Wellcome Sanger Institute | LinkedIn (original) (raw)

Research Services

Hinxton, Cambridgeshire 80,395 followers

The Wellcome Sanger Institute is a world leading genomics research centre.

About us

The Wellcome Sanger Institute is a world leader in genomics research. We generate and analyse data at a scale not easily possible elsewhere. We apply and explore genomic technologies to advance the understanding of biology and improve health. Our ambition is vast – we take on projects that are not possible anywhere else. We use the power of genome sequencing to understand and harness the information in DNA. Funded by Wellcome, we have the freedom and support to push the boundaries of genomics. Our findings are used to improve health and to understand life on Earth.

Industry

Research Services

Company size

501-1,000 employees

Headquarters

Hinxton, Cambridgeshire

Type

Nonprofit

Founded

1992

Specialties

genetic sequencing, bioinformatics, medical research, software development, conservation, malaria, cancer, genomics, research, scientific research, science innovation, and big data

Locations

Employees at Wellcome Sanger Institute

Updates

80,395 followers
6h Edited
By mapping the impact of inherited genetic differences across children with kidney cancer, scientists hope they can help anticipate the development of tumours before they fully form. 🧬 In the future, this could lead to more tailored treatment plans for children with Wilms tumour. Wilms tumour is a type of kidney cancer that largely affects children under the age of five. In about 30 per cent of children with Wilms tumour, there is an inherited genetic change that increases the risk of developing this cancer. New research suggests that these inherited genetic changes predetermine how tumours develop, respond to certain treatments, and whether there is a higher risk of an individual developing secondary cancers later in life. 💬 Sam Behjati, a co-senior author of this study, said: “Our research illustrates the power of collaborative genomic research to answer important clinical questions. At the moment, we treat all children with a predisposition the same, meaning that some children get too much and others too little treatment. Our findings indicate that we may be able to personalise treatment on the basis of genetic information. Moreover, since we now know the precise sequence of genetic changes that lead from predisposition to cancer, we may be able to screen for tumours more effectively and even begin to entertain the possibility of prevention.” Read the full story, here: ⤵️https://lnkd.in/eVHhjxvEThis work was a collaboration with Cambridge University Hospitals NHS Foundation Trust, Great Ormond Street Hospital for Children NHS Foundation Trust, The Little Princess Trust, and others.
Predicting how childhood kidney cancers develop sanger.ac.uk
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This important collaboration with the icddr,b Centre for Climate-Change and Health (iCCH) in Chakaria will help understand the health impacts related to climate change and explore possible solutions. 🔎 Nicholas Thomson, based at the Sanger Institute, is co-lead on this project and attended the kick-off meeting earlier this month. 💬 “There appear to be unusual patterns of disease within these coastal communities that may be explained by changes in both the environment and our bodies. We are here to combine cutting-edge technology and research, along with decades of community engagement and research that icddr,b has conducted, to better understand these problems. Chakaria is a key site for understanding why so many communities around the world are experiencing similar health impacts from climate change and to develop mitigating solutions to benefit them.” This research aims to investigate the role of rising sea levels and salinated drinking water on the gut microbiome and human health in coastal regions of Bangladesh that are already impacted by climate change. In particular, the research will investigate the impact of rising sea levels on health concerns such as gastrointestinal diseases, miscarriage, and preterm birth. To find out more, visit https://lnkd.in/gzGp9Nh3Read more about how the Sanger Institute is involved, here https://lnkd.in/dUk4W7CD

95,070 followers
1w Edited
icddr,b Centre for Climate-Change and Health (iCCH) launched in Chakaria: A platform for measuring global climate-related health impacts in Bangladesh There is not enough evidence available on how the adverse effects of climate change, such as sea level rise, increased temperatures, and salinity, impact health and well-being in the most affected regions of Bangladesh and beyond. For over 25 years, icddr,b has been collecting health, demographic, climate and environmental data through its Health and Demographic Surveillance System (HDSS) in Chakaria, Cox’s Bazar. Scientists at icddr,b have found an association between the impact of climate change and increased rates of miscarriage, preterm birth, childhood mortality, gastrointestinal diseases like diarrhoea, and mortality from kidney diseases in this community. To understand the health impacts related to climate change and exploring mitigating solutions, icddr,b in collaboration with the Wellcome Sanger Institute (WSI) inaugurated icddr,b Centre for Climate-Change and Health (iCCH) in Chakaria. Additionally, a research project titled, “Measuring the Global Impact of Climate Change on Human Health from a Local Sentinel Site” has been initiated with support from the Wellcome Trust, UK. icddr,b Executive Director Dr Tahmeed Ahmed said, “It is still unclear how and to what extent climate change, particularly increased salinity, disrupts the normal gut microbiota and intestinal ecosystem. We look forward to future observations from iCCH, which have the potential to lead to more effective solutions for climate change and its impact on global health.” Dr Manzoor Ahmed Hanifi, Scientist at icddr,b and Principal Investigator of the study said,” This study will track 1,000 individuals in the Chakaria HDSS area over 30 months, collecting data on health, food security, dietary diversity, and nutrition. This will be integrated with existing climate and environmental data to assess the impact of climate change on health in the region. The findings will help inform policy, support interventions, strengthen resilience, and guide future research. These results could benefit Bangladesh's coastal population and similar communities globally.” Professor Nicholas Thomson, Head of the Parasites and Microbes Programme at the WSI and Co-PI of the study, said, “There appear to be unusual patterns of disease within these coastal communities that may be explained by changes in both the environment and our bodies. We are here to combine cutting-edge technology and research, along with decades of community engagement and research that icddr,b has conducted, to better understand these problems. Chakaria is a key site for understanding why so many communities around the world are experiencing similar health impacts from climate change and to develop mitigating solutions to benefit them.” Read more: https://lnkd.in/gzGp9Nh3 Wellcome Trust Wellcome Sanger Institute
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DNA damage can go unrepaired for years, which can create multiple chances to generate harmful mutations that could lead to cancer, research has revealed. 🧬 Our researchers and their collaborators analysed family trees of hundreds of single cells from individuals and found that some DNA damage can remain unrepaired through multiple rounds of cell division. Particularly in blood stem cells, DNA damage may persist for two to three years on average. These findings change the way researchers think about mutations, and have implications for understanding the development of cancer. Michael Spencer Chapman, first author at the Wellcome Sanger Institute and the Barts Cancer Institute (Queen Mary University of London), said: “With these family trees, we can link the relationships of hundreds of cells from one person right back to conception, meaning we can track back through the divisions each cell has gone through. It’s these large-scale, novel datasets that have led us to this unexpected finding that some forms of DNA damage can last for a long time without being repaired. This study is a prime example of exploratory science – you don't always know what you're going to find until you look; you have to stay curious.” Check out the full story here ⤵️https://lnkd.in/e9TWEPm6
DNA damage can last unrepaired for years, changing our view of mutations sanger.ac.uk
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Wellcome Sanger Institute | LinkedIn (original) (raw)

Research Services

Hinxton, Cambridgeshire 80,395 followers

The Wellcome Sanger Institute is a world leading genomics research centre.

About us

Locations

Employees at Wellcome Sanger Institute

Updates

Join now to see what you are missing

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