Álisson Carvalho Gonçalves | Universidade Federal do Triângulo Mineiro (UFTM) (original) (raw)
Papers by Álisson Carvalho Gonçalves
Background Inappropriate food handling is the main cause of foodborne illnesses. Food handlers pe... more Background Inappropriate food handling is the main cause of foodborne illnesses. Food handlers perform important functions to preserve the hygiene food that can be a source of transmission of various pathogens. Objective The aim of this study was to evaluate the presence of intestinal parasites and microorganisms indicators of fecal contamination (thermotolerant coliforms) in the hands of food handlers of a teaching hospital in Uberaba, Minas Gerais state, Brazil. Method Samples from the hands of 44 food handlers of a teaching hospital were analyzed. Thermotolerant coliforms were counted by the Most Probable Number method using samples obtained by smearing. The subungual content was subjected to parasitological analysis under microscopy. Results 15.9% (7/44) of the samples were positive for the presence of thermotolerant coliforms and 9.1% (4/44) of the subungual contents were positive for intestinal protozoa (3 Blastocystis spp. and 1 Giardia spp.). Conclusion Results indicate cont...
Experimental Gerontology, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Journal of Bodywork and Movement Therapies, 2020
Background: One of the adverse effects of cancer treatments is the exacerbation of inflammation, ... more Background: One of the adverse effects of cancer treatments is the exacerbation of inflammation, which generates numerous limitations and contributes to the development of several comorbidities and the recurrence of cancer itself. Physical exercise (PE) has been proposed as an efficient complementary strategy to combat the inflammatory effects of oncological treatments and to prevent the development of comorbidities, but its adequate application in breast cancer survivors (BCS) requires the establishment of consensuses and practical recommendations. Objective: This study aimed to review the randomized controlled trials that evaluated the influence of PE in the inflammatory profile of BCS. Methods: The search for articles published between 1999 and 2020 was done in PsycINFO, PubMed, Cochrane, Science Direct, and Scopus databases. Results: Current knowledge reveals the effectiveness of PE in the functional independence and health of BCS. Evidence of the capacity of PE to improve the inflammatory profile and the immune response in BCS has also been described. However, the heterogeneity of the studies regarding structural training variables, types of exercise, stages of intervention, and severity of the disease, still do not allow the establishment of precise guidelines for the prescription and progression of exercise to improve the inflammatory process in BCS. Discussion:. This review suggests a possible strategy to be used in the assessment, training prescription, and rehabilitation of BCS, to support the development of new studies and the work of exercise professionals in the prescription and application of physical training to improve health and inflammatory status in BCS.
Cadernos Saúde Coletiva, 2018
Resumo Introdução Manipuladores de alimentos que trabalham em hospitais frequentemente fornecem a... more Resumo Introdução Manipuladores de alimentos que trabalham em hospitais frequentemente fornecem alimentos a indivíduos com imunidade reduzida, os quais são mais suscetíveis à aquisição de doenças infecciosas de origem alimentar. Objetivo O objetivo deste trabalho foi avaliar a presença de enteroparasitos e coliformes termotolerantes nas mãos dos manipuladores de alimentos de um hospital de ensino de Uberaba, Minas Gerais. Método Foram analisadas amostras das mãos de 44 manipuladores de alimentos de um hospital de ensino. Os coliformes termotolerantes foram contados pelo método do Número Mais Provável, a partir de amostra obtida por esfregaço. O conteúdo subungueal foi submetido à análise parasitológica, observado em microscópio. Resultados 15,9% (7/44) das amostras foram positivas para ocorrência de coliformes termotolerantes e 9,1% (4/44) dos conteúdos subungueais foram positivos para protozoários intestinais (3 Blastocystis spp. e 1 Giardia spp.). Conclusão Os resultados indicam c...
JPEN. Journal of parenteral and enteral nutrition, Jan 22, 2018
The subjective global assessment (SGA) is a powerful tool for nutrition status assessment. Our ai... more The subjective global assessment (SGA) is a powerful tool for nutrition status assessment. Our aim was to compare vitamin C serum levels among patients classified as A, B, or C in the SGA. One hundred-and-fifty adults in the wards of the University Hospital participated in this study. Except for SGA, all cases were submitted to anthropometry, bioelectrical impedance analysis (BIA), and 24-hour dietary recall. Laboratory data included blood hemoglobin, serum ferritin, serum albumin, transferrin, C-reactive protein (CRP), and vitamin C. Acute phase response was defined by serum CRP > 0.5 mg/dL; low serum vitamin C was defined by serum levels < 0.4 mg/dL. Analysis of variance and χ tests were used to compare groups; P < 0.05 was considered significant. Patients were diagnosed as SGA A (n = 76), B (n = 38), or C (n = 36) and showed different anthropometry and BIA. The same occurred, respectively, with vitamin C (median; range, in mg/day) intake (55.0; 4.7-140.6 vs 34.0; 10.3-24...
Journal of Integrative Medicine, 2019
Objective: This study aimed to evaluate the influence of oral supplementation with benfotiamine o... more Objective: This study aimed to evaluate the influence of oral supplementation with benfotiamine on oxidative stress in the liver, heart and muscles of endurance-trained mice. Methods: Twenty-five male BALB/c mice were allocated to the following treatment groups: standard diet and sedentary activity (Sta-Sed), benfotiamine-supplemented diet and sedentary activity (Ben-Sed), standard diet and training activity (Sta-Tr) and benfotiamine-supplemented diet and training activity (Ben-Tr). The training comprised 6 weeks of endurance swimming training. The concentration of thiobarbituric acid reactive substances (TBARS), carbonylated proteins, total thiols and non-protein thiols was analyzed in the liver, heart and tibialis anterior muscle. Results: In the muscle, TBARS concentration in the Sta-Sed group was higher than that in other groups; in the heart, TBARS concentration in the Sta-Sed and Ben-Tr groups was higher than that in the Ben-Sed group. The carbonyl content of the muscle tissues was higher in the Sta-Sed group than in both supplemented groups. In liver, the carbonyl content was lower in the Ben-Sed group than in the Sta-Sed group. The level of total thiols was lower in the Ben-Sed group than in the Sta-Tr group. In the heart, the level of total thiols was higher in the Ben-Sed group than in the Ben-Tr group. The concentration of non-protein thiols in the muscle was higher in the Ben-Sed group than in the Ben-Tr group, whereas in the heart, concentration of non-protein thiols of Sta-Tr group was lower than that of Sta-Sed group. Conclusion: The results show that benfotiamine is an efficient antioxidant for the anterior tibialis muscle and heart; however, swimming training did not alter redox status. Please cite this article as: Gonçalves AC, Moreira EJS, Portari GV. Benfotiamine supplementation prevents oxidative stress in anterior tibialis muscle and heart. J Integr Med. 2019; Epub ahead of print. 2 / 14
Acta Scientiarum. Health Sciences, 2019
High levels of reactive oxygen species can trigger an imbalance in redox status, which generates ... more High levels of reactive oxygen species can trigger an imbalance in redox status, which generates oxidative damage in macromolecules. The present study aimed to investigate the influence of oral supplementation with benfotiamine on oxidative stress and antioxidant activity in muscle of trained mice. Twenty-five male Balb/c mice were placed in groups. Sta-Sed: standard diet and sedentary (n = 6); Ben-Sed: benfotiamine supplemented and sedentary (n = 6); Sta-Tr: standard diet and trained (n = 6); and Ben-Tr: benfotiamine supplemented and trained (n = 7). Standard diet was AIN-93 growth and supplemented diet was AIN-93 with benfotiamine (500 mg kg-1). Trained mice were submitted to 6-weeks of endurance swimming training. The concentration of thiobarbituric acid reactive substances (TBARS), non-protein thiols, catalase (CAT) and superoxide dismutase activities (SOD) were analyzed in the gastrocnemius muscle. TBARS concentration was lower in the Ben-Tr group than in Ben-Sed and Sta-Tr gro...
Life sciences, 2021
AIMS The present study aimed to verify the effects of resistance training (RT) and successive det... more AIMS The present study aimed to verify the effects of resistance training (RT) and successive detraining on body composition, muscle strength and lipid profile as primary outcome, and the oxidative stress and inflammatory markers as second outcome of postmenopausal BC survivors undergoing tamoxifen (TA). MAIN METHODS Fourteen postmenopausal BC survivors underwent 12 weeks of resistance exercise training and subsequently 12 weeks of detraining. Anthropometric parameters, lipid profile, muscle strength, inflammatory cytokines and the oxidative stress markers, were assessed before, after the training period and after detraining period. KEY FINDINGS One-way ANOVA showed that fat mass decrease (39.4 ± 6.9 to 37.7 ± 6.8%) and free-fat mass increase (39.3 ± 4.9 to 40.3 ± 5.6%) after resistance exercise training. Muscle strength increased in response to training but decreased after the detraining period. Triglycerides (156 ± 45 to 123 ± 43 mg/dL) and total cholesterol (202 ± 13 to 186 ± 16 ...
O metabolismo energetico e o principal produtor de especies reativas de oxigenio (ERO). Desta man... more O metabolismo energetico e o principal produtor de especies reativas de oxigenio (ERO). Desta maneira, exercicio intenso aumenta a producao de ERO, podendo causar estresse oxidativo. O objetivo deste estudo foi avaliar o estresse oxidativo provocado por uma sessao de exercicio exaustivo em corredores fundistas treinados. Onze corredores foram submetidos a protocolo de exercicio incremental exaustivo em esteira. Foi coletado 4mL de sangue antes, imediatamente e 24 horas apos o protocolo de esforco. A concentracao plasmatica de malondialdeido (MDA) foi utilizada como marcador de dano oxidativo, determinada por cromatografia liquida de alta eficiencia. Para avaliar as alteracoes nos sistemas antioxidantes, a atividade das enzimas superoxido dismutase (SOD) e catalase (CAT), e a concentracao de tiois nao-proteicos foram avaliadas por espectrofotometria. A concentracao de MDA foi maior 24 horas apos o exercicio em relacao ao periodo imediatamente apos. A atividade da CAT foi maior 24 ho...
Os altos niveis de especies reativas de oxigenio podem desencadear um desequilibrio no estado red... more Os altos niveis de especies reativas de oxigenio podem desencadear um desequilibrio no estado redox capaz de gerar danos oxidativos a macromoleculas. O presente estudo objetivou investigar a influencia da suplementacao oral com benfotiamina sobre o estresse oxidativo e a atividade antioxidante no musculo de camundongos treinados. Vinte e cinco ratos Balb / c machos foram alocados nos grupos Pad-Sed: dieta padrao e sedentario (n=6); Ben-Sed: suplementacao com benfotiamina e sedentario (n=6); Sta-Tr: dieta padrao e treinado (n=6); Ben-Tr: Suplementacao com benfotiamina e treinado (n=7). Os camundongos treinados foram submetidos a treinamento de endurance em natacao durante 6 semanas, com um teste de exaustao ao final do protocolo de treinamento. A concentracao de malondialdeido livre (MDA), proteinas ligadas a malondialdeido (PrMDA) e tiois nao proteicos bem como a atividade das enzimas catalase (CAT) e superoxido dismutase (SOD) foram analisadas no musculo gastrocnemio. Nao houve dif...
Vitamin B1 is a micronutrient essential to humans, and it is a generic term utilized to describe ... more Vitamin B1 is a micronutrient essential to humans, and it is a generic term utilized to describe the existent forms of thiamine, that is, nonphosphorylated thiamine, mono-, di- and triphosphates. Thiamine diphosphate is the biologically active form of thiamine and is a cofactor of several metabolic processes, mainly in energy metabolism. However, thiamine has shown antioxidant potential in distinct pro-oxidant conditions. Oxidative stress mediates the harmful effects of alcohol intake, including liver and neural damage. Moreover, alcoholism is related to thiamine deficiency, caused by poor intake or failure in thiamine uptake and/or transport. In fact, several studies have shown positive effects of thiamine supplementation against the damage caused by chronic alcohol intake. In addition, thiamine analogs supplementation prevents oxidative damage in different pro-oxidant conditions. Thus, thiamine supplementation may be part of the treatment against health disturbances caused by high...
O ciclismo indoor e um exercicio ritmico e ciclico capaz de promover adaptacoes metabolicas, musc... more O ciclismo indoor e um exercicio ritmico e ciclico capaz de promover adaptacoes metabolicas, musculares e cardiorrespiratorias. Os treinos da modalidade podem aumentar a demanda energetica ao ponto que exija o metabolismo dos carboidratos. Assim, o objetivo deste estudo foi observar os reflexos da ingestao aguda de carboidratos sobre o desempenho em um treino de ciclismo indoor. Este estudo foi conduzido em modelo duplo-cego, cross-over, aleatorizado. Participaram sete ciclistas recreativos do genero masculino, com idade 36,28 ± 4,33 anos, peso 77 ± 8,86 kg. Durante duas aulas similares de ciclismo indoor com duracao de 80 minutos, os participantes ingeriram bebidas placebo (PLA) ou suplementada (SUP) com dextrose (0,7g/kg), ofertadas em tres momentos, 10 minutos antes do inicio, 25 e 50 minutos de exercicio. A glicemia foi mensurada 10 minutos antes, no inicio, nos minutos 35 e 60 e ao termino do treino. Ao final do treino, foram registrados glicemia, distância percorrida, rotacoes...
Introduction: High intensity exercise causes an increase in reactive oxygen species production, w... more Introduction: High intensity exercise causes an increase in reactive oxygen species production, which can be harmful to the health and function of several organ tissues. Objective: To analyze the effect of supplementation with α-lipoic acid against the oxidative stress in the heart and liver of endurance-trained mice submitted to the exhaustive endurance exercise bout. Methods: Thirty-two male mice were submitted to 6-week endurance swimming training, and divided in two groups according to supplementation protocol, α-lipoic acid or vehicle, during the last two weeks. The last training session was destined to the exhaustive exercise bout. It was analyzed the lipid peroxidation, oxidative damage to proteins and antioxidant marker in liver and heart immediately (0h) and four-hours (4h) after the exhaustive exercise in both groups. Results: The heart of supplemented animals showed a lower protein damage and higher levels of antioxidant in 0h and 4h. In the liver, lipid peroxidation was ...
Background Inappropriate food handling is the main cause of foodborne illnesses. Food handlers pe... more Background Inappropriate food handling is the main cause of foodborne illnesses. Food handlers perform important functions to preserve the hygiene food that can be a source of transmission of various pathogens. Objective The aim of this study was to evaluate the presence of intestinal parasites and microorganisms indicators of fecal contamination (thermotolerant coliforms) in the hands of food handlers of a teaching hospital in Uberaba, Minas Gerais state, Brazil. Method Samples from the hands of 44 food handlers of a teaching hospital were analyzed. Thermotolerant coliforms were counted by the Most Probable Number method using samples obtained by smearing. The subungual content was subjected to parasitological analysis under microscopy. Results 15.9% (7/44) of the samples were positive for the presence of thermotolerant coliforms and 9.1% (4/44) of the subungual contents were positive for intestinal protozoa (3 Blastocystis spp. and 1 Giardia spp.). Conclusion Results indicate cont...
Experimental Gerontology, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Journal of Bodywork and Movement Therapies, 2020
Background: One of the adverse effects of cancer treatments is the exacerbation of inflammation, ... more Background: One of the adverse effects of cancer treatments is the exacerbation of inflammation, which generates numerous limitations and contributes to the development of several comorbidities and the recurrence of cancer itself. Physical exercise (PE) has been proposed as an efficient complementary strategy to combat the inflammatory effects of oncological treatments and to prevent the development of comorbidities, but its adequate application in breast cancer survivors (BCS) requires the establishment of consensuses and practical recommendations. Objective: This study aimed to review the randomized controlled trials that evaluated the influence of PE in the inflammatory profile of BCS. Methods: The search for articles published between 1999 and 2020 was done in PsycINFO, PubMed, Cochrane, Science Direct, and Scopus databases. Results: Current knowledge reveals the effectiveness of PE in the functional independence and health of BCS. Evidence of the capacity of PE to improve the inflammatory profile and the immune response in BCS has also been described. However, the heterogeneity of the studies regarding structural training variables, types of exercise, stages of intervention, and severity of the disease, still do not allow the establishment of precise guidelines for the prescription and progression of exercise to improve the inflammatory process in BCS. Discussion:. This review suggests a possible strategy to be used in the assessment, training prescription, and rehabilitation of BCS, to support the development of new studies and the work of exercise professionals in the prescription and application of physical training to improve health and inflammatory status in BCS.
Cadernos Saúde Coletiva, 2018
Resumo Introdução Manipuladores de alimentos que trabalham em hospitais frequentemente fornecem a... more Resumo Introdução Manipuladores de alimentos que trabalham em hospitais frequentemente fornecem alimentos a indivíduos com imunidade reduzida, os quais são mais suscetíveis à aquisição de doenças infecciosas de origem alimentar. Objetivo O objetivo deste trabalho foi avaliar a presença de enteroparasitos e coliformes termotolerantes nas mãos dos manipuladores de alimentos de um hospital de ensino de Uberaba, Minas Gerais. Método Foram analisadas amostras das mãos de 44 manipuladores de alimentos de um hospital de ensino. Os coliformes termotolerantes foram contados pelo método do Número Mais Provável, a partir de amostra obtida por esfregaço. O conteúdo subungueal foi submetido à análise parasitológica, observado em microscópio. Resultados 15,9% (7/44) das amostras foram positivas para ocorrência de coliformes termotolerantes e 9,1% (4/44) dos conteúdos subungueais foram positivos para protozoários intestinais (3 Blastocystis spp. e 1 Giardia spp.). Conclusão Os resultados indicam c...
JPEN. Journal of parenteral and enteral nutrition, Jan 22, 2018
The subjective global assessment (SGA) is a powerful tool for nutrition status assessment. Our ai... more The subjective global assessment (SGA) is a powerful tool for nutrition status assessment. Our aim was to compare vitamin C serum levels among patients classified as A, B, or C in the SGA. One hundred-and-fifty adults in the wards of the University Hospital participated in this study. Except for SGA, all cases were submitted to anthropometry, bioelectrical impedance analysis (BIA), and 24-hour dietary recall. Laboratory data included blood hemoglobin, serum ferritin, serum albumin, transferrin, C-reactive protein (CRP), and vitamin C. Acute phase response was defined by serum CRP > 0.5 mg/dL; low serum vitamin C was defined by serum levels < 0.4 mg/dL. Analysis of variance and χ tests were used to compare groups; P < 0.05 was considered significant. Patients were diagnosed as SGA A (n = 76), B (n = 38), or C (n = 36) and showed different anthropometry and BIA. The same occurred, respectively, with vitamin C (median; range, in mg/day) intake (55.0; 4.7-140.6 vs 34.0; 10.3-24...
Journal of Integrative Medicine, 2019
Objective: This study aimed to evaluate the influence of oral supplementation with benfotiamine o... more Objective: This study aimed to evaluate the influence of oral supplementation with benfotiamine on oxidative stress in the liver, heart and muscles of endurance-trained mice. Methods: Twenty-five male BALB/c mice were allocated to the following treatment groups: standard diet and sedentary activity (Sta-Sed), benfotiamine-supplemented diet and sedentary activity (Ben-Sed), standard diet and training activity (Sta-Tr) and benfotiamine-supplemented diet and training activity (Ben-Tr). The training comprised 6 weeks of endurance swimming training. The concentration of thiobarbituric acid reactive substances (TBARS), carbonylated proteins, total thiols and non-protein thiols was analyzed in the liver, heart and tibialis anterior muscle. Results: In the muscle, TBARS concentration in the Sta-Sed group was higher than that in other groups; in the heart, TBARS concentration in the Sta-Sed and Ben-Tr groups was higher than that in the Ben-Sed group. The carbonyl content of the muscle tissues was higher in the Sta-Sed group than in both supplemented groups. In liver, the carbonyl content was lower in the Ben-Sed group than in the Sta-Sed group. The level of total thiols was lower in the Ben-Sed group than in the Sta-Tr group. In the heart, the level of total thiols was higher in the Ben-Sed group than in the Ben-Tr group. The concentration of non-protein thiols in the muscle was higher in the Ben-Sed group than in the Ben-Tr group, whereas in the heart, concentration of non-protein thiols of Sta-Tr group was lower than that of Sta-Sed group. Conclusion: The results show that benfotiamine is an efficient antioxidant for the anterior tibialis muscle and heart; however, swimming training did not alter redox status. Please cite this article as: Gonçalves AC, Moreira EJS, Portari GV. Benfotiamine supplementation prevents oxidative stress in anterior tibialis muscle and heart. J Integr Med. 2019; Epub ahead of print. 2 / 14
Acta Scientiarum. Health Sciences, 2019
High levels of reactive oxygen species can trigger an imbalance in redox status, which generates ... more High levels of reactive oxygen species can trigger an imbalance in redox status, which generates oxidative damage in macromolecules. The present study aimed to investigate the influence of oral supplementation with benfotiamine on oxidative stress and antioxidant activity in muscle of trained mice. Twenty-five male Balb/c mice were placed in groups. Sta-Sed: standard diet and sedentary (n = 6); Ben-Sed: benfotiamine supplemented and sedentary (n = 6); Sta-Tr: standard diet and trained (n = 6); and Ben-Tr: benfotiamine supplemented and trained (n = 7). Standard diet was AIN-93 growth and supplemented diet was AIN-93 with benfotiamine (500 mg kg-1). Trained mice were submitted to 6-weeks of endurance swimming training. The concentration of thiobarbituric acid reactive substances (TBARS), non-protein thiols, catalase (CAT) and superoxide dismutase activities (SOD) were analyzed in the gastrocnemius muscle. TBARS concentration was lower in the Ben-Tr group than in Ben-Sed and Sta-Tr gro...
Life sciences, 2021
AIMS The present study aimed to verify the effects of resistance training (RT) and successive det... more AIMS The present study aimed to verify the effects of resistance training (RT) and successive detraining on body composition, muscle strength and lipid profile as primary outcome, and the oxidative stress and inflammatory markers as second outcome of postmenopausal BC survivors undergoing tamoxifen (TA). MAIN METHODS Fourteen postmenopausal BC survivors underwent 12 weeks of resistance exercise training and subsequently 12 weeks of detraining. Anthropometric parameters, lipid profile, muscle strength, inflammatory cytokines and the oxidative stress markers, were assessed before, after the training period and after detraining period. KEY FINDINGS One-way ANOVA showed that fat mass decrease (39.4 ± 6.9 to 37.7 ± 6.8%) and free-fat mass increase (39.3 ± 4.9 to 40.3 ± 5.6%) after resistance exercise training. Muscle strength increased in response to training but decreased after the detraining period. Triglycerides (156 ± 45 to 123 ± 43 mg/dL) and total cholesterol (202 ± 13 to 186 ± 16 ...
O metabolismo energetico e o principal produtor de especies reativas de oxigenio (ERO). Desta man... more O metabolismo energetico e o principal produtor de especies reativas de oxigenio (ERO). Desta maneira, exercicio intenso aumenta a producao de ERO, podendo causar estresse oxidativo. O objetivo deste estudo foi avaliar o estresse oxidativo provocado por uma sessao de exercicio exaustivo em corredores fundistas treinados. Onze corredores foram submetidos a protocolo de exercicio incremental exaustivo em esteira. Foi coletado 4mL de sangue antes, imediatamente e 24 horas apos o protocolo de esforco. A concentracao plasmatica de malondialdeido (MDA) foi utilizada como marcador de dano oxidativo, determinada por cromatografia liquida de alta eficiencia. Para avaliar as alteracoes nos sistemas antioxidantes, a atividade das enzimas superoxido dismutase (SOD) e catalase (CAT), e a concentracao de tiois nao-proteicos foram avaliadas por espectrofotometria. A concentracao de MDA foi maior 24 horas apos o exercicio em relacao ao periodo imediatamente apos. A atividade da CAT foi maior 24 ho...
Os altos niveis de especies reativas de oxigenio podem desencadear um desequilibrio no estado red... more Os altos niveis de especies reativas de oxigenio podem desencadear um desequilibrio no estado redox capaz de gerar danos oxidativos a macromoleculas. O presente estudo objetivou investigar a influencia da suplementacao oral com benfotiamina sobre o estresse oxidativo e a atividade antioxidante no musculo de camundongos treinados. Vinte e cinco ratos Balb / c machos foram alocados nos grupos Pad-Sed: dieta padrao e sedentario (n=6); Ben-Sed: suplementacao com benfotiamina e sedentario (n=6); Sta-Tr: dieta padrao e treinado (n=6); Ben-Tr: Suplementacao com benfotiamina e treinado (n=7). Os camundongos treinados foram submetidos a treinamento de endurance em natacao durante 6 semanas, com um teste de exaustao ao final do protocolo de treinamento. A concentracao de malondialdeido livre (MDA), proteinas ligadas a malondialdeido (PrMDA) e tiois nao proteicos bem como a atividade das enzimas catalase (CAT) e superoxido dismutase (SOD) foram analisadas no musculo gastrocnemio. Nao houve dif...
Vitamin B1 is a micronutrient essential to humans, and it is a generic term utilized to describe ... more Vitamin B1 is a micronutrient essential to humans, and it is a generic term utilized to describe the existent forms of thiamine, that is, nonphosphorylated thiamine, mono-, di- and triphosphates. Thiamine diphosphate is the biologically active form of thiamine and is a cofactor of several metabolic processes, mainly in energy metabolism. However, thiamine has shown antioxidant potential in distinct pro-oxidant conditions. Oxidative stress mediates the harmful effects of alcohol intake, including liver and neural damage. Moreover, alcoholism is related to thiamine deficiency, caused by poor intake or failure in thiamine uptake and/or transport. In fact, several studies have shown positive effects of thiamine supplementation against the damage caused by chronic alcohol intake. In addition, thiamine analogs supplementation prevents oxidative damage in different pro-oxidant conditions. Thus, thiamine supplementation may be part of the treatment against health disturbances caused by high...
O ciclismo indoor e um exercicio ritmico e ciclico capaz de promover adaptacoes metabolicas, musc... more O ciclismo indoor e um exercicio ritmico e ciclico capaz de promover adaptacoes metabolicas, musculares e cardiorrespiratorias. Os treinos da modalidade podem aumentar a demanda energetica ao ponto que exija o metabolismo dos carboidratos. Assim, o objetivo deste estudo foi observar os reflexos da ingestao aguda de carboidratos sobre o desempenho em um treino de ciclismo indoor. Este estudo foi conduzido em modelo duplo-cego, cross-over, aleatorizado. Participaram sete ciclistas recreativos do genero masculino, com idade 36,28 ± 4,33 anos, peso 77 ± 8,86 kg. Durante duas aulas similares de ciclismo indoor com duracao de 80 minutos, os participantes ingeriram bebidas placebo (PLA) ou suplementada (SUP) com dextrose (0,7g/kg), ofertadas em tres momentos, 10 minutos antes do inicio, 25 e 50 minutos de exercicio. A glicemia foi mensurada 10 minutos antes, no inicio, nos minutos 35 e 60 e ao termino do treino. Ao final do treino, foram registrados glicemia, distância percorrida, rotacoes...
Introduction: High intensity exercise causes an increase in reactive oxygen species production, w... more Introduction: High intensity exercise causes an increase in reactive oxygen species production, which can be harmful to the health and function of several organ tissues. Objective: To analyze the effect of supplementation with α-lipoic acid against the oxidative stress in the heart and liver of endurance-trained mice submitted to the exhaustive endurance exercise bout. Methods: Thirty-two male mice were submitted to 6-week endurance swimming training, and divided in two groups according to supplementation protocol, α-lipoic acid or vehicle, during the last two weeks. The last training session was destined to the exhaustive exercise bout. It was analyzed the lipid peroxidation, oxidative damage to proteins and antioxidant marker in liver and heart immediately (0h) and four-hours (4h) after the exhaustive exercise in both groups. Results: The heart of supplemented animals showed a lower protein damage and higher levels of antioxidant in 0h and 4h. In the liver, lipid peroxidation was ...