Guillermo Flores | UNAM Universidad Nacional Autónoma de México (original) (raw)
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Papers by Guillermo Flores
Medicina Interna de Mexico
Feocromocitoma durante el primer trimestre del embarazo: reporte de un caso y revisión de la bibl... more Feocromocitoma durante el primer trimestre del embarazo: reporte de un caso y revisión de la bibliografía Caso clínico
Reumatología Clínica (English Edition), 2014
A 59-year-old female with a history of injection of an oily material in the buttocks 11 years ago... more A 59-year-old female with a history of injection of an oily material in the buttocks 11 years ago. She developed symmetric additive polyarthritis as well as superior and inferior airways involvement. There was no evidence of granulomatosis with polyangiitis (Wegener). She had several serum autoantibodies and a skin biopsy showed a foreign body granuloma. The diagnosis of adjuvant induced autoimmune/inflammatory syndrome was made. The pulmonary involvement was an atypical manifestation at the onset of disease.
Case Reports in Rheumatology, 2020
Rhupus" syndrome is a rare condition that describes the coexistence of systemic lupus erythematos... more Rhupus" syndrome is a rare condition that describes the coexistence of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), which prevalence among patients with SLE varies from 0.01% to 9.7%. ere are few reported cases of the association between autoimmune hemolytic anemia and rheumatoid arthritis with systemic lupus erythematosus (rhupus). We report a rare case of rhupus in a 29-year-old woman, associated with autoimmune hemolytic anemia.
BMC Nephrology, 2002
Background: Bilateral emphysematous pyelonephritis is a life threatening condition usually occurr... more Background: Bilateral emphysematous pyelonephritis is a life threatening condition usually occurring in diabetics. Management of this condition has traditionally been aggressive and surgery is considered mandatory. However, this is itself a hazardous intervention in a septic, unstable patient with circulatory or liver failure. When bilateral disease is present, the need for long-term dialysis is obviously unavoidable. Case presentation: We herein report one of the few cases of bilateral emphysematous pyelonephritis successfully managed by non-surgical treatment.
![Research paper thumbnail of [Sixty-five year old woman with sudden dysphonia, fever and productive cough]](https://attachments.academia-assets.com/96570783/thumbnails/1.jpg)
](Gaceta médica de México
Cruz-Ruiz y cols.
Journal of Clinical Investigation, 1995
The purpose of this study was to define the mechanism whereby agonists that increase free cytosol... more The purpose of this study was to define the mechanism whereby agonists that increase free cytosolic calcium (Ca,2+) affect intracellular pH (pH1) in smooth muscle. Rat aortic vascular smooth muscle cells grown on coverslips were loaded with BCECF/AM or fura-2/AM for continuous monitoring of pHi or Ca,2+, respectively, in a HCO3/CO2containing medium. Recovery from rapid increases in Cal2+ produced by 1 juM angiotensin (Ang) II (A Ca,2+-229±43 nM) or 1 pzM ionomycin (A Ca,-`-148±19 nM) was accompanied by a fall in pH' (A pH,,-0.064±0.0085 P < 0.01, and-0.05±0.012 pH units, P < 0.01, respectively). Neither the fall in pH, nor the rise in Ca,2' elicited by Ang II was prevented by pretreatment with agents which block the action of this agonist on pH, via the stimulation of the ClI HC03 exchangers (DIDS, 50 jM) or the NaI/H+ antiporter (EIPA, 50 ,uM). In the presence of DIDS and ELPA, Ang II produced a fall in pHi (A pH.,-0.050+0.014, P < 0.01) and a rise in Ca,2+ (A Ca2' 252±157 nM, P < 0.01). That the change in pH; was secondary to changes in Cal2+ was inferred from the finding that, when the rise in Ca,2' elicited by Ang II was prevented by preincubation with a Ca2+ buffer, BAPTA (60 jLM), the fall in pH, was abolished as well (A pHj, 0.0014±0.0046). The pH, fall produced by Ang II and ionomycin was prevented by cadmium at a very low concentration (20 nM) which is known to inhibit plasma membrane Ca2+-ATPase activity (A pH,-0.002±0.0006 and-0.0016 pH units, respectively). Cadmium also blunted Ca,2+ recovery after Ang II and ionomycin. These findings suggest that the fall in pH, produced by these agents is due to H+ entry coupled to Ca2+ extrusion via the plasma membrane Ca2+-ATPase. Our results indicate that agonists that increase Ca,2+ cause intracellular acidification as a result of Ca2+/H+ exchange across the plasma membrane.
Hypertension, 1996
The aim of the present study was to define the effects of angiotensin II (Ang II) and Ang-(1-7) o... more The aim of the present study was to define the effects of angiotensin II (Ang II) and Ang-(1-7) on free cytosolic Na + (Na + i ), intracellular pH (pH i ), and the Na + -H + antiporter in cultured vascular smooth muscle cells from rat aorta. Cells were loaded with either BCECF-AM or SBFI-AM for measurement of pH i and Na + i , respectively. Ang II (10 −6 mol/L) caused a rapid rise in Na + i followed by a progressive increase that peaked at about 10 minutes (from 11±1.5 to 16±1.5 mmol/L, P <.001), whereas Ang-(1-7) (10 −6 mol/L) did not affect Na + i significantly (from 11.5±1.1 to 11.8±0.07 mmol/L). The effect of Ang II on Na + i was concentration dependent (ΔNa + i , 5.1±0.9, 3.8±0.6, 1.6±0.6, and 0.14±0.18 mmol/L with decreasing concentrations of 10 −6 , 10 −7 , 10 −8 , and 10 −9 mol/L, respectively). Ang II caused a brief acidification followed by an increase in pH i (from 7.34±0.03 to 7.43±0.03 after 10 minutes, P <.005), and Ang-(1-7) had no significant effect on pH i (fr...
American Journal of Kidney Diseases, 1996
Journal of Oral and Maxillofacial Surgery, 1993
The American Journal of the Medical Sciences, 2001
Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)... more Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is an uncommon complication of treatment with the new class of antidepressant agents, the selective serotonin reuptake inhibitors (SSRIs). Most of the reported cases were associated with fluoxetine; only 2 have previously been described in association with citalopram. We describe an elderly woman who presented with severe symptomatic hyponatremia caused by the SIADH during therapy with citalopram. Because the use of SSRIs is becoming more popular among elderly depressed patients, the present case and the other 2 reported previously emphasize the need for greater awareness of the development of this serious and potentially fatal complication also in association with citalopram therapy and suggest that serum sodium levels should be monitored closely in elderly patients during treatment with citalopram.
Medicina Interna de Mexico
Feocromocitoma durante el primer trimestre del embarazo: reporte de un caso y revisión de la bibl... more Feocromocitoma durante el primer trimestre del embarazo: reporte de un caso y revisión de la bibliografía Caso clínico
Reumatología Clínica (English Edition), 2014
A 59-year-old female with a history of injection of an oily material in the buttocks 11 years ago... more A 59-year-old female with a history of injection of an oily material in the buttocks 11 years ago. She developed symmetric additive polyarthritis as well as superior and inferior airways involvement. There was no evidence of granulomatosis with polyangiitis (Wegener). She had several serum autoantibodies and a skin biopsy showed a foreign body granuloma. The diagnosis of adjuvant induced autoimmune/inflammatory syndrome was made. The pulmonary involvement was an atypical manifestation at the onset of disease.
Case Reports in Rheumatology, 2020
Rhupus" syndrome is a rare condition that describes the coexistence of systemic lupus erythematos... more Rhupus" syndrome is a rare condition that describes the coexistence of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), which prevalence among patients with SLE varies from 0.01% to 9.7%. ere are few reported cases of the association between autoimmune hemolytic anemia and rheumatoid arthritis with systemic lupus erythematosus (rhupus). We report a rare case of rhupus in a 29-year-old woman, associated with autoimmune hemolytic anemia.
BMC Nephrology, 2002
Background: Bilateral emphysematous pyelonephritis is a life threatening condition usually occurr... more Background: Bilateral emphysematous pyelonephritis is a life threatening condition usually occurring in diabetics. Management of this condition has traditionally been aggressive and surgery is considered mandatory. However, this is itself a hazardous intervention in a septic, unstable patient with circulatory or liver failure. When bilateral disease is present, the need for long-term dialysis is obviously unavoidable. Case presentation: We herein report one of the few cases of bilateral emphysematous pyelonephritis successfully managed by non-surgical treatment.
Gaceta médica de México
Cruz-Ruiz y cols.
Journal of Clinical Investigation, 1995
The purpose of this study was to define the mechanism whereby agonists that increase free cytosol... more The purpose of this study was to define the mechanism whereby agonists that increase free cytosolic calcium (Ca,2+) affect intracellular pH (pH1) in smooth muscle. Rat aortic vascular smooth muscle cells grown on coverslips were loaded with BCECF/AM or fura-2/AM for continuous monitoring of pHi or Ca,2+, respectively, in a HCO3/CO2containing medium. Recovery from rapid increases in Cal2+ produced by 1 juM angiotensin (Ang) II (A Ca,2+-229±43 nM) or 1 pzM ionomycin (A Ca,-`-148±19 nM) was accompanied by a fall in pH' (A pH,,-0.064±0.0085 P < 0.01, and-0.05±0.012 pH units, P < 0.01, respectively). Neither the fall in pH, nor the rise in Ca,2' elicited by Ang II was prevented by pretreatment with agents which block the action of this agonist on pH, via the stimulation of the ClI HC03 exchangers (DIDS, 50 jM) or the NaI/H+ antiporter (EIPA, 50 ,uM). In the presence of DIDS and ELPA, Ang II produced a fall in pHi (A pH.,-0.050+0.014, P < 0.01) and a rise in Ca,2+ (A Ca2' 252±157 nM, P < 0.01). That the change in pH; was secondary to changes in Cal2+ was inferred from the finding that, when the rise in Ca,2' elicited by Ang II was prevented by preincubation with a Ca2+ buffer, BAPTA (60 jLM), the fall in pH, was abolished as well (A pHj, 0.0014±0.0046). The pH, fall produced by Ang II and ionomycin was prevented by cadmium at a very low concentration (20 nM) which is known to inhibit plasma membrane Ca2+-ATPase activity (A pH,-0.002±0.0006 and-0.0016 pH units, respectively). Cadmium also blunted Ca,2+ recovery after Ang II and ionomycin. These findings suggest that the fall in pH, produced by these agents is due to H+ entry coupled to Ca2+ extrusion via the plasma membrane Ca2+-ATPase. Our results indicate that agonists that increase Ca,2+ cause intracellular acidification as a result of Ca2+/H+ exchange across the plasma membrane.
Hypertension, 1996
The aim of the present study was to define the effects of angiotensin II (Ang II) and Ang-(1-7) o... more The aim of the present study was to define the effects of angiotensin II (Ang II) and Ang-(1-7) on free cytosolic Na + (Na + i ), intracellular pH (pH i ), and the Na + -H + antiporter in cultured vascular smooth muscle cells from rat aorta. Cells were loaded with either BCECF-AM or SBFI-AM for measurement of pH i and Na + i , respectively. Ang II (10 −6 mol/L) caused a rapid rise in Na + i followed by a progressive increase that peaked at about 10 minutes (from 11±1.5 to 16±1.5 mmol/L, P <.001), whereas Ang-(1-7) (10 −6 mol/L) did not affect Na + i significantly (from 11.5±1.1 to 11.8±0.07 mmol/L). The effect of Ang II on Na + i was concentration dependent (ΔNa + i , 5.1±0.9, 3.8±0.6, 1.6±0.6, and 0.14±0.18 mmol/L with decreasing concentrations of 10 −6 , 10 −7 , 10 −8 , and 10 −9 mol/L, respectively). Ang II caused a brief acidification followed by an increase in pH i (from 7.34±0.03 to 7.43±0.03 after 10 minutes, P <.005), and Ang-(1-7) had no significant effect on pH i (fr...
American Journal of Kidney Diseases, 1996
Journal of Oral and Maxillofacial Surgery, 1993
The American Journal of the Medical Sciences, 2001
Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)... more Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is an uncommon complication of treatment with the new class of antidepressant agents, the selective serotonin reuptake inhibitors (SSRIs). Most of the reported cases were associated with fluoxetine; only 2 have previously been described in association with citalopram. We describe an elderly woman who presented with severe symptomatic hyponatremia caused by the SIADH during therapy with citalopram. Because the use of SSRIs is becoming more popular among elderly depressed patients, the present case and the other 2 reported previously emphasize the need for greater awareness of the development of this serious and potentially fatal complication also in association with citalopram therapy and suggest that serum sodium levels should be monitored closely in elderly patients during treatment with citalopram.