George Karypis | University of Minnesota (original) (raw)
Papers by George Karypis
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Motivation: Alpha-helical transmembrane proteins mediate many key biological pro- cesses and repr... more Motivation: Alpha-helical transmembrane proteins mediate many key biological pro- cesses and represent 20-30% of all genes in many organisms. Due to the diculties in experimentally determining their high-resolution 3D struc- ture, computational methods that predict their topology (transmembrane helical segments and their orientation) are essential in advancing the un- derstanding of membrane proteins' structures and functions. 2 Methods: We developed
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Journal of Bioinformatics and Computational Biology, 2010
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Proceedings Seventeenth IEEE Symposium on Reliable Distributed Systems (Cat. No.98CB36281), 1998
ABSTRACT
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Proceedings 42nd IEEE Symposium on Foundations of Computer Science, 2001
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Proceedings of the IEEE/ACM SC98 Conference, 1998
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Proceedings of the 1999 International Conference on Parallel Processing, 1999
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Proceedings 9th Heterogeneous Computing Workshop (HCW 2000) (Cat. No.PR00556), 2000
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CHO cells, the workhorses of the biopharmaceutical industry, are derived from the Chinese hamster... more CHO cells, the workhorses of the biopharmaceutical industry, are derived from the Chinese hamster, arguably making it the most economically important industrial organism. The synergistic application of high-throughput sequencing technologies, along with the existing CHO EST collection as backbone, enabled the efficient assembly of the Chinese hamster genome. The current assembly (~2.5Gb), constituting over two billion sequence reads, includes more than 25,000 annotated genes across a range of functional classes. This has allowed a global comparative analysis with the mouse, rat and human genomes. Furthermore, the investigation of regulatory features including promoters, CpG Islands and microRNAs has opened up new avenues for manipulating individual gene expression as well as genome level interventions. In addition, this work aims to study the genetic variation underlying economically important productivity traits in CHO cells, by a comparative genomics approach, with diploid hamster...
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Methods and Algorithms, 2010
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Proceedings of the 2007 SIAM International Conference on Data Mining, 2007
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Motivation: Alpha-helical transmembrane proteins mediate many key biological pro- cesses and repr... more Motivation: Alpha-helical transmembrane proteins mediate many key biological pro- cesses and represent 20-30% of all genes in many organisms. Due to the diculties in experimentally determining their high-resolution 3D struc- ture, computational methods that predict their topology (transmembrane helical segments and their orientation) are essential in advancing the un- derstanding of membrane proteins' structures and functions. 2 Methods: We developed
Bookmarks Related papers MentionsView impact
Journal of Bioinformatics and Computational Biology, 2010
Bookmarks Related papers MentionsView impact
Proceedings Seventeenth IEEE Symposium on Reliable Distributed Systems (Cat. No.98CB36281), 1998
ABSTRACT
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Proceedings 42nd IEEE Symposium on Foundations of Computer Science, 2001
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Proceedings of the IEEE/ACM SC98 Conference, 1998
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Proceedings of the 1999 International Conference on Parallel Processing, 1999
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Proceedings 9th Heterogeneous Computing Workshop (HCW 2000) (Cat. No.PR00556), 2000
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CHO cells, the workhorses of the biopharmaceutical industry, are derived from the Chinese hamster... more CHO cells, the workhorses of the biopharmaceutical industry, are derived from the Chinese hamster, arguably making it the most economically important industrial organism. The synergistic application of high-throughput sequencing technologies, along with the existing CHO EST collection as backbone, enabled the efficient assembly of the Chinese hamster genome. The current assembly (~2.5Gb), constituting over two billion sequence reads, includes more than 25,000 annotated genes across a range of functional classes. This has allowed a global comparative analysis with the mouse, rat and human genomes. Furthermore, the investigation of regulatory features including promoters, CpG Islands and microRNAs has opened up new avenues for manipulating individual gene expression as well as genome level interventions. In addition, this work aims to study the genetic variation underlying economically important productivity traits in CHO cells, by a comparative genomics approach, with diploid hamster...
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Methods and Algorithms, 2010
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Proceedings of the 2007 SIAM International Conference on Data Mining, 2007
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