Diogo Van Bavel | Universidade Federal do Rio de Janeiro (UFRJ) (original) (raw)

Uploads

Papers by Diogo Van Bavel

Research paper thumbnail of Confiabilidade na identificação do limiar de anaerobiose ventilatória pelo método visual gráfico

ASSOBRAFIR Ciência, 2021

Este é um artigo publicado em acesso aberto (Open Access) e distribuído sob a licença Creative Co... more Este é um artigo publicado em acesso aberto (Open Access) e distribuído sob a licença Creative Commons Attribution NonComercial ShareAlike License, que permite uso, distribuição e reprodução em qualquer meio, sem restrições desde que sem fins comerciais e que o trabalho original seja corretamente citado e de forma que não indique endosso ao trabalho feito. Adicionalmente, qualquer trabalho derivado deverá ser publicado sob a mesma licença. Resumo Introdução: O Teste cardiopulmonar de exercício (TCPE) é o método padrão ouro na determinação de variáveis utilizadas na avaliação da capacidade funcional (CF). Um parâmetro bem consolidado é o limiar de anaerobiose ventilatório (LAV), que pode ser identificado por meio da análise visual das variáveis ventilatórias, sendo um método subjetivo. Objetivo: Analisar a confiabilidade na identificação do LAV pelo método visual gráfico por três observadores treinados e independentes diante de um banco de dados de TCPE. Métodos: Trata-se de um estudo, transversal e retrospectivo, realizado com 100 indivíduos de ambos os sexos (53 homens e 47 mulheres), com idade média de 49,77±16,55 anos. Os valores de VO 2 pico absoluto e relativo médios foram de 1,5 ±0,8 L/min e 19,0 ±10,7 mL/Kg/min, respectivamente. O TCPE foi realizado em cicloergômetro, com incremento de carga de 5 a 20 W/min, até a exaustão. Três avaliadores independentes realizaram a determinação do LAV, por meio da análise visual das variáveis ventilatórias. Resultados: Não houve diferença estatística entre as análises realizadas pelos avaliadores em nenhuma das variáveis. Foram encontradas correlações significativas fortes [tempo (s): r=0,87; r=0,79; r=0,78] e muito fortes [VO 2 relativo (mL/kg/min) (r= 0,95; r=0,91; r=0,89) e VO 2 absoluto (L/min) (r= 0,94; r=0,90; r=0,87)] entre os avaliadores. Também foram encontradas concordâncias boas entre os avaliadores [tempo (s): 93%; 94%; 93%; VO 2 absoluto (L/min) (95%; 89%; 91%; VO 2 relativo (mL/kg/min): 92%; 94%; 94%]. Conclusão: O método de análise visual por três observadores mostrou-se uma ferramenta confiável para identificar o LAV nos testes analisados.

Research paper thumbnail of Additional file 1: of Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study

Supplementary data tables. (ZIP 671 kb)

Research paper thumbnail of Exertional Rhabdomyolysis after Military Training Paralleled by Systemic Microvascular Dysfunction and Plasma Cytokine Increase: A Case Report

Arquivos Brasileiros de Cardiologia, 2019

Research paper thumbnail of Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults

Nutrition journal, Jan 15, 2014

Dietary creatine supplementation (CrS) is a practice commonly adopted by physically active indivi... more Dietary creatine supplementation (CrS) is a practice commonly adopted by physically active individuals. However, the effects of CrS on systemic microvascular reactivity and density have never been reported. Additionally, CrS is able to influence blood levels of homocysteine, resulting in presumed effects on vascular endothelial function. Thus, we investigated the effects of CrS on the systemic microcirculation and on homocysteine levels in healthy young individuals. This open-label study was performed on a group of 40 healthy male, moderately physically active subjects aged 27.7 ± 13.4 years who received one week of CrS at a dose of 20 g/day of commercially available micronized creatine monohydrate. Laser speckle contrast imaging was used in the evaluation of cutaneous microvascular reactivity, and intra-vital video microscopy was used to evaluate skin capillary density and reactivity, before and after CrS. CrS did not alter plasma levels of homocysteine, although CrS increased crea...

Research paper thumbnail of Praças Públicas e Possibilidades Lúdicas

Licere, Mar 1, 2016

Resumo: O objetivo deste trabalho foi analisar as condições das instalações de lazer em duas (2) ... more Resumo: O objetivo deste trabalho foi analisar as condições das instalações de lazer em duas (2) praças públicas do bairro Copacabana, município do Rio de janeiro. A partir disso, podemos inferir questões acerca da relação entre conservação dos espaços estatais e as possibilidades de lazer para o conjunto da população. Esta pesquisa utilizou uma analise crítica com observação participante e entrevistas com usuários e funcionários de limpeza, segurança e conservação que atuam nas praças. Concluímos haver sérios problemas de conversação em ambas as praças, que implicam numa precarização e restrição das possibilidades de utilização desses equipamentos públicos.

Research paper thumbnail of Effect of combined physical exercise program on improving the functional capacity and the cardiac autonomic modulation of Chagas cardiomyopathy

Motriz: Revista de Educação Física, 2021

Aims: Patients with Chagas cardiomyopathy (ChC) could have a significant reduction in functional ... more Aims: Patients with Chagas cardiomyopathy (ChC) could have a significant reduction in functional capacity (FC). This study aimed to report the effect of a 24-week combined physical exercise program on the FC of a patient with ChC. Methods: A woman, 44 years old, with positive serology for ChC in stage B2 has submitted the following assessments: i) Physical assessment: ii) Cardiopulmonary exercise test; iii) Test of 1-maximum Repetition, iv) Evaluation of cardiac autonomic modulation by heart rate variability (HRV). Results: The results obtained revealed a reduction in the anthropometric parameters and the SBP after training. Additionally, we observed an improvement in FC (aerobic and strength condiction) and cardiac autonomic modulation after 24 weeks of combined training. Conclusion: Our findings show that of a 24-week combined physical exercise program improved either FC or HRVof the patient with ChC.

Research paper thumbnail of Effects of dietary supplementation with creatine on homocysteinemia and systemic microvascular endothelial function in individuals adhering to vegan diets

Fundamental & Clinical Pharmacology

Research paper thumbnail of High-intensity interval training or continuous training, combined or not with fasting, in obese or overweight women with cardiometabolic risk factors: study protocol for a randomised clinical trial

BMJ open, Jan 28, 2018

Physical inactivity and increased caloric intake play important roles in the pathophysiology of o... more Physical inactivity and increased caloric intake play important roles in the pathophysiology of obesity. Increasing physical activity and modifying eating behaviours are first-line interventions, frequently hampered by lack of time to exercise and difficulties in coping with different diets. High-intensity interval training (HIIT) may be a time-efficient method compared with moderate-intensity continuous training (CT). Conversely, diets with a fasting component may be more effective than other complex and restrictive diets, as it essentially limits caloric intake to a specified period without major diet composition changes. Therefore, the combination of HIIT and fasting may provide incremental benefits in terms of effectiveness and time efficiency in obese and sedentary populations. The aim of this study is to determine the effect of HIIT versus CT, combined or not with fasting, on microcirculatory function, cardiometabolic parameters, anthropometric indices, cardiorespiratory fitne...

Research paper thumbnail of Effects of Riot Control Training on Systemic Microvascular Reactivity and Capillary Density

Military medicine, Jan 14, 2018

The main aim of the present study is to evaluate the effects of strenuous exercise, related to sp... more The main aim of the present study is to evaluate the effects of strenuous exercise, related to special military training for riot control, on systemic microvascular endothelial function and skin capillary density. Endothelium-dependent microvascular reactivity was evaluated in the forearm skin of healthy military trainees (age 23.4 ± 2.3 yr; n = 15) using laser speckle contrast imaging coupled with cutaneous acetylcholine (ACh) iontophoresis and post-occlusive reactive hyperemia (PORH). Functional capillary density was assessed using high-resolution, intra-vital color microscopy in the dorsum of the middle phalanx. Capillary recruitment (capillary reserve) was evaluated using PORH. Microcirculatory tests were performed before and after a 5-wk special military training for riot control. Microvascular endothelium-dependent vasodilatory responses were markedly and significantly reduced after training, compared with values obtained before training. The peak values of microvascular condu...

Research paper thumbnail of Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study

BMC Cardiovascular Disorders, 2016

The aim of the present study was to evaluate changes in microvascular density and reactivity in p... more The aim of the present study was to evaluate changes in microvascular density and reactivity in patients with type 1 diabetes (T1D) resulting from low intensity chronic exercise training. This study included 22 (34 ± 7 years) consecutive outpatients with T1D and disease duration > 6 years. We used intravital video-microscopy to measure basal skin capillary density and capillary recruitment using post-occlusive reactive hyperemia (PORH) in the dorsum of the fingers. Endothelium-dependent and -independent vasodilation of the skin microcirculation was evaluated in the forearm with a laser Doppler flow monitoring (LDF) system in combination with acetylcholine and sodium nitroprusside iontophoresis, PORH and local thermal hyperemia. The basal mean capillary density (MCD) after exercise training was significantly higher than before exercise (134 ± 25 vs. 119 ± 19 capillaries/mm(2), respectively; P = 0.0013). MCD during PORH was also higher after exercise (140 ± 26 vs. 121 ± 24 capillaries/mm(2), respectively; P < 0.0001). Endothelium-dependent capillary recruitment during PORH was also significantly higher after exercise (140 ± 26 vs. 134 ± 25 capillaries/mm(2), respectively; P < 0.0012). There were no significant changes in skin microvascular reactivity after exercise as investigated using LDF. Our results showed that low intensity aerobic exercise, performed four times per week for 12 weeks by patients with T1D, induces significant increases in microvascular density and endothelial-dependent capillary reactivity. ClinicalTrials.gov NCT02441504 . Registered 7 May 2015.

Research paper thumbnail of Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults

Nutrition journal, Jan 15, 2014

Dietary creatine supplementation (CrS) is a practice commonly adopted by physically active indivi... more Dietary creatine supplementation (CrS) is a practice commonly adopted by physically active individuals. However, the effects of CrS on systemic microvascular reactivity and density have never been reported. Additionally, CrS is able to influence blood levels of homocysteine, resulting in presumed effects on vascular endothelial function. Thus, we investigated the effects of CrS on the systemic microcirculation and on homocysteine levels in healthy young individuals. This open-label study was performed on a group of 40 healthy male, moderately physically active subjects aged 27.7 ± 13.4 years who received one week of CrS at a dose of 20 g/day of commercially available micronized creatine monohydrate. Laser speckle contrast imaging was used in the evaluation of cutaneous microvascular reactivity, and intra-vital video microscopy was used to evaluate skin capillary density and reactivity, before and after CrS. CrS did not alter plasma levels of homocysteine, although CrS increased crea...

Research paper thumbnail of Confiabilidade na identificação do limiar de anaerobiose ventilatória pelo método visual gráfico

ASSOBRAFIR Ciência, 2021

Este é um artigo publicado em acesso aberto (Open Access) e distribuído sob a licença Creative Co... more Este é um artigo publicado em acesso aberto (Open Access) e distribuído sob a licença Creative Commons Attribution NonComercial ShareAlike License, que permite uso, distribuição e reprodução em qualquer meio, sem restrições desde que sem fins comerciais e que o trabalho original seja corretamente citado e de forma que não indique endosso ao trabalho feito. Adicionalmente, qualquer trabalho derivado deverá ser publicado sob a mesma licença. Resumo Introdução: O Teste cardiopulmonar de exercício (TCPE) é o método padrão ouro na determinação de variáveis utilizadas na avaliação da capacidade funcional (CF). Um parâmetro bem consolidado é o limiar de anaerobiose ventilatório (LAV), que pode ser identificado por meio da análise visual das variáveis ventilatórias, sendo um método subjetivo. Objetivo: Analisar a confiabilidade na identificação do LAV pelo método visual gráfico por três observadores treinados e independentes diante de um banco de dados de TCPE. Métodos: Trata-se de um estudo, transversal e retrospectivo, realizado com 100 indivíduos de ambos os sexos (53 homens e 47 mulheres), com idade média de 49,77±16,55 anos. Os valores de VO 2 pico absoluto e relativo médios foram de 1,5 ±0,8 L/min e 19,0 ±10,7 mL/Kg/min, respectivamente. O TCPE foi realizado em cicloergômetro, com incremento de carga de 5 a 20 W/min, até a exaustão. Três avaliadores independentes realizaram a determinação do LAV, por meio da análise visual das variáveis ventilatórias. Resultados: Não houve diferença estatística entre as análises realizadas pelos avaliadores em nenhuma das variáveis. Foram encontradas correlações significativas fortes [tempo (s): r=0,87; r=0,79; r=0,78] e muito fortes [VO 2 relativo (mL/kg/min) (r= 0,95; r=0,91; r=0,89) e VO 2 absoluto (L/min) (r= 0,94; r=0,90; r=0,87)] entre os avaliadores. Também foram encontradas concordâncias boas entre os avaliadores [tempo (s): 93%; 94%; 93%; VO 2 absoluto (L/min) (95%; 89%; 91%; VO 2 relativo (mL/kg/min): 92%; 94%; 94%]. Conclusão: O método de análise visual por três observadores mostrou-se uma ferramenta confiável para identificar o LAV nos testes analisados.

Research paper thumbnail of Additional file 1: of Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study

Supplementary data tables. (ZIP 671 kb)

Research paper thumbnail of Exertional Rhabdomyolysis after Military Training Paralleled by Systemic Microvascular Dysfunction and Plasma Cytokine Increase: A Case Report

Arquivos Brasileiros de Cardiologia, 2019

Research paper thumbnail of Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults

Nutrition journal, Jan 15, 2014

Dietary creatine supplementation (CrS) is a practice commonly adopted by physically active indivi... more Dietary creatine supplementation (CrS) is a practice commonly adopted by physically active individuals. However, the effects of CrS on systemic microvascular reactivity and density have never been reported. Additionally, CrS is able to influence blood levels of homocysteine, resulting in presumed effects on vascular endothelial function. Thus, we investigated the effects of CrS on the systemic microcirculation and on homocysteine levels in healthy young individuals. This open-label study was performed on a group of 40 healthy male, moderately physically active subjects aged 27.7 ± 13.4 years who received one week of CrS at a dose of 20 g/day of commercially available micronized creatine monohydrate. Laser speckle contrast imaging was used in the evaluation of cutaneous microvascular reactivity, and intra-vital video microscopy was used to evaluate skin capillary density and reactivity, before and after CrS. CrS did not alter plasma levels of homocysteine, although CrS increased crea...

Research paper thumbnail of Praças Públicas e Possibilidades Lúdicas

Licere, Mar 1, 2016

Resumo: O objetivo deste trabalho foi analisar as condições das instalações de lazer em duas (2) ... more Resumo: O objetivo deste trabalho foi analisar as condições das instalações de lazer em duas (2) praças públicas do bairro Copacabana, município do Rio de janeiro. A partir disso, podemos inferir questões acerca da relação entre conservação dos espaços estatais e as possibilidades de lazer para o conjunto da população. Esta pesquisa utilizou uma analise crítica com observação participante e entrevistas com usuários e funcionários de limpeza, segurança e conservação que atuam nas praças. Concluímos haver sérios problemas de conversação em ambas as praças, que implicam numa precarização e restrição das possibilidades de utilização desses equipamentos públicos.

Research paper thumbnail of Effect of combined physical exercise program on improving the functional capacity and the cardiac autonomic modulation of Chagas cardiomyopathy

Motriz: Revista de Educação Física, 2021

Aims: Patients with Chagas cardiomyopathy (ChC) could have a significant reduction in functional ... more Aims: Patients with Chagas cardiomyopathy (ChC) could have a significant reduction in functional capacity (FC). This study aimed to report the effect of a 24-week combined physical exercise program on the FC of a patient with ChC. Methods: A woman, 44 years old, with positive serology for ChC in stage B2 has submitted the following assessments: i) Physical assessment: ii) Cardiopulmonary exercise test; iii) Test of 1-maximum Repetition, iv) Evaluation of cardiac autonomic modulation by heart rate variability (HRV). Results: The results obtained revealed a reduction in the anthropometric parameters and the SBP after training. Additionally, we observed an improvement in FC (aerobic and strength condiction) and cardiac autonomic modulation after 24 weeks of combined training. Conclusion: Our findings show that of a 24-week combined physical exercise program improved either FC or HRVof the patient with ChC.

Research paper thumbnail of Effects of dietary supplementation with creatine on homocysteinemia and systemic microvascular endothelial function in individuals adhering to vegan diets

Fundamental & Clinical Pharmacology

Research paper thumbnail of High-intensity interval training or continuous training, combined or not with fasting, in obese or overweight women with cardiometabolic risk factors: study protocol for a randomised clinical trial

BMJ open, Jan 28, 2018

Physical inactivity and increased caloric intake play important roles in the pathophysiology of o... more Physical inactivity and increased caloric intake play important roles in the pathophysiology of obesity. Increasing physical activity and modifying eating behaviours are first-line interventions, frequently hampered by lack of time to exercise and difficulties in coping with different diets. High-intensity interval training (HIIT) may be a time-efficient method compared with moderate-intensity continuous training (CT). Conversely, diets with a fasting component may be more effective than other complex and restrictive diets, as it essentially limits caloric intake to a specified period without major diet composition changes. Therefore, the combination of HIIT and fasting may provide incremental benefits in terms of effectiveness and time efficiency in obese and sedentary populations. The aim of this study is to determine the effect of HIIT versus CT, combined or not with fasting, on microcirculatory function, cardiometabolic parameters, anthropometric indices, cardiorespiratory fitne...

Research paper thumbnail of Effects of Riot Control Training on Systemic Microvascular Reactivity and Capillary Density

Military medicine, Jan 14, 2018

The main aim of the present study is to evaluate the effects of strenuous exercise, related to sp... more The main aim of the present study is to evaluate the effects of strenuous exercise, related to special military training for riot control, on systemic microvascular endothelial function and skin capillary density. Endothelium-dependent microvascular reactivity was evaluated in the forearm skin of healthy military trainees (age 23.4 ± 2.3 yr; n = 15) using laser speckle contrast imaging coupled with cutaneous acetylcholine (ACh) iontophoresis and post-occlusive reactive hyperemia (PORH). Functional capillary density was assessed using high-resolution, intra-vital color microscopy in the dorsum of the middle phalanx. Capillary recruitment (capillary reserve) was evaluated using PORH. Microcirculatory tests were performed before and after a 5-wk special military training for riot control. Microvascular endothelium-dependent vasodilatory responses were markedly and significantly reduced after training, compared with values obtained before training. The peak values of microvascular condu...

Research paper thumbnail of Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study

BMC Cardiovascular Disorders, 2016

The aim of the present study was to evaluate changes in microvascular density and reactivity in p... more The aim of the present study was to evaluate changes in microvascular density and reactivity in patients with type 1 diabetes (T1D) resulting from low intensity chronic exercise training. This study included 22 (34 ± 7 years) consecutive outpatients with T1D and disease duration > 6 years. We used intravital video-microscopy to measure basal skin capillary density and capillary recruitment using post-occlusive reactive hyperemia (PORH) in the dorsum of the fingers. Endothelium-dependent and -independent vasodilation of the skin microcirculation was evaluated in the forearm with a laser Doppler flow monitoring (LDF) system in combination with acetylcholine and sodium nitroprusside iontophoresis, PORH and local thermal hyperemia. The basal mean capillary density (MCD) after exercise training was significantly higher than before exercise (134 ± 25 vs. 119 ± 19 capillaries/mm(2), respectively; P = 0.0013). MCD during PORH was also higher after exercise (140 ± 26 vs. 121 ± 24 capillaries/mm(2), respectively; P < 0.0001). Endothelium-dependent capillary recruitment during PORH was also significantly higher after exercise (140 ± 26 vs. 134 ± 25 capillaries/mm(2), respectively; P < 0.0012). There were no significant changes in skin microvascular reactivity after exercise as investigated using LDF. Our results showed that low intensity aerobic exercise, performed four times per week for 12 weeks by patients with T1D, induces significant increases in microvascular density and endothelial-dependent capillary reactivity. ClinicalTrials.gov NCT02441504 . Registered 7 May 2015.

Research paper thumbnail of Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults

Nutrition journal, Jan 15, 2014

Dietary creatine supplementation (CrS) is a practice commonly adopted by physically active indivi... more Dietary creatine supplementation (CrS) is a practice commonly adopted by physically active individuals. However, the effects of CrS on systemic microvascular reactivity and density have never been reported. Additionally, CrS is able to influence blood levels of homocysteine, resulting in presumed effects on vascular endothelial function. Thus, we investigated the effects of CrS on the systemic microcirculation and on homocysteine levels in healthy young individuals. This open-label study was performed on a group of 40 healthy male, moderately physically active subjects aged 27.7 ± 13.4 years who received one week of CrS at a dose of 20 g/day of commercially available micronized creatine monohydrate. Laser speckle contrast imaging was used in the evaluation of cutaneous microvascular reactivity, and intra-vital video microscopy was used to evaluate skin capillary density and reactivity, before and after CrS. CrS did not alter plasma levels of homocysteine, although CrS increased crea...