Fernando Rico-Villademoros | Universidad de Granada (original) (raw)

Papers by Fernando Rico-Villademoros

Research paper thumbnail of A Systematic Review on the Association between Schizophrenia and Bipolar Disorder with Chronic Obstructive Pulmonary Disease

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Research paper thumbnail of Initial monotherapy with eslicarbazepine acetate for the management of adult patients with focal epilepsy in clinical practice: a meta-analysis of observational studies

International Journal of Neuroscience

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Research paper thumbnail of Use of waterpipes and other substances in adolescents: Prevalence and potential associations with mental and behavioral well-being, a cross-sectional study

Tobacco Prevention & Cessation, 2021

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Research paper thumbnail of Evaluación de la función sexual en mujeres y hombres con fibromialgia

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Research paper thumbnail of The effect of quetiapine on aggresive/hostility symptoms in patients with schizophrenia

European Neuropsychopharmacology, 2002

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Research paper thumbnail of A Real-World Study on Antidepressant-Associated Sexual Dysfunction in 2144 Outpatients: The SALSEX I Study

Archives of Sexual Behavior, 2019

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Research paper thumbnail of Primer semestre

Un artículo científico original trata de contar la historia de una investigación. Es una historia... more Un artículo científico original trata de contar la historia de una investigación. Es una historia en cuatro capítulos, cada uno de los cuales debe proporcionar una información concreta: • Introducción: ¿cuál fue la pregunta de investi­ gación? • Material (o pacientes) y métodos: ¿cómo la es­ tudiamos? • Resultados: ¿qué encontramos? • Discusión: ¿cuáles son las implicaciones de los resultados obtenidos? El comienzo de nuestra historia, la introducción, tiene como objetivo atraer la atención del lector (¡y del editor de la revista!), algo a lo que contribuirán también el título y el resumen del artículo. Para ello es necesario ir al corazón de la investigación: cuál es la pregunta a la que pretendía dar respuesta el estudio y de dónde surgió (la razón de ser del estudio). La pregunta de investigación es el punto clave de cualquier estudio, ya que nos dice el valor que tiene esa inves­ tigación en el marco del conocimiento actual y condiciona el diseño del estudio, el segundo punto en...

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Research paper thumbnail of How does a physician decide which pharmacotherapeutic option to select for acute migraine attacks?

Expert Opinion on Pharmacotherapy

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Research paper thumbnail of Concise report Suicide attempts and risk of suicide in patients with fibromyalgia: a survey in Spanish patients

Objectives. Depression, chronic pain and sleep disturbances frequently co-exist in FM and have sh... more Objectives. Depression, chronic pain and sleep disturbances frequently co-exist in FM and have shown to be independently related with suicidal behaviours. The present survey was performed to evaluate the prevalence of previous suicide attempts in patients with FM and its potential relationship with sociodemo-graphic and clinical characteristics of the disease. Methods. A concise survey was sent to patients of seven associations of patients with FM. In addition to the inquiry concerning the number, if any, and characteristics of suicide attempts, the survey included questions about sociodemographic and clinical data of patients as well as the revised FM impact ques-tionnaire (FIQR) and the Plutchik suicide risk scale. Results. One hundred and eighty patients answered the survey. Thirty (16.7%) of them reported one to three previous suicide attempts. Drug poisoning was the most frequently employed method for suicide attempt (70%). No relevant differences were found between suicide att...

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Research paper thumbnail of La introducción de un artículo científico original: el minusvalorado corazón del estudio

The introduction of an original paper should attract the reader�s attention and explain why the r... more The introduction of an original paper should attract the reader�s attention and explain why the researchers undertook the study. The key elements of its structure are: the study rationale, the research question, and the study design. When discussing the study rationale, we should move from what is known about the topic to what is not known, telling the reader where the study question came from and why it was important to answer that question. The introduction may be concluded by stating the research question (sometimes presented as the study hypothesis or objectives) or by briefly describing the study design (i.e. how we answered the question). Regarding style, the introduction should be well organized and short (preferably one page), and should maintain continuity from sentence to sentence.

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Research paper thumbnail of Amitriptyline for the treatment of fibromyalgia: a comprehensive review

Expert Review of Neurotherapeutics, 2015

Fibromyalgia is characterized by chronic generalized pain accompanied by a wide range of clinical... more Fibromyalgia is characterized by chronic generalized pain accompanied by a wide range of clinical manifestations. Most clinical practice guidelines recommend multidisciplinary treatment using a combination of pharmacological and non-pharmacological therapies. The tricyclic antidepressant amitriptyline has been most thoroughly studied in fibromyalgia. Amitriptyline has been evaluated in placebo-controlled studies, and it has served as an active comparator to other therapeutic interventions in the treatment of fibromyalgia. In addition, several systematic reviews and meta-analyses have evaluated its efficacy and safety for the treatment of fibromyalgia. Data from individual studies as well as from systematic reviews indicate that low doses (10-75 mg/day) of amitriptyline are effective for the treatment of fibromyalgia and, despite the limited quality of the data, they do not seem to be associated with relevant tolerability or safety issues. Consistent with some clinical guidelines, we believe amitriptyline in low doses should be considered a first-line drug for the treatment of fibromyalgia.

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Research paper thumbnail of Psychometric properties of the Spanish version of the screening scale for DSM-IV Generalized Anxiety Disorder of Carroll and Davidson

Actas espanolas de psiquiatria

The aim was to validate the Spanish version of the screening scale for DSM-IV General Anxiety Dis... more The aim was to validate the Spanish version of the screening scale for DSM-IV General Anxiety Disorder of Carroll and Davidson for use in research and clinical practice in Spain for screening and assessing specific anxiety symptoms of patients with Generalized Anxiety Disorder (GAD). Observational, prospective, multisite, study comparing between patients with DSM-IV diagnosis of GAD (group A), starting or switching treatment (group A1) or stable patients (group A2), followed-up for 6 months (group A1) or 2 weeks (group A2) versus healthy control subjects (group B), assessed in a single visit. Among 223 valuable subjects the scale showed: a) adequate feasibility with a mean time of administration: 6.53 and 4.49 min (TD: 5.48 and 3.56) in groups A and B, and percentage of patients without response <5 %; b) adequate reliability (Kuder-Richardson coefficient: 0.85 and 0.79 in groups A1 and A2, and CCI coefficient: 0.89 in group A2); c) adequate validity, showing capability for discri...

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Research paper thumbnail of Current concepts in the treatment of fibromyalgia

The treatment of fibromyalgia involves the use of different kinds of therapeutic modalities. Amon... more The treatment of fibromyalgia involves the use of different kinds of therapeutic modalities. Among pharmacologic treatments, several antidepressants and pregabalin, an alfa2delta blocker, are the best studied drugs and have the highest degree of evidence for efficacy. Other drugs that may be used and have at least a positive randomized clinical trial include sodium oxybate, two 5-HT3 receptor antagonists and pramipexole. As it is not an inflammatory disease, NSAIDs are not useful in the long-term management of fibromyalgia, but the combination of tramadolol with paracetamol has been shown to be effective. Non-pharmacologic therapies include physical and psychological alternatives. Educating patients to understand their disease is helpful when combined with other non-pharmacologic alternatives, but has little efficacy by itself. Exercise, particularly aerobic exercise, has been shown to improve pain, depressed mood and quality of life. Cognitive-behavioral therapy has been shown to i...

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Research paper thumbnail of An update on pharmacotherapy for the treatment of fibromyalgia

Expert Opinion on Pharmacotherapy, 2015

Fibromyalgia is a syndrome characterized by chronic generalized pain in addition to different sym... more Fibromyalgia is a syndrome characterized by chronic generalized pain in addition to different symptoms such as fatigue, sleep disturbances, stiffness, cognitive impairment, and psychological distress. Multidisciplinary treatment combining pharmacological and nonpharmacological therapies is advised. Publications describing randomized controlled trials and long-term extension studies evaluating drug treatment for fibromyalgia were searched in PubMed and Scopus and included in this review. Different drugs are recommended for the treatment of fibromyalgia by different published guidelines, although only three of them have been approved for this indication by the US FDA, and none have been approved by the European Medicines Agency. According to the available evidence, pregabalin, duloxetine and milnacipran should be the drugs of choice for the treatment of this disease, followed by amitriptyline and cyclobenzaprine. Other drugs with at least one positive clinical trial include some selective serotonin reuptake inhibitors, moclobemide, pirlindole, gabapentin, tramadol, tropisetron, sodium oxybate and nabilone. None of the currently available drugs are fully effective against the whole spectrum of fibromyalgia symptoms, namely pain, fatigue, sleep disturbances and depression, among the most relevant symptoms. Combination therapy is an option that needs to be more thoroughly investigated in clinical trials.

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Research paper thumbnail of Current status of atypical antipsychotics for the treatment of fibromyalgia

Drugs of today (Barcelona, Spain : 1998), 2014

The treatment of fibromyalgia requires pharmacological and nonpharmacological therapies. The phar... more The treatment of fibromyalgia requires pharmacological and nonpharmacological therapies. The pharmacological treatment of fibromyalgia is limited to a few drugs that have been demonstrated to be moderately effective in some but not all dimensions of the disease. Therefore, the search for new drugs to treat this condition is warranted. Atypical antipsychotics offered an attractive alternative because they had been shown to be active against several key symptoms of fibromyalgia. The results of open-label studies, however, appear to indicate that atypical antipsychotics are poorly tolerated in patients with fibromyalgia, and only quetiapine XR has been studied in randomized controlled trials. Quetiapine XR has demonstrated effectiveness in treating comorbid major depression, anxiety and sleep disturbance. However, in two randomized controlled trials, quetiapine XR was not differentiated from placebo and failed to demonstrate noninferiority to amitriptyline in terms of improving overall...

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Research paper thumbnail of Effects of pool-based exercise in fibromyalgia symptomatology and sleep quality: a prospective randomised comparison between stretching and Ai Chi

Clinical and experimental rheumatology

To evaluate the effectiveness and tolerability of two pool-based physical therapies, stretching a... more To evaluate the effectiveness and tolerability of two pool-based physical therapies, stretching and Ai Chi, in fibromyalgia symptomatology and sleep quality. Eighty-one patients, randomly assigned to stretching (n=39) or Ai Chi (n=42), received 18 physiotherapy sessions and were evaluated at baseline, at treatment termination, and after 4 and 12 weeks of follow-up. Main outcome measures were the Fibromyalgia Impact Questionnaire (FIQ) and the Pittsburgh Sleep Quality Index (PSQI). Secondary outcome measures included the Beck Depression Inventory (BDI), the State and Trait Anxiety Inventory (STAI), and the SF-12 Health Survey (SF-12). Data analysis was done with repeated measures ANOVA and effect size estimation. No differences were found between groups but significant reduction in the FIQ and the PSQI scores were observed in Ai Chi but not in stretching group, with larger effect sizes and longer effect duration on sleep measures. BDI scores decreased in stretching but not in Ai Chi ...

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Research paper thumbnail of PMW4 Validation of the Spanish Version of the Selfesteem and Relationship (Sear) Questionnaire for Men with Erectile Dysfunction (Ed)

Value in Health, 2004

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Research paper thumbnail of Is antipsychotic-induced weight gain related to sexual dysfunction?

European Neuropsychopharmacology, 2002

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Research paper thumbnail of P.8.a.006 An open-label trial of pregabalin effectiveness and tolerability in the prophylactic treatment of chronic migraine

European Neuropsychopharmacology, 2008

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Research paper thumbnail of Risk of bias in observational studies of interventions: the case of antipsychotic-induced diabetes

The Lancet Psychiatry, 2016

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Research paper thumbnail of A Systematic Review on the Association between Schizophrenia and Bipolar Disorder with Chronic Obstructive Pulmonary Disease

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Research paper thumbnail of Initial monotherapy with eslicarbazepine acetate for the management of adult patients with focal epilepsy in clinical practice: a meta-analysis of observational studies

International Journal of Neuroscience

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Research paper thumbnail of Use of waterpipes and other substances in adolescents: Prevalence and potential associations with mental and behavioral well-being, a cross-sectional study

Tobacco Prevention & Cessation, 2021

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Research paper thumbnail of Evaluación de la función sexual en mujeres y hombres con fibromialgia

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The effect of quetiapine on aggresive/hostility symptoms in patients with schizophrenia

European Neuropsychopharmacology, 2002

Bookmarks Related papers MentionsView impact

Research paper thumbnail of A Real-World Study on Antidepressant-Associated Sexual Dysfunction in 2144 Outpatients: The SALSEX I Study

Archives of Sexual Behavior, 2019

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Primer semestre

Un artículo científico original trata de contar la historia de una investigación. Es una historia... more Un artículo científico original trata de contar la historia de una investigación. Es una historia en cuatro capítulos, cada uno de los cuales debe proporcionar una información concreta: • Introducción: ¿cuál fue la pregunta de investi­ gación? • Material (o pacientes) y métodos: ¿cómo la es­ tudiamos? • Resultados: ¿qué encontramos? • Discusión: ¿cuáles son las implicaciones de los resultados obtenidos? El comienzo de nuestra historia, la introducción, tiene como objetivo atraer la atención del lector (¡y del editor de la revista!), algo a lo que contribuirán también el título y el resumen del artículo. Para ello es necesario ir al corazón de la investigación: cuál es la pregunta a la que pretendía dar respuesta el estudio y de dónde surgió (la razón de ser del estudio). La pregunta de investigación es el punto clave de cualquier estudio, ya que nos dice el valor que tiene esa inves­ tigación en el marco del conocimiento actual y condiciona el diseño del estudio, el segundo punto en...

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Research paper thumbnail of How does a physician decide which pharmacotherapeutic option to select for acute migraine attacks?

Expert Opinion on Pharmacotherapy

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Research paper thumbnail of Concise report Suicide attempts and risk of suicide in patients with fibromyalgia: a survey in Spanish patients

Objectives. Depression, chronic pain and sleep disturbances frequently co-exist in FM and have sh... more Objectives. Depression, chronic pain and sleep disturbances frequently co-exist in FM and have shown to be independently related with suicidal behaviours. The present survey was performed to evaluate the prevalence of previous suicide attempts in patients with FM and its potential relationship with sociodemo-graphic and clinical characteristics of the disease. Methods. A concise survey was sent to patients of seven associations of patients with FM. In addition to the inquiry concerning the number, if any, and characteristics of suicide attempts, the survey included questions about sociodemographic and clinical data of patients as well as the revised FM impact ques-tionnaire (FIQR) and the Plutchik suicide risk scale. Results. One hundred and eighty patients answered the survey. Thirty (16.7%) of them reported one to three previous suicide attempts. Drug poisoning was the most frequently employed method for suicide attempt (70%). No relevant differences were found between suicide att...

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Research paper thumbnail of La introducción de un artículo científico original: el minusvalorado corazón del estudio

The introduction of an original paper should attract the reader�s attention and explain why the r... more The introduction of an original paper should attract the reader�s attention and explain why the researchers undertook the study. The key elements of its structure are: the study rationale, the research question, and the study design. When discussing the study rationale, we should move from what is known about the topic to what is not known, telling the reader where the study question came from and why it was important to answer that question. The introduction may be concluded by stating the research question (sometimes presented as the study hypothesis or objectives) or by briefly describing the study design (i.e. how we answered the question). Regarding style, the introduction should be well organized and short (preferably one page), and should maintain continuity from sentence to sentence.

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Research paper thumbnail of Amitriptyline for the treatment of fibromyalgia: a comprehensive review

Expert Review of Neurotherapeutics, 2015

Fibromyalgia is characterized by chronic generalized pain accompanied by a wide range of clinical... more Fibromyalgia is characterized by chronic generalized pain accompanied by a wide range of clinical manifestations. Most clinical practice guidelines recommend multidisciplinary treatment using a combination of pharmacological and non-pharmacological therapies. The tricyclic antidepressant amitriptyline has been most thoroughly studied in fibromyalgia. Amitriptyline has been evaluated in placebo-controlled studies, and it has served as an active comparator to other therapeutic interventions in the treatment of fibromyalgia. In addition, several systematic reviews and meta-analyses have evaluated its efficacy and safety for the treatment of fibromyalgia. Data from individual studies as well as from systematic reviews indicate that low doses (10-75 mg/day) of amitriptyline are effective for the treatment of fibromyalgia and, despite the limited quality of the data, they do not seem to be associated with relevant tolerability or safety issues. Consistent with some clinical guidelines, we believe amitriptyline in low doses should be considered a first-line drug for the treatment of fibromyalgia.

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Research paper thumbnail of Psychometric properties of the Spanish version of the screening scale for DSM-IV Generalized Anxiety Disorder of Carroll and Davidson

Actas espanolas de psiquiatria

The aim was to validate the Spanish version of the screening scale for DSM-IV General Anxiety Dis... more The aim was to validate the Spanish version of the screening scale for DSM-IV General Anxiety Disorder of Carroll and Davidson for use in research and clinical practice in Spain for screening and assessing specific anxiety symptoms of patients with Generalized Anxiety Disorder (GAD). Observational, prospective, multisite, study comparing between patients with DSM-IV diagnosis of GAD (group A), starting or switching treatment (group A1) or stable patients (group A2), followed-up for 6 months (group A1) or 2 weeks (group A2) versus healthy control subjects (group B), assessed in a single visit. Among 223 valuable subjects the scale showed: a) adequate feasibility with a mean time of administration: 6.53 and 4.49 min (TD: 5.48 and 3.56) in groups A and B, and percentage of patients without response <5 %; b) adequate reliability (Kuder-Richardson coefficient: 0.85 and 0.79 in groups A1 and A2, and CCI coefficient: 0.89 in group A2); c) adequate validity, showing capability for discri...

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Research paper thumbnail of Current concepts in the treatment of fibromyalgia

The treatment of fibromyalgia involves the use of different kinds of therapeutic modalities. Amon... more The treatment of fibromyalgia involves the use of different kinds of therapeutic modalities. Among pharmacologic treatments, several antidepressants and pregabalin, an alfa2delta blocker, are the best studied drugs and have the highest degree of evidence for efficacy. Other drugs that may be used and have at least a positive randomized clinical trial include sodium oxybate, two 5-HT3 receptor antagonists and pramipexole. As it is not an inflammatory disease, NSAIDs are not useful in the long-term management of fibromyalgia, but the combination of tramadolol with paracetamol has been shown to be effective. Non-pharmacologic therapies include physical and psychological alternatives. Educating patients to understand their disease is helpful when combined with other non-pharmacologic alternatives, but has little efficacy by itself. Exercise, particularly aerobic exercise, has been shown to improve pain, depressed mood and quality of life. Cognitive-behavioral therapy has been shown to i...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of An update on pharmacotherapy for the treatment of fibromyalgia

Expert Opinion on Pharmacotherapy, 2015

Fibromyalgia is a syndrome characterized by chronic generalized pain in addition to different sym... more Fibromyalgia is a syndrome characterized by chronic generalized pain in addition to different symptoms such as fatigue, sleep disturbances, stiffness, cognitive impairment, and psychological distress. Multidisciplinary treatment combining pharmacological and nonpharmacological therapies is advised. Publications describing randomized controlled trials and long-term extension studies evaluating drug treatment for fibromyalgia were searched in PubMed and Scopus and included in this review. Different drugs are recommended for the treatment of fibromyalgia by different published guidelines, although only three of them have been approved for this indication by the US FDA, and none have been approved by the European Medicines Agency. According to the available evidence, pregabalin, duloxetine and milnacipran should be the drugs of choice for the treatment of this disease, followed by amitriptyline and cyclobenzaprine. Other drugs with at least one positive clinical trial include some selective serotonin reuptake inhibitors, moclobemide, pirlindole, gabapentin, tramadol, tropisetron, sodium oxybate and nabilone. None of the currently available drugs are fully effective against the whole spectrum of fibromyalgia symptoms, namely pain, fatigue, sleep disturbances and depression, among the most relevant symptoms. Combination therapy is an option that needs to be more thoroughly investigated in clinical trials.

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Research paper thumbnail of Current status of atypical antipsychotics for the treatment of fibromyalgia

Drugs of today (Barcelona, Spain : 1998), 2014

The treatment of fibromyalgia requires pharmacological and nonpharmacological therapies. The phar... more The treatment of fibromyalgia requires pharmacological and nonpharmacological therapies. The pharmacological treatment of fibromyalgia is limited to a few drugs that have been demonstrated to be moderately effective in some but not all dimensions of the disease. Therefore, the search for new drugs to treat this condition is warranted. Atypical antipsychotics offered an attractive alternative because they had been shown to be active against several key symptoms of fibromyalgia. The results of open-label studies, however, appear to indicate that atypical antipsychotics are poorly tolerated in patients with fibromyalgia, and only quetiapine XR has been studied in randomized controlled trials. Quetiapine XR has demonstrated effectiveness in treating comorbid major depression, anxiety and sleep disturbance. However, in two randomized controlled trials, quetiapine XR was not differentiated from placebo and failed to demonstrate noninferiority to amitriptyline in terms of improving overall...

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Research paper thumbnail of Effects of pool-based exercise in fibromyalgia symptomatology and sleep quality: a prospective randomised comparison between stretching and Ai Chi

Clinical and experimental rheumatology

To evaluate the effectiveness and tolerability of two pool-based physical therapies, stretching a... more To evaluate the effectiveness and tolerability of two pool-based physical therapies, stretching and Ai Chi, in fibromyalgia symptomatology and sleep quality. Eighty-one patients, randomly assigned to stretching (n=39) or Ai Chi (n=42), received 18 physiotherapy sessions and were evaluated at baseline, at treatment termination, and after 4 and 12 weeks of follow-up. Main outcome measures were the Fibromyalgia Impact Questionnaire (FIQ) and the Pittsburgh Sleep Quality Index (PSQI). Secondary outcome measures included the Beck Depression Inventory (BDI), the State and Trait Anxiety Inventory (STAI), and the SF-12 Health Survey (SF-12). Data analysis was done with repeated measures ANOVA and effect size estimation. No differences were found between groups but significant reduction in the FIQ and the PSQI scores were observed in Ai Chi but not in stretching group, with larger effect sizes and longer effect duration on sleep measures. BDI scores decreased in stretching but not in Ai Chi ...

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Research paper thumbnail of PMW4 Validation of the Spanish Version of the Selfesteem and Relationship (Sear) Questionnaire for Men with Erectile Dysfunction (Ed)

Value in Health, 2004

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Is antipsychotic-induced weight gain related to sexual dysfunction?

European Neuropsychopharmacology, 2002

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Research paper thumbnail of P.8.a.006 An open-label trial of pregabalin effectiveness and tolerability in the prophylactic treatment of chronic migraine

European Neuropsychopharmacology, 2008

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Risk of bias in observational studies of interventions: the case of antipsychotic-induced diabetes

The Lancet Psychiatry, 2016

Bookmarks Related papers MentionsView impact