Codruţa Lăzureanu | University Of Medicine And Pharmacy Timisoara (original) (raw)
Papers by Codruţa Lăzureanu
Diagnostics, Feb 14, 2022
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Polish Journal of Pathology, 2019
Colorectal cancer (CRC) remains a major public health burden worldwide, despite increased knowled... more Colorectal cancer (CRC) remains a major public health burden worldwide, despite increased knowledge on its pathogenesis and advances in therapy. We aimed to evaluate a new histological grading system based on poorly differentiated clusters (PDCs) counting-the PDCs grade (PDCs-G), and its clinicopathological and prognostic significance, compared to the World Health Organisation (WHO) grading system (WHO grade). We reviewed 71 surgical resection specimens for CRC from the Emergency County Hospital "Pius Brînzeu" Timisoara. The cases were graded using the WHO grade and the PDCs-G, with further analysis of their association with the other recognised prognostic parameters. Using the WHO grade, 9% of the analysed cases were G1, 80% G2, 11% G3, and none of the tumours was graded G4, while in the PDCs-G 16% were G1, 45% G2, and 39% G3. In multivariate analysis PDCs-G was significantly associated with the American Joint Committee on Cancer stage of the disease (AJCC stage) (p = 0.0003), depth of invasion (pT) (p = 0.0084), nodal status (LNM) (p < 0.0001), lymphovascular invasion (LVI) (p < 0.0001), perineural invasion (PNI) (p < 0.0052), and tumour border configuration (p < 0.0001). The novel grading system based on PDCs counting is an additional histological tool in the evaluation of CRC and a promising new prognostic factor for these patients.
Anatomical Sciences Education, 2021
Several alternatives to formalin‐stored physical specimens have been described in medical literat... more Several alternatives to formalin‐stored physical specimens have been described in medical literature, but only a few studies have addressed the issue of learning outcomes when these materials were employed. The aim of this study was to conduct a prospective controlled study to assess student performance in learning anatomic pathology when adding three‐dimensional (3D) virtual models as adjunct teaching materials in the study of macroscopic lesions. Third‐year medical students (n = 501) enrolled at the Victor Babes University of Medicine and Pharmacy in Timisoara, Romania, were recruited to participate. Student performance was assessed through questionnaires. Students performed worse with new method, with poorer results in terms of overall (mean 77.6% ±SD 11.8% vs. 83.6% ±10.5) and individual question scores (percentage of questions with maximum score 34.6% ±25.6 vs. 47.7 ± 24.6). This decreased performance was generalizable, as it was observed across all language divisions and was i...
Revista de Chimie, 2001
Differentiated thyroid carcinomas are heterogeneous diseases with clinical and morphological feat... more Differentiated thyroid carcinomas are heterogeneous diseases with clinical and morphological features insufficient to predict their clinical behavior. The expression of tissue-specific transcription factors that control differentiated phenotype can be an additional method in evaluating the aggressiveness of a tumor, when differentiation markers and malignant phenotype of tumor cells are inconclusive. The expression of thyroid transcription factor-1 (TTF-1) is limited to thyroid follicular cells; it is a nuclear protein expressed in the epithelial cells of the thyroid, lungs and diencephalon. Using the monoclonal mouse antibody, clone 8G7G3/1, we examined the immunohistochemical expression of TTF-1 protein in 26 thyroid carcinomas (22 papillary carcinomas � PTC, 2 follicular carcinomas � FTC, 2 anaplastic carcinomas - AC), 4 follicular adenomas � FA, 10 benign thyroid lesions as underlying diseases (multinodular goiter � 3, Hashimoto thyroiditis � 3, Graves Basedow disease - 4) and s...
Diagnostic Pathology, 2016
Introduction/ Background The immunohistochemical expression of the Ki-67 protein is routinely use... more Introduction/ Background The immunohistochemical expression of the Ki-67 protein is routinely used for diagnostic and grading purposes of various tumors. The most common use of automation process for Ki-67 quantification is represented by breast tumors. Aims We aimed to analyze the accuracy of digital quantification of Ki-67 expression in non-breast tumors. Methods We selected all the available Ki-67 stained slides done in 2014 at the County Emergency Hospital Timisoara, Ro- mania, excluding breast tumors. Images of the stained slides (10 images/slide on average, depending on the size of the specimen) were acquired on a Leica DMD108. We performed preprocessing (autolevels) in IrfanView and Ki-67 quantification in Fiji (ImageJ distribution) using ImmunoRatio plugin. Results Proper image segmentation was identified on 25 cases. The best segmentation was obtained in lymphoid and central nervous system (CNS) tumors. Lower Ki-67 values than the ones manually reported were identified in 1...
Diagnostic Pathology, 2016
Introduction/ Background The medical school students in Timisoara, Romania have been studying pat... more Introduction/ Background The medical school students in Timisoara, Romania have been studying pathology slides in microscopy labs according to a protocol which uses classical PowerrPoint presentations as guides for understanding the microscopic features of diseases, followed by individual examination of the glass slides under the microscope. Aims We aimed to assess the impact of replacing those presentations with virtual slides (VS). Methods In the middle of the semester, for the benign tumors microscopy lab, which is presented over the course of 2 weeks, we used 3 VS, while the other 3 slides were presented in the classical PowerPoint manner. All attending students from the 3rd year of the Medical School of the University of Medicine and Pharmacy “Victor Babes” Timisoara were asked to fill out an anonymous questionnaire at the end of the lab, in which they graded the difficulty in identifying lesions, chose the best/least understood lesion and pointed out the best manner of present...
Bosnian Journal of Basic Medical Sciences, 2021
The aim of our study was to assess the prognostic value of the two new grading systems based on t... more The aim of our study was to assess the prognostic value of the two new grading systems based on the quantification of tumor budding - TB (GBd) and poorly differentiated clusters - PDCs (PDCs-G) in colorectal carcinomas (CRC). We performed a retrospective study on 71 CRC patients who underwent surgery at the Emergency County Hospital, Timișoara. CRC cases were classified based on haematoxylin-eosin slides, using the conventional grading system, GBd and PDCs-G, respectively. We used two-tier and three-tier grading schemes for each system. Subsequently, we evaluated associations with other prognostic factors in CRC. Based on the three-tier GBd (GBd-3t) most cases (34/69, 49.27%) were classified as G3Bd-3t, while based on the conventional grading system, the majority of the cases (55/69, 79.71%) were considered G2. On the other hand, based on the three-tier PDCs-G system (PDCs-G-3t), most cases (31/69, 44.93%) were PDCs-G2-3t. We also noted a more significant association of GBd-3t wi...
Chirurgia (Bucharest, Romania : 1990)
Granular cell tumors (GCT) are uncommon soft tissue neoplasms of presumed neural origin that rare... more Granular cell tumors (GCT) are uncommon soft tissue neoplasms of presumed neural origin that rarely involve the male external genitalia. Penile lesions are distinctly uncommon with less than 20 cases reported till now. In the present paper we describe the clinicopathological and immunohistochemical findings in a case of GCT of the penis shaft in a 31-years-old man. On physical examination the patient was found to have a small ovoid mass, 20 x 10 mm in diameter, at the left postero-lateral area of the penis' base. The mass was firm on palpation with no fixation on the neighboring tissues. The lesion was completely excised under loco-regional anesthesia. The surgical specimen was an ovoid, gray-white, elastic mass, of 10 x 5 mm. Microscopically, the tumor was moderately cellular and was composed of polygonal-shaped cells with abundant granular eosinophilic cytoplasm. Tumor cells were disposed in nests, cords, and trabeculae and showed perineural invasion. The tumor presented bland...
tmj.ro
Introducere: Proteina anti-apoptotica bcl-2 este investigată extensiv în relaţie cu prognosticul ... more Introducere: Proteina anti-apoptotica bcl-2 este investigată extensiv în relaţie cu prognosticul şi cu predicţia raspunsului la terapie al carcinoamelor mamare. Lucrarea de faţă analizează, pe un lot de carcinoame mamare diagnosticate la femei în postmenopauză, expresia proteinei bcl-2 în corelaţie cu alţi factori clinici şi imunohistochimici (IHC) de prognostic. Material şi metodă: Au fost analizate 40 de carcinoame mamare diagnosticate la femei în postmenopauză. Studiul IHC s-a realizat cu anticorpii monoclonali anti-bcl2, anti-ER, anti-PR, anti-Ki-67, tehnica LSAB2, vizualizare cu DAB. Rezultate: Expresia protooncogenei bcl-2 a fost identificată în 55% din carcinoamele mamare invazive. ER si PR au fost pozitivi în 55% şi respectiv 57,5% din cazuri. 30% din carcinoame au prezentat un indice Ki-67≤10%, în timp ce restul de 70% au demonstrat un indice Ki-67 > 10%. Bcl-2 a fost exprimat în 100% din tumorile T1 şi în 64% din tumorile T1+T2. 63,2% din tumorile GI+GII au prezentat reacţie pozitivă pentru bcl-2. 77% şi 83% din tumorile ER şi respectiv PR-pozitive au fost bcl-2-pozitive. 92% din tumorile cu activitate proliferativă joasă au prezentat reacţie pozitivă pentru bcl-2. Tumorile N 0 au fost în proporţie de 67% bcl-2 pozitive, în timp ce în grupul tumorilor N+, 46% au fost bcl-2 pozitive. Concluzii: La femeile postmenopauzale cu cancer mamar, proteina bcl-2 a fost semnificativ exprimată în tumorile de dimensiuni reduse, bine/mediu diferenţiate, cu receptori hormonali prezenţi şi cu activitate proliferativă redusă. Sunt necesare studii mai largi care să stabilească utilitatea includerii markerului în panelul de anticorpi ce stabileşte profilul molecular al carcinoamelor mamare.
We assessed the immunohistochemical expression of c-erbB-2 transmembrane receptor in 15 primary l... more We assessed the immunohistochemical expression of c-erbB-2 transmembrane receptor in 15 primary lung carcinomas using the polyclonal antibody anti-human c-erbB-2 oncoprotein. Tissue fragments routinely processed (formalin-fixed and paraffin-embedded) were then investigated for c-erbB-2 oncoprotein expression using the Avidin-Biotin Complex staining method. Tumor cells showed positive c-erbB-2 expression in 86.6% of non small cell lung carcinomas (NSCLC). Positive c-erbB-2 immunoreaction correlated with the advanced stage of the disease, with lymph node involvement and high metastasis rate. The results obtained suggest that tissue overexpression of c-erbB-2 protein in NSCLC characterizes a group of tumors with an aggressive clinical-biological behavior and poor prognosis; c-erbB-2 protein can be considered a useful tumor marker in the morphological diagnosis and monitoring the clinical behavior of these neoplasms.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2016
Anterior ischemic optic neuropathies (AIONs) represent a segmental infarction of the optic nerve ... more Anterior ischemic optic neuropathies (AIONs) represent a segmental infarction of the optic nerve head (ONH) supplied by the posterior ciliary arteries (PCAs). Blood supply blockage can occur with or without arterial inflammation. For this reason, there are two types of AIONs: non-arteritic (NA-AION), and arteritic (A-AION), the latter is almost invariably due to giant cell arteritis (GCA). GCA is a primary vasculitis that predominantly affects extracranial medium-sized arteries, particularly the branches of the external carotid arteries (including superficial temporal arteries - TAs). One patient with clinical suspicion of acute left AION was examined at admission following a complex protocol including color Doppler imaging (CDI) of orbital vessels, and color duplex sonography of the TAs and of the carotid arteries. She presented an equivocal combination of an abrupt, painless, and severe vision loss in the left eye, and an atypical diffuse hyperemic left optic disc edema. She had c...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2018
Although osteochondral fractures of the lateral femoral condyle are uncommon, fixation of the fra... more Although osteochondral fractures of the lateral femoral condyle are uncommon, fixation of the fragments is recommended, mostly when is about young athletes with such post-traumatic pathology. We present a case of a professional handball player teenager female, with a lateral femur condylar osteochondral fracture after a fall with the right knee in extension and in internal rotation. Magnetic resonance imaging (MRI) showed an osteochondral fracture of the lateral femoral condyle, 34.6 mm on long axis, impossible to manage arthroscopically, because of the size and the location of the detached fragment. The solution was the lateral knee arthrotomy allowing the evacuation of the hemarthrosis and preparation of the fracture site, then reduction and fixation of the fracture with absorbable cannulated pins. This procedure is of choice only when is enough bone in the detached fragment to permit the internal fixation and bone-to-bone healing with cartilaginous tissue stabilization through th...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2008
A rare case of amelanotic vulvar melanoma is presented. The patient was a 71-year-old woman compl... more A rare case of amelanotic vulvar melanoma is presented. The patient was a 71-year-old woman complaining of vulvar itching and yellowish vaginal discharge who underwent a complete gynecological evaluation during which a suspicious grey-whitish mass on her vulva was observed. The tumor presented superficial ulceration and was located in the upper half of the labia minora and clitoris. Initially it was suspected to be a vulvar carcinoma. A biopsy was taken and a histopathological suspicion of amelanotic melanoma was rendered. The mass was radically excised and the diagnosis was confirmed using HMB-45, Melan-A and anti-S-100 protein antibodies. Malignant melanoma is readily diagnosed by the presence of melanin granules. Although amelanotic melanoma contains a few melanin granules, it is often difficult to differentiate it from other non-epithelial malignant tumors. This report describes a case of amelanotic melanoma of the vulva, which was correctly diagnosed by immunohistochemical stai...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2008
Schwannomas of the lip are rare, benign neoplasms which vary in size. The diagnosis is typically ... more Schwannomas of the lip are rare, benign neoplasms which vary in size. The diagnosis is typically made at the time of surgery following biopsy and surgical resection is the mainstay of treatment. We present one case of lip schwannoma: the patient was 25-year-old and he has presented to otorhinolaryngologist for a non-dolorous tumor on the mucosal side of his inferior lip, which was increasing in size for the last six months. The tumor had a superficial ulceration and infection. Initially it was suspected to be a papilloma. The tumor was radically removed, and the sections were stained with Hematoxylin-Eosin. The tumor was encapsulated and showed two different pattern of growth. Antoni A areas displayed spindle cells closely packed together with palisading of nuclei. Verocay bodies, which were presented in Antoni A areas, are whorled formations of palisading tumor cells. The cells of neoplasm were monotone. Only few spindle cells were moderately pleomorphic, but mitotic figures were u...
Diagnostics, Feb 14, 2022
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Polish Journal of Pathology, 2019
Colorectal cancer (CRC) remains a major public health burden worldwide, despite increased knowled... more Colorectal cancer (CRC) remains a major public health burden worldwide, despite increased knowledge on its pathogenesis and advances in therapy. We aimed to evaluate a new histological grading system based on poorly differentiated clusters (PDCs) counting-the PDCs grade (PDCs-G), and its clinicopathological and prognostic significance, compared to the World Health Organisation (WHO) grading system (WHO grade). We reviewed 71 surgical resection specimens for CRC from the Emergency County Hospital "Pius Brînzeu" Timisoara. The cases were graded using the WHO grade and the PDCs-G, with further analysis of their association with the other recognised prognostic parameters. Using the WHO grade, 9% of the analysed cases were G1, 80% G2, 11% G3, and none of the tumours was graded G4, while in the PDCs-G 16% were G1, 45% G2, and 39% G3. In multivariate analysis PDCs-G was significantly associated with the American Joint Committee on Cancer stage of the disease (AJCC stage) (p = 0.0003), depth of invasion (pT) (p = 0.0084), nodal status (LNM) (p < 0.0001), lymphovascular invasion (LVI) (p < 0.0001), perineural invasion (PNI) (p < 0.0052), and tumour border configuration (p < 0.0001). The novel grading system based on PDCs counting is an additional histological tool in the evaluation of CRC and a promising new prognostic factor for these patients.
Anatomical Sciences Education, 2021
Several alternatives to formalin‐stored physical specimens have been described in medical literat... more Several alternatives to formalin‐stored physical specimens have been described in medical literature, but only a few studies have addressed the issue of learning outcomes when these materials were employed. The aim of this study was to conduct a prospective controlled study to assess student performance in learning anatomic pathology when adding three‐dimensional (3D) virtual models as adjunct teaching materials in the study of macroscopic lesions. Third‐year medical students (n = 501) enrolled at the Victor Babes University of Medicine and Pharmacy in Timisoara, Romania, were recruited to participate. Student performance was assessed through questionnaires. Students performed worse with new method, with poorer results in terms of overall (mean 77.6% ±SD 11.8% vs. 83.6% ±10.5) and individual question scores (percentage of questions with maximum score 34.6% ±25.6 vs. 47.7 ± 24.6). This decreased performance was generalizable, as it was observed across all language divisions and was i...
Revista de Chimie, 2001
Differentiated thyroid carcinomas are heterogeneous diseases with clinical and morphological feat... more Differentiated thyroid carcinomas are heterogeneous diseases with clinical and morphological features insufficient to predict their clinical behavior. The expression of tissue-specific transcription factors that control differentiated phenotype can be an additional method in evaluating the aggressiveness of a tumor, when differentiation markers and malignant phenotype of tumor cells are inconclusive. The expression of thyroid transcription factor-1 (TTF-1) is limited to thyroid follicular cells; it is a nuclear protein expressed in the epithelial cells of the thyroid, lungs and diencephalon. Using the monoclonal mouse antibody, clone 8G7G3/1, we examined the immunohistochemical expression of TTF-1 protein in 26 thyroid carcinomas (22 papillary carcinomas � PTC, 2 follicular carcinomas � FTC, 2 anaplastic carcinomas - AC), 4 follicular adenomas � FA, 10 benign thyroid lesions as underlying diseases (multinodular goiter � 3, Hashimoto thyroiditis � 3, Graves Basedow disease - 4) and s...
Diagnostic Pathology, 2016
Introduction/ Background The immunohistochemical expression of the Ki-67 protein is routinely use... more Introduction/ Background The immunohistochemical expression of the Ki-67 protein is routinely used for diagnostic and grading purposes of various tumors. The most common use of automation process for Ki-67 quantification is represented by breast tumors. Aims We aimed to analyze the accuracy of digital quantification of Ki-67 expression in non-breast tumors. Methods We selected all the available Ki-67 stained slides done in 2014 at the County Emergency Hospital Timisoara, Ro- mania, excluding breast tumors. Images of the stained slides (10 images/slide on average, depending on the size of the specimen) were acquired on a Leica DMD108. We performed preprocessing (autolevels) in IrfanView and Ki-67 quantification in Fiji (ImageJ distribution) using ImmunoRatio plugin. Results Proper image segmentation was identified on 25 cases. The best segmentation was obtained in lymphoid and central nervous system (CNS) tumors. Lower Ki-67 values than the ones manually reported were identified in 1...
Diagnostic Pathology, 2016
Introduction/ Background The medical school students in Timisoara, Romania have been studying pat... more Introduction/ Background The medical school students in Timisoara, Romania have been studying pathology slides in microscopy labs according to a protocol which uses classical PowerrPoint presentations as guides for understanding the microscopic features of diseases, followed by individual examination of the glass slides under the microscope. Aims We aimed to assess the impact of replacing those presentations with virtual slides (VS). Methods In the middle of the semester, for the benign tumors microscopy lab, which is presented over the course of 2 weeks, we used 3 VS, while the other 3 slides were presented in the classical PowerPoint manner. All attending students from the 3rd year of the Medical School of the University of Medicine and Pharmacy “Victor Babes” Timisoara were asked to fill out an anonymous questionnaire at the end of the lab, in which they graded the difficulty in identifying lesions, chose the best/least understood lesion and pointed out the best manner of present...
Bosnian Journal of Basic Medical Sciences, 2021
The aim of our study was to assess the prognostic value of the two new grading systems based on t... more The aim of our study was to assess the prognostic value of the two new grading systems based on the quantification of tumor budding - TB (GBd) and poorly differentiated clusters - PDCs (PDCs-G) in colorectal carcinomas (CRC). We performed a retrospective study on 71 CRC patients who underwent surgery at the Emergency County Hospital, Timișoara. CRC cases were classified based on haematoxylin-eosin slides, using the conventional grading system, GBd and PDCs-G, respectively. We used two-tier and three-tier grading schemes for each system. Subsequently, we evaluated associations with other prognostic factors in CRC. Based on the three-tier GBd (GBd-3t) most cases (34/69, 49.27%) were classified as G3Bd-3t, while based on the conventional grading system, the majority of the cases (55/69, 79.71%) were considered G2. On the other hand, based on the three-tier PDCs-G system (PDCs-G-3t), most cases (31/69, 44.93%) were PDCs-G2-3t. We also noted a more significant association of GBd-3t wi...
Chirurgia (Bucharest, Romania : 1990)
Granular cell tumors (GCT) are uncommon soft tissue neoplasms of presumed neural origin that rare... more Granular cell tumors (GCT) are uncommon soft tissue neoplasms of presumed neural origin that rarely involve the male external genitalia. Penile lesions are distinctly uncommon with less than 20 cases reported till now. In the present paper we describe the clinicopathological and immunohistochemical findings in a case of GCT of the penis shaft in a 31-years-old man. On physical examination the patient was found to have a small ovoid mass, 20 x 10 mm in diameter, at the left postero-lateral area of the penis' base. The mass was firm on palpation with no fixation on the neighboring tissues. The lesion was completely excised under loco-regional anesthesia. The surgical specimen was an ovoid, gray-white, elastic mass, of 10 x 5 mm. Microscopically, the tumor was moderately cellular and was composed of polygonal-shaped cells with abundant granular eosinophilic cytoplasm. Tumor cells were disposed in nests, cords, and trabeculae and showed perineural invasion. The tumor presented bland...
tmj.ro
Introducere: Proteina anti-apoptotica bcl-2 este investigată extensiv în relaţie cu prognosticul ... more Introducere: Proteina anti-apoptotica bcl-2 este investigată extensiv în relaţie cu prognosticul şi cu predicţia raspunsului la terapie al carcinoamelor mamare. Lucrarea de faţă analizează, pe un lot de carcinoame mamare diagnosticate la femei în postmenopauză, expresia proteinei bcl-2 în corelaţie cu alţi factori clinici şi imunohistochimici (IHC) de prognostic. Material şi metodă: Au fost analizate 40 de carcinoame mamare diagnosticate la femei în postmenopauză. Studiul IHC s-a realizat cu anticorpii monoclonali anti-bcl2, anti-ER, anti-PR, anti-Ki-67, tehnica LSAB2, vizualizare cu DAB. Rezultate: Expresia protooncogenei bcl-2 a fost identificată în 55% din carcinoamele mamare invazive. ER si PR au fost pozitivi în 55% şi respectiv 57,5% din cazuri. 30% din carcinoame au prezentat un indice Ki-67≤10%, în timp ce restul de 70% au demonstrat un indice Ki-67 > 10%. Bcl-2 a fost exprimat în 100% din tumorile T1 şi în 64% din tumorile T1+T2. 63,2% din tumorile GI+GII au prezentat reacţie pozitivă pentru bcl-2. 77% şi 83% din tumorile ER şi respectiv PR-pozitive au fost bcl-2-pozitive. 92% din tumorile cu activitate proliferativă joasă au prezentat reacţie pozitivă pentru bcl-2. Tumorile N 0 au fost în proporţie de 67% bcl-2 pozitive, în timp ce în grupul tumorilor N+, 46% au fost bcl-2 pozitive. Concluzii: La femeile postmenopauzale cu cancer mamar, proteina bcl-2 a fost semnificativ exprimată în tumorile de dimensiuni reduse, bine/mediu diferenţiate, cu receptori hormonali prezenţi şi cu activitate proliferativă redusă. Sunt necesare studii mai largi care să stabilească utilitatea includerii markerului în panelul de anticorpi ce stabileşte profilul molecular al carcinoamelor mamare.
We assessed the immunohistochemical expression of c-erbB-2 transmembrane receptor in 15 primary l... more We assessed the immunohistochemical expression of c-erbB-2 transmembrane receptor in 15 primary lung carcinomas using the polyclonal antibody anti-human c-erbB-2 oncoprotein. Tissue fragments routinely processed (formalin-fixed and paraffin-embedded) were then investigated for c-erbB-2 oncoprotein expression using the Avidin-Biotin Complex staining method. Tumor cells showed positive c-erbB-2 expression in 86.6% of non small cell lung carcinomas (NSCLC). Positive c-erbB-2 immunoreaction correlated with the advanced stage of the disease, with lymph node involvement and high metastasis rate. The results obtained suggest that tissue overexpression of c-erbB-2 protein in NSCLC characterizes a group of tumors with an aggressive clinical-biological behavior and poor prognosis; c-erbB-2 protein can be considered a useful tumor marker in the morphological diagnosis and monitoring the clinical behavior of these neoplasms.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2016
Anterior ischemic optic neuropathies (AIONs) represent a segmental infarction of the optic nerve ... more Anterior ischemic optic neuropathies (AIONs) represent a segmental infarction of the optic nerve head (ONH) supplied by the posterior ciliary arteries (PCAs). Blood supply blockage can occur with or without arterial inflammation. For this reason, there are two types of AIONs: non-arteritic (NA-AION), and arteritic (A-AION), the latter is almost invariably due to giant cell arteritis (GCA). GCA is a primary vasculitis that predominantly affects extracranial medium-sized arteries, particularly the branches of the external carotid arteries (including superficial temporal arteries - TAs). One patient with clinical suspicion of acute left AION was examined at admission following a complex protocol including color Doppler imaging (CDI) of orbital vessels, and color duplex sonography of the TAs and of the carotid arteries. She presented an equivocal combination of an abrupt, painless, and severe vision loss in the left eye, and an atypical diffuse hyperemic left optic disc edema. She had c...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2018
Although osteochondral fractures of the lateral femoral condyle are uncommon, fixation of the fra... more Although osteochondral fractures of the lateral femoral condyle are uncommon, fixation of the fragments is recommended, mostly when is about young athletes with such post-traumatic pathology. We present a case of a professional handball player teenager female, with a lateral femur condylar osteochondral fracture after a fall with the right knee in extension and in internal rotation. Magnetic resonance imaging (MRI) showed an osteochondral fracture of the lateral femoral condyle, 34.6 mm on long axis, impossible to manage arthroscopically, because of the size and the location of the detached fragment. The solution was the lateral knee arthrotomy allowing the evacuation of the hemarthrosis and preparation of the fracture site, then reduction and fixation of the fracture with absorbable cannulated pins. This procedure is of choice only when is enough bone in the detached fragment to permit the internal fixation and bone-to-bone healing with cartilaginous tissue stabilization through th...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2008
A rare case of amelanotic vulvar melanoma is presented. The patient was a 71-year-old woman compl... more A rare case of amelanotic vulvar melanoma is presented. The patient was a 71-year-old woman complaining of vulvar itching and yellowish vaginal discharge who underwent a complete gynecological evaluation during which a suspicious grey-whitish mass on her vulva was observed. The tumor presented superficial ulceration and was located in the upper half of the labia minora and clitoris. Initially it was suspected to be a vulvar carcinoma. A biopsy was taken and a histopathological suspicion of amelanotic melanoma was rendered. The mass was radically excised and the diagnosis was confirmed using HMB-45, Melan-A and anti-S-100 protein antibodies. Malignant melanoma is readily diagnosed by the presence of melanin granules. Although amelanotic melanoma contains a few melanin granules, it is often difficult to differentiate it from other non-epithelial malignant tumors. This report describes a case of amelanotic melanoma of the vulva, which was correctly diagnosed by immunohistochemical stai...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2008
Schwannomas of the lip are rare, benign neoplasms which vary in size. The diagnosis is typically ... more Schwannomas of the lip are rare, benign neoplasms which vary in size. The diagnosis is typically made at the time of surgery following biopsy and surgical resection is the mainstay of treatment. We present one case of lip schwannoma: the patient was 25-year-old and he has presented to otorhinolaryngologist for a non-dolorous tumor on the mucosal side of his inferior lip, which was increasing in size for the last six months. The tumor had a superficial ulceration and infection. Initially it was suspected to be a papilloma. The tumor was radically removed, and the sections were stained with Hematoxylin-Eosin. The tumor was encapsulated and showed two different pattern of growth. Antoni A areas displayed spindle cells closely packed together with palisading of nuclei. Verocay bodies, which were presented in Antoni A areas, are whorled formations of palisading tumor cells. The cells of neoplasm were monotone. Only few spindle cells were moderately pleomorphic, but mitotic figures were u...