Julio César Cortés Medina | Universidad Michoacana de San Nicolás de Hidalgo (original) (raw)

Papers by Julio César Cortés Medina

Introduction: Necrotiz ing vascul it is of the central nervous system due to varicella zoster vir... more Introduction: Necrotiz ing vascul it is of the central nervous system due to varicella zoster virus (VZV) infection implicates an infrequent entity due to direct invasion of the blood vessels. The objective is to present the cl in ical case of a parenchymal hemorrhage associated with herpes zoster cerebral vasculitis. Case report: A 19-year-old man with history of recent VZV infect ion presents with severe headache, left hemiparesis, a Glasgow coma scale of 9 points, right anisocoria secondary to parenchymal hemorrhage. The histopathological diagnosis was compatible with viral necrotiz ing vascul it is . Conclusions: Cerebral vasculitis is a rare cause of intracranial hemorrhage that should be suspected in a patient with history of recent VVZ infection. Magnetic resonance imaging and conventional angiography studies are useful elements in the diagnosis; however, they are poor indicators of the presence or vasculitis. Thus, the diagnosis does not rely on a s ingle method, but on the ...

vasculitis necrotizante del sistema nervioso central secundaria a infección por el virus varicela zoster (VVZ) , 2011

Introducción: La vasculitis necrotizante del sistema nervioso central secundaria a infección por ... more Introducción: La vasculitis necrotizante del sistema nervioso central secundaria a infección por el virus varicela zoster (VVZ) constituye una rara entidad resultado de la invasión directa de los vasos sanguíneos. El objetivo es dar a conocer el caso clínico de una hemorragia parenquimatosa como resultado de una vasculitis cerebral por herpes zoster.

Caso clínico: Un hombre de 19 años de edad con antecedente de infección primaria por VVZ unos días antes de su ingreso, se presenta con cefalea súbita de severa intensidad, hemiparesia izquierda, escala de coma de Glasgow de 9 puntos, anisocoria a expensas de pupila derecha, secundarios a hemorragia parenquimatosa. El diagnóstico histopatológico fue compatible con vasculitis necrotizante de origen viral.

Conclusiones: La vasculitis cerebral constituye una causa rara de hemorragia intracraneana que debe ser de sospecha en un paciente con historia de infección reciente por VVZ. Los estudios de resonancia magnética y angiografía convencional son elementos útiles en el diagnóstico; sin embargo, son pobres indicadores de la presencia de vasculitis. Por lo tanto, el diagnóstico no depende de un solo método, sino de la correlación clínica, imagenológica e histopatológica.

Palabras clave: Hemorragia cerebral. Herpes-Zoster. Sistema Nervioso Central. Vasculitis.

Brain tumor research and treatment, 2013

Primary spinal cord melanoma is a rare central nervous system malignant tumor. Usually it resembl... more Primary spinal cord melanoma is a rare central nervous system malignant tumor. Usually it resembles an intradural extramedullary (IDEM) nerve sheath tumor or melanoma. We experienced a patient with upper thoracic primary IDEM spinal cord melanoma who was diagnosed to be with hydrocephalus and without intracranial lesions. Initial symptoms of the patient were related to the hydrocephalus and the primary spinal cord melanoma was diagnosed eight months later. At the first operation, complete resection was impossible and the patient refused additional radiotherapy or chemotherapy. At 22 months after surgery, the patient revisited our institution with recurrent both leg weakness. Leptomeningeal dissemination was present in the whole spinal cord and only partial resection of tumor was performed. The symptoms slightly improved after surgery. Primary spinal cord melanoma is extremely rare but complete resection and additional radiotherapy or chemotherapy can prolong the disease free interva...

ACS Medicinal Chemistry Letters, 2013

Herein, we report the lead optimization of amrinone−phenylalanine based GPR142 agonists. Structur... more Herein, we report the lead optimization of amrinone−phenylalanine based GPR142 agonists. Structure− activity relationship studies led to the discovery of aminopyrazole−phenylalanine carboxylic acid 22, which exhibited good agonistic activity, high target selectivity, desirable pharmacokinetic properties, and no cytochrome P450 or hERG liability. Compound 22, together with its orally bioavailable ethyl ester prodrug 23, were found to be suitable for in vivo proof-of-concept studies. Compound 23 displayed good efficacy in a mouse oral glucose tolerance test (OGTT). Compound 22 showed GPR142 dependent stimulation of insulin secretion in isolated mouse islets and demonstrated a statistically significant glucose lowering effect in a mouse model bearing transplanted human islets.

Introduction: Necrotiz ing vascul it is of the central nervous system due to varicella zoster vir... more Introduction: Necrotiz ing vascul it is of the central nervous system due to varicella zoster virus (VZV) infection implicates an infrequent entity due to direct invasion of the blood vessels. The objective is to present the cl in ical case of a parenchymal hemorrhage associated with herpes zoster cerebral vasculitis. Case report: A 19-year-old man with history of recent VZV infect ion presents with severe headache, left hemiparesis, a Glasgow coma scale of 9 points, right anisocoria secondary to parenchymal hemorrhage. The histopathological diagnosis was compatible with viral necrotiz ing vascul it is . Conclusions: Cerebral vasculitis is a rare cause of intracranial hemorrhage that should be suspected in a patient with history of recent VVZ infection. Magnetic resonance imaging and conventional angiography studies are useful elements in the diagnosis; however, they are poor indicators of the presence or vasculitis. Thus, the diagnosis does not rely on a s ingle method, but on the ...

vasculitis necrotizante del sistema nervioso central secundaria a infección por el virus varicela zoster (VVZ) , 2011

Introducción: La vasculitis necrotizante del sistema nervioso central secundaria a infección por ... more Introducción: La vasculitis necrotizante del sistema nervioso central secundaria a infección por el virus varicela zoster (VVZ) constituye una rara entidad resultado de la invasión directa de los vasos sanguíneos. El objetivo es dar a conocer el caso clínico de una hemorragia parenquimatosa como resultado de una vasculitis cerebral por herpes zoster.

Caso clínico: Un hombre de 19 años de edad con antecedente de infección primaria por VVZ unos días antes de su ingreso, se presenta con cefalea súbita de severa intensidad, hemiparesia izquierda, escala de coma de Glasgow de 9 puntos, anisocoria a expensas de pupila derecha, secundarios a hemorragia parenquimatosa. El diagnóstico histopatológico fue compatible con vasculitis necrotizante de origen viral.

Conclusiones: La vasculitis cerebral constituye una causa rara de hemorragia intracraneana que debe ser de sospecha en un paciente con historia de infección reciente por VVZ. Los estudios de resonancia magnética y angiografía convencional son elementos útiles en el diagnóstico; sin embargo, son pobres indicadores de la presencia de vasculitis. Por lo tanto, el diagnóstico no depende de un solo método, sino de la correlación clínica, imagenológica e histopatológica.

Palabras clave: Hemorragia cerebral. Herpes-Zoster. Sistema Nervioso Central. Vasculitis.

Brain tumor research and treatment, 2013

Primary spinal cord melanoma is a rare central nervous system malignant tumor. Usually it resembl... more Primary spinal cord melanoma is a rare central nervous system malignant tumor. Usually it resembles an intradural extramedullary (IDEM) nerve sheath tumor or melanoma. We experienced a patient with upper thoracic primary IDEM spinal cord melanoma who was diagnosed to be with hydrocephalus and without intracranial lesions. Initial symptoms of the patient were related to the hydrocephalus and the primary spinal cord melanoma was diagnosed eight months later. At the first operation, complete resection was impossible and the patient refused additional radiotherapy or chemotherapy. At 22 months after surgery, the patient revisited our institution with recurrent both leg weakness. Leptomeningeal dissemination was present in the whole spinal cord and only partial resection of tumor was performed. The symptoms slightly improved after surgery. Primary spinal cord melanoma is extremely rare but complete resection and additional radiotherapy or chemotherapy can prolong the disease free interva...

ACS Medicinal Chemistry Letters, 2013

Herein, we report the lead optimization of amrinone−phenylalanine based GPR142 agonists. Structur... more Herein, we report the lead optimization of amrinone−phenylalanine based GPR142 agonists. Structure− activity relationship studies led to the discovery of aminopyrazole−phenylalanine carboxylic acid 22, which exhibited good agonistic activity, high target selectivity, desirable pharmacokinetic properties, and no cytochrome P450 or hERG liability. Compound 22, together with its orally bioavailable ethyl ester prodrug 23, were found to be suitable for in vivo proof-of-concept studies. Compound 23 displayed good efficacy in a mouse oral glucose tolerance test (OGTT). Compound 22 showed GPR142 dependent stimulation of insulin secretion in isolated mouse islets and demonstrated a statistically significant glucose lowering effect in a mouse model bearing transplanted human islets.