Mark Gonzalez | University of Illinois at Chicago (original) (raw)

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Papers by Mark Gonzalez

Research paper thumbnail of Hip Biomechanics

Research paper thumbnail of Hip Biomechanics

Research paper thumbnail of Failed Total Hip Arthroplasty

Research paper thumbnail of Pullout Strength After Multiple Reinsertions in Radial Bone Fixation

Hand (New York, N.Y.), Jan 6, 2018

Due to bone cutting loss from self-tapping screws (STS), progressive destruction of bone can occu... more Due to bone cutting loss from self-tapping screws (STS), progressive destruction of bone can occur with each reinsertion during surgery. When considering the use of jigs that utilize multiple insertions such as those seen in ulnar and radial shortening osteotomy systems, or scenarios where a screw needs to be removed and reinserted due to some technical issue, this can be concerning, as multiple studies examining the effects of multiple reinsertions and the relationship between insertional torque and pullout strength have had mixed results. Insertional torque and pullout strength were experimentally measured following multiple reinsertions of STS for up to 5 total insertions for various densities and locations along radial sawbone shafts. Torque and pullout strength were significantly greater in middle segments of the radial shaft. Our trials corroborate previous literature regarding a significant reduction in fixation between 1 and 2 insertions; beyond this, there was no significan...

Research paper thumbnail of IL-11 facilitates a novel connection between RA joint fibroblasts and endothelial cells

Angiogenesis, Jan 11, 2018

IL-11 has been detected in inflamed joints; however, its role in the pathogenesis of arthritis is... more IL-11 has been detected in inflamed joints; however, its role in the pathogenesis of arthritis is not yet clear. Studies were conducted to characterize the expression and functional significance of IL-11 and IL-11Rα in rheumatoid arthritis (RA). IL-11 levels were elevated in RA synovial fluid (SF) compared to osteoarthritis (OA) SF and plasma from RA, OA and normal individuals (NLs). Morphologic studies established that IL-11 was detected in lining fibroblasts and macrophages in addition to sublining endothelial cells and macrophages at higher levels in RA compared to NL synovial tissues. Since IL-11Rα was exclusively expressed in RA fibroblasts and endothelial cells, macrophages were not involved in IL-11 effector function. Ligation of IL-11 to IL-11Rα strongly provoked fibroblast infiltration into RA joint, while cell proliferation was unaffected by this process. Secretion of IL-8 and VEGF from IL-11 activated RA fibroblasts was responsible for the indirect effect of IL-11 on endo...

Research paper thumbnail of Factors Influencing Total Hip Arthroplasty in Obese Patients

Operative Techniques in Orthopaedics

Research paper thumbnail of Segmental acetabular rim defects, bone loss, oversizing, and press fit cup in total hip arthroplasty evaluated with a probabilistic finite element analysis

International Orthopaedics, 2016

Research paper thumbnail of Surgical Risks and Costs of Care are Greater in Patients Who Are Super Obese and Undergoing THA

Clinical Orthopaedics and Related Research®, 2016

Research paper thumbnail of Comparison of Potential Nerve Scar Agents in the Rat Model

Journal of Reconstructive Microsurgery Open, 2016

Research paper thumbnail of The Failed Total Knee Arthroplasty: Evaluation and Etiology

The Journal of the American Academy of Orthopaedic Surgeons, 2004

Research paper thumbnail of Gender Role in Total Knee Arthroplasty: A Retrospective Analysis of Perioperative Outcomes in US Patients

The Journal of Arthroplasty, 2016

Research paper thumbnail of Proprioception After Arthroplasty: Role of the Posterior Cruciate Ligament

Clinical Orthopaedics and Related Research, Nov 1, 1996

Research paper thumbnail of Fracture of a Metal-Backed Acetabular Component in Total Hip Arthroplasty A Case Report

Clinical Orthopaedics and Related Research, Aug 1, 1988

Research paper thumbnail of De Quervain's Disease

Research paper thumbnail of Spaghetti Wrist": Management and Results

Plastic and Reconstructive Surgery, 1998

Research paper thumbnail of Upper extremity dog bite wounds and infections

Journal of Surgical Orthopaedic Advances, Feb 1, 2005

Research paper thumbnail of Patellar Implant with Variable Weights for Knee Repair Surgery

Research paper thumbnail of System and Method for Prosthetic Fitting and Balancing in Joints

Research paper thumbnail of Risk and Cost of 90-Day Complications in Morbidly and Superobese Patients After Total Knee Arthroplasty

The Journal of arthroplasty, Jan 10, 2016

This study investigated the risk and cost of postoperative complications associated with morbid a... more This study investigated the risk and cost of postoperative complications associated with morbid and super obesity after total knee arthroplasty (TKA). A retrospective cohort study was conducted of patients who underwent TKA using Medicare hospital claims data. The International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code V85.4x was used to identify morbidly obese patients (body mass index [BMI] ≥40 kg/m(2)) and superobese patients (BMI ≥50 kg/m(2)) in 2011-2013. Patients without any BMI-related diagnosis codes were used as controls. Twelve complications occurred in the 90-day period after TKA were analyzed using multivariate Cox models, adjusting for patient demographic, morbidity, and institutional factors. In addition, hospital charges and payments were compared from primary surgery through subsequent 90 days. Morbidly obese patients showed a significantly elevated risk in most complications examined, with a 2-fold or higher risk in dislocation...

Research paper thumbnail of Rim Defect Repair in Healthy and Osteoporotic Patients Using Cement Augmentation Rim Defect Repair in Healthy and Osteoporotic Patients Using Cement Augmentation

Research paper thumbnail of Hip Biomechanics

Research paper thumbnail of Hip Biomechanics

Research paper thumbnail of Failed Total Hip Arthroplasty

Research paper thumbnail of Pullout Strength After Multiple Reinsertions in Radial Bone Fixation

Hand (New York, N.Y.), Jan 6, 2018

Due to bone cutting loss from self-tapping screws (STS), progressive destruction of bone can occu... more Due to bone cutting loss from self-tapping screws (STS), progressive destruction of bone can occur with each reinsertion during surgery. When considering the use of jigs that utilize multiple insertions such as those seen in ulnar and radial shortening osteotomy systems, or scenarios where a screw needs to be removed and reinserted due to some technical issue, this can be concerning, as multiple studies examining the effects of multiple reinsertions and the relationship between insertional torque and pullout strength have had mixed results. Insertional torque and pullout strength were experimentally measured following multiple reinsertions of STS for up to 5 total insertions for various densities and locations along radial sawbone shafts. Torque and pullout strength were significantly greater in middle segments of the radial shaft. Our trials corroborate previous literature regarding a significant reduction in fixation between 1 and 2 insertions; beyond this, there was no significan...

Research paper thumbnail of IL-11 facilitates a novel connection between RA joint fibroblasts and endothelial cells

Angiogenesis, Jan 11, 2018

IL-11 has been detected in inflamed joints; however, its role in the pathogenesis of arthritis is... more IL-11 has been detected in inflamed joints; however, its role in the pathogenesis of arthritis is not yet clear. Studies were conducted to characterize the expression and functional significance of IL-11 and IL-11Rα in rheumatoid arthritis (RA). IL-11 levels were elevated in RA synovial fluid (SF) compared to osteoarthritis (OA) SF and plasma from RA, OA and normal individuals (NLs). Morphologic studies established that IL-11 was detected in lining fibroblasts and macrophages in addition to sublining endothelial cells and macrophages at higher levels in RA compared to NL synovial tissues. Since IL-11Rα was exclusively expressed in RA fibroblasts and endothelial cells, macrophages were not involved in IL-11 effector function. Ligation of IL-11 to IL-11Rα strongly provoked fibroblast infiltration into RA joint, while cell proliferation was unaffected by this process. Secretion of IL-8 and VEGF from IL-11 activated RA fibroblasts was responsible for the indirect effect of IL-11 on endo...

Research paper thumbnail of Factors Influencing Total Hip Arthroplasty in Obese Patients

Operative Techniques in Orthopaedics

Research paper thumbnail of Segmental acetabular rim defects, bone loss, oversizing, and press fit cup in total hip arthroplasty evaluated with a probabilistic finite element analysis

International Orthopaedics, 2016

Research paper thumbnail of Surgical Risks and Costs of Care are Greater in Patients Who Are Super Obese and Undergoing THA

Clinical Orthopaedics and Related Research®, 2016

Research paper thumbnail of Comparison of Potential Nerve Scar Agents in the Rat Model

Journal of Reconstructive Microsurgery Open, 2016

Research paper thumbnail of The Failed Total Knee Arthroplasty: Evaluation and Etiology

The Journal of the American Academy of Orthopaedic Surgeons, 2004

Research paper thumbnail of Gender Role in Total Knee Arthroplasty: A Retrospective Analysis of Perioperative Outcomes in US Patients

The Journal of Arthroplasty, 2016

Research paper thumbnail of Proprioception After Arthroplasty: Role of the Posterior Cruciate Ligament

Clinical Orthopaedics and Related Research, Nov 1, 1996

Research paper thumbnail of Fracture of a Metal-Backed Acetabular Component in Total Hip Arthroplasty A Case Report

Clinical Orthopaedics and Related Research, Aug 1, 1988

Research paper thumbnail of De Quervain's Disease

Research paper thumbnail of Spaghetti Wrist": Management and Results

Plastic and Reconstructive Surgery, 1998

Research paper thumbnail of Upper extremity dog bite wounds and infections

Journal of Surgical Orthopaedic Advances, Feb 1, 2005

Research paper thumbnail of Patellar Implant with Variable Weights for Knee Repair Surgery

Research paper thumbnail of System and Method for Prosthetic Fitting and Balancing in Joints

Research paper thumbnail of Risk and Cost of 90-Day Complications in Morbidly and Superobese Patients After Total Knee Arthroplasty

The Journal of arthroplasty, Jan 10, 2016

This study investigated the risk and cost of postoperative complications associated with morbid a... more This study investigated the risk and cost of postoperative complications associated with morbid and super obesity after total knee arthroplasty (TKA). A retrospective cohort study was conducted of patients who underwent TKA using Medicare hospital claims data. The International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code V85.4x was used to identify morbidly obese patients (body mass index [BMI] ≥40 kg/m(2)) and superobese patients (BMI ≥50 kg/m(2)) in 2011-2013. Patients without any BMI-related diagnosis codes were used as controls. Twelve complications occurred in the 90-day period after TKA were analyzed using multivariate Cox models, adjusting for patient demographic, morbidity, and institutional factors. In addition, hospital charges and payments were compared from primary surgery through subsequent 90 days. Morbidly obese patients showed a significantly elevated risk in most complications examined, with a 2-fold or higher risk in dislocation...

Research paper thumbnail of Rim Defect Repair in Healthy and Osteoporotic Patients Using Cement Augmentation Rim Defect Repair in Healthy and Osteoporotic Patients Using Cement Augmentation

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