Erdal Eren | Uludag University (original) (raw)

Papers by Erdal Eren

Güncel Pediatri, 2017

Amac Tip 1 diyabetli birey ve ailelerin teknolojik cihazlara ilgisi giderek artmaktadir. Devamli ... more Amac Tip 1 diyabetli birey ve ailelerin teknolojik cihazlara ilgisi giderek artmaktadir. Devamli kan seker takibinin ailelerde olusturdugu guven ve rahatliktan dolayi ulkemizde piyasaya surulmese de “Freestyle Libre (Abbott)” isimli cihazin kullaniminda artis dikkati cekmektedir. Burada cihazini kullanan diyabetik bireylerin verileri, ailelerin cihaz ile ilgili tecrube, memnuniyet ve sorunlari arastirilmistir. Gerec ve Yontemler : Diyabetli ailelerin olusturdugu sosyal platformdaki toplulukta, web tabanli bir anket ile degerlendirme yapildi. Anket, diyabetiklerin yas, cinsiyet, ortalama Hba1c, diyabetin suresi gibi sorularin yaninda cihaz ile ilgili farkli sorulari iceriyordu. Anket anne ve/veya babalar tarafinca dolduruldu. Tekrar yanitlar, eksik veriler, 18 yas ustu bireyler calismadan cikarildi. Bulgular: Calismaya dahil edilen 72 olgunun ortalama yasi 8,29 yil olup, %42’si erkekti. Diyabet suresi 2,6 yil, son HbA1c ortalamasi %7,27 saptandi. Cihazin ortalama 5,6 ay (15 gun-19 a...

Iranian Journal of Pediatrics, 2014

Objective: Obesity increases cardiac diseases by increasing tendency to atherosclerosis. Our aim ... more Objective: Obesity increases cardiac diseases by increasing tendency to atherosclerosis. Our aim was to define epicardial adipose tissue thickness, and its related factors in obese children. Methods: Total of 94 patients were divided into obesity with metabolic syndrome (MS) (n=30), obesity without MS (n=33), and control (n=31) groups. Auxological values with fasting glucose, fasting insulin, alanine transaminase, serum lipid levels, and high sensitive C-reactive protein levels were evaluated. Epicardial adipose tissue thickness, interventricular septum thickness and left ventricular mass were measured by echocardiography. Findings: Weight, body mass index, waist circumference, insulin, alanine transaminase, and high sensitive C-reactive protein values were markedly higher in obesity group when compared with controls (P<0.001). Epicardial adipose tissue thickness was 0.64±0.23 cm in obesity with MS; 0.60±0.20 cm in obesity without MS, and 0.27±0.12 cm in control group (P<0.001...

Turkish Journal of Trauma and Emergency Surgery

BACKGROUND: This present study was designed to evaluate the effect of restrictions on fracture ad... more BACKGROUND: This present study was designed to evaluate the effect of restrictions on fracture admission to a Level-1 tertiary trauma hospital between COVID-19 pandemic and pre-pandemic restriction time intervals that included groups of younger than <20-years-old, 20-65-years-old, and older than aged >65-years-old. METHODS: Patients who were hospitalized and treated for orthopedic treatment between 10 March and 1 June during the pandemic period were retrospectively analyzed. Control group consisted of patients admitted to the hospital in the same time interval in 2019. The patients were divided into three groups, under 20 years of age, between 20 and 65 years of age, and over 65 years of age. The patients' data included age, gender, trauma mechanism, fracture type, and any COVID-19 radiological or clinical symptoms. RESULTS: The number of patients >65-years-old admitted to the orthopedic trauma center was high at pandemic intervals compared to pre-pandemic time. When the groups were compared for patients of 20-65-years-old; there was a significant difference for the fracture type (p<0.05). Lower extremity fractures were high at pre-pandemic group, whereas multiple traumas were high at pandemic group. For subgroup 20-65 ages, low-energy traumas were higher at pre-pandemic group, whereas high-energy traumas were more frequent at the pandemic group. CONCLUSION: We observed a decrease in fracture admission to orthopedic trauma centers during COVID-19 pandemic for subgroups of <20-years-old and 20-65-years-old ages, whereas there was a significant increase for >65-years-old age, most of them related to the osteoporotic hip fractures. So that older age group should be encouraged to mobilize at home and have permission to walk and make physical activity to avoid osteoporosis for a limited time daily.

The Journal of Pediatric Research

The aim of this study was to investigate the effect of the Triple P-Positive Parenting Training P... more The aim of this study was to investigate the effect of the Triple P-Positive Parenting Training Program which was applied to the parents of children and adolescents with type 1 diabetes (TID) diagnosis aged 3-12 years on parental attitude, parental mental health, and child behavior. Materials and Methods: The research was conducted in a quasiexperimental manner. The sample of the research consisted of 32 parents who had children with T1D diagnosis aged 3-12 years and who agreed to participate in the study. Data were collected using the Family Background Questionnaire, General Health Questionnaire, Strengths and Difficulties Questionnaire, Parental Attitude Research Instrument, Conflict Behavior Questionnaire and Parent Satisfaction Questionnaire. Group Triple P Programme was implemented with the all group for 8 weeks. Data were collected immediately after the programme. Data were evaluated by using multidirectional variance analysis, t-test and chi-square test. Results: It has been shown that the Group Triple P applied to the parents of the children who had children with T1D diagnosis positively affects the mental health of the parents, their parental attitudes and the problematic behaviour of the children and the parents had less conflict with their children and the children had less conflict with their parents. Conclusion: It is suggested to carry out studies in different centers and cities with Group Triple P Programme, to widen the use of Group Triple P Programme, to plan researches where Group Triple P programme and other programmes currently used in country would be compared.

Journal of Clinical Research in Pediatric Endocrinology

No large study has been conducted to date to compare the effectiveness of prednisolone, alendrona... more No large study has been conducted to date to compare the effectiveness of prednisolone, alendronate and pamidronate as first-line treatment in children with hypercalcemia due to vitamin D intoxication. The aim was to perform a multicenter, retrospective study assessing clinical characteristics and treatment results. Methods: A standard questionnaire was uploaded to an online national database system to collect data on children with hypercalcemia (serum calcium level >10.5 mg/dL) due to vitamin D intoxication [serum 25-hydroxyvitamin D (25(OH)D) level >150 ng/mL] who were treated in pediatric endocrinology clinics. Results: Seventy-four children [median (range) age 1.06 (0.65-1.60) years, 45 males (61%) from 11 centers] were included. High-dose vitamin D intake was evident in 77% of the cases. At diagnosis, serum calcium, phosphorus, alkaline phosphatase, 25(OH)D and parathyroid hormone concentrations were 15±3.2 mg/dL, 5.2±1.2 mg/dL, 268±132 IU/L, 322 (236-454) ng/mL, and 5.5 (3-10.5) pg/ mL, respectively. Calcium levels showed moderate correlation with 25(OH)D levels (r s =0.402, p<0.001). Patients were designated into five groups according to the initial specific treatment regimens (hydration-only, prednisolone, alendronate, pamidronate, and

Proceedings

Mutations in the gene for fibroblast growth factor receptor 3 (FGFR3) are implicated in achondrop... more Mutations in the gene for fibroblast growth factor receptor 3 (FGFR3) are implicated in achondroplasia, an autosomal-dominant form of short-limbed dwarfism. The present study involves a combination of clinical exome sequencing, targeted resequencing and protein modeling methods to decipher the pathobiology of achondroplasia with psychomotor delay in a two-year-old child. Accordingly, the resulting genetic information establishes the frequent FGFR3 c.1138G>A (p.G380R) mutation as the single hit causing pediatric achondroplasia with psychomotor delay, while the predicted model stresses the importance of a phenylalanyl residue (F384) in enhancing the dimerization potential of the receptor’s transmembrane domain via a cation‒π interaction with the newly introduced arginyl residue. Overall, the likely involvement of FGFR3G380R in psychomotor delay calls for comprehensive clinical assessment in achondroplastic children, although the precise mechanism by which the mutant receptor result...

Journal of clinical research in pediatric endocrinology, Nov 23, 2018

To assess the incidence of type 1 diabetes mellitus (T1DM) in children under 18 years of age in t... more To assess the incidence of type 1 diabetes mellitus (T1DM) in children under 18 years of age in the northwest region of Turkey during 2013-2015. All newly diagnosed T1DM cases were recorded prospectively during 2013-2015. Total as well as gender and age group specific (0-4, 5-9, 10-14 and 15-17 age) mean incidences per 100.000 per year were calculated. There were 1773 patients diagnosed during 2013-2015 (588 cases in 2013, 592 cases in 2014, 593 cases in 2015). Of these, 862 (48.6%) were girls and 911(51.4%) were boys. The mean age at diagnosis was 9.2±4.2 years and it was not significantly different between girls (9.0±4.1 years) and boys (9.4±4.4 years) (p=0.052). The crude mean incidence was 8.99/100.000 (95% CI: 8.58-9.42). Although mean incidence was similar between boys [8.98/100.000 (CI:8.40 to 9.58)] and girls [9.01/100.000 (CI:8.42 to 9.63)], there was male predominance in all groups except for 5-9 year age group. The standardized mean incidence was 9.02/100.000 according to...

Journal of clinical research in pediatric endocrinology, Jan 20, 2017

Type 1 diabetes mellitus (T1DM) is a chronic disease, which ranks third in the children under 16 ... more Type 1 diabetes mellitus (T1DM) is a chronic disease, which ranks third in the children under 16 years old. Expressed emotion (EE) is a term that indicates a specific family climate including lack of emotional support (LES), irritability and emotional over-involvement. It is known that the family environment is highly important on glycemic control in diabetic adolescents. In this study the relationship between perceived EE and glycemic control in adolescents diagnosed with T1DM not accompanied by psychopathology will be investigated. This study was completed with 49 adolescents with T1DM and 50 adolescents as control group. All participants evaluated by researchers and adolescents with psychopathology and intellectually disability were excluded from the study. Perceived EE was measured by the Shortened Level of Expressed Emotion Scale (SLEES) and blood sugar regulation was assessed by HbA1c levels. In our study adolescents with T1DM showed a significant difference in perceived EE (p...

Güncel Pediatri, 2016

Retrospective Evaluation of Patients Diagnosed with Osteogenesis Imperfecta Osteogenesis imperfec... more Retrospective Evaluation of Patients Diagnosed with Osteogenesis Imperfecta Osteogenesis imperfecta (OI) is a hereditary disease that destroys the quality of life by continous bone fractures. Osteogenesis imperfecta according to the most used classification is divided into four clinic types. Type I patientes are normal or slightly short with blue sclera but no bone deformities. Patients with type II show lethal progression in perinatal period, several vertebra and long bone fractures at birth and dark scleras. Type III babies have dark scleras with triangular face, evident short height, scoliosis and deformities due to intrauterine fractures. Type IV are patients with grey or white scleras and slightly short height, scoliosis and bone deformities. In recent years three more clinical types have been added to the previous classification. The objective of our study is to retrospectively evaluate patients diagnosed with OI and come up with helpful data that will assist developing new diagnosis and treatment protocols. Patients followed-up and diagnosed with osteogenesis imperfecta at Uludağ University Faculty of Medicine Pediatric Endocrinology outpatient clinic between January 2010 and December 2014 were included in to the study. A total of thirty patients were investigated, two patients were left out of the study because they did not continue with the follow-up, 28 patients were included in the study. Cases were divided into autosomal dominant four clinical types according to Silence classification. Out of the 28 cases in our study, 14 (50%) were boys, 14 (50%) were girls, and median age was 7.48±5.09 years. Median v age at diagnosis was 25.59±39.59 months. Ten cases (47.6%) had a family history of osteogenesis imperfecta, and 7 cases (25.0%) had consanguineous family marriage history. The cases were divided into autosomal dominant four clinic types according to Silence classification as follows; 13 cases (46.4%) type I, 10 cases (35.7%) type III, and 5 cases (17.9%) type IV. The mean average basal DEXA (Dual-Energy X-Ray Absorptiometry) Z score before treatment was-4.76±1.56 whereas after treatment the score was-2.27±1.36 (p<0.001). Median height SDS increased from-2.61±2.78 to-1.87±2.34 (p<0.001), median weight SDS (Standard Deviation Score) increased from-1.68±2.71 to-0.79±2.17 (p<0.001), and body mass index SDS increased from-2.18±2.60 to-1.28±2.36 (p<0.001). Treatment of OI with pamidronate was seen to facilitate increase in bone mineral density, decrease in number of fractures and pain, and improvement of the patient's quality of life by inreased mobility. Pamidronate is one of the most effective treatment of OI until a more effective treatment is found. However since the long-term side effect of pamidronate on bones is not clearly known, we think that randomised controlled studies stil need to be done to determine the optimal period interval, and dose for bisphosphonate use.

Güncel Pediatri, 2015

Dilate kardiyomiyopati (KMP) çocuklarda kalp yetmezliğinin önemli bir nedenidir. Çoğunlukla trans... more Dilate kardiyomiyopati (KMP) çocuklarda kalp yetmezliğinin önemli bir nedenidir. Çoğunlukla transplantasyon ihtiyacı duyulan bu hastalıkta nadiren medikal tedavi ile tam iyileşme sağlanabilir. Burada KMP ve rikets tanılarıyla izlenen bir olgu sunulmuştur. Olgu Sunumu: Üç aylık olgu çocuk endokrin polikliniğine kalsiyum (Ca) düşüklüğü nedeniyle yönlendirilmişti. Fizik muayenede el bileklerinde genişleme, geniş ön fontanel dikkati çekiyordu. Laboratuvar değerlendirmede, Ca 6,8 mg/dl, fosfor 4,9 mg/dl, alkalin fosfataz 1637 U/L, paratiroid hormon 191,2 pg/ ml, 25 hidroksi vitamin D düzeyi 5,7 ng/ml saptandı. El bilek grafisinde raşitizmle uyumlu bulgular vardı. Ekokardiyogramda geniş sol ventrikül, hipokinetik kalp kası, ejeksiyon fraksiyonu %42, fraksiyonel kısalma %20 idi. Vitamin D eksikliği tanısıyla önce Ca laktat tedavisi ardından D vitamin tedavisi başlandı. Tedavinin 3. ayında radyolojik bulguların düzeldi ve rikets bulguları kayboldu. Ekokardiyogram bulguları normale döndü. Tedaviden sonra kardiyak fonksiyonların düzelmeye başlaması nedeniyle olguda vitamin D eksikliğine bağlı dilate KMP düşünüldü. Nutrisyonel riketsin endemik olduğu bölgelerde dilate KMP'nin etyolojik değerlendirmesinde vitamin D eksikliği tanısı düşünülmeli, tedavinin dramatik iyileşme sağlayabileceği akılda tutulmalıdır.

Journal of Clinical Research in Pediatric Endocrinology, 2015

Children with Turner syndrome (TS) have a specific growth pattern that is quite different from th... more Children with Turner syndrome (TS) have a specific growth pattern that is quite different from that of healthy children. Many countries have population-specific growth charts for TS. Considering national and ethnic differences, we undertook this multicenter collaborative study to construct growth charts and reference values for height, weight and body mass index (BMI) from 3 years of age to adulthood for spontaneous growth of Turkish girls with TS. Methods: Cross-sectional height and weight data of 842 patients with TS, younger than 18 years of age and before starting any therapy, were evaluated. Results: The data were processed to calculate the 3 rd , 10 th , 25 th , 50 th , 75 th , 90 th and 97 th percentile values for defined ages and to construct growth curves for height-forage , weight-forage and BMI-forage of girls with TS. The growth pattern of TS girls in this series resembled the growth pattern of TS girls in other reports, but there were differences in height between our series and the others. Conclusion: This study provides disease-specific growth charts for Turkish girls with TS. These disease-specific national growth charts will serve to improve the evaluation of growth and its management with growth-promoting therapeutic agents in TS patients.

Journal of clinical research in pediatric endocrinology, Jan 5, 2015

Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosom... more Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) ...

Dicle Medical Journal / Dicle Tıp Dergisi, 2013

Objective: In this study, we aimed to evaluate cases of meningitis for epidemiologic, clinical, l... more Objective: In this study, we aimed to evaluate cases of meningitis for epidemiologic, clinical, laboratory findings and the treatment response. Materials and methods: We evaluated ninety two patients whose diagnosis were meningitis retrospectively between January 2010 and December 2011, for age, gender, presenting symptoms, physical examination, laboratory findings and treatments. The patients who were hospitalized with central nervous system infection were diagnosed as meningitis by examination of cerebrospinal fluid (CSF) under a microscope and evaluation of biochemical (glucose, protein, chloride) results and / or culture. Results: Fifty patients were male and 42 were female, mean age was 4.2 ± 4.1 years. The most common symptoms were fever (91.3%), vomiting (87.0%), headache (68.5%), and convulsion (20.7%). On physical examination in descending order neck stiffness (60.9%), Brudzinski phenomenon (50%), Kernig sign (46.7%), altered consciousness (16.3%) and rash (2.2%) were detected. When patients were classified in terms of clinical and laboratory findings; bacterial meningitis was determined 53.4%, aseptic in 38% and tuberculous meningitis in 7,6%. CSF and blood culture were positive in 13 of and seven of the cases respectively. The most frequent complications were seizures, cranial nerve palsy, hydrocephalus and the syndrome of inappropriate ADH. Mortality rate was determined as 2.2%. Conclusion: The patients especially with symptoms of fever, vomiting, headache and convulsions, meningitis should be considered primary disease.

The Journal of Clinical Endocrinology & Metabolism, 2014

J Clin Res Pediatr En …, 2012

Nephrology Dialysis Transplantation, 2007

J Clin Res Pediatr En …, 2011

Archives of Disease in Childhood, 1952

Percentiles versus Standard Deviations Standards of growth in current use employ either the perce... more Percentiles versus Standard Deviations Standards of growth in current use employ either the percentile division outlined above or else a division of the healthy population by standard deviations* (e.g. Sontag and Revnolds, 1945). In * The standard deviation (a) is a measure of the spread of a frequency distribution. It is particularly appropriate to Gaussian distributions, in which the correspondence of various multiples of a to various percentiles can be seen from Figs. IA and lB. It is estimated from a sample of readings as the square root of the sum of the squares of the desiations of the readings from their mean divided by one less than the number of readings.

Journal of Clinical …, 2011

We are sorry, but NCBI web applications do not support your browser, and may not function properl... more We are sorry, but NCBI web applications do not support your browser, and may not function properly. More information here... ... J Clin Res Pediatr Endocrinol. 2011 June; 3(2): 6569. ... Copyright © Journal of Clinical Research in Pediatric Endocrinology, Published by ...