Jerry Krishnan | University of Illinois at Chicago (original) (raw)
Papers by Jerry Krishnan
This interview with authors Kim Erwin and Dr. Jerry Krishnan summarizes a case study in which des... more This interview with authors Kim Erwin and Dr. Jerry Krishnan summarizes a case study in which design methods were applied to a comparative effectiveness trial of 3 interventions in the Emergency Room for children presenting with uncontrolled asthma.
Journal of Asthma, 2003
... Also, we did not measure all asthma-related self-care/management factors that might differ ..... more ... Also, we did not measure all asthma-related self-care/management factors that might differ ... relapse following treatment for acute asthma among adults presenting to the emergency department ... New-onset bronchospasm or recrudescence of asthma associated with cocaine abuse ...
Annals of the American Thoracic Society, 2015
In obstructive sleep apnea, hypoxic ventilatory sensitivity may affect the degree of hypoxic stre... more In obstructive sleep apnea, hypoxic ventilatory sensitivity may affect the degree of hypoxic stress and sleep disruption that occurs in response to upper airway obstruction. We induced (1 ) sleep- induced hypoxia (SIH) or (2 ) sleep fragmentation (SF) without hypoxia for 5 days (12-hour light/dark cycle) in two inbred mouse strains with low (A/J) and high (DBA/2J) hypoxic ventilatory
Chronic obstructive pulmonary diseases (Miami, Fla.)
About 1 in 5 patients hospitalized for exacerbations of chronic obstructive pulmonary disease (CO... more About 1 in 5 patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD) in the United States are readmitted within 30 days. The U.S. Centers for Medicare and Medicaid Services has recently expanded its Hospital Readmissions Reduction Program to financially penalize hospitals with higher than expected all-cause 30-day readmission rates following a hospitalization for COPD exacerbation. In October 2013, the COPD Foundation convened a multi-stakeholder National COPD Readmissions Summit to summarize our understanding of how to reduce hospital readmissions in patients hospitalized for COPD exacerbations. Over 225 individuals participated in the Summit, including patients, clinicians, health service researchers, policy makers and representatives of academic health care centers, industry, and payers. Summit participants recommend that programs to reduce hospital readmissions: 1) Include specific recommendations about how to promote COPD self-management skills t...
AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium, 2014
Earlier studies on hospitalization risk are largely based on regression models. To our knowledge,... more Earlier studies on hospitalization risk are largely based on regression models. To our knowledge, network modeling of multiple comorbidities is novel and inherently enables multidimensional scoring and unbiased feature reduction. Network modeling was conducted using an independent validation design starting from 38,695 patients, 1,446,581 visits, and 430 distinct clinical facilities/hospitals. Odds ratios (OR) were calculated for every pair of comorbidity using patient counts and compared their tendency with hospitalization rates and ED visits. Network topology analyses were performed, defining significant comorbidity associations as having OR≥5 & False-Discovery-Rate≤10(-7). Four COPD-associated comorbidity sub-networks emerged, incorporating multiple clinical systems: (i) metabolic syndrome, (ii) substance abuse and mental disorder, (iii) pregnancy-associated conditions, and (iv) fall-related injury. The latter two have not been reported yet. Features prioritized from the network ...
American journal of respiratory and critical care medicine, Jan 15, 2004
Weaning protocols can improve outcomes, but their efficacy may vary with patient and staff charac... more Weaning protocols can improve outcomes, but their efficacy may vary with patient and staff characteristics. In this prospective, controlled trial, we compared protocol-based weaning to usual, physician-directed weaning in a closed medical intensive care unit (ICU) with high physician staffing levels and structured, system-based rounds. Adult patients requiring mechanical ventilation for more than 24 hours were assigned to usual care (UC) or protocol weaning based on their hospital identification number. Patients assigned to UC (n=145) were managed at their physicians' discretion. Patients assigned to protocol (n=154) underwent daily screening and a spontaneous breathing trial by respiratory and nursing staff without physician intervention. There were no significant baseline differences in patient characteristics between groups. The proportion of patients (protocol vs. UC) who successfully discontinued mechanical ventilation (74.7% vs. 75.2%, p=0.92), duration of mechanical venti...
The American Journal of Medicine, 2015
Respiratory Medicine, 2011
COPD: Journal of Chronic Obstructive Pulmonary Disease, 2010
ICD-9-CM diagnosis codes are increasingly used to estimate the burden of disease, as well as to e... more ICD-9-CM diagnosis codes are increasingly used to estimate the burden of disease, as well as to evaluate the quality of care and outcomes of various conditions. Acute exacerbations of COPD (AE-COPD) are common and associated with substantial health and financial burden in the U.S. Whether published algorithms that employ different combinations of ICD-9-CM codes to identify patients hospitalized for AE-COPD yield similar or different estimates of disease burden is unclear. In this study, the Nationwide Inpatient Sample from years 2000-2006 was used to identify and compare the number of hospitalizations, healthcare utilization, and outcomes for patients hospitalized for AE-COPD in the U.S. AE-COPD was identified using five different published ICD-9-CM algorithms. Estimates of the annual number of hospitalizations for AE-COPD in the U.S. varied more than 2-fold (e.g., 421,000 to 870,000 in 2006). Outcomes and healthcare utilization of patients hospitalized for AE-COPD varied substantially, depending on the algorithm used (e.g., in-hospital mortality 2.0% to 5.1%, total hospital days 2.0 to 5.1 million in 2006). Observed trends in the number of hospitalizations over the 7-year period varied depending on which algorithm was used. In conclusion, the estimated health burden and trends in hospitalizations for AE-COPD in the United States differ, depending on which ICD-9-CM algorithm is used. To improve our understanding of the burden of AE-COPD and to ensure that quality of care initiatives are not misdirected, a validated approach to identifying patients hospitalized for AE-COPD is needed.
The Lancet Respiratory Medicine, 2014
The Lancet Respiratory Medicine, 2013
ABSTRACT The J=2-1(3p-3s) neon-like XUV laser transitions, at 23.2nm and 23.6nm, were used to dem... more ABSTRACT The J=2-1(3p-3s) neon-like XUV laser transitions, at 23.2nm and 23.6nm, were used to demonstrate the system. A refraction compensating double plasma acting as the injector provided the ASE source for these lines. An X-ray multi layer concave mirror allowed for control of the intensity and divergence, and thereby the coherence, of the injector beam into the amplifier
A 55 year old man with chronic lymphocytic leukaemia (CLL) and rheumatoid arthritis (RA), treated... more A 55 year old man with chronic lymphocytic leukaemia (CLL) and rheumatoid arthritis (RA), treated for four years with methotrexate (MTX), who developed a B cell non-Hodgkin's lymphoma (B-NHL), is described. The tumour was localised to the shoulder and axillary lymph nodes, and positive for Epstein-Barr viral antigens. After failure of radiation and chemotherapy, a complete remission was achieved with
Respiratory Research, 2011
JAMA, 2014
In asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes. It is ... more In asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes. It is not known if supplementing inhaled corticosteroids with oral vitamin D3 improves outcomes in patients with asthma and vitamin D insufficiency. To evaluate if vitamin D supplementation would improve the clinical efficacy of inhaled corticosteroids in patients with symptomatic asthma and lower vitamin D levels. The VIDA (Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness in Asthma) randomized, double-blind, parallel, placebo-controlled trial studying adult patients with symptomatic asthma and a serum 25-hydroxyvitamin D level of less than 30 ng/mL was conducted across 9 academic US medical centers in the National Heart, Lung, and Blood Institute's AsthmaNet network, with enrollment starting in April 2011 and follow-up complete by January 2014. After a run-in period that included treatment with an inhaled corticosteroid, 408 patients were randomized. Oral vitamin D3 (100,000 IU once, then 4000 IU/d for 28 weeks; n = 201) or placebo (n = 207) was added to inhaled ciclesonide (320 µg/d). If asthma control was achieved after 12 weeks, ciclesonide was tapered to 160 µg/d for 8 weeks, then to 80 µg/d for 8 weeks if asthma control was maintained. The primary outcome was time to first asthma treatment failure (a composite outcome of decline in lung function and increases in use of β-agonists, systemic corticosteroids, and health care). Treatment with vitamin D3 did not alter the rate of first treatment failure during 28 weeks (28% [95% CI, 21%-34%] with vitamin D3 vs 29% [95% CI, 23%-35%] with placebo; adjusted hazard ratio, 0.9 [95% CI, 0.6-1.3]). Of 14 prespecified secondary outcomes, 9 were analyzed, including asthma exacerbation; of those 9, the only statistically significant outcome was a small difference in the overall dose of ciclesonide required to maintain asthma control (111.3 µg/d [95% CI, 102.2-120.4 µg/d] in the vitamin D3 group vs 126.2 µg/d [95% CI, 117.2-135.3 µg/d] in the placebo group; difference of 14.9 µg/d [95% CI, 2.1-27.7 µg/d]). Vitamin D3 did not reduce the rate of first treatment failure or exacerbation in adults with persistent asthma and vitamin D insufficiency. These findings do not support a strategy of therapeutic vitamin D3 supplementation in patients with symptomatic asthma. clinicaltrials.gov Identifier: NCT01248065.
Journal of Allergy and Clinical Immunology, 2014
Pediatric Asthma, Allergy & Immunology, 2007
Innercity Black children are at high risk for asthma morbidity. Asthma specialists may im-prove a... more Innercity Black children are at high risk for asthma morbidity. Asthma specialists may im-prove asthma outcomes. Understanding specialist use among innercity Black children may provide insight into asthma care in this population. We hypothesized that increased asthma ...
Pediatric Asthma, Allergy & Immunology, 2006
... NADIA N. HANSEL, MD, MPH,1 CYNTHIA S. RAND, Ph.D.,1 JERRY A. KRISHNAN, MD, Ph.D.,1,3 SANDE OK... more ... NADIA N. HANSEL, MD, MPH,1 CYNTHIA S. RAND, Ph.D.,1 JERRY A. KRISHNAN, MD, Ph.D.,1,3 SANDE OKELO, MD,2 PATRICK N. BREYSSE, Ph.D.,4 PEYTON A. EGGLESTON, MD,2 ... 11. Hansel NN, Eggleston PA, Krishnan JA, Curtin-Brosnan J, Rand CS, Patino CM, et al. ...
This interview with authors Kim Erwin and Dr. Jerry Krishnan summarizes a case study in which des... more This interview with authors Kim Erwin and Dr. Jerry Krishnan summarizes a case study in which design methods were applied to a comparative effectiveness trial of 3 interventions in the Emergency Room for children presenting with uncontrolled asthma.
Journal of Asthma, 2003
... Also, we did not measure all asthma-related self-care/management factors that might differ ..... more ... Also, we did not measure all asthma-related self-care/management factors that might differ ... relapse following treatment for acute asthma among adults presenting to the emergency department ... New-onset bronchospasm or recrudescence of asthma associated with cocaine abuse ...
Annals of the American Thoracic Society, 2015
In obstructive sleep apnea, hypoxic ventilatory sensitivity may affect the degree of hypoxic stre... more In obstructive sleep apnea, hypoxic ventilatory sensitivity may affect the degree of hypoxic stress and sleep disruption that occurs in response to upper airway obstruction. We induced (1 ) sleep- induced hypoxia (SIH) or (2 ) sleep fragmentation (SF) without hypoxia for 5 days (12-hour light/dark cycle) in two inbred mouse strains with low (A/J) and high (DBA/2J) hypoxic ventilatory
Chronic obstructive pulmonary diseases (Miami, Fla.)
About 1 in 5 patients hospitalized for exacerbations of chronic obstructive pulmonary disease (CO... more About 1 in 5 patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD) in the United States are readmitted within 30 days. The U.S. Centers for Medicare and Medicaid Services has recently expanded its Hospital Readmissions Reduction Program to financially penalize hospitals with higher than expected all-cause 30-day readmission rates following a hospitalization for COPD exacerbation. In October 2013, the COPD Foundation convened a multi-stakeholder National COPD Readmissions Summit to summarize our understanding of how to reduce hospital readmissions in patients hospitalized for COPD exacerbations. Over 225 individuals participated in the Summit, including patients, clinicians, health service researchers, policy makers and representatives of academic health care centers, industry, and payers. Summit participants recommend that programs to reduce hospital readmissions: 1) Include specific recommendations about how to promote COPD self-management skills t...
AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium, 2014
Earlier studies on hospitalization risk are largely based on regression models. To our knowledge,... more Earlier studies on hospitalization risk are largely based on regression models. To our knowledge, network modeling of multiple comorbidities is novel and inherently enables multidimensional scoring and unbiased feature reduction. Network modeling was conducted using an independent validation design starting from 38,695 patients, 1,446,581 visits, and 430 distinct clinical facilities/hospitals. Odds ratios (OR) were calculated for every pair of comorbidity using patient counts and compared their tendency with hospitalization rates and ED visits. Network topology analyses were performed, defining significant comorbidity associations as having OR≥5 & False-Discovery-Rate≤10(-7). Four COPD-associated comorbidity sub-networks emerged, incorporating multiple clinical systems: (i) metabolic syndrome, (ii) substance abuse and mental disorder, (iii) pregnancy-associated conditions, and (iv) fall-related injury. The latter two have not been reported yet. Features prioritized from the network ...
American journal of respiratory and critical care medicine, Jan 15, 2004
Weaning protocols can improve outcomes, but their efficacy may vary with patient and staff charac... more Weaning protocols can improve outcomes, but their efficacy may vary with patient and staff characteristics. In this prospective, controlled trial, we compared protocol-based weaning to usual, physician-directed weaning in a closed medical intensive care unit (ICU) with high physician staffing levels and structured, system-based rounds. Adult patients requiring mechanical ventilation for more than 24 hours were assigned to usual care (UC) or protocol weaning based on their hospital identification number. Patients assigned to UC (n=145) were managed at their physicians' discretion. Patients assigned to protocol (n=154) underwent daily screening and a spontaneous breathing trial by respiratory and nursing staff without physician intervention. There were no significant baseline differences in patient characteristics between groups. The proportion of patients (protocol vs. UC) who successfully discontinued mechanical ventilation (74.7% vs. 75.2%, p=0.92), duration of mechanical venti...
The American Journal of Medicine, 2015
Respiratory Medicine, 2011
COPD: Journal of Chronic Obstructive Pulmonary Disease, 2010
ICD-9-CM diagnosis codes are increasingly used to estimate the burden of disease, as well as to e... more ICD-9-CM diagnosis codes are increasingly used to estimate the burden of disease, as well as to evaluate the quality of care and outcomes of various conditions. Acute exacerbations of COPD (AE-COPD) are common and associated with substantial health and financial burden in the U.S. Whether published algorithms that employ different combinations of ICD-9-CM codes to identify patients hospitalized for AE-COPD yield similar or different estimates of disease burden is unclear. In this study, the Nationwide Inpatient Sample from years 2000-2006 was used to identify and compare the number of hospitalizations, healthcare utilization, and outcomes for patients hospitalized for AE-COPD in the U.S. AE-COPD was identified using five different published ICD-9-CM algorithms. Estimates of the annual number of hospitalizations for AE-COPD in the U.S. varied more than 2-fold (e.g., 421,000 to 870,000 in 2006). Outcomes and healthcare utilization of patients hospitalized for AE-COPD varied substantially, depending on the algorithm used (e.g., in-hospital mortality 2.0% to 5.1%, total hospital days 2.0 to 5.1 million in 2006). Observed trends in the number of hospitalizations over the 7-year period varied depending on which algorithm was used. In conclusion, the estimated health burden and trends in hospitalizations for AE-COPD in the United States differ, depending on which ICD-9-CM algorithm is used. To improve our understanding of the burden of AE-COPD and to ensure that quality of care initiatives are not misdirected, a validated approach to identifying patients hospitalized for AE-COPD is needed.
The Lancet Respiratory Medicine, 2014
The Lancet Respiratory Medicine, 2013
ABSTRACT The J=2-1(3p-3s) neon-like XUV laser transitions, at 23.2nm and 23.6nm, were used to dem... more ABSTRACT The J=2-1(3p-3s) neon-like XUV laser transitions, at 23.2nm and 23.6nm, were used to demonstrate the system. A refraction compensating double plasma acting as the injector provided the ASE source for these lines. An X-ray multi layer concave mirror allowed for control of the intensity and divergence, and thereby the coherence, of the injector beam into the amplifier
A 55 year old man with chronic lymphocytic leukaemia (CLL) and rheumatoid arthritis (RA), treated... more A 55 year old man with chronic lymphocytic leukaemia (CLL) and rheumatoid arthritis (RA), treated for four years with methotrexate (MTX), who developed a B cell non-Hodgkin's lymphoma (B-NHL), is described. The tumour was localised to the shoulder and axillary lymph nodes, and positive for Epstein-Barr viral antigens. After failure of radiation and chemotherapy, a complete remission was achieved with
Respiratory Research, 2011
JAMA, 2014
In asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes. It is ... more In asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes. It is not known if supplementing inhaled corticosteroids with oral vitamin D3 improves outcomes in patients with asthma and vitamin D insufficiency. To evaluate if vitamin D supplementation would improve the clinical efficacy of inhaled corticosteroids in patients with symptomatic asthma and lower vitamin D levels. The VIDA (Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness in Asthma) randomized, double-blind, parallel, placebo-controlled trial studying adult patients with symptomatic asthma and a serum 25-hydroxyvitamin D level of less than 30 ng/mL was conducted across 9 academic US medical centers in the National Heart, Lung, and Blood Institute's AsthmaNet network, with enrollment starting in April 2011 and follow-up complete by January 2014. After a run-in period that included treatment with an inhaled corticosteroid, 408 patients were randomized. Oral vitamin D3 (100,000 IU once, then 4000 IU/d for 28 weeks; n = 201) or placebo (n = 207) was added to inhaled ciclesonide (320 µg/d). If asthma control was achieved after 12 weeks, ciclesonide was tapered to 160 µg/d for 8 weeks, then to 80 µg/d for 8 weeks if asthma control was maintained. The primary outcome was time to first asthma treatment failure (a composite outcome of decline in lung function and increases in use of β-agonists, systemic corticosteroids, and health care). Treatment with vitamin D3 did not alter the rate of first treatment failure during 28 weeks (28% [95% CI, 21%-34%] with vitamin D3 vs 29% [95% CI, 23%-35%] with placebo; adjusted hazard ratio, 0.9 [95% CI, 0.6-1.3]). Of 14 prespecified secondary outcomes, 9 were analyzed, including asthma exacerbation; of those 9, the only statistically significant outcome was a small difference in the overall dose of ciclesonide required to maintain asthma control (111.3 µg/d [95% CI, 102.2-120.4 µg/d] in the vitamin D3 group vs 126.2 µg/d [95% CI, 117.2-135.3 µg/d] in the placebo group; difference of 14.9 µg/d [95% CI, 2.1-27.7 µg/d]). Vitamin D3 did not reduce the rate of first treatment failure or exacerbation in adults with persistent asthma and vitamin D insufficiency. These findings do not support a strategy of therapeutic vitamin D3 supplementation in patients with symptomatic asthma. clinicaltrials.gov Identifier: NCT01248065.
Journal of Allergy and Clinical Immunology, 2014
Pediatric Asthma, Allergy & Immunology, 2007
Innercity Black children are at high risk for asthma morbidity. Asthma specialists may im-prove a... more Innercity Black children are at high risk for asthma morbidity. Asthma specialists may im-prove asthma outcomes. Understanding specialist use among innercity Black children may provide insight into asthma care in this population. We hypothesized that increased asthma ...
Pediatric Asthma, Allergy & Immunology, 2006
... NADIA N. HANSEL, MD, MPH,1 CYNTHIA S. RAND, Ph.D.,1 JERRY A. KRISHNAN, MD, Ph.D.,1,3 SANDE OK... more ... NADIA N. HANSEL, MD, MPH,1 CYNTHIA S. RAND, Ph.D.,1 JERRY A. KRISHNAN, MD, Ph.D.,1,3 SANDE OKELO, MD,2 PATRICK N. BREYSSE, Ph.D.,4 PEYTON A. EGGLESTON, MD,2 ... 11. Hansel NN, Eggleston PA, Krishnan JA, Curtin-Brosnan J, Rand CS, Patino CM, et al. ...