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Research paper thumbnail of ChemInform Abstract: Synthesis of meso-Tetravinyl Porphyrins Through 1-Selenoallyl Cationic Species

Research paper thumbnail of Synthesis of meso-tetravinyl porphyrins through 1-selenoallyl cationic species

Journal of the Chemical Society, Chemical Communications, 1986

Research paper thumbnail of Synthesis of a new chiral porphyrin ligand and its Mn (III) complex as catalyst in asymmetric alkene epoxidation

Journal of Molecular Catalysis, 1993

A new chiral ligand, meso-tetrafenchylidenylmethylporphyrin, as well as the corresponding mangane... more A new chiral ligand, meso-tetrafenchylidenylmethylporphyrin, as well as the corresponding manganese(III)porphyrin have been synthesized. The first results on the catalytic asymetric epoxidation of styrenes and of unfunctionalized aliphatic alkenes, using sodium hypochlorite as oxygen source, are reported.

Research paper thumbnail of Identification of the released tag by MALDI/MS direct analysis from tissue sections after ISH or ICC. Validation of the concept using comparison of classical detection methods : DIG for oligonucleotide probes and DAB or FITC detection for secondary antibody. MALDI Tag imaging experiments were suc...

Research paper thumbnail of ChemInform Abstract: Synthesis of meso-Tetraalkynylporphyrins Using 1-Seleno-2-alkynyl Cation Precursors

Research paper thumbnail of Synthesis of meso-tetraalkylnyl porphyrins using 1-seleno-2-alkynyl cation precursors

Tetrahedron Letters, 1992

... Synthesis of meso-tetraalkylnyl porphyrins using 1-seleno-2-alkynyl cation precursors. Gottfr... more ... Synthesis of meso-tetraalkylnyl porphyrins using 1-seleno-2-alkynyl cation precursors. Gottfreid Proess , Dirk Pankert and Laszlo Hevesi , *. Department of Chemistry, Facultés Universitaires Notre-Dame de la Paix, 61, rue de Bruxelles, B 5000 NAMUR, Belgium. ...

Research paper thumbnail of Synthesis and partial characterization of a new low gap polymer: poly-2(5)-propenylidenepyrrole

Research paper thumbnail of MALDI tissue imaging using conjugates cleavable by fast fragmentation

Research paper thumbnail of DNTP conjugated to peptide via a UV cleavable linker

Research paper thumbnail of Antibody conjugated to peptide via a UV cleavable linker

Research paper thumbnail of Use of conjugates with linkers cleavable by photodissociation or fragmentation for mass spectrometry analysis of tissue sections

CITATION 1 READS 13 8 authors, including: Some of the authors of this publication are also workin... more CITATION 1 READS 13 8 authors, including: Some of the authors of this publication are also working on these related projects: Identification of factors of the acute phase of the inflammatory response in rat model of spinal cord injury View project Structural elucidation by mass spectrometry applied to metabolomics and MS/MS data bank View project Isabelle Fournier ML_consult 49 PUBLICATIONS 2,071 CITATIONS SEE PROFILE All content following this page was uploaded by Michel Salzet on 17 June 2015.

Research paper thumbnail of Direct profiling and MALDI Imaging in clinical proteomic

Molecular and cellular Proteomics, 2006

MALDI direct analysis and MALDI imaging of tissues have shown to be a very powerful tool by local... more MALDI direct analysis and MALDI imaging of tissues have shown to be a very powerful tool by localizing molecules in tissue and by avoiding extraction, pre-purification, separation. Nevertheless, this new method requires new developments to increase sensitivity and specificity. We propose here a new concept and evolutions of each step of MALDI Imaging analysis. New matrices called Ionic matrices were synthesized to be especially well adapted for a good crystallization, sensitivity and resolution compared to the classical matrices. ...

Research paper thumbnail of New insights in sample preparation for MALDI Imaging and new developments to approach specific MALDI imaging of the transcriptome

54 th ASMS Conference Proceedings, 2006

New insights in sample preparation for MALDI Imaging and new developments to approach specific MA... more New insights in sample preparation for MALDI Imaging and new developments to approach specific MALDI imaging of the transcriptome. I Fournier, R Lemaire, M Wisztorski, J Stauber, O Jardin-Mathe, C Van Camp, M Deschamps, G Proess, R Day, M Salzet 54 th ASMS Conference Proceedings, 2006. Abstract not available. 17 Instruments and Measurements(SO).

Research paper thumbnail of New developments in MALDI imaging mass spectrometry for pathological proteomic studies: introduction to a novel concept, the specific MALDI imaging

Mol. Cell. Proteomics, 2006

Research paper thumbnail of Tag-Mass:  Specific Molecular Imaging of Transcriptome and Proteome by Mass Spectrometry Based on Photocleavable Tag

Journal of Proteome Research, 2007

We present a new development of the Tag-Mass concept based on a photocleavable linker with tagged... more We present a new development of the Tag-Mass concept based on a photocleavable linker with tagged molecules for polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) quantification coupled to mass spectrometry. PCR-MS and immunosorbent assay-MS with tagged oligonucleotides, bases, and antibodies will allow the acquisition of multiplexed information from genomic, transcriptomic, and proteomic experiments. This is a novel application of Tag-Mass from tissue imaging to fluid quantification and will open doors to several clinical applications ranging from biomarker-driven gene modulation to use at the patient's bedside following treatment.

Research paper thumbnail of ChemInform Abstract: Synthesis of meso-Tetravinyl Porphyrins Through 1-Selenoallyl Cationic Species

Research paper thumbnail of Synthesis of meso-tetravinyl porphyrins through 1-selenoallyl cationic species

Journal of the Chemical Society, Chemical Communications, 1986

Research paper thumbnail of Synthesis of a new chiral porphyrin ligand and its Mn (III) complex as catalyst in asymmetric alkene epoxidation

Journal of Molecular Catalysis, 1993

A new chiral ligand, meso-tetrafenchylidenylmethylporphyrin, as well as the corresponding mangane... more A new chiral ligand, meso-tetrafenchylidenylmethylporphyrin, as well as the corresponding manganese(III)porphyrin have been synthesized. The first results on the catalytic asymetric epoxidation of styrenes and of unfunctionalized aliphatic alkenes, using sodium hypochlorite as oxygen source, are reported.

Research paper thumbnail of Identification of the released tag by MALDI/MS direct analysis from tissue sections after ISH or ICC. Validation of the concept using comparison of classical detection methods : DIG for oligonucleotide probes and DAB or FITC detection for secondary antibody. MALDI Tag imaging experiments were suc...

Research paper thumbnail of ChemInform Abstract: Synthesis of meso-Tetraalkynylporphyrins Using 1-Seleno-2-alkynyl Cation Precursors

Research paper thumbnail of Synthesis of meso-tetraalkylnyl porphyrins using 1-seleno-2-alkynyl cation precursors

Tetrahedron Letters, 1992

... Synthesis of meso-tetraalkylnyl porphyrins using 1-seleno-2-alkynyl cation precursors. Gottfr... more ... Synthesis of meso-tetraalkylnyl porphyrins using 1-seleno-2-alkynyl cation precursors. Gottfreid Proess , Dirk Pankert and Laszlo Hevesi , *. Department of Chemistry, Facultés Universitaires Notre-Dame de la Paix, 61, rue de Bruxelles, B 5000 NAMUR, Belgium. ...

Research paper thumbnail of Synthesis and partial characterization of a new low gap polymer: poly-2(5)-propenylidenepyrrole

Research paper thumbnail of MALDI tissue imaging using conjugates cleavable by fast fragmentation

Research paper thumbnail of DNTP conjugated to peptide via a UV cleavable linker

Research paper thumbnail of Antibody conjugated to peptide via a UV cleavable linker

Research paper thumbnail of Use of conjugates with linkers cleavable by photodissociation or fragmentation for mass spectrometry analysis of tissue sections

CITATION 1 READS 13 8 authors, including: Some of the authors of this publication are also workin... more CITATION 1 READS 13 8 authors, including: Some of the authors of this publication are also working on these related projects: Identification of factors of the acute phase of the inflammatory response in rat model of spinal cord injury View project Structural elucidation by mass spectrometry applied to metabolomics and MS/MS data bank View project Isabelle Fournier ML_consult 49 PUBLICATIONS 2,071 CITATIONS SEE PROFILE All content following this page was uploaded by Michel Salzet on 17 June 2015.

Research paper thumbnail of Direct profiling and MALDI Imaging in clinical proteomic

Molecular and cellular Proteomics, 2006

MALDI direct analysis and MALDI imaging of tissues have shown to be a very powerful tool by local... more MALDI direct analysis and MALDI imaging of tissues have shown to be a very powerful tool by localizing molecules in tissue and by avoiding extraction, pre-purification, separation. Nevertheless, this new method requires new developments to increase sensitivity and specificity. We propose here a new concept and evolutions of each step of MALDI Imaging analysis. New matrices called Ionic matrices were synthesized to be especially well adapted for a good crystallization, sensitivity and resolution compared to the classical matrices. ...

Research paper thumbnail of New insights in sample preparation for MALDI Imaging and new developments to approach specific MALDI imaging of the transcriptome

54 th ASMS Conference Proceedings, 2006

New insights in sample preparation for MALDI Imaging and new developments to approach specific MA... more New insights in sample preparation for MALDI Imaging and new developments to approach specific MALDI imaging of the transcriptome. I Fournier, R Lemaire, M Wisztorski, J Stauber, O Jardin-Mathe, C Van Camp, M Deschamps, G Proess, R Day, M Salzet 54 th ASMS Conference Proceedings, 2006. Abstract not available. 17 Instruments and Measurements(SO).

Research paper thumbnail of New developments in MALDI imaging mass spectrometry for pathological proteomic studies: introduction to a novel concept, the specific MALDI imaging

Mol. Cell. Proteomics, 2006

Research paper thumbnail of Tag-Mass:  Specific Molecular Imaging of Transcriptome and Proteome by Mass Spectrometry Based on Photocleavable Tag

Journal of Proteome Research, 2007

We present a new development of the Tag-Mass concept based on a photocleavable linker with tagged... more We present a new development of the Tag-Mass concept based on a photocleavable linker with tagged molecules for polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) quantification coupled to mass spectrometry. PCR-MS and immunosorbent assay-MS with tagged oligonucleotides, bases, and antibodies will allow the acquisition of multiplexed information from genomic, transcriptomic, and proteomic experiments. This is a novel application of Tag-Mass from tissue imaging to fluid quantification and will open doors to several clinical applications ranging from biomarker-driven gene modulation to use at the patient's bedside following treatment.

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