Aline Mina | UNAM Universidad Nacional Autónoma de México (original) (raw)

Papers by Aline Mina

Research paper thumbnail of Prevalence of Lactose Malabsorption in Mexican Children: Importance of Measuring Methane in Expired Air

Archives of Medical Research, 2013

Background and Aims. To compare the prevalence of lactose malabsorption (LM) in children by analy... more Background and Aims. To compare the prevalence of lactose malabsorption (LM) in children by analyzing hydrogen content in expired air vs. the inclusion of methane excretion. Methods. A total of 138 children (4e17 years old) attending different boarding schools in Mexico were included in this study. To measure H 2 and CH 4 in expired air, breath samples were collected before administering whole milk (240 mL for 4-to 6-year-old children and 360 mL for 7-to 17-year-old children) and at 60, 120, 180, and 240 min afterward. A coprological examination was also carried out. Results. Methane production prevalence was 47.8% (29.7% of the children produced methane and hydrogen, whereas 18.1% produced methane only). When measuring only exhaled hydrogen in expired air (H 2 20ppm),prevalenceofLMwas3120 ppm), prevalence of LM was 31%; however, when methane concentration was considered (H 2 þ (CH 4 x 2)) 20ppm),prevalenceofLMwas3118 ppm, prevalence increased significantly to 44%. Among children with LM, 51.6% presented intestinal parasites. Conclusions. Methane should be measured in exhaled air to improve diagnosis of LM in populations with a high prevalence of methane production. Ó 2013 IMSS.

Research paper thumbnail of Utility of <sup>13</sup>C-methacetin breath test in predicting long-term survival of patients with decompensated cirrhosis

Journal of breath research, Jan 26, 2017

The 13C-methacetin breath test (13C-MeBT) is a noninvasive tool that allows evaluation of the fun... more The 13C-methacetin breath test (13C-MeBT) is a noninvasive tool that allows evaluation of the functional activity of the liver and the prediction of liver cirrhosis. Nevertheless, there is no information on its potential utility to predict long-term survival in patients with liver disease. Methods: Patients with cirrhosis were selected. All patients underwent a complete clinical assessment, standard biochemical tests, and 13C-MeBT at the beginning of the study. Death was recorded during the three years of follow-up. Survival curves were calculated by the Kaplan Meier method, and Cox proportional risk models were used to identify predictive factors. The ability to classify the overall risk was assessed by the C statistic. Results: One hundred twenty-three patients were included. A significant inverse correlation was found between delta over baseline at the 15 minute point (DOB15) after ingestion of 13C-methacetin and the Child-Pugh score (r=-0.411, p<0.001). In multivari...

Research paper thumbnail of Effect of a Lifestyle Intervention in Children With Obesity and Nonalcoholic Fatty Liver Disease

Topics in Clinical Nutrition, 2017

This project showed nutritional education as an effective strategy to improve primary alterations... more This project showed nutritional education as an effective strategy to improve primary alterations in liver function associated with nonalcoholic fatty liver disease (NAFLD) in obese children who had NAFLD in Mexico. Researchers evaluated the effect of a 4-month nutritional counseling program on hepatic abnormalities associated with NAFLD in 46 participants. They attended nutrition counseling sessions with their parents or guardians every 15 days during the intervention. Body mass index (BMI) decreased in 93.5% of children, and ALT (alanine aminotransferase) levels decreased in 87%. Simultaneously, BMI, ALT, and AST (aspartate aminotransferase) decreased in 38 of 46 participants (82.6%).

Research paper thumbnail of Prevalence of minimal hepatic encephalopathy and quality of life in patients with decompensated cirrhosis

Hepatology Research, 2013

Aim: Minimal hepatic encephalopathy (MHE) affects more than 30% of patients with cirrhosis, and i... more Aim: Minimal hepatic encephalopathy (MHE) affects more than 30% of patients with cirrhosis, and it has been suggested that despite no recognizable clinical symptoms of neurological abnormalities, it may affect health-related quality of life (HRQL); however, this fact remains controversial. The aim of our study was to evaluate the prevalence of MHE and HRQL in patients diagnosed with decompensated cirrhosis.

Research paper thumbnail of Prevalence of Lactose Malabsorption in Mexican Children: Importance of Measuring Methane in Expired Air

Archives of Medical Research, 2013

Background and Aims. To compare the prevalence of lactose malabsorption (LM) in children by analy... more Background and Aims. To compare the prevalence of lactose malabsorption (LM) in children by analyzing hydrogen content in expired air vs. the inclusion of methane excretion. Methods. A total of 138 children (4e17 years old) attending different boarding schools in Mexico were included in this study. To measure H 2 and CH 4 in expired air, breath samples were collected before administering whole milk (240 mL for 4-to 6-year-old children and 360 mL for 7-to 17-year-old children) and at 60, 120, 180, and 240 min afterward. A coprological examination was also carried out. Results. Methane production prevalence was 47.8% (29.7% of the children produced methane and hydrogen, whereas 18.1% produced methane only). When measuring only exhaled hydrogen in expired air (H 2 20ppm),prevalenceofLMwas3120 ppm), prevalence of LM was 31%; however, when methane concentration was considered (H 2 þ (CH 4 x 2)) 20ppm),prevalenceofLMwas3118 ppm, prevalence increased significantly to 44%. Among children with LM, 51.6% presented intestinal parasites.

Research paper thumbnail of Prevalence of Lactose Malabsorption in Mexican Children: Importance of Measuring Methane in Expired Air

Archives of Medical Research, 2013

Background and Aims. To compare the prevalence of lactose malabsorption (LM) in children by analy... more Background and Aims. To compare the prevalence of lactose malabsorption (LM) in children by analyzing hydrogen content in expired air vs. the inclusion of methane excretion. Methods. A total of 138 children (4e17 years old) attending different boarding schools in Mexico were included in this study. To measure H 2 and CH 4 in expired air, breath samples were collected before administering whole milk (240 mL for 4-to 6-year-old children and 360 mL for 7-to 17-year-old children) and at 60, 120, 180, and 240 min afterward. A coprological examination was also carried out. Results. Methane production prevalence was 47.8% (29.7% of the children produced methane and hydrogen, whereas 18.1% produced methane only). When measuring only exhaled hydrogen in expired air (H 2 20ppm),prevalenceofLMwas3120 ppm), prevalence of LM was 31%; however, when methane concentration was considered (H 2 þ (CH 4 x 2)) 20ppm),prevalenceofLMwas3118 ppm, prevalence increased significantly to 44%. Among children with LM, 51.6% presented intestinal parasites. Conclusions. Methane should be measured in exhaled air to improve diagnosis of LM in populations with a high prevalence of methane production. Ó 2013 IMSS.

Research paper thumbnail of Utility of <sup>13</sup>C-methacetin breath test in predicting long-term survival of patients with decompensated cirrhosis

Journal of breath research, Jan 26, 2017

The 13C-methacetin breath test (13C-MeBT) is a noninvasive tool that allows evaluation of the fun... more The 13C-methacetin breath test (13C-MeBT) is a noninvasive tool that allows evaluation of the functional activity of the liver and the prediction of liver cirrhosis. Nevertheless, there is no information on its potential utility to predict long-term survival in patients with liver disease. Methods: Patients with cirrhosis were selected. All patients underwent a complete clinical assessment, standard biochemical tests, and 13C-MeBT at the beginning of the study. Death was recorded during the three years of follow-up. Survival curves were calculated by the Kaplan Meier method, and Cox proportional risk models were used to identify predictive factors. The ability to classify the overall risk was assessed by the C statistic. Results: One hundred twenty-three patients were included. A significant inverse correlation was found between delta over baseline at the 15 minute point (DOB15) after ingestion of 13C-methacetin and the Child-Pugh score (r=-0.411, p<0.001). In multivari...

Research paper thumbnail of Effect of a Lifestyle Intervention in Children With Obesity and Nonalcoholic Fatty Liver Disease

Topics in Clinical Nutrition, 2017

This project showed nutritional education as an effective strategy to improve primary alterations... more This project showed nutritional education as an effective strategy to improve primary alterations in liver function associated with nonalcoholic fatty liver disease (NAFLD) in obese children who had NAFLD in Mexico. Researchers evaluated the effect of a 4-month nutritional counseling program on hepatic abnormalities associated with NAFLD in 46 participants. They attended nutrition counseling sessions with their parents or guardians every 15 days during the intervention. Body mass index (BMI) decreased in 93.5% of children, and ALT (alanine aminotransferase) levels decreased in 87%. Simultaneously, BMI, ALT, and AST (aspartate aminotransferase) decreased in 38 of 46 participants (82.6%).

Research paper thumbnail of Prevalence of minimal hepatic encephalopathy and quality of life in patients with decompensated cirrhosis

Hepatology Research, 2013

Aim: Minimal hepatic encephalopathy (MHE) affects more than 30% of patients with cirrhosis, and i... more Aim: Minimal hepatic encephalopathy (MHE) affects more than 30% of patients with cirrhosis, and it has been suggested that despite no recognizable clinical symptoms of neurological abnormalities, it may affect health-related quality of life (HRQL); however, this fact remains controversial. The aim of our study was to evaluate the prevalence of MHE and HRQL in patients diagnosed with decompensated cirrhosis.

Research paper thumbnail of Prevalence of Lactose Malabsorption in Mexican Children: Importance of Measuring Methane in Expired Air

Archives of Medical Research, 2013

Background and Aims. To compare the prevalence of lactose malabsorption (LM) in children by analy... more Background and Aims. To compare the prevalence of lactose malabsorption (LM) in children by analyzing hydrogen content in expired air vs. the inclusion of methane excretion. Methods. A total of 138 children (4e17 years old) attending different boarding schools in Mexico were included in this study. To measure H 2 and CH 4 in expired air, breath samples were collected before administering whole milk (240 mL for 4-to 6-year-old children and 360 mL for 7-to 17-year-old children) and at 60, 120, 180, and 240 min afterward. A coprological examination was also carried out. Results. Methane production prevalence was 47.8% (29.7% of the children produced methane and hydrogen, whereas 18.1% produced methane only). When measuring only exhaled hydrogen in expired air (H 2 20ppm),prevalenceofLMwas3120 ppm), prevalence of LM was 31%; however, when methane concentration was considered (H 2 þ (CH 4 x 2)) 20ppm),prevalenceofLMwas3118 ppm, prevalence increased significantly to 44%. Among children with LM, 51.6% presented intestinal parasites.