Elena Karabeleski | Ss. Cyril and Methodius University (UKIM) (Univerzitet "Sv. Kiril i Metodij" - Skopje) (original) (raw)
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Nutrition products that are delivered via the gastrointestinal (GI) tract as tube feeding are val... more Nutrition products that are delivered via the gastrointestinal (GI) tract as tube feeding are valuable option for improving organ function and immune-competence, aiding in recovery process and reducing the reconvalescence period. Enteral nutrition (EN) is indicated in unconscious patients, disease related malnutrition, anorexia, upper GI obstruction or dysfunction, malabsorption, stroke, etc. EN is recommended even in patients without obvious undernutrition, if the patient will be unable to eat for more than 7 days preoperatively. It is also recommended for patients who are not able to maintain oral intake above 60% of recommended intake for more than 10 days. In addition, delay of surgery for preoperative EN is recommended for patients at severe nutritional risk, with at least one of the following: weight loss > 10–15% within 6 months, BMI < 18.5 kg/m 2 , serum albumin < 30 g/L (with no evidence of hepatic or renal dysfunction). The benefits from EN include: better clinica...
A number of studies have revealed significant relationships between cognitive performance and ave... more A number of studies have revealed significant relationships between cognitive performance and average phenylalanine (Phe) levels in children with phenylketonuria (PKU), but only a few studies have been conducted to examine relationships between cognitive performance and variability (fluctuations) in Phe levels. In the current study, we examined a variety of indices of Phe control to determine which index best predicted IQ and executive abilities in 47 school-age children with early-and continuously-treated PKU. Indices of Phe control were mean Phe, the index of dietary control, change in Phe with age, and several indices of variability in Phe (standard deviation, standard error of estimate, and percentage of spikes). These indices were computed over the lifetime and during 3 developmental epochs (< 5, 5.0-9.9, and ≥ 10 yrs. of age). Results indicated that variability in Phe was generally a stronger predictor of cognitive performance than other indices of Phe control. In addition, executive performance was better predicted by variability in Phe during older than younger developmental epochs. These results indicate that variability in Phe should be carefully controlled to maximize cognitive outcomes, and that Phe control should not be liberalized as children with PKU age.
Nutrition products that are delivered via the gastrointestinal (GI) tract as tube feeding are val... more Nutrition products that are delivered via the gastrointestinal (GI) tract as tube feeding are valuable option for improving organ function and immune-competence, aiding in recovery process and reducing the reconvalescence period. Enteral nutrition (EN) is indicated in unconscious patients, disease related malnutrition, anorexia, upper GI obstruction or dysfunction, malabsorption, stroke, etc. EN is recommended even in patients without obvious undernutrition, if the patient will be unable to eat for more than 7 days preoperatively. It is also recommended for patients who are not able to maintain oral intake above 60% of recommended intake for more than 10 days. In addition, delay of surgery for preoperative EN is recommended for patients at severe nutritional risk, with at least one of the following: weight loss > 10–15% within 6 months, BMI < 18.5 kg/m 2 , serum albumin < 30 g/L (with no evidence of hepatic or renal dysfunction). The benefits from EN include: better clinica...
A number of studies have revealed significant relationships between cognitive performance and ave... more A number of studies have revealed significant relationships between cognitive performance and average phenylalanine (Phe) levels in children with phenylketonuria (PKU), but only a few studies have been conducted to examine relationships between cognitive performance and variability (fluctuations) in Phe levels. In the current study, we examined a variety of indices of Phe control to determine which index best predicted IQ and executive abilities in 47 school-age children with early-and continuously-treated PKU. Indices of Phe control were mean Phe, the index of dietary control, change in Phe with age, and several indices of variability in Phe (standard deviation, standard error of estimate, and percentage of spikes). These indices were computed over the lifetime and during 3 developmental epochs (< 5, 5.0-9.9, and ≥ 10 yrs. of age). Results indicated that variability in Phe was generally a stronger predictor of cognitive performance than other indices of Phe control. In addition, executive performance was better predicted by variability in Phe during older than younger developmental epochs. These results indicate that variability in Phe should be carefully controlled to maximize cognitive outcomes, and that Phe control should not be liberalized as children with PKU age.