Anderson Aguillón | Universidad Industrial de Santander (original) (raw)

Uploads

Papers by Anderson Aguillón

Nanoparticles represent drug delivery systems suitable for most administration routes. Over the y... more Nanoparticles represent drug delivery systems suitable for most administration routes. Over the years, a variety of natural and synthetic polymers have been explored for the preparation of nanoparticles, of which Poly(lactic acid) (PLA), Poly(glycolic acid) (PGA), and their copolymers (PLGA) have been extensively investigated because of their biocompatibility and biodegradability. Nanoparticles act as potential carries for several classes of drugs such as anticancer agents, antihypertensive agents, immunomodulators, and hormones; and macromolecules such as nucleic acids, proteins, peptides, and antibodies. Th e options available for preparation have increased with advances in traditional methods, and many novel techniques for preparation of drug-loaded nanoparticles are being developed and refi ned. Th e various methods used for preparation of nanoparticles with their advantages and limitations have been discussed. Th e crux of the problem is the stability of nanoparticles after preparation, which is being addressed by freeze-drying using diff erent classes of lyoprotectants. Nanoparticles can be designed for the site-specifi c delivery of drugs. Th e targeting capability of nanoparticles is infl uenced by particle size, surface charge, surface modifi cation, and hydrophobicity. Fınally, the performance of nanoparticles in vivo is infl uenced by morphological characteristics, surface chemistry, and molecular weight. Careful design of these delivery systems with respect to target and route of administration may solve some of the problems faced by new classes of active molecules.

Nanoparticles represent drug delivery systems suitable for most administration routes. Over the y... more Nanoparticles represent drug delivery systems suitable for most administration routes. Over the years, a variety of natural and synthetic polymers have been explored for the preparation of nanoparticles, of which Poly(lactic acid) (PLA), Poly(glycolic acid) (PGA), and their copolymers (PLGA) have been extensively investigated because of their biocompatibility and biodegradability. Nanoparticles act as potential carries for several classes of drugs such as anticancer agents, antihypertensive agents, immunomodulators, and hormones; and macromolecules such as nucleic acids, proteins, peptides, and antibodies. Th e options available for preparation have increased with advances in traditional methods, and many novel techniques for preparation of drug-loaded nanoparticles are being developed and refi ned. Th e various methods used for preparation of nanoparticles with their advantages and limitations have been discussed. Th e crux of the problem is the stability of nanoparticles after preparation, which is being addressed by freeze-drying using diff erent classes of lyoprotectants. Nanoparticles can be designed for the site-specifi c delivery of drugs. Th e targeting capability of nanoparticles is infl uenced by particle size, surface charge, surface modifi cation, and hydrophobicity. Fınally, the performance of nanoparticles in vivo is infl uenced by morphological characteristics, surface chemistry, and molecular weight. Careful design of these delivery systems with respect to target and route of administration may solve some of the problems faced by new classes of active molecules.