Rosemari T Oliveira | Universidade Federal do Rio Grande do Sul (original) (raw)

Papers by Rosemari T Oliveira

Research paper thumbnail of Ressecção Cirúrgica Associada À Quimioterapia Adjuvante No Tratamento De Leiomiossarcoma Intestinal Felino

Research paper thumbnail of Electrochemical therapy to treat cancer (in vivo treatment)

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2007

The aim of this paper is to present the evaluations and results attained by our research group fr... more The aim of this paper is to present the evaluations and results attained by our research group from the clinical applications of Electrochemical Therapy (EChT in short) on tumors, specifically of cats and dogs. Our in vivo results indicate that EChT is an effective cancer treatment. Application of EChT in human beings was approved by National Health Surveillance Agency, which is linked to the Brazilian Ministry of Health. To make EChT available for cancer patients in the Brazil, basic studies were conducted and a Phase I clinical trial was started.

Research paper thumbnail of Uso do 5Fluorouracil associado à cirurgia como terapêutica para o carcinoma de células escamosas em cães 5Fluorouracil associated to surgery as a therapy for squamous cell carcinoma in dogs

The squamous cell carcinoma is a malignant neoplasm of epidermal origin. The 5-fluorouracil is an... more The squamous cell carcinoma is a malignant neoplasm of epidermal origin. The 5-fluorouracil is an anticancer agent commonly administered by parenteral route, and its topical use in humans is also described. This paper reports two cases of squamous cell carcinoma in dogs that presented ventral nodes in the abdominal region. In both cases the animals were submitted to neoadjuvant antineoplastic

Research paper thumbnail of Cervical tumoral calcinosis in dog

Calcinosis circumscripta or tumoral calcinosis is an ectopic mineralization that presents itself ... more Calcinosis circumscripta or tumoral calcinosis is an ectopic mineralization that presents itself in the form of calcium deposit in soft tissues and can be disclosed in many species. Some authors recommend to use the term tumoral calcinosis when deposition of calcium salts occur in the periarticular tissue and calcinosis circumscripta when it happens in t he subcutaneous tissue. It can

Research paper thumbnail of Adenomatose pulmonar ("jaagsiekte") em ovino no Rio Grande de Sul

Research paper thumbnail of Sex reversal in Nile tilapia (Oreochromis niloticus) using a nonsteroidal aromatase inhibitor

Journal of Experimental Zoology, 2001

Several studies have demonstrated that steroid hormones can influence sex differentiation in nonm... more Several studies have demonstrated that steroid hormones can influence sex differentiation in nonmammalian vertebrates and it has been hypothesized that male and female sex differentiation are driven by androgen and estrogen hormones, respectively. Estrogen biosynthesis is mediated by the steroidogenic enzyme cytochrome P450 aromatase, which converts androgens to estrogens. In the present study we examined the efficacy of a potent nonsteroidal aromatase inhibitor incorporated into the food, on sex reversal of Nile tilapia (Oreochromis niloticus) larvae. Nile tilapia larvae were divided in seven groups, which were fed with diets containing different amounts of the aromatase inhibitor Fadrozole (0, 50, 75 and 100 mg/kg) during 15 and 30 days, starting 9 days after hatching. Independent of the period, the proportion of males was significantly higher in the treated groups. Treatment with the highest doses (75 and 100 mg/kg) for 30 days produced 100% males. Histological examination revealed no differences in gonadal tissues between control males and treated fish. Furthermore, one intersex fish was identified in the group treated with 50 mg Fadrozole/kg for 30 days. This study reports that a 100% Nile tilapia male population can be obtained by suppressing aromatase activity and suggests that besides steroid hormones, nonsteroidal compounds, such as aromatase inhibitors, have potential for production of monosex population in tilapia.

Research paper thumbnail of Pre- and postnatal toxicity of the commercial glyphosate formulation in Wistar rats

Archives of Toxicology, 2007

Glyphosate is the active ingredient and polyoxyethyleneamine is the surfactant present in the her... more Glyphosate is the active ingredient and polyoxyethyleneamine is the surfactant present in the herbicide Roundup formulation commercialized in Brazil. The aim of this study was to assess the reproductive effects of glyphosate-Roundup on male and female offspring of Wistar rats exposed during pregnancy and lactation. Dams were treated orally with water or 50, 150 or 450 mg/kg glyphosate during pregnancy (21-23 days) and lactation (21 days). These doses do not correspond to human exposure levels. The results showed that glyphosate-Roundup did not induce maternal toxicity but induced adverse reproductive effects on male offspring rats: a decrease in sperm number per epididymis tail and in daily sperm production during adulthood, an increase in the percentage of abnormal sperms and a dose-related decrease in the serum testosterone level at puberty, and signs of individual spermatid degeneration during both periods. There was only a vaginal canal-opening delay in the exposed female offspring. These findings suggest that in utero and lactational exposure to glyphosate-Roundup may induce significant adverse effects on the reproductive system of male Wistar rats at puberty and during adulthood.

Research paper thumbnail of Ressecção Cirúrgica Associada À Quimioterapia Adjuvante No Tratamento De Leiomiossarcoma Intestinal Felino

Research paper thumbnail of Electrochemical therapy to treat cancer (in vivo treatment)

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2007

The aim of this paper is to present the evaluations and results attained by our research group fr... more The aim of this paper is to present the evaluations and results attained by our research group from the clinical applications of Electrochemical Therapy (EChT in short) on tumors, specifically of cats and dogs. Our in vivo results indicate that EChT is an effective cancer treatment. Application of EChT in human beings was approved by National Health Surveillance Agency, which is linked to the Brazilian Ministry of Health. To make EChT available for cancer patients in the Brazil, basic studies were conducted and a Phase I clinical trial was started.

Research paper thumbnail of Uso do 5Fluorouracil associado à cirurgia como terapêutica para o carcinoma de células escamosas em cães 5Fluorouracil associated to surgery as a therapy for squamous cell carcinoma in dogs

The squamous cell carcinoma is a malignant neoplasm of epidermal origin. The 5-fluorouracil is an... more The squamous cell carcinoma is a malignant neoplasm of epidermal origin. The 5-fluorouracil is an anticancer agent commonly administered by parenteral route, and its topical use in humans is also described. This paper reports two cases of squamous cell carcinoma in dogs that presented ventral nodes in the abdominal region. In both cases the animals were submitted to neoadjuvant antineoplastic

Research paper thumbnail of Cervical tumoral calcinosis in dog

Calcinosis circumscripta or tumoral calcinosis is an ectopic mineralization that presents itself ... more Calcinosis circumscripta or tumoral calcinosis is an ectopic mineralization that presents itself in the form of calcium deposit in soft tissues and can be disclosed in many species. Some authors recommend to use the term tumoral calcinosis when deposition of calcium salts occur in the periarticular tissue and calcinosis circumscripta when it happens in t he subcutaneous tissue. It can

Research paper thumbnail of Adenomatose pulmonar ("jaagsiekte") em ovino no Rio Grande de Sul

Research paper thumbnail of Sex reversal in Nile tilapia (Oreochromis niloticus) using a nonsteroidal aromatase inhibitor

Journal of Experimental Zoology, 2001

Several studies have demonstrated that steroid hormones can influence sex differentiation in nonm... more Several studies have demonstrated that steroid hormones can influence sex differentiation in nonmammalian vertebrates and it has been hypothesized that male and female sex differentiation are driven by androgen and estrogen hormones, respectively. Estrogen biosynthesis is mediated by the steroidogenic enzyme cytochrome P450 aromatase, which converts androgens to estrogens. In the present study we examined the efficacy of a potent nonsteroidal aromatase inhibitor incorporated into the food, on sex reversal of Nile tilapia (Oreochromis niloticus) larvae. Nile tilapia larvae were divided in seven groups, which were fed with diets containing different amounts of the aromatase inhibitor Fadrozole (0, 50, 75 and 100 mg/kg) during 15 and 30 days, starting 9 days after hatching. Independent of the period, the proportion of males was significantly higher in the treated groups. Treatment with the highest doses (75 and 100 mg/kg) for 30 days produced 100% males. Histological examination revealed no differences in gonadal tissues between control males and treated fish. Furthermore, one intersex fish was identified in the group treated with 50 mg Fadrozole/kg for 30 days. This study reports that a 100% Nile tilapia male population can be obtained by suppressing aromatase activity and suggests that besides steroid hormones, nonsteroidal compounds, such as aromatase inhibitors, have potential for production of monosex population in tilapia.

Research paper thumbnail of Pre- and postnatal toxicity of the commercial glyphosate formulation in Wistar rats

Archives of Toxicology, 2007

Glyphosate is the active ingredient and polyoxyethyleneamine is the surfactant present in the her... more Glyphosate is the active ingredient and polyoxyethyleneamine is the surfactant present in the herbicide Roundup formulation commercialized in Brazil. The aim of this study was to assess the reproductive effects of glyphosate-Roundup on male and female offspring of Wistar rats exposed during pregnancy and lactation. Dams were treated orally with water or 50, 150 or 450 mg/kg glyphosate during pregnancy (21-23 days) and lactation (21 days). These doses do not correspond to human exposure levels. The results showed that glyphosate-Roundup did not induce maternal toxicity but induced adverse reproductive effects on male offspring rats: a decrease in sperm number per epididymis tail and in daily sperm production during adulthood, an increase in the percentage of abnormal sperms and a dose-related decrease in the serum testosterone level at puberty, and signs of individual spermatid degeneration during both periods. There was only a vaginal canal-opening delay in the exposed female offspring. These findings suggest that in utero and lactational exposure to glyphosate-Roundup may induce significant adverse effects on the reproductive system of male Wistar rats at puberty and during adulthood.