Cândida Manuel | Universidade Lusófona do Porto (original) (raw)
Papers by Cândida Manuel
chemical precipitation Abstract. The wet mechanochemical process (MC) and chemical precipitation ... more chemical precipitation Abstract. The wet mechanochemical process (MC) and chemical precipitation (CP) used to prepare hydroxyapatite (HA) and tricalcium phosphate (TCP) nanoparticles proved to be successful. In mechanochemical treatment, water and ethanol were used as a solvent but the last one improved particles agglomeration and decreased HA formation. This effect was also observed when aging temperature was decreased in wet chemical precipitation. Introduction. Calcium phosphate based ceramics have proved to be attractive materials for orthopaedic applications. Among these bioceramics, particular attention has been given to hydroxyapatite and tricalcium phosphate due to its bioactivity and biocompatibility. The search for materials similar to the main mineral component of bone led to the development of nanoparticles. Several methods
Key Engineering Materials, 2003
INEB – Instituto de Engenharia Biomédica, Lab. de Biomateriais, Universidade do Porto, Rua do Cam... more INEB – Instituto de Engenharia Biomédica, Lab. de Biomateriais, Universidade do Porto, Rua do Campo Alegre, 823, 4150 -180 Porto, Portugal, cmmanuel@fe.up.pt Rensselaer Poly. Institute, Materials Science and Engineering Dep., Troy, NY, 12180-3590 USA, fosterm5@rpi.edu, doremr@rpi.edu Universidade do Porto, Faculdade de Engenharia, Dep. de Engenharia Metalúrgica e Materiais, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal E-mail: fjmont@fe.up.pt Universidade Fernando Pessoa, Faculdade de Ciências da Saúde, Rua Carlos da Maia, 296, 4200-150 Porto, Portugal, mpferraz@ufp.up.pt Rensselaer Poly. Institute, Department of Biomedical Engineering, Troy, NY, USA, bizios@rpi.edu
ABSTRACT: Hydroxyapatite (HA) has been widely used as a biocompatible ceramic in many areas of me... more ABSTRACT: Hydroxyapatite (HA) has been widely used as a biocompatible ceramic in many areas of medicine, but mainly for contact with bone tissue, due to its resemblance to mineral bone. In mammals, the skeleton presents a carbonated and partially substituted apatite, based on nanocrystal aggregates, and associated with collagen, building up 3-D structures present in various bone tissue conformations like trabecular or cancellous bone. There has been growing interest in developing bioactive synthetic ceramics that could closely mimic natural apatite characteristics. This review presents some of the most well known forms of obtaining, by precipitation methods, nanophased HA. Some traditional and more recent developments vis-à-vis the possible HA nanoparticles applications are discussed.(Journal of Applied Biomaterials & Biomechanics 2004; 2: 74-80)
Journal of Biomedical Materials Research Part A, 2016
Tese de doutoramento. Ciências de Engenharia. Faculdade de Engenharia. Universidade do Porto. 2007
Dissertação apresentada para obtenção do grau de Mestre em Engenharia dos Processos Químicos, na ... more Dissertação apresentada para obtenção do grau de Mestre em Engenharia dos Processos Químicos, na Faculdade de Engenharia da Universidade do Porto, sob a orientação do Prof. Doutor José Inácio Martins
Colloids and Surfaces B: Biointerfaces, 2015
Journal of applied biomaterials & biomechanics : JABB
Hydroxyapatite (HA) has been widely used as a biocompatible ceramic in many areas of medicine, bu... more Hydroxyapatite (HA) has been widely used as a biocompatible ceramic in many areas of medicine, but mainly for contact with bone tissue, due to its resemblance to mineral bone. In mammals, the skeleton presents a carbonated and partially substituted apatite, based on nanocrystal aggregates, and associated with collagen, building up 3-D structures present in various bone tissue conformations like trabecular or cancellous bone. There has been growing interest in developing bioactive synthetic ceramics that could closely mimic natural apatite characteristics. This review presents some of the most well known forms of obtaining, by precipitation methods, nanophased HA. Some traditional and more recent developments vis-à-vis the pos-sible HA nanoparticles applications are discussed.
Key Engineering Materials, 2003
International microbiology : the official journal of the Spanish Society for Microbiology, 2013
Surfaces of medical implants are generally designed to encourage soft- and/or hard-tissue adheren... more Surfaces of medical implants are generally designed to encourage soft- and/or hard-tissue adherence, eventually leading to tissue- or osseo-integration. Unfortunately, this feature may also encourage bacterial adhesion and biofilm formation. To understand the mechanisms of bone tissue infection associated with contaminated biomaterials, a detailed understanding of bacterial adhesion and subsequent biofilm formation on biomaterial surfaces is needed. In this study, a continuous-flow modular reactor composed of several modular units placed in parallel was designed to evaluate the activity of circulating bacterial suspensions and thus their predilection for biofilm formation during 72 h of incubation. Hydroxyapatite discs were placed in each modular unit and then removed at fixed times to quantify biofilm accumulation. Biofilm formation on each replicate of material, unchanged in structure, morphology, or cell density, was reproducibly observed. The modular reactor therefore proved to ...
Journal of Biomaterials Applications, 2014
Colloid and Polymer Science, 2005
chemical precipitation Abstract. The wet mechanochemical process (MC) and chemical precipitation ... more chemical precipitation Abstract. The wet mechanochemical process (MC) and chemical precipitation (CP) used to prepare hydroxyapatite (HA) and tricalcium phosphate (TCP) nanoparticles proved to be successful. In mechanochemical treatment, water and ethanol were used as a solvent but the last one improved particles agglomeration and decreased HA formation. This effect was also observed when aging temperature was decreased in wet chemical precipitation. Introduction. Calcium phosphate based ceramics have proved to be attractive materials for orthopaedic applications. Among these bioceramics, particular attention has been given to hydroxyapatite and tricalcium phosphate due to its bioactivity and biocompatibility. The search for materials similar to the main mineral component of bone led to the development of nanoparticles. Several methods
Key Engineering Materials, 2003
INEB – Instituto de Engenharia Biomédica, Lab. de Biomateriais, Universidade do Porto, Rua do Cam... more INEB – Instituto de Engenharia Biomédica, Lab. de Biomateriais, Universidade do Porto, Rua do Campo Alegre, 823, 4150 -180 Porto, Portugal, cmmanuel@fe.up.pt Rensselaer Poly. Institute, Materials Science and Engineering Dep., Troy, NY, 12180-3590 USA, fosterm5@rpi.edu, doremr@rpi.edu Universidade do Porto, Faculdade de Engenharia, Dep. de Engenharia Metalúrgica e Materiais, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal E-mail: fjmont@fe.up.pt Universidade Fernando Pessoa, Faculdade de Ciências da Saúde, Rua Carlos da Maia, 296, 4200-150 Porto, Portugal, mpferraz@ufp.up.pt Rensselaer Poly. Institute, Department of Biomedical Engineering, Troy, NY, USA, bizios@rpi.edu
ABSTRACT: Hydroxyapatite (HA) has been widely used as a biocompatible ceramic in many areas of me... more ABSTRACT: Hydroxyapatite (HA) has been widely used as a biocompatible ceramic in many areas of medicine, but mainly for contact with bone tissue, due to its resemblance to mineral bone. In mammals, the skeleton presents a carbonated and partially substituted apatite, based on nanocrystal aggregates, and associated with collagen, building up 3-D structures present in various bone tissue conformations like trabecular or cancellous bone. There has been growing interest in developing bioactive synthetic ceramics that could closely mimic natural apatite characteristics. This review presents some of the most well known forms of obtaining, by precipitation methods, nanophased HA. Some traditional and more recent developments vis-à-vis the possible HA nanoparticles applications are discussed.(Journal of Applied Biomaterials & Biomechanics 2004; 2: 74-80)
Journal of Biomedical Materials Research Part A, 2016
Tese de doutoramento. Ciências de Engenharia. Faculdade de Engenharia. Universidade do Porto. 2007
Dissertação apresentada para obtenção do grau de Mestre em Engenharia dos Processos Químicos, na ... more Dissertação apresentada para obtenção do grau de Mestre em Engenharia dos Processos Químicos, na Faculdade de Engenharia da Universidade do Porto, sob a orientação do Prof. Doutor José Inácio Martins
Colloids and Surfaces B: Biointerfaces, 2015
Journal of applied biomaterials & biomechanics : JABB
Hydroxyapatite (HA) has been widely used as a biocompatible ceramic in many areas of medicine, bu... more Hydroxyapatite (HA) has been widely used as a biocompatible ceramic in many areas of medicine, but mainly for contact with bone tissue, due to its resemblance to mineral bone. In mammals, the skeleton presents a carbonated and partially substituted apatite, based on nanocrystal aggregates, and associated with collagen, building up 3-D structures present in various bone tissue conformations like trabecular or cancellous bone. There has been growing interest in developing bioactive synthetic ceramics that could closely mimic natural apatite characteristics. This review presents some of the most well known forms of obtaining, by precipitation methods, nanophased HA. Some traditional and more recent developments vis-à-vis the pos-sible HA nanoparticles applications are discussed.
Key Engineering Materials, 2003
International microbiology : the official journal of the Spanish Society for Microbiology, 2013
Surfaces of medical implants are generally designed to encourage soft- and/or hard-tissue adheren... more Surfaces of medical implants are generally designed to encourage soft- and/or hard-tissue adherence, eventually leading to tissue- or osseo-integration. Unfortunately, this feature may also encourage bacterial adhesion and biofilm formation. To understand the mechanisms of bone tissue infection associated with contaminated biomaterials, a detailed understanding of bacterial adhesion and subsequent biofilm formation on biomaterial surfaces is needed. In this study, a continuous-flow modular reactor composed of several modular units placed in parallel was designed to evaluate the activity of circulating bacterial suspensions and thus their predilection for biofilm formation during 72 h of incubation. Hydroxyapatite discs were placed in each modular unit and then removed at fixed times to quantify biofilm accumulation. Biofilm formation on each replicate of material, unchanged in structure, morphology, or cell density, was reproducibly observed. The modular reactor therefore proved to ...
Journal of Biomaterials Applications, 2014
Colloid and Polymer Science, 2005