Anna Ponomarenko | National University of "Kyiv-Mohyla Academy" (original) (raw)

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Research paper thumbnail of Histogenesis of central lung cancer: cytological investigation

Experimental Oncology, 2020

AIM To study the features of the bronchial mucosa lesion in relation to centrally growing lung ca... more AIM To study the features of the bronchial mucosa lesion in relation to centrally growing lung cancer (LC) according to diagnostic fibrobronchoscopy in comparison with the results of cytomorphological data to determine the possible origin of tumor growth (histogenesis). PATIENTS AND METHODS The data of fibrobronchoscopy and cytological findings based on the materials of 75 patients with a clinical diagnosis of LC were studied and compared. By the sum of the numerous cytomorphological features of epithelial cells and their components, the cells of the cylindrical epithelium and LC of various histological types were identified. The cells in bronchial smears and bronchial lavage were stained by Pappenheim and Papanicolau. Diagnostic material was examined by light microscopy. RESULTS We have found that in a part of the patients (49%), the tumors with exophytic growth in the bronchus are covered with a cylindrical epithelium, which indirectly indicates the origin of cancer growth under the epithelial layer. In cytological preparations of 51% patients, cancer cells were found, which confirms the tumor invasion into the bronchial mucosa. In 48 (64%) patients, fibrobronchoscopy revealed that the examined bronchus was compressed from 50% to pinpoint width, evidencing that tumor growth develops from the outside, peribronchially. CONCLUSION The obtained data indirectly confirm the development of central LC from type II pneumocytes, which are found in the glands of the submucous membrane of the bronchus. However, it does not exlude the development of this type of LC from the basal cell of the bronchial epithelium.

Research paper thumbnail of Новий підхід у вивченні розповсюдження раку легені по паренхімі (попередні дані) / A new approach in the study of the spread of lung cancer in the parenchyma (preliminary data)

Research paper thumbnail of Комплексні морфологічні дослідження для уточнення гістогенезу раку легені

Research paper thumbnail of Lung cancer and alveolar epithelium

Research paper thumbnail of Показники ядерець перехідного типу в альвеолярному епітелії при помірнодиференційованому плоскоклітинному раку легені / Indicators of transitional nucleoli in alveolar epithelium in moderately differentiated squamous cell lung cancer

Research paper thumbnail of Brohchoscopic and cytological studies in the central growth of lung cancer

Research paper thumbnail of Гістологічні типи пухлин жирової тканини та їх характеристика / Histological types of adipose tissue tumors and their characteristics

Research paper thumbnail of Cytological research of exophytic tumors of the bronchi and the growth pattern of lung cancer

NaUKMA Research Papers. Biology and Ecology, 2021

Background. The study of the growth of lung cancer (LC) has an important clinical significance fo... more Background. The study of the growth of lung cancer (LC) has an important clinical significance for morphological verification, the choice of the treatment method, and the determining of prognosis. Investigation of this question allows to clarify the histogenesis of LC. The aim of our study was to compare the results of cytological studies of the material obtained during flexible bronchoscopy (FBS) and scrapings from the operated tumors of the bronchi to clarify the nature of LC growth. Design. To study the growth of tumors in the bronchi in relation to the bronchial mucosa, the cytological examination of the material obtained by FBS and scrapings from the surface of the operated bronchial tumors of 31 patients has been performed. Results. In the preoperative period, in the material of FBS, tumor cells were found only in 1/3 of patients. To obtain the optimal material from exophytic tumors of the bronchus, scrapings were carried out from the entire surface surgical material of the sa...

Research paper thumbnail of Рак легені і квантитативна оцінка клітин паренхіми -цитологічне дослідження (попередні дані) / Lung cancer and quantitative evaluation of parenchymal cells -cytological examination (preliminary data)

Research paper thumbnail of Рак легені і альвеолярний епітелій/Lung cancer and alveolar epithelium

Research paper thumbnail of Overview of Globus-M2 spherical tokamak results at the enhanced values of magnetic field and plasma current

Research paper thumbnail of Features of growth of peripheral lung cancer according to the results of macroscopic and cytological research

NaUKMA Research Papers. Biology and Ecology

Research paper thumbnail of Histogenesis of central lung cancer: cytological investigation

Experimental Oncology, 2020

AIM To study the features of the bronchial mucosa lesion in relation to centrally growing lung ca... more AIM To study the features of the bronchial mucosa lesion in relation to centrally growing lung cancer (LC) according to diagnostic fibrobronchoscopy in comparison with the results of cytomorphological data to determine the possible origin of tumor growth (histogenesis). PATIENTS AND METHODS The data of fibrobronchoscopy and cytological findings based on the materials of 75 patients with a clinical diagnosis of LC were studied and compared. By the sum of the numerous cytomorphological features of epithelial cells and their components, the cells of the cylindrical epithelium and LC of various histological types were identified. The cells in bronchial smears and bronchial lavage were stained by Pappenheim and Papanicolau. Diagnostic material was examined by light microscopy. RESULTS We have found that in a part of the patients (49%), the tumors with exophytic growth in the bronchus are covered with a cylindrical epithelium, which indirectly indicates the origin of cancer growth under the epithelial layer. In cytological preparations of 51% patients, cancer cells were found, which confirms the tumor invasion into the bronchial mucosa. In 48 (64%) patients, fibrobronchoscopy revealed that the examined bronchus was compressed from 50% to pinpoint width, evidencing that tumor growth develops from the outside, peribronchially. CONCLUSION The obtained data indirectly confirm the development of central LC from type II pneumocytes, which are found in the glands of the submucous membrane of the bronchus. However, it does not exlude the development of this type of LC from the basal cell of the bronchial epithelium.

Research paper thumbnail of Новий підхід у вивченні розповсюдження раку легені по паренхімі (попередні дані) / A new approach in the study of the spread of lung cancer in the parenchyma (preliminary data)

Research paper thumbnail of Комплексні морфологічні дослідження для уточнення гістогенезу раку легені

Research paper thumbnail of Lung cancer and alveolar epithelium

Research paper thumbnail of Показники ядерець перехідного типу в альвеолярному епітелії при помірнодиференційованому плоскоклітинному раку легені / Indicators of transitional nucleoli in alveolar epithelium in moderately differentiated squamous cell lung cancer

Research paper thumbnail of Brohchoscopic and cytological studies in the central growth of lung cancer

Research paper thumbnail of Гістологічні типи пухлин жирової тканини та їх характеристика / Histological types of adipose tissue tumors and their characteristics

Research paper thumbnail of Cytological research of exophytic tumors of the bronchi and the growth pattern of lung cancer

NaUKMA Research Papers. Biology and Ecology, 2021

Background. The study of the growth of lung cancer (LC) has an important clinical significance fo... more Background. The study of the growth of lung cancer (LC) has an important clinical significance for morphological verification, the choice of the treatment method, and the determining of prognosis. Investigation of this question allows to clarify the histogenesis of LC. The aim of our study was to compare the results of cytological studies of the material obtained during flexible bronchoscopy (FBS) and scrapings from the operated tumors of the bronchi to clarify the nature of LC growth. Design. To study the growth of tumors in the bronchi in relation to the bronchial mucosa, the cytological examination of the material obtained by FBS and scrapings from the surface of the operated bronchial tumors of 31 patients has been performed. Results. In the preoperative period, in the material of FBS, tumor cells were found only in 1/3 of patients. To obtain the optimal material from exophytic tumors of the bronchus, scrapings were carried out from the entire surface surgical material of the sa...

Research paper thumbnail of Рак легені і квантитативна оцінка клітин паренхіми -цитологічне дослідження (попередні дані) / Lung cancer and quantitative evaluation of parenchymal cells -cytological examination (preliminary data)

Research paper thumbnail of Рак легені і альвеолярний епітелій/Lung cancer and alveolar epithelium

Research paper thumbnail of Overview of Globus-M2 spherical tokamak results at the enhanced values of magnetic field and plasma current

Research paper thumbnail of Features of growth of peripheral lung cancer according to the results of macroscopic and cytological research

NaUKMA Research Papers. Biology and Ecology

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