Kedar Prasad | The University of Iowa (original) (raw)

Papers by Kedar Prasad

Research paper thumbnail of Simultaneous Activation of Nrf2 and Elevation of Dietary and Endogenous Antioxidant Chemicals for Cancer Prevention in Humans

Journal of the American College of Nutrition, Jan 7, 2015

Despite extensive studies in cancer prevention, the incidence of cancer is increasing. We review ... more Despite extensive studies in cancer prevention, the incidence of cancer is increasing. We review studies that have identified several biochemical and genetic defects as well as potential carcinogens in the diet, environmental factors, and lifestyle-related habits. Two of the biochemical abnormalities increased oxidative stress and chronic inflammation, and chronic exposure to carcinogens and mutagens play a significant role in the initiation of multistage carcinogenesis. Therefore, attenuation of these biochemical defects may be useful in reducing the incidence of cancer. Activation of the transcriptional factor called nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which enhances the levels of antioxidant enzymes and phase-2-detoxifying enzymes by complex mechanisms, may be one of the ways to reduce oxidative stress and chronic inflammation. Antioxidant enzymes destroy free radicals by catalysis, whereas phase-2-detoxifying enzymes remove potential carcinogens by converting the...

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Research paper thumbnail of Short microwave pulses cause ultrastructural membrane damage in neuroblastoma cells

Journal of Ultrastructure Research, 1980

... Printing Office, Washington, DC DURNEY, CH, JOHNSON, CC, BARBER, PW, MASSOUDI, H., AND ISKAND... more ... Printing Office, Washington, DC DURNEY, CH, JOHNSON, CC, BARBER, PW, MASSOUDI, H., AND ISKANDER, MF (1978) Radio-frequency Radiation Dosimetry Handbook, 2nd ed., Report SAM-TR-78-22, Interim Report USAF School of Aerospace Medicine ... Cambridge Phil. ...

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Research paper thumbnail of SPECTROSCOPIC STUDIES OF SUBSTANTIA NIGRA PIGMENT IN HUMAN SUBJECTS

Journal of Neurochemistry, 1967

... exp. Neurol. 24,398. FOLEY JM and BAXTER D. (1958) J. Neuropath. exp. Neurol. 17, 586. ... 18... more ... exp. Neurol. 24,398. FOLEY JM and BAXTER D. (1958) J. Neuropath. exp. Neurol. 17, 586. ... 18,250. HILLER A., PLAZIN J. and VAN SLYKE D. D. (1948) J. biol. Chem. 176,1401. 20,76. Page 10. 716 MH VAN WOERT, K. N. PRASAD and D. C. BORG ...

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Research paper thumbnail of Effect of Dopamine on DNA X-irradiated in Vitro

International Journal of Radiation Biology, 1968

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Research paper thumbnail of Radioprotective Effect of Prostaglandin and an Inhibitor of Cyclic Nucleotide Phosphodiesterase on Mammalian Cells in Culture

International Journal of Radiation Biology, 1972

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Research paper thumbnail of Iproniazid (marsilid) reverses dopamine-effect and stimulates the growth of mouse neuroblastoma in vitro

Experientia, 1971

ABSTRACT Zusammenfassung Die hemmende Wirkung von Dopamin auf die Zellteilung von Neuroblastoma b... more ABSTRACT Zusammenfassung Die hemmende Wirkung von Dopamin auf die Zellteilung von Neuroblastoma beruht wahrscheinlich nicht auf dem Effekt seines desaminierten Metaboliten, obwohl sie durch den MAO-Hemmer Marsilid aufgehoben wird.

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Research paper thumbnail of Intervention with Multiple Micronutrients Including Dietary and Endogenous Antioxidants for Healthy Aging

Aging and Age-Related Disorders, 2010

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Research paper thumbnail of Differentiation of neuroblastoma cell culture, x-irradiation versus cyclic amp. Abstr

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Research paper thumbnail of Regulation of cyclic amp binding proteins and cyclic amp-dependent protein kinase activity in mouse neuroblastoma cells in culture. Abstr

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Research paper thumbnail of Cyclic amp-induced differentiation of neuroblastoma cells in culture, changes in the adenylate cyclase response to catecholamines. Abstr

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Research paper thumbnail of Vitamin c increases the lethal effect of therapeutic agents on neural tumor cells in culture. Abstr

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Research paper thumbnail of Premier Micronutrient Corporation (PMC)'s Product Safety Statement

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Research paper thumbnail of Effect of cytochalasin b and vinblastine on x-ray, dibutyryl cyclic amp and prostaglandin-induced differentiation of mouse neuroblastoma cell culture

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Research paper thumbnail of Cyclic amp binding proteins. Their possible significance in the malignancy of neural and nonneural tumor cells. Abstr

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Research paper thumbnail of Levels of cyclic amp and cyclic amp phosphodiesterase during differentiation of mouse neuroblastoma cells in culture. Abstr

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Research paper thumbnail of Review article Rationale for using multiple antioxidants in protecting humans against low doses of ionizing radiation

Health risks of low doses of ionizing radiation (10 cGy or less) may not be accurately estimated ... more Health risks of low doses of ionizing radiation (10 cGy or less) may not be accurately estimated in humans by epidemiological study or mathematical modelling because of several inherent confounding factors including environmental, dietary and biological variables that cannot be accounted for in any radio- epidemiological study. In addition, the expression of radiation-induced damage in humans not only depends upon total dose, dose rate, linear energy transfer (LET), and fractionation and protraction of total doses, but also on repair mechanisms, bystander effects, and exposure to chemical carcinogens, tumour promoters and other toxins. It also depends upon the levels of anti-carcinogenic and anti-tumour promoting agents. Low doses of ionizing radiation should not be considered insignificant with regard to increasing the incidence of somatic mutations (neoplastic and non-neoplastic diseases) and heritable mutations in humans owing to its interaction with other toxins that can enhance...

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Research paper thumbnail of Human radiation biology

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Research paper thumbnail of Binding of cyclic nucleotides with proteins in malignant and adenosine cyclic 3':5'-monophosphate-induced "differentiated" neuroblastoma cells in culture

Cancer Research

The binding of adenosine cyclic 3':5'-monophosphate (cyclic AMP) with soluble (100,000 X ... more The binding of adenosine cyclic 3':5'-monophosphate (cyclic AMP) with soluble (100,000 X g supernatant), pellet, and total homogenate proteins from cyclic AMP-induced "differentiated" mouse neuroblastoma cells increased by about two-fold. The extent of binding with soluble proteins was higher than that with pellet proteins. The binding of cyclic AMP with soluble proteins from 5'-adenosine monophosphate-treated, serum-free medium-treated, sodium butyrate-treated, 6-thioguanine-treated, or X-irradiated neuroblastoma cells did not significantly change. When the soluble proteins containing bound cyclic [3H]AMP were filtered through a Sephadex G-25 column, the relative amount of protein-bound cyclic [3H]AMP in differentiated cells was greater than that in malignant cells, but the amount of free cyclic [3H]AMP was correspondingly less. The electrophoretic characteristics of cyclic AMP-binding proteins of differentiated and malignant cells were identical. There were t...

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Research paper thumbnail of Handbook of Radiobiology

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Research paper thumbnail of CRC handbook of radiobiology

The author presents Development of Radiobiology. A Review. Basic Cell Biology. Physics of Radiati... more The author presents Development of Radiobiology. A Review. Basic Cell Biology. Physics of Radiation Biology. Cellular Radiation Damage. Modifications of Cellular Radiation Damage. Repair of Radiation Damage. Molecular Radiation Biology. Radiation Syndromes and their Modifications. Radiation Damage of Skin and Mucous Membrane. Radiation Damage of Nervous Tissue. Radiation Damage of Reproductive Organs. Radiation Damage of Other Organ Systems. Radiation Immunology. Background, Medical and Commercial Sources. Radiation Injuries to Human Fetuses. Radiation-Induced Genetic Damage. Radiation Carcinogenesis: Tissue Culture Model. Radiation Carcinogenesis: Animal Model. Radiation Carcinogenesis: Human Model. Radiation Carcinogenesis: Secondary Neoplasms. After Therapy of Tumors. Other Late Effects: Aging, Cataract, Aplastic Anemia. Maximum Permissible Dose (MPD). Radiation Response of Human Tumor. Radioisotopes in Biology and Medicine.

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Research paper thumbnail of Simultaneous Activation of Nrf2 and Elevation of Dietary and Endogenous Antioxidant Chemicals for Cancer Prevention in Humans

Journal of the American College of Nutrition, Jan 7, 2015

Despite extensive studies in cancer prevention, the incidence of cancer is increasing. We review ... more Despite extensive studies in cancer prevention, the incidence of cancer is increasing. We review studies that have identified several biochemical and genetic defects as well as potential carcinogens in the diet, environmental factors, and lifestyle-related habits. Two of the biochemical abnormalities increased oxidative stress and chronic inflammation, and chronic exposure to carcinogens and mutagens play a significant role in the initiation of multistage carcinogenesis. Therefore, attenuation of these biochemical defects may be useful in reducing the incidence of cancer. Activation of the transcriptional factor called nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which enhances the levels of antioxidant enzymes and phase-2-detoxifying enzymes by complex mechanisms, may be one of the ways to reduce oxidative stress and chronic inflammation. Antioxidant enzymes destroy free radicals by catalysis, whereas phase-2-detoxifying enzymes remove potential carcinogens by converting the...

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Research paper thumbnail of Short microwave pulses cause ultrastructural membrane damage in neuroblastoma cells

Journal of Ultrastructure Research, 1980

... Printing Office, Washington, DC DURNEY, CH, JOHNSON, CC, BARBER, PW, MASSOUDI, H., AND ISKAND... more ... Printing Office, Washington, DC DURNEY, CH, JOHNSON, CC, BARBER, PW, MASSOUDI, H., AND ISKANDER, MF (1978) Radio-frequency Radiation Dosimetry Handbook, 2nd ed., Report SAM-TR-78-22, Interim Report USAF School of Aerospace Medicine ... Cambridge Phil. ...

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Research paper thumbnail of SPECTROSCOPIC STUDIES OF SUBSTANTIA NIGRA PIGMENT IN HUMAN SUBJECTS

Journal of Neurochemistry, 1967

... exp. Neurol. 24,398. FOLEY JM and BAXTER D. (1958) J. Neuropath. exp. Neurol. 17, 586. ... 18... more ... exp. Neurol. 24,398. FOLEY JM and BAXTER D. (1958) J. Neuropath. exp. Neurol. 17, 586. ... 18,250. HILLER A., PLAZIN J. and VAN SLYKE D. D. (1948) J. biol. Chem. 176,1401. 20,76. Page 10. 716 MH VAN WOERT, K. N. PRASAD and D. C. BORG ...

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Research paper thumbnail of Effect of Dopamine on DNA X-irradiated in Vitro

International Journal of Radiation Biology, 1968

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Research paper thumbnail of Radioprotective Effect of Prostaglandin and an Inhibitor of Cyclic Nucleotide Phosphodiesterase on Mammalian Cells in Culture

International Journal of Radiation Biology, 1972

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Research paper thumbnail of Iproniazid (marsilid) reverses dopamine-effect and stimulates the growth of mouse neuroblastoma in vitro

Experientia, 1971

ABSTRACT Zusammenfassung Die hemmende Wirkung von Dopamin auf die Zellteilung von Neuroblastoma b... more ABSTRACT Zusammenfassung Die hemmende Wirkung von Dopamin auf die Zellteilung von Neuroblastoma beruht wahrscheinlich nicht auf dem Effekt seines desaminierten Metaboliten, obwohl sie durch den MAO-Hemmer Marsilid aufgehoben wird.

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Research paper thumbnail of Intervention with Multiple Micronutrients Including Dietary and Endogenous Antioxidants for Healthy Aging

Aging and Age-Related Disorders, 2010

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Research paper thumbnail of Differentiation of neuroblastoma cell culture, x-irradiation versus cyclic amp. Abstr

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Regulation of cyclic amp binding proteins and cyclic amp-dependent protein kinase activity in mouse neuroblastoma cells in culture. Abstr

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Cyclic amp-induced differentiation of neuroblastoma cells in culture, changes in the adenylate cyclase response to catecholamines. Abstr

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Research paper thumbnail of Vitamin c increases the lethal effect of therapeutic agents on neural tumor cells in culture. Abstr

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Research paper thumbnail of Premier Micronutrient Corporation (PMC)'s Product Safety Statement

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Research paper thumbnail of Effect of cytochalasin b and vinblastine on x-ray, dibutyryl cyclic amp and prostaglandin-induced differentiation of mouse neuroblastoma cell culture

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Cyclic amp binding proteins. Their possible significance in the malignancy of neural and nonneural tumor cells. Abstr

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Levels of cyclic amp and cyclic amp phosphodiesterase during differentiation of mouse neuroblastoma cells in culture. Abstr

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Review article Rationale for using multiple antioxidants in protecting humans against low doses of ionizing radiation

Health risks of low doses of ionizing radiation (10 cGy or less) may not be accurately estimated ... more Health risks of low doses of ionizing radiation (10 cGy or less) may not be accurately estimated in humans by epidemiological study or mathematical modelling because of several inherent confounding factors including environmental, dietary and biological variables that cannot be accounted for in any radio- epidemiological study. In addition, the expression of radiation-induced damage in humans not only depends upon total dose, dose rate, linear energy transfer (LET), and fractionation and protraction of total doses, but also on repair mechanisms, bystander effects, and exposure to chemical carcinogens, tumour promoters and other toxins. It also depends upon the levels of anti-carcinogenic and anti-tumour promoting agents. Low doses of ionizing radiation should not be considered insignificant with regard to increasing the incidence of somatic mutations (neoplastic and non-neoplastic diseases) and heritable mutations in humans owing to its interaction with other toxins that can enhance...

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Research paper thumbnail of Human radiation biology

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Research paper thumbnail of Binding of cyclic nucleotides with proteins in malignant and adenosine cyclic 3':5'-monophosphate-induced "differentiated" neuroblastoma cells in culture

Cancer Research

The binding of adenosine cyclic 3':5'-monophosphate (cyclic AMP) with soluble (100,000 X ... more The binding of adenosine cyclic 3':5'-monophosphate (cyclic AMP) with soluble (100,000 X g supernatant), pellet, and total homogenate proteins from cyclic AMP-induced "differentiated" mouse neuroblastoma cells increased by about two-fold. The extent of binding with soluble proteins was higher than that with pellet proteins. The binding of cyclic AMP with soluble proteins from 5'-adenosine monophosphate-treated, serum-free medium-treated, sodium butyrate-treated, 6-thioguanine-treated, or X-irradiated neuroblastoma cells did not significantly change. When the soluble proteins containing bound cyclic [3H]AMP were filtered through a Sephadex G-25 column, the relative amount of protein-bound cyclic [3H]AMP in differentiated cells was greater than that in malignant cells, but the amount of free cyclic [3H]AMP was correspondingly less. The electrophoretic characteristics of cyclic AMP-binding proteins of differentiated and malignant cells were identical. There were t...

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Research paper thumbnail of Handbook of Radiobiology

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Research paper thumbnail of CRC handbook of radiobiology

The author presents Development of Radiobiology. A Review. Basic Cell Biology. Physics of Radiati... more The author presents Development of Radiobiology. A Review. Basic Cell Biology. Physics of Radiation Biology. Cellular Radiation Damage. Modifications of Cellular Radiation Damage. Repair of Radiation Damage. Molecular Radiation Biology. Radiation Syndromes and their Modifications. Radiation Damage of Skin and Mucous Membrane. Radiation Damage of Nervous Tissue. Radiation Damage of Reproductive Organs. Radiation Damage of Other Organ Systems. Radiation Immunology. Background, Medical and Commercial Sources. Radiation Injuries to Human Fetuses. Radiation-Induced Genetic Damage. Radiation Carcinogenesis: Tissue Culture Model. Radiation Carcinogenesis: Animal Model. Radiation Carcinogenesis: Human Model. Radiation Carcinogenesis: Secondary Neoplasms. After Therapy of Tumors. Other Late Effects: Aging, Cataract, Aplastic Anemia. Maximum Permissible Dose (MPD). Radiation Response of Human Tumor. Radioisotopes in Biology and Medicine.

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