Astrid Hutabarat | University of Indonesia (original) (raw)
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Papers by Astrid Hutabarat
Dental Journal
Background: Class II malocclusion is one of the main orthodontic issues for patients in seeking t... more Background: Class II malocclusion is one of the main orthodontic issues for patients in seeking treatment. The prevalence of class II malocclusion varies in different populations. Variation in skeletal profile is mainly controlled internally by a regulatory gene. Runt-related transcription factor-2 (Runx2) plays a role in osteoblast differentiation and is highly expressed during development. Purpose: This study aimed to evaluate the relation of regulatory gene variation in the Runx2 promoter with class II malocclusion. Methods: DNA samples were acquired from 95 orthodontic patients in Jakarta, Indonesia, who were divided into two groups: class I skeletal malocclusion (control group) and class II malocclusion. A single nucleotide polymorphism was investigated using the polymerase chain reaction and restriction fragment length polymorphism techniques. The distribution of alleles was assessed using the Hardy-Weinberg test. The relationship between polymorphism and skeletal variation wa...
Journal of International Dental and Medical Research, 2017
Osteoporosis is a multifactorial disease with a recognized, but not well defined, genetic compone... more Osteoporosis is a multifactorial disease with a recognized, but not well defined, genetic component. Many contributing candidate genes have a role in bone metabolism, such as the gene encoding for interleukin-6 (IL-6). Previous work on the relationship between IL-6 with osteoporosis suggested that IL-6 can increase the number of osteoclasts and lead to lower bone mass density (BMD). However, the influence of IL-6 –G174C polymorphism on postmenopausal women with osteoporotic risk still needs further research. The aim of this study was to examine the relationship between the Interleukin-6 -G174C gene polymorphism and osteoporosis risk in postmenopausal women. We collected 100 blood samples from postmenopausal Indonesian women (23 with normal BMD and 77 with osteoporosis) for analysis using PCR-RFLP with the NlaIII enzyme. The results showed that 96 (96%) of the subjects in the study population carried the GG genotype, 4 (4%) had the GC genotype, and none had the CC genotype. No signif...
In order to create an evidence-based orthognathic surgery planning protocol, an investigation of ... more In order to create an evidence-based orthognathic surgery planning protocol, an investigation of two popular model surgery techniques, the Lockwood keyspacer and the Eastman anatomically-orientated system was carried. This determined (a) the accuracy of positioning of the maxillary cast according to the prescribed treatment plan and (b) the relocation of the maxilla after a simulated Le Fort I down fracture osteotomy using the intermediate wafer as a guide. Fifteen patients-five Class II division 1, five Class II division 2, and five Class III-were included in the study. All the measurements were taken with Erickson's vertically mounted electronic calliper and variations from the treatment plan were analysed.
Dental Journal
Background: Class II malocclusion is one of the main orthodontic issues for patients in seeking t... more Background: Class II malocclusion is one of the main orthodontic issues for patients in seeking treatment. The prevalence of class II malocclusion varies in different populations. Variation in skeletal profile is mainly controlled internally by a regulatory gene. Runt-related transcription factor-2 (Runx2) plays a role in osteoblast differentiation and is highly expressed during development. Purpose: This study aimed to evaluate the relation of regulatory gene variation in the Runx2 promoter with class II malocclusion. Methods: DNA samples were acquired from 95 orthodontic patients in Jakarta, Indonesia, who were divided into two groups: class I skeletal malocclusion (control group) and class II malocclusion. A single nucleotide polymorphism was investigated using the polymerase chain reaction and restriction fragment length polymorphism techniques. The distribution of alleles was assessed using the Hardy-Weinberg test. The relationship between polymorphism and skeletal variation wa...
Journal of International Dental and Medical Research, 2017
Osteoporosis is a multifactorial disease with a recognized, but not well defined, genetic compone... more Osteoporosis is a multifactorial disease with a recognized, but not well defined, genetic component. Many contributing candidate genes have a role in bone metabolism, such as the gene encoding for interleukin-6 (IL-6). Previous work on the relationship between IL-6 with osteoporosis suggested that IL-6 can increase the number of osteoclasts and lead to lower bone mass density (BMD). However, the influence of IL-6 –G174C polymorphism on postmenopausal women with osteoporotic risk still needs further research. The aim of this study was to examine the relationship between the Interleukin-6 -G174C gene polymorphism and osteoporosis risk in postmenopausal women. We collected 100 blood samples from postmenopausal Indonesian women (23 with normal BMD and 77 with osteoporosis) for analysis using PCR-RFLP with the NlaIII enzyme. The results showed that 96 (96%) of the subjects in the study population carried the GG genotype, 4 (4%) had the GC genotype, and none had the CC genotype. No signif...
In order to create an evidence-based orthognathic surgery planning protocol, an investigation of ... more In order to create an evidence-based orthognathic surgery planning protocol, an investigation of two popular model surgery techniques, the Lockwood keyspacer and the Eastman anatomically-orientated system was carried. This determined (a) the accuracy of positioning of the maxillary cast according to the prescribed treatment plan and (b) the relocation of the maxilla after a simulated Le Fort I down fracture osteotomy using the intermediate wafer as a guide. Fifteen patients-five Class II division 1, five Class II division 2, and five Class III-were included in the study. All the measurements were taken with Erickson's vertically mounted electronic calliper and variations from the treatment plan were analysed.