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Papers by Jose Antonio Gutierrez Suarez

Research paper thumbnail of Observation of the Suppression of the Flux of Cosmic Rays above 4×1019eV

Physical Review Letters, 2008

Research paper thumbnail of La Educación Ambiental a Distancia de profesoras pinareñas desde la tecnología e ducativa en comunidades rurales

... ó. n. oma de Madrid, 4. pág. 97-116, 1999. Solano, David. * : Comunicación y generación de co... more ... ó. n. oma de Madrid, 4. pág. 97-116, 1999. Solano, David. * : Comunicación y generación de conciencia ambiental. Artículo publicado en Tópicos de Educación Ambiental, MX 3(7): 52-57. SEMARNAT-UNAM, Junio 2001. Trellez, E. y C. Quiroz (1995). Formaci. ó. n. ...

Research paper thumbnail of Generation, annotation and analysis of ESTs from Trichoderma harzianum CECT 2413

BMC Genomics, 2006

Background The filamentous fungus Trichoderma harzianum is used as biological control agent of se... more Background The filamentous fungus Trichoderma harzianum is used as biological control agent of several plant-pathogenic fungi. In order to study the genome of this fungus, a functional genomics project called "TrichoEST" was developed to give insights into genes involved in biological control activities using an approach based on the generation of expressed sequence tags (ESTs). Results Eight different cDNA libraries from T. harzianum strain CECT 2413 were constructed. Different growth conditions involving mainly different nutrient conditions and/or stresses were used. We here present the analysis of the 8,710 ESTs generated. A total of 3,478 unique sequences were identified of which 81.4% had sequence similarity with GenBank entries, using the BLASTX algorithm. Using the Gene Ontology hierarchy, we performed the annotation of 51.1% of the unique sequences and compared its distribution among the gene libraries. Additionally, the InterProScan algorithm was used in order to further characterize the sequences. The identification of the putatively secreted proteins was also carried out. Later, based on the EST abundance, we examined the highly expressed genes and a hydrophobin was identified as the gene expressed at the highest level. We compared our collection of ESTs with the previous collections obtained from Trichoderma species and we also compared our sequence set with different complete eukaryotic genomes from several animals, plants and fungi. Accordingly, the presence of similar sequences in different kingdoms was also studied. Conclusion This EST collection and its annotation provide a significant resource for basic and applied research on T. harzianum, a fungus with a high biotechnological interest

Research paper thumbnail of Correlation of the Highest-Energy Cosmic Rays with Nearby Extragalactic Objects

Science, 2007

Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a... more Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above ~ 6x10^{19} electron volts and the positions of active galactic nuclei (AGN) lying within ~ 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar spatial distribution are possible sources.

Research paper thumbnail of Operations of and Future Plans for the Pierre Auger Observatory

Technical reports on operations and features of the Pierre Auger Observatory, including ongoing a... more Technical reports on operations and features of the Pierre Auger Observatory, including ongoing and planned enhancements and the status of the future northern hemisphere portion of the Observatory. Contributions to the 31st International Cosmic Ray Conference, Lodz, Poland, July 2009.

Research paper thumbnail of Effect of standard nicotinamide in the prevention of type 1 diabetes in first degree relatives of persons with type 1 diabetes

Autoimmunity, 2006

Nicotinamide has been used with success to prevent type 1 diabetes in animal models and humans. T... more Nicotinamide has been used with success to prevent type 1 diabetes in animal models and humans. This vitamin B3 derivative has attracting effects on beta-cell protection and regeneration. To evaluate the effect of standard nicotinamide administration on type 1 diabetes prevention in first degree relatives of persons with type 1 diabetes as well as on the concentrations of islet-cell-related autoantibodies, insulin secretion and peripheral sensitivity. A randomized double-blind placebo controlled intervention trial was conducted in 40 first degree relatives of type 1 diabetic patients. Persistence of ICA (…

Research paper thumbnail of Factors related to the chronicity and evolution of hepatitis C infection in patients co-infected by the human immunodeficiency virus

Clinical Microbiology and Infection, 2002

Research paper thumbnail of Operadores en espacios de funciones analíticas

Research paper thumbnail of Limit on the diffuse flux of ultrahigh energy tau neutrinos with the surface detector of the Pierre Auger Observatory

Research paper thumbnail of ISAAC NEWTON

Research paper thumbnail of A mechanism for randomness

Research paper thumbnail of Chaos-induced true randomness

Physica A-statistical Mechanics and Its Applications, 2002

Research paper thumbnail of From exactly solvable chaotic maps to stochastic dynamics

Physica D-nonlinear Phenomena, 2003

Research paper thumbnail of Observation of the Suppression of the Flux of Cosmic Rays above 4×1019eV

Physical Review Letters, 2008

Research paper thumbnail of La Educación Ambiental a Distancia de profesoras pinareñas desde la tecnología e ducativa en comunidades rurales

... ó. n. oma de Madrid, 4. pág. 97-116, 1999. Solano, David. * : Comunicación y generación de co... more ... ó. n. oma de Madrid, 4. pág. 97-116, 1999. Solano, David. * : Comunicación y generación de conciencia ambiental. Artículo publicado en Tópicos de Educación Ambiental, MX 3(7): 52-57. SEMARNAT-UNAM, Junio 2001. Trellez, E. y C. Quiroz (1995). Formaci. ó. n. ...

Research paper thumbnail of Generation, annotation and analysis of ESTs from Trichoderma harzianum CECT 2413

BMC Genomics, 2006

Background The filamentous fungus Trichoderma harzianum is used as biological control agent of se... more Background The filamentous fungus Trichoderma harzianum is used as biological control agent of several plant-pathogenic fungi. In order to study the genome of this fungus, a functional genomics project called "TrichoEST" was developed to give insights into genes involved in biological control activities using an approach based on the generation of expressed sequence tags (ESTs). Results Eight different cDNA libraries from T. harzianum strain CECT 2413 were constructed. Different growth conditions involving mainly different nutrient conditions and/or stresses were used. We here present the analysis of the 8,710 ESTs generated. A total of 3,478 unique sequences were identified of which 81.4% had sequence similarity with GenBank entries, using the BLASTX algorithm. Using the Gene Ontology hierarchy, we performed the annotation of 51.1% of the unique sequences and compared its distribution among the gene libraries. Additionally, the InterProScan algorithm was used in order to further characterize the sequences. The identification of the putatively secreted proteins was also carried out. Later, based on the EST abundance, we examined the highly expressed genes and a hydrophobin was identified as the gene expressed at the highest level. We compared our collection of ESTs with the previous collections obtained from Trichoderma species and we also compared our sequence set with different complete eukaryotic genomes from several animals, plants and fungi. Accordingly, the presence of similar sequences in different kingdoms was also studied. Conclusion This EST collection and its annotation provide a significant resource for basic and applied research on T. harzianum, a fungus with a high biotechnological interest

Research paper thumbnail of Correlation of the Highest-Energy Cosmic Rays with Nearby Extragalactic Objects

Science, 2007

Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a... more Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above ~ 6x10^{19} electron volts and the positions of active galactic nuclei (AGN) lying within ~ 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar spatial distribution are possible sources.

Research paper thumbnail of Operations of and Future Plans for the Pierre Auger Observatory

Technical reports on operations and features of the Pierre Auger Observatory, including ongoing a... more Technical reports on operations and features of the Pierre Auger Observatory, including ongoing and planned enhancements and the status of the future northern hemisphere portion of the Observatory. Contributions to the 31st International Cosmic Ray Conference, Lodz, Poland, July 2009.

Research paper thumbnail of Effect of standard nicotinamide in the prevention of type 1 diabetes in first degree relatives of persons with type 1 diabetes

Autoimmunity, 2006

Nicotinamide has been used with success to prevent type 1 diabetes in animal models and humans. T... more Nicotinamide has been used with success to prevent type 1 diabetes in animal models and humans. This vitamin B3 derivative has attracting effects on beta-cell protection and regeneration. To evaluate the effect of standard nicotinamide administration on type 1 diabetes prevention in first degree relatives of persons with type 1 diabetes as well as on the concentrations of islet-cell-related autoantibodies, insulin secretion and peripheral sensitivity. A randomized double-blind placebo controlled intervention trial was conducted in 40 first degree relatives of type 1 diabetic patients. Persistence of ICA (…

Research paper thumbnail of Factors related to the chronicity and evolution of hepatitis C infection in patients co-infected by the human immunodeficiency virus

Clinical Microbiology and Infection, 2002

Research paper thumbnail of Operadores en espacios de funciones analíticas

Research paper thumbnail of Limit on the diffuse flux of ultrahigh energy tau neutrinos with the surface detector of the Pierre Auger Observatory

Research paper thumbnail of ISAAC NEWTON

Research paper thumbnail of A mechanism for randomness

Research paper thumbnail of Chaos-induced true randomness

Physica A-statistical Mechanics and Its Applications, 2002

Research paper thumbnail of From exactly solvable chaotic maps to stochastic dynamics

Physica D-nonlinear Phenomena, 2003