Guillermo Gonzalez | Universidad Nacional Autónoma de Honduras (original) (raw)

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Papers by Guillermo Gonzalez

A prospective study on the treatment of retinoblastoma in 72 patients

Cancer, 1991

Seventy-two patients with retinoblastoma (RTB) (unilateral [47 patients] and bilateral [25 patien... more Seventy-two patients with retinoblastoma (RTB) (unilateral [47 patients] and bilateral [25 patients]) were studied for a period of 6 years. Treatment consisted of enucleation of those eyes that had severe involvement and was followed by radiation therapy and/or chemotherapy (systemic or intrathecal) according to clinical pathologic staging. All patients who underwent nonsurgical treatment received systemic chemotherapy. Intrathecal chemotherapy was administered when there was involvement of the central nervous system. Nonsurgical treatment consisted of radiation therapy and/or light coagulation, followed by enucleation if there was no response. The overall survival rates were 79% for unilateral disease (median follow-up time, 63 months) and 72% for bilateral disease (median follow-up time, 81 months). Vision was regained in 14 of 21 conserved eyes.

Treatment of retinoblastoma.Results obtained from a prospective study of 51 patients

Cancer, 1988

During 4 years, 51 patients with retinoblastoma were studied (unilateral 32, and bilateral 19). T... more During 4 years, 51 patients with retinoblastoma were studied (unilateral 32, and bilateral 19). Treatment consisted of enucleation of those eyes which showed massive involvement followed by radiotherapy when there was optic nerve and/or orbit involvement. Systemic chemotherapy was administered to all patients who underwent nonsurgical treatment and when the histologic examination showed choroidal optic nerve head and/or optic nerve involvement or residual tumor after enucleation. When there was compromise of the central nervous system intrathecal chemotherapy was administered. Nonsurgical treatment consisted of radiotherapy and/or light coagulation. Survival was 90.6% for unilateral cases and 84.2% for the bilateral. The median follow-up was 31 months and 29 months, respectively. Of 19 conservated eyeballs, 16 preserve useful vision (63%).

Icarus, 2001

We propose the concept of a "Galactic Habitable Zone" (GHZ). Analogous to the Circumstellar Habit... more We propose the concept of a "Galactic Habitable Zone" (GHZ). Analogous to the Circumstellar Habitable Zone (CHZ), the GHZ is that region in the Milky Way where an Earth-like planet can retain liquid water on its surface and provide a long-term habitat for animal-like aerobic life. In this paper we examine the dependence of the GHZ on Galactic chemical evolution. The single most important factor is likely the dependence of terrestrial planet mass on the metallicity of its birth cloud. We estimate, very approximately, that a metallicity at least half that of the Sun is required to build a habitable terrestrial planet. The mass of a terrestrial planet has important consequences for interior heat loss, volatile inventory, and loss of atmosphere. A key issue is the production of planets that sustain plate tectonics, a critical recycling process that provides feedback to stabilize atmospheric temperatures on planets with oceans and atmospheres. Due to the more recent decline from the early intense star formation activity in the Milky Way, the concentration in the interstellar medium of the geophysically important radioisotopes 40 K, 235,238 U, and 232 Th has been declining relative to Fe, an abundant element in the Earth. Also likely important are the relative abundances of Si and Mg to Fe, which affects the mass of the core relative to the mantle in a terrestrial planet. All these elements and isotopes vary with time and location in the Milky Way; thus, planetary systems forming in other locations and times in the Milky Way with the same metallicity as the Sun will not necessarily form habitable Earth-like planets. As a result of the radial Galactic metallicity gradient, the outer limit of the GHZ is set primarily by the minimum required metallicity to build large terrestrial planets. Regions of the Milky Way least likely to contain Earth-mass planets are the halo (including globular clusters), the thick disk, and the outer thin disk. The bulge should contain Earth-mass planets, but stars in it have a mix of elements different from the Sun's. The existence of a luminosity-metallicity correlation among galaxies of all types means that many galaxies are too metal-poor to contain Earth-mass planets. Based on the observed luminosity function of nearby galaxies in the visual passband, we estimate that (1) the Milky Way is among the 1.3% most luminous (and hence most metal-rich) galaxies and (2) about 23% of stars in a typical ensemble of galaxies are more metal-rich than the average star in the Milky Way. The GHZ zone concept can be easily extrapolated to the universe as a whole, especially with regard to the changing star formation rate and its effect on metallicity and abundances of the long-lived radioisotopes.

Oecologia, 2001

Nestling birds produced later in the season are hypothesized to be of poor quality with a low pro... more Nestling birds produced later in the season are hypothesized to be of poor quality with a low probability of survival and recruitment. In a Spanish population of house martins (Delichon urbica), we first compared reproductive success, immune responses and morphological traits between the first and the second broods. Second, we investigated the effects of an ectoparasite treatment and breeding date on the recapture rate the following year. Due probably to a reverse situation in weather conditions during the experiment, with more rain during rearing of the first brood, nestlings reared during the second brood were in better condition and had stronger immune responses compared with nestlings from the first brood. Contrary to other findings on house martins, we found a similar recapture rate for chicks reared during the first and the second brood. Furthermore, ectoparasitic house martin bugs had no significant effect on the recapture rate. Recaptured birds had similar morphology but higher immunoglobulin levels when nestlings compared with non-recaptured birds. This result implies that a measure of immune function is a better predictor of survival than body condition per se.

Behavioral Ecology and Sociobiology, 1999

The immunocompetence handicap hypothesis postulates that secondary sexual traits are honest signa... more The immunocompetence handicap hypothesis postulates that secondary sexual traits are honest signals of male quality because steroid hormones (such as corticosteroids and sex steroids), which are supposed to favor the development of secondary sexual traits, may also have immunosuppressive effects. Certain secondary sexual traits are not only used as mate choice signals but also play a role as badges of status. In the house sparrow (Passer domesticus), males have a bib of black feathers which is used both as a signal of social status in male-male interactions and by females when choosing a mate. We investigated the relationships between bib size and cellular immune response in male house sparrows during and outside the reproductive season. Males with large badges were found to have lower levels of immunocompetence, as assessed using a T-cell-mediated immunity assay, during the reproductive season, as predicted by the immunocompetence handicap hypothesis. Conversely, in November, the correlation between badge size and cellular immune response was positive, possibly reflecting the better access to trophic resources of large-badged dominant males in winter flocks.

Behavioral Ecology and Sociobiology, 2001

Female preference for mates with elaborated ornaments has often been explained on the basis that ... more Female preference for mates with elaborated ornaments has often been explained on the basis that exaggerated secondary sexual traits might reflect individual quality and females might gather direct and indirect benefits in mating with such males. Sexual signals must however also entail costs to be reliable indicators of male quality. Androgens have been suggested as a physiological link between sexual signals and individual quality for several reasons, including their immunosuppressive effect. In this study, we tested two hypotheses linked to the hormonal basis of sexual signal expression. First, we investigated whether testosterone is correlated with the size of the black feather bib on the throat of male house sparrows (Passer domesticus) – a trait involved in intra- and inter-sexual selection. Second, we tested whether testosterone affects the seasonal exposure of the trait. Observational work conducted in 1998 showed that the testosterone level was positively correlated with badge size both in spring and in the subsequent fall, after molt. In 1999, we experimentally reduced spring testosterone levels using silastic implants filled with cyproterone acetate, an antiandrogen. Male house sparrows implanted with cyproterone acetate showed reduced exposure of the badge, because the white tips of the black feathers of the badge wore off later than in control males implanted with empty silastic tubes. This result suggests that testosterone can be causally involved in the expression of a secondary sexual trait in house sparrows, at least in terms of its seasonal exposure.

American Naturalist, 2003

fected by the workload required to feed the brood. Overall, this study stresses the magnitude of ... more fected by the workload required to feed the brood. Overall, this study stresses the magnitude of costs associated with mounting immune responses and the ecological and evolutionary consequences for natural populations.

Journal of Animal Ecology, 1999

We tested the condition-dependent hypothesis of sexual advertisement in house sparrows (Passer do... more We tested the condition-dependent hypothesis of sexual advertisement in house sparrows (Passer domesticus). Male house sparrows have a bib of black feathers which serves as both a badge of social status and as a cue for female choice. We manipulated environmental conditions during the premoult period of juvenile house sparrows kept in outdoor aviaries. Birds were assigned to two treatments differing in the amount of dietary proteins, which are known to aect the expression of immune response in birds. We tested whether birds in the protein-rich group had better immune responses and developed larger bibs than birds reared on a protein-poor diet. We also checked whether immune response was a predictor of survival and parasite resistance. 2. Individuals with higher cellular immune response at capture had greater probability to survive during the 3 months of the experiment, and they had a higher probability to recover from infection with Haemoproteus sp. (a blood parasite). Conversely, birds with high immunoglobulin concentrations at capture had a higher probability of mortality. 3. Birds on the protein-rich diet had a higher cellular immune response compared to birds in the protein-poor treatment. Humoral immune response showed the opposite pattern, being higher for birds in the protein-poor treatment. We did not ®nd any eect of food quality on the development of the badge, assessed as the size of the trait and its colour properties. 4. In conclusion, our results support the view that immune defences are important for survival and parasite resistance in natural populations, and that they might be costly to produce. On the other hand, we did not ®nd support for the conditiondependent hypothesis of sexual advertisement, suggesting that the badge may not be a costly trait to produce. However, badge size could re¯ect other aspects of condition. The kind of pigments involved in colour signals may be the key factor determining the production costs of such traits.