Harry Putrawan | University of Indonesia (original) (raw)

Papers by Harry Putrawan

Research paper thumbnail of Correlation between Interleukin-1β serum level with severity of airway obstruction in Exacerbation Chronic obstructive pulmonary disease (COPD)

Nusantara Medical Science Journal, 2022

Introduction: To observe the relation between Interleukin-1β with exacerbation of Chronic Obstruc... more Introduction: To observe the relation between Interleukin-1β with exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Methods: This study was designed for a cross-sectional study. 65 acute exacerbation COPD patients were selected. The serum level of Interleukin-1β was recorded. Results: Most of the subjects are men (95,4%), moderate smokers (41,5%), normal BMI (61,5%), more than 60 years old (73,8%), have more than 2 exacerbations in a year (67%), severe airway obstruction (41,5%) and mostly in group D (80%). The mean level of Interleukin-1β was 1.63 pg/ml range from 0,009-17,62 pg/ml. Kruskal Wallis analysis test noticed significant differentiation mean serum level of Interleukin-1β in several groups of GOLD. p<0,05. There was no correlation between serum level of IL-1β with the severity of airway obstruction (GOLD) p>0.05. Conclusions: there was no correlation between the severity of airway obstruction with serum level of IL-1β in acute exacerbation of COPD. ther...

Research paper thumbnail of Prevalence of pulmonary hypertension in indonesian patients with stable chronic obstructive pulmonary disease

Journal of Natural Science, Biology and Medicine

IntroductIon Chronic obstructive pulmonary disease (COPD) is a fourth common cause of mortality a... more IntroductIon Chronic obstructive pulmonary disease (COPD) is a fourth common cause of mortality and is a major cause of disability worldwide. [1] The most common cause of mortality among COPD patients is due to the abnormalities of cardiovascular system. [2] Accumulation evidence suggests that cardiovascular disease is a major complication in COPD. [3] Long-term reduced intra-alveolar oxygen pressure also implicated in the pulmonary circulation with the consequences such as pulmonary hypertension (HT). Various studies showed a variable prevalence of pulmonary HT in patients with COPD, from 25% to 90%. [4] Systemic inflammation that occurred in COPD could also indirectly increase the risk cardiovascular disease. Changes of pathophysiology in COPD played a direct role in the cardiac function. Moreover, emphysema and lung hyperinflation could disturb the left ventricular filling and therefore reduced the cardiac output and resulted in HT and right cardiac failure. [5,6] Increased vascular pressure in pulmonary arteries, endothelial dysfunction, accompanied by alveolar hypoxia-induced pulmonary vascular cells' proliferation was common in individuals with mild-moderate COPD. Furthermore, early changes in the structure and function of right ventricle could lead to reduced left ventricular function. [7-9] The current study reveals the prevalence of pulmonary HT based on echocardiography and identified the associated factors related to pulmonary HT in Indonesian patients with COPD. Methods This is a cross-sectional survey conducted in the COPD outpatient clinic at the Persahabatan Hospital, Jakarta, Background: Pulmonary hypertension (HT) is a common comorbidity and implicated in the cardiac-related mortality in chronic obstructive pulmonary disease (COPD) patients. Echocardiography provides accurate and rapid information to detect pulmonary HT. The prevalence of HT among Indonesian patients with COPD, however, remains unclear. The aim of this study is to elucidate the prevalence of pulmonary HT based on echocardiography findings in stable COPD Indonesian patients at the Persahabatan Hospital, Jakarta, Indonesia. Methods: This is a cross-sectional study among stable COPD patients who visit COPD Outpatient Clinics in Persahabatan Hospital, Jakarta, Indonesia, from January to June 2017. Medical history interview, physical examination, spirometry, and echocardiography were performed to all participants who meet the criteria. Results: A total of seventy subjects with COPD performed echocardiography with a mean age of 65.68 ± 7.65 years old. Most of subjects were men (95.7%). There were 30% participants with pulmonary HT and 8.6% participants with right ventricle dilatation. Statistical analysis revealed a significant association between pulmonary HT and forced expiratory volume in 1 s (FEV1) <30% and body mass index (BMI). Conclusion: Pulmonary HT is frequent in Indonesian patients with COPD and is associated with severe airway obstruction as well as reduced BMI; therefore, pulmonary HT should be well managed in a holistic manner to prevent the deteriorating conditions.

Research paper thumbnail of Correlation between Interleukin-1β serum level with severity of airway obstruction in Exacerbation Chronic obstructive pulmonary disease (COPD)

Nusantara Medical Science Journal, 2022

Introduction: To observe the relation between Interleukin-1β with exacerbation of Chronic Obstruc... more Introduction: To observe the relation between Interleukin-1β with exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Methods: This study was designed for a cross-sectional study. 65 acute exacerbation COPD patients were selected. The serum level of Interleukin-1β was recorded. Results: Most of the subjects are men (95,4%), moderate smokers (41,5%), normal BMI (61,5%), more than 60 years old (73,8%), have more than 2 exacerbations in a year (67%), severe airway obstruction (41,5%) and mostly in group D (80%). The mean level of Interleukin-1β was 1.63 pg/ml range from 0,009-17,62 pg/ml. Kruskal Wallis analysis test noticed significant differentiation mean serum level of Interleukin-1β in several groups of GOLD. p<0,05. There was no correlation between serum level of IL-1β with the severity of airway obstruction (GOLD) p>0.05. Conclusions: there was no correlation between the severity of airway obstruction with serum level of IL-1β in acute exacerbation of COPD. ther...

Research paper thumbnail of Prevalence of pulmonary hypertension in indonesian patients with stable chronic obstructive pulmonary disease

Journal of Natural Science, Biology and Medicine

IntroductIon Chronic obstructive pulmonary disease (COPD) is a fourth common cause of mortality a... more IntroductIon Chronic obstructive pulmonary disease (COPD) is a fourth common cause of mortality and is a major cause of disability worldwide. [1] The most common cause of mortality among COPD patients is due to the abnormalities of cardiovascular system. [2] Accumulation evidence suggests that cardiovascular disease is a major complication in COPD. [3] Long-term reduced intra-alveolar oxygen pressure also implicated in the pulmonary circulation with the consequences such as pulmonary hypertension (HT). Various studies showed a variable prevalence of pulmonary HT in patients with COPD, from 25% to 90%. [4] Systemic inflammation that occurred in COPD could also indirectly increase the risk cardiovascular disease. Changes of pathophysiology in COPD played a direct role in the cardiac function. Moreover, emphysema and lung hyperinflation could disturb the left ventricular filling and therefore reduced the cardiac output and resulted in HT and right cardiac failure. [5,6] Increased vascular pressure in pulmonary arteries, endothelial dysfunction, accompanied by alveolar hypoxia-induced pulmonary vascular cells' proliferation was common in individuals with mild-moderate COPD. Furthermore, early changes in the structure and function of right ventricle could lead to reduced left ventricular function. [7-9] The current study reveals the prevalence of pulmonary HT based on echocardiography and identified the associated factors related to pulmonary HT in Indonesian patients with COPD. Methods This is a cross-sectional survey conducted in the COPD outpatient clinic at the Persahabatan Hospital, Jakarta, Background: Pulmonary hypertension (HT) is a common comorbidity and implicated in the cardiac-related mortality in chronic obstructive pulmonary disease (COPD) patients. Echocardiography provides accurate and rapid information to detect pulmonary HT. The prevalence of HT among Indonesian patients with COPD, however, remains unclear. The aim of this study is to elucidate the prevalence of pulmonary HT based on echocardiography findings in stable COPD Indonesian patients at the Persahabatan Hospital, Jakarta, Indonesia. Methods: This is a cross-sectional study among stable COPD patients who visit COPD Outpatient Clinics in Persahabatan Hospital, Jakarta, Indonesia, from January to June 2017. Medical history interview, physical examination, spirometry, and echocardiography were performed to all participants who meet the criteria. Results: A total of seventy subjects with COPD performed echocardiography with a mean age of 65.68 ± 7.65 years old. Most of subjects were men (95.7%). There were 30% participants with pulmonary HT and 8.6% participants with right ventricle dilatation. Statistical analysis revealed a significant association between pulmonary HT and forced expiratory volume in 1 s (FEV1) <30% and body mass index (BMI). Conclusion: Pulmonary HT is frequent in Indonesian patients with COPD and is associated with severe airway obstruction as well as reduced BMI; therefore, pulmonary HT should be well managed in a holistic manner to prevent the deteriorating conditions.