Yann Charli-Joseph | Universidad Nacional Autónoma de México (original) (raw)

Papers by Yann Charli-Joseph

The American Journal of Dermatopathology, 2013

carcinoma. The degree of cellularity, atypia of the cells, mitotic rate, and evidence of vascular... more carcinoma. The degree of cellularity, atypia of the cells, mitotic rate, and evidence of vascular or lymphatic invasion can be useful but not definitive. Various markers have been used to ascertain the identity of these tumors, including ER, PR, S-100, cytokeratins, carcinoembryonic antigen, alphalactalbumin, HMFG-1 and -2 (human milk fat globulins), MUC1, MUC2, EMA (epithelial membrane antigen), myoepithelial markers such as p63 and smooth muscle actin, podoplanin, GCDFP 15, epidermal growth factor receptor, and E-cadherin, but none is perfect. 1-4 A recent report demonstrated that a panel of p63, CK5, CK14, CK17, and mammaglobin had 100% sensitivity and 91% specificity in distinguishing these two. 5 However, it included only 23 cases and has not been confirmed by others. Clinically, cutaneous metastases usually develop rapidly, over a course of weeks to months, and there are frequently multiple lesions. Also, although in majority of the cases, a primary tumor can be found in metastases of breast cancer, there have been cases of metastases without a primary tumor. In conclusion, more research is required to further differentiate these entities, and long-term follow-up is essential in the care of these patients.

The American Journal of Dermatopathology, 2013

carcinoma. The degree of cellularity, atypia of the cells, mitotic rate, and evidence of vascular... more carcinoma. The degree of cellularity, atypia of the cells, mitotic rate, and evidence of vascular or lymphatic invasion can be useful but not definitive. Various markers have been used to ascertain the identity of these tumors, including ER, PR, S-100, cytokeratins, carcinoembryonic antigen, alphalactalbumin, HMFG-1 and -2 (human milk fat globulins), MUC1, MUC2, EMA (epithelial membrane antigen), myoepithelial markers such as p63 and smooth muscle actin, podoplanin, GCDFP 15, epidermal growth factor receptor, and E-cadherin, but none is perfect. 1-4 A recent report demonstrated that a panel of p63, CK5, CK14, CK17, and mammaglobin had 100% sensitivity and 91% specificity in distinguishing these two. 5 However, it included only 23 cases and has not been confirmed by others. Clinically, cutaneous metastases usually develop rapidly, over a course of weeks to months, and there are frequently multiple lesions. Also, although in majority of the cases, a primary tumor can be found in metastases of breast cancer, there have been cases of metastases without a primary tumor. In conclusion, more research is required to further differentiate these entities, and long-term follow-up is essential in the care of these patients.