patient with schizophrenia on clozapine treatment who had an episode of heat stroke. Case description During a heat wave in January and February 2014, a patient with schizophrenia who was on treatment with clozapine was initially referred for differential diagnose between systemic infection and neuroleptic malignant syndrome, but was finally diagnosed with heat stroke and treated with control of body temperature and hydration. Comments This report aims to alert clinicians take this condition into consideration among other differential diagnoses, especially nowadays with the rise in global temperatures, and to highlight the need for accurate diagnosis of clinical events during pharmacological intervention, in order to improve treatment decisions and outcomes.

Nutrients, 2016

Background: Patients with schizophrenia (SZ) are generally overweight or obese and have several m... more Background: Patients with schizophrenia (SZ) are generally overweight or obese and have several metabolic disorders. Additionally, such patients have a lower life expectancy and the main cause of their increased mortality is cardiovascular disease (CVD). The objective of this study was to determine the efficacy of resveratrol supplementation on serum glucose and CVD risk factors in individuals with SZ. Methods and Results: This is a four-week randomized, double-blind controlled trial (registration No.: NCT 02062190) in which 19 men with a diagnosis of SZ, aged 18 to 65, were assigned to either a resveratrol supplement group (200 mg/day) or a placebo group (200 mg/day). In short, we did not observe significant changes after resveratrol supplementation. In the placebo group, we found a significant increase in total cholesterol levels (p = 0.024) and in LDL-cholesterol (p = 0.002), as well as a decrease in body fat percentage (p = 0.038). The placebo group also showed an increase in triglycerides (9.19%) and a reduction in HDL-cholesterol (4.88%). In the resveratrol group, triglycerides decreased (7.64%). Conclusion: In summary, oral resveratrol in reasonably low dosages (200 mg daily) brought no differences to body weight, waist circumference, glucose, and total cholesterol. It was possible to note that the lipid profile in the placebo group worsened and, although no significant differences were found, we can assume that resveratrol might prevent lipid profile damage and that the intervention affected the lipoprotein metabolism at various levels.

International Neuropsychiatric Disease Journal, 2016

Revista De Psiquiatria Do Rio Grande Do Sul, 2005

Revista Brasileira De Terapia Comportamental E Cognitiva, Nov 2, 2014