M. Kvernebo | Oslo University Hospital (original) (raw)

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Papers by M. Kvernebo

Research paper thumbnail of Assessments of skin and tongue microcirculation reveals major changes in porcine sepsis

Clinical Physiology and Functional Imaging, 2010

Research paper thumbnail of Diffuse reflectance spectroscopy: Systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation

Microvascular Research, 2011

The microvascular oxygen saturation (SmvO2) in the skin and tongue (sublingual mucosa) in pigs (n... more The microvascular oxygen saturation (SmvO2) in the skin and tongue (sublingual mucosa) in pigs (n=6) was characterised using diffuse reflectance spectroscopy (DRS). The correlation between arterial oxygen saturation (SaO2) and SmvO2 as well as the spatial heterogeneity of SmvO2 was examined during hypoxia. DRS uses shallow-penetrating visible light to assess microvascular oxygen saturation (SmvO2) in superficial tissue. Hypoxia was induced

Research paper thumbnail of Assessments of skin and tongue microcirculation reveals major changes in porcine sepsis

Clinical Physiology and Functional Imaging, 2010

Aim: To examine the relation between central hemodynamics, clinical severity and microvascular fi... more Aim: To examine the relation between central hemodynamics, clinical severity and microvascular findings in tongue and skin during sepsis. Materials and methods: Skin and tongue microcirculation was examined using laser Doppler and video microscopy techniques before and 200 min after inducing sepsis in pigs (n = 6) by inactivated Neisseria meningitides and in two control animals. Results: All infected pigs developed clinical signs of sepsis. Pericapillary bleedings developed in the tongue in the two pigs with the most severe disease. Capillary density increased in the groin skin in infected pigs after 200 min as compared to baseline (P < 0AE02). In the same period, mean capillary flow velocity was reduced in groin skin and tongue in septic pigs (P < 0AE02). At 200 min a fraction of capillaries had developed Ôno flowÕ or Ôbrisk flowÕ, patterns hardly seen at baseline. Laser Doppler perfusion was reduced in ear and tongue after 200 min (P < 0AE02 for both). The described pathology was more pronounced in the pigs with the most severe sepsis. Conclusion: Capillary bleedings may be used as an early indication of severe sepsis. Examination of skin and tongue microcirculations may be used to characterize severity of sepsis and possibly to assess effect of treatment.

Research paper thumbnail of P25-19 Can the clinical presentation of erythromelalgia (EM) differentiate between patients with and without mutations in Nav1.7?

Clinical Neurophysiology, 2010

Research paper thumbnail of Diffuse reflectance spectroscopy: Systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation

Microvascular research, 2011

The microvascular oxygen saturation (SmvO(2)) in the skin and tongue (sublingual mucosa) in pigs ... more The microvascular oxygen saturation (SmvO(2)) in the skin and tongue (sublingual mucosa) in pigs (n=6) was characterised using diffuse reflectance spectroscopy (DRS). The correlation between arterial oxygen saturation (SaO(2)) and SmvO(2) as well as the spatial heterogeneity of SmvO(2) was examined during hypoxia. DRS uses shallow-penetrating visible light to assess microvascular oxygen saturation (SmvO(2)) in superficial tissue. Hypoxia was induced by gradual reduction in ventilation or reduction of the inspiratory oxygen fraction. The spatial heterogeneity of SmvO(2) was expressed as the coefficient of variation (CV) of repeated SmvO(2) measurements. Baseline SmvO(2) before interventions was 20.2% (10.3%-38.1%, median with range) in groin skin, 32.9% (13.0%-49.3%) in the ear and 42.2% (32.1%-51.5%) in the tongue. SmvO(2) in the groin was significantly lower than venous oxygen saturation (SvO(2)) (p<0.05) and SmvO(2) in the tongue (p=0.03). There was a significant linear correla...

Research paper thumbnail of Assessments of skin and tongue microcirculation reveals major changes in porcine sepsis

Clinical Physiology and Functional Imaging, 2010

Research paper thumbnail of Diffuse reflectance spectroscopy: Systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation

Microvascular Research, 2011

The microvascular oxygen saturation (SmvO2) in the skin and tongue (sublingual mucosa) in pigs (n... more The microvascular oxygen saturation (SmvO2) in the skin and tongue (sublingual mucosa) in pigs (n=6) was characterised using diffuse reflectance spectroscopy (DRS). The correlation between arterial oxygen saturation (SaO2) and SmvO2 as well as the spatial heterogeneity of SmvO2 was examined during hypoxia. DRS uses shallow-penetrating visible light to assess microvascular oxygen saturation (SmvO2) in superficial tissue. Hypoxia was induced

Research paper thumbnail of Assessments of skin and tongue microcirculation reveals major changes in porcine sepsis

Clinical Physiology and Functional Imaging, 2010

Aim: To examine the relation between central hemodynamics, clinical severity and microvascular fi... more Aim: To examine the relation between central hemodynamics, clinical severity and microvascular findings in tongue and skin during sepsis. Materials and methods: Skin and tongue microcirculation was examined using laser Doppler and video microscopy techniques before and 200 min after inducing sepsis in pigs (n = 6) by inactivated Neisseria meningitides and in two control animals. Results: All infected pigs developed clinical signs of sepsis. Pericapillary bleedings developed in the tongue in the two pigs with the most severe disease. Capillary density increased in the groin skin in infected pigs after 200 min as compared to baseline (P < 0AE02). In the same period, mean capillary flow velocity was reduced in groin skin and tongue in septic pigs (P < 0AE02). At 200 min a fraction of capillaries had developed Ôno flowÕ or Ôbrisk flowÕ, patterns hardly seen at baseline. Laser Doppler perfusion was reduced in ear and tongue after 200 min (P < 0AE02 for both). The described pathology was more pronounced in the pigs with the most severe sepsis. Conclusion: Capillary bleedings may be used as an early indication of severe sepsis. Examination of skin and tongue microcirculations may be used to characterize severity of sepsis and possibly to assess effect of treatment.

Research paper thumbnail of P25-19 Can the clinical presentation of erythromelalgia (EM) differentiate between patients with and without mutations in Nav1.7?

Clinical Neurophysiology, 2010

Research paper thumbnail of Diffuse reflectance spectroscopy: Systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation

Microvascular research, 2011

The microvascular oxygen saturation (SmvO(2)) in the skin and tongue (sublingual mucosa) in pigs ... more The microvascular oxygen saturation (SmvO(2)) in the skin and tongue (sublingual mucosa) in pigs (n=6) was characterised using diffuse reflectance spectroscopy (DRS). The correlation between arterial oxygen saturation (SaO(2)) and SmvO(2) as well as the spatial heterogeneity of SmvO(2) was examined during hypoxia. DRS uses shallow-penetrating visible light to assess microvascular oxygen saturation (SmvO(2)) in superficial tissue. Hypoxia was induced by gradual reduction in ventilation or reduction of the inspiratory oxygen fraction. The spatial heterogeneity of SmvO(2) was expressed as the coefficient of variation (CV) of repeated SmvO(2) measurements. Baseline SmvO(2) before interventions was 20.2% (10.3%-38.1%, median with range) in groin skin, 32.9% (13.0%-49.3%) in the ear and 42.2% (32.1%-51.5%) in the tongue. SmvO(2) in the groin was significantly lower than venous oxygen saturation (SvO(2)) (p<0.05) and SmvO(2) in the tongue (p=0.03). There was a significant linear correla...

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