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Papers by Sanjana Sathrasala

Research paper thumbnail of Quantitative analysis of tear angiogenic factors in retinopathy of prematurity: a pilot biomarker study

Journal of American Association for Pediatric Ophthalmology and Strabismus

Research paper thumbnail of Quantitative Analysis of VEGF in Infant Tears as a Biomarker for ROP

Investigative Ophthalmology & Visual Science, Jun 21, 2021

Research paper thumbnail of Coats-like Exudative Vitreoretinopathy in Retinitis Pigmentosa

Ophthalmology Retina, 2020

Objective: To provide a comprehensive review of the ocular manifestations, outcomes, and genetic ... more Objective: To provide a comprehensive review of the ocular manifestations, outcomes, and genetic findings in patients with Coats-like retinitis pigmentosa (RP).

Research paper thumbnail of Ocular Manifestations of Cutis Marmorata Telangiectatica Congenita

Ophthalmology Retina, 2019

Purpose: To describe the range of ocular manifestations in cutis marmorata telangectatica congeni... more Purpose: To describe the range of ocular manifestations in cutis marmorata telangectatica congenita (CMTC).

Research paper thumbnail of Role of optical coherence tomography in identifying sub-optimal stent positioning and predicting major adverse cardiac events in a comparative study with angiography: a CLIO-OPCI II sub-study

Coronary artery disease, Jan 24, 2018

Quantitative coronary angiography (QCA) is the gold standard for evaluating correct stenting, des... more Quantitative coronary angiography (QCA) is the gold standard for evaluating correct stenting, despite its limitation in recognizing features indicative of suboptimal deployment. This subanalysis of the CLI-OPCI II registry addressed the role of optical coherence tomography (OCT) to verify whether suboptimal OCT deployment occurs in the presence of an optimal angiographic result. We retrospectively analyzed 125 lesions in the 105 patients with major adverse cardiac events of the CLI-OPCI II. Every lesion was evaluated with OCT and angiography, including visual and QCA assessment. Optimal angiographic result was defined as residual stenosis of less than 30% at QCA and absence of haziness at visual angiography. The following OCT features of suboptimal stenting were considered: edge dissection (linear rim of tissue with a width >200 μm), reference lumen narrowing (lumen area <4.5 mm in the presence of significant residual plaque adjacent to stent endings), and in-stent narrowing (...

Research paper thumbnail of Exploring Multimodal Ocular Imaging for Retinal Biomarkers of Alzheimer’s Disease, Frontotemporal Dementia, and Cognitively Normal Subjects

Background and ObjectivesAlzheimer’s disease (AD) and frontotemporal dementia (FTD) are difficult... more Background and ObjectivesAlzheimer’s disease (AD) and frontotemporal dementia (FTD) are difficult to reliably differentiate clinically. While their distinct pathologies may be captured by existing diagnostic modalities, these are expensive, time-consuming, and often inaccessible. Dementias are associated with visual dysfunctions, perhaps due to changes in the retina, a developmental outgrowth of the central nervous system. We explore the role of multimodal ocular imaging in the diagnosis of two dementias, AD and FTD.MethodsWe recruited 5 AD participants, 2 FTD participants, and 9 age-matched controls. Each participant underwent comprehensive ophthalmologic examination and imaging (optical coherence tomography (OCT), OCT-angiography (OCTA), wide-field fundus photography, near-infrared imaging, and fundus autofluorescence). Ocular findings were correlated with cerebral amyloid burden, as measured by [11C]PiB PET.ResultsOCT analysis identified a trend toward differences in retinal nerv...

Research paper thumbnail of Surgical repair of primary non-complex rhegmatogenous retinal detachment in the modern era of small-gauge vitrectomy

BMJ Open Ophthalmology, 2021

Objective To report anatomic and visual outcomes of pars plana vitrectomy (PPV), as well as scler... more Objective To report anatomic and visual outcomes of pars plana vitrectomy (PPV), as well as scleral buckling (SB) and PPV/SB as surgical treatments for the management of primary, non-complex rhegmatogenous retinal detachment (RRD). Methods and analysis Data from 751 eyes that underwent PPV, SB or combined PPV/SB as a surgical treatment for primary non-complex RRD with at least 3 months of follow-up were analysed to determine rates of single surgery anatomic success (SSAS) and final anatomic success (FAS). Patients or the public were not involved in the design, conduct or reporting of this research. Results PPV accounted for 89.0% (n=668), PPV/SB for 6.8% (n=51) and SB for 4.2% (n=32) cases. Overall SSAS (91.2% PPV, 84.3% PPV/SB, 93.8% SB; p=0.267) and FAS (96.7% PPV, 94.1% PPV/SB and 100.0% SB; p=0.221) were reported for the three surgical groups. SSAS and FAS were similar for lens status, macular detachment status and the presence or absence of inferior retinal breaks for each of t...

Research paper thumbnail of Quantitative analysis of tear angiogenic factors in retinopathy of prematurity: a pilot biomarker study

Journal of American Association for Pediatric Ophthalmology and Strabismus

Research paper thumbnail of Quantitative Analysis of VEGF in Infant Tears as a Biomarker for ROP

Investigative Ophthalmology & Visual Science, Jun 21, 2021

Research paper thumbnail of Coats-like Exudative Vitreoretinopathy in Retinitis Pigmentosa

Ophthalmology Retina, 2020

Objective: To provide a comprehensive review of the ocular manifestations, outcomes, and genetic ... more Objective: To provide a comprehensive review of the ocular manifestations, outcomes, and genetic findings in patients with Coats-like retinitis pigmentosa (RP).

Research paper thumbnail of Ocular Manifestations of Cutis Marmorata Telangiectatica Congenita

Ophthalmology Retina, 2019

Purpose: To describe the range of ocular manifestations in cutis marmorata telangectatica congeni... more Purpose: To describe the range of ocular manifestations in cutis marmorata telangectatica congenita (CMTC).

Research paper thumbnail of Role of optical coherence tomography in identifying sub-optimal stent positioning and predicting major adverse cardiac events in a comparative study with angiography: a CLIO-OPCI II sub-study

Coronary artery disease, Jan 24, 2018

Quantitative coronary angiography (QCA) is the gold standard for evaluating correct stenting, des... more Quantitative coronary angiography (QCA) is the gold standard for evaluating correct stenting, despite its limitation in recognizing features indicative of suboptimal deployment. This subanalysis of the CLI-OPCI II registry addressed the role of optical coherence tomography (OCT) to verify whether suboptimal OCT deployment occurs in the presence of an optimal angiographic result. We retrospectively analyzed 125 lesions in the 105 patients with major adverse cardiac events of the CLI-OPCI II. Every lesion was evaluated with OCT and angiography, including visual and QCA assessment. Optimal angiographic result was defined as residual stenosis of less than 30% at QCA and absence of haziness at visual angiography. The following OCT features of suboptimal stenting were considered: edge dissection (linear rim of tissue with a width >200 μm), reference lumen narrowing (lumen area <4.5 mm in the presence of significant residual plaque adjacent to stent endings), and in-stent narrowing (...

Research paper thumbnail of Exploring Multimodal Ocular Imaging for Retinal Biomarkers of Alzheimer’s Disease, Frontotemporal Dementia, and Cognitively Normal Subjects

Background and ObjectivesAlzheimer’s disease (AD) and frontotemporal dementia (FTD) are difficult... more Background and ObjectivesAlzheimer’s disease (AD) and frontotemporal dementia (FTD) are difficult to reliably differentiate clinically. While their distinct pathologies may be captured by existing diagnostic modalities, these are expensive, time-consuming, and often inaccessible. Dementias are associated with visual dysfunctions, perhaps due to changes in the retina, a developmental outgrowth of the central nervous system. We explore the role of multimodal ocular imaging in the diagnosis of two dementias, AD and FTD.MethodsWe recruited 5 AD participants, 2 FTD participants, and 9 age-matched controls. Each participant underwent comprehensive ophthalmologic examination and imaging (optical coherence tomography (OCT), OCT-angiography (OCTA), wide-field fundus photography, near-infrared imaging, and fundus autofluorescence). Ocular findings were correlated with cerebral amyloid burden, as measured by [11C]PiB PET.ResultsOCT analysis identified a trend toward differences in retinal nerv...

Research paper thumbnail of Surgical repair of primary non-complex rhegmatogenous retinal detachment in the modern era of small-gauge vitrectomy

BMJ Open Ophthalmology, 2021

Objective To report anatomic and visual outcomes of pars plana vitrectomy (PPV), as well as scler... more Objective To report anatomic and visual outcomes of pars plana vitrectomy (PPV), as well as scleral buckling (SB) and PPV/SB as surgical treatments for the management of primary, non-complex rhegmatogenous retinal detachment (RRD). Methods and analysis Data from 751 eyes that underwent PPV, SB or combined PPV/SB as a surgical treatment for primary non-complex RRD with at least 3 months of follow-up were analysed to determine rates of single surgery anatomic success (SSAS) and final anatomic success (FAS). Patients or the public were not involved in the design, conduct or reporting of this research. Results PPV accounted for 89.0% (n=668), PPV/SB for 6.8% (n=51) and SB for 4.2% (n=32) cases. Overall SSAS (91.2% PPV, 84.3% PPV/SB, 93.8% SB; p=0.267) and FAS (96.7% PPV, 94.1% PPV/SB and 100.0% SB; p=0.221) were reported for the three surgical groups. SSAS and FAS were similar for lens status, macular detachment status and the presence or absence of inferior retinal breaks for each of t...