Cynthia Corley | University of North Carolina at Chapel Hill (original) (raw)

Papers by Cynthia Corley

Research paper thumbnail of The chemometric resolution and quantification of overlapped peaks form comprehensive two-dimensional liquid chromatography

Journal of Chromatography A, Nov 1, 2005

The chemometric resolution and quantification of overlapped peaks from comprehensive two-dimensio... more The chemometric resolution and quantification of overlapped peaks from comprehensive two-dimensional (2D) liquid chromatography (LC × LC) data are demonstrated. The LC × LC data is produced from an in-house LC × LC analyzer that couples an anion-exchange column via a multi-port valve with a reversed-phase column connected to a UV absorbance detector. Three test mixtures, each containing a target analyte, are subjected to partial LC × LC separations to simulate likely cases of signal overlap. The resulting unresolved target-analyte signals are then analyzed by the standard-addition method and two chemometric methods. The LC × LC analyses of a test mixture and its corresponding standard-addition mixture results in two data matrices, one for each mixture. The stacking of these two data matrices produces a data structure that can then be analyzed by trilinear chemometric methods. One method, the generalized rank annihilation method (GRAM), uses a non-iterative eigenvalue-based approach to mathematically resolve overlapped trilinear signals. The other method, parallel factor analysis (PARAFAC), uses an iterative approach to resolve trilinear signals by the optimization of initial estimates using alternating least squares and signal constraints. In this paper, GRAM followed by PARAFAC analysis is shown to produce better qualitative and quantitative results than using each method separately. For instance, for all three test mixtures, the GRAM-PARAFAC approach improved quantitative accuracy by at least a factor of 4 and quantitative precision by more than 2 when compared to GRAM alone. This paper also introduces a new means of correcting run-to-run retention time shifts in comprehensive 2D chromatographic data.

Research paper thumbnail of Crystal structures and Hirshfeld surface analysis of a series of 4-O-arylperfluoropyridines

Acta Crystallographica Section E: Crystallographic Communications, Jul 4, 2019

Five new crystal structures of perfluoropyridine substituted in the 4-position with phenoxy, 4-br... more Five new crystal structures of perfluoropyridine substituted in the 4-position with phenoxy, 4-bromophenoxy, naphthalen-2-yloxy, 6-bromonaphthalen-2yloxy, and 4,4 0-biphenoxy are reported, viz. 2,3,5,6-tetrafluoro-4-phenoxypyridine, C 11 H 5 F 4 NO (I), 4-(4-bromophenoxy)-2,3,5,6-tetrafluoropyridine, C 11 H 4 BrF 4 NO (II), 2,3,5,6-tetrafluoro-4-[(naphthalen-2-yl)oxy]pyridine, C 15 H 7 F 4 NO (III), 4-[(6-bromonaphthalen-2-yl)oxy]-2,3,5,6-tetrafluoropyridine, C 15 H 6 BrF 4 NO (IV), and 2,2 0-bis[(perfluoropyridin-4-yl)oxy]-1,1 0-biphenyl, C 22 H 8 F 8 N 2 O 2 (V). The dihedral angles between the aromatic ring systems in I-IV are 78.74 (8), 56.35 (8), 74.30 (7), and 64.34 (19) , respectively. The complete molecule of V is generated by a crystallographic twofold axis: the dihedral angle between the pyridine ring and adjacent phenyl ring is 80.89 (5) and the equivalent angle between the biphenyl rings is 27.30 (5). In each crystal, the packing is driven by C-HÁ Á ÁF interactions, along with a variety of C-FÁ Á Á, C-HÁ Á Á, C-BrÁ Á ÁN, C-HÁ Á ÁN, and C-BrÁ Á Á contacts. Hirshfeld surface analysis was conducted to aid in the visualization of these various influences on the packing. research communications

Research paper thumbnail of Fulleride Ionic Liquids

ECS Meeting Abstracts, 2006

not Available.

Research paper thumbnail of Characterization of a stable leuprolide formulation for one year in an implantable device

Kluwer Academic Publishers eBooks, Dec 2, 2005

Research paper thumbnail of Recycling of 1,2-Dimethyl-3-propylimidazolium bis(trifluoromethylsulfonyl)imide Ionic Liquid by Stacked Cation and Anion Exchange Adsorption-Desorption

Research paper thumbnail of Decontamination Reactions of Chemical Warfare Agent Simulants with Alcohols in the Basic Ionic Liquid Tetramethylammonium Hydroxide/1,2-Dimethyl-3-propylimidazolium Bis(trifluoromethylsulfonyl)amide

Industrial & Engineering Chemistry Research, Apr 15, 2008

Research paper thumbnail of Reactions of Chemical Warfare Agent Simulants in the Common Ion Binary Ionic Liquid 1,2-Dimethyl-3-propylimidazolium/Copper(II) Bis(trifluoromethylsulfonyl)amide

Industrial & Engineering Chemistry Research, May 26, 2009

Ionic liquids have the potential for being ideal alternatives for organic solvents in chemical wa... more Ionic liquids have the potential for being ideal alternatives for organic solvents in chemical warfare agent reactions and demilitarization processes. They are considered to be an excellent substitute, because of their extraordinarily wide liquid range, low melting points, chemical ...

Research paper thumbnail of Total Synthesis of Tailorable Fluorinated Pyridine-Based Polymers for High Performance Applications

University of Colorado Colorado Springs. Kraemer Family Library, May 1, 2018

Research paper thumbnail of Pyridine-functionalized linear and network step-growth fluoropolymers

Journal of Fluorine Chemistry, 2020

Research paper thumbnail of Perfluoropyridine as a Scaffold for Semifluorinated Thiol‐ene Networks with Readily Tunable Thermal Properties

Macromolecular Chemistry and Physics, 2020

Two new trifunctional alkene monomers based on the highly modular perfluoropyridine scaffold are ... more Two new trifunctional alkene monomers based on the highly modular perfluoropyridine scaffold are synthesized with an aliphatic and an aromatic moiety, 4‐penten‐1‐ol and eugenol, respectively. The monomers are the basis for thiol‐ene thermoset materials, formulated against a difunctional or trifunctional thiol. Systems based on these novel monomers have a wide range of thermal properties, with glass transition temperatures (Tgs) spanning from −42 to 21 °C. Mixed systems obey the Fox equation, and Tgs of the mixtures can be tuned to specific values in that range. Thermal degradation temperatures follow a similar trend, with decomposition temperatures ranging from 274 to 348 °C in nitrogen with varying compositions having tailorability therein. This new class of semifluorinated thermoset materials with tunable thermal properties has several potential applications within the aerospace industry, such as sealants and coatings, where stability and survivability at high temperatures in hars...

Research paper thumbnail of CCDC 1854635: Experimental Crystal Structure Determination

Research paper thumbnail of CCDC 1996450: Experimental Crystal Structure Determination

Research paper thumbnail of 4. TITLE AND SUBTITLE Di(cyanate Ester) Networks Based on Alternative Fluorinated Bisphenols with Extremely Low Water Uptake

Public reporting burden for this collection of information is estimated to average 1 hour per res... more Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this

Research paper thumbnail of Macromolecular Networks Containing Fluorinated Cyclic Moieties

Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information is est... more Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 12 December 2015 2. RE...

Research paper thumbnail of Density Functional Theory Investigation of Fulvene-Derivatized Fullerenes as Candidates for Organic Solar Cells

Research paper thumbnail of Single-crystal X-ray diffraction dataset for 3,5-difluoro-2,6-bis(4-iodophenoxy)-4-phenoxypyridine

Research paper thumbnail of Utilizing the regioselectivity of perfluoropyridine towards the preparation of phenyoxyacetylene precursors for partially fluorinated polymers of diverse architecture

Journal of Fluorine Chemistry, 2019

Research paper thumbnail of Theoretical Explanation of Reaction Site Selectivity in the Addition of a Phenoxy Group to Perfluoropyridine

The Journal of Physical Chemistry A, 2019

Research paper thumbnail of Crystal structures and Hirshfeld surface analysis of a series of 4-O-arylperfluoropyridines

Research paper thumbnail of Recycling of 1,2-Dimethyl-3-propylimidazolium bis(trifluoromethylsulfonyl)imide Ionic Liquid by Stacked Cation and Anion Exchange Adsorption-Desorption

Separations, 2019

There are many advantages to using ionic liquids as solvents or catalysts in chemical processes. ... more There are many advantages to using ionic liquids as solvents or catalysts in chemical processes. Their non-volatile characteristic and high cost, however, can pose economic, environmental, and long-term health concerns. As such, the recovery and recycling of ionic liquids have become essential to mitigate their environmental impact and to reduce costs. Numerous recovery and recycling methods have been reported, including distillation, extraction, membrane separation (a.k.a. filtration), adsorption, crystallization, gravity, and electrochemical separation. Whereas most of these methods recover both cations and anions of the ionic liquid as ion pairs, recycling methods such as single-phase ion exchange or mixed-ion exchange/non-ionic adsorption methods recover only one of the ionic liquid ions, typically the cation. These methods are frequently used for the recycling of ionic liquids having simple anions such as chloride or acetate, but are seldom employed for ionic liquids consisting...

Research paper thumbnail of The chemometric resolution and quantification of overlapped peaks form comprehensive two-dimensional liquid chromatography

Journal of Chromatography A, Nov 1, 2005

The chemometric resolution and quantification of overlapped peaks from comprehensive two-dimensio... more The chemometric resolution and quantification of overlapped peaks from comprehensive two-dimensional (2D) liquid chromatography (LC × LC) data are demonstrated. The LC × LC data is produced from an in-house LC × LC analyzer that couples an anion-exchange column via a multi-port valve with a reversed-phase column connected to a UV absorbance detector. Three test mixtures, each containing a target analyte, are subjected to partial LC × LC separations to simulate likely cases of signal overlap. The resulting unresolved target-analyte signals are then analyzed by the standard-addition method and two chemometric methods. The LC × LC analyses of a test mixture and its corresponding standard-addition mixture results in two data matrices, one for each mixture. The stacking of these two data matrices produces a data structure that can then be analyzed by trilinear chemometric methods. One method, the generalized rank annihilation method (GRAM), uses a non-iterative eigenvalue-based approach to mathematically resolve overlapped trilinear signals. The other method, parallel factor analysis (PARAFAC), uses an iterative approach to resolve trilinear signals by the optimization of initial estimates using alternating least squares and signal constraints. In this paper, GRAM followed by PARAFAC analysis is shown to produce better qualitative and quantitative results than using each method separately. For instance, for all three test mixtures, the GRAM-PARAFAC approach improved quantitative accuracy by at least a factor of 4 and quantitative precision by more than 2 when compared to GRAM alone. This paper also introduces a new means of correcting run-to-run retention time shifts in comprehensive 2D chromatographic data.

Research paper thumbnail of Crystal structures and Hirshfeld surface analysis of a series of 4-O-arylperfluoropyridines

Acta Crystallographica Section E: Crystallographic Communications, Jul 4, 2019

Five new crystal structures of perfluoropyridine substituted in the 4-position with phenoxy, 4-br... more Five new crystal structures of perfluoropyridine substituted in the 4-position with phenoxy, 4-bromophenoxy, naphthalen-2-yloxy, 6-bromonaphthalen-2yloxy, and 4,4 0-biphenoxy are reported, viz. 2,3,5,6-tetrafluoro-4-phenoxypyridine, C 11 H 5 F 4 NO (I), 4-(4-bromophenoxy)-2,3,5,6-tetrafluoropyridine, C 11 H 4 BrF 4 NO (II), 2,3,5,6-tetrafluoro-4-[(naphthalen-2-yl)oxy]pyridine, C 15 H 7 F 4 NO (III), 4-[(6-bromonaphthalen-2-yl)oxy]-2,3,5,6-tetrafluoropyridine, C 15 H 6 BrF 4 NO (IV), and 2,2 0-bis[(perfluoropyridin-4-yl)oxy]-1,1 0-biphenyl, C 22 H 8 F 8 N 2 O 2 (V). The dihedral angles between the aromatic ring systems in I-IV are 78.74 (8), 56.35 (8), 74.30 (7), and 64.34 (19) , respectively. The complete molecule of V is generated by a crystallographic twofold axis: the dihedral angle between the pyridine ring and adjacent phenyl ring is 80.89 (5) and the equivalent angle between the biphenyl rings is 27.30 (5). In each crystal, the packing is driven by C-HÁ Á ÁF interactions, along with a variety of C-FÁ Á Á, C-HÁ Á Á, C-BrÁ Á ÁN, C-HÁ Á ÁN, and C-BrÁ Á Á contacts. Hirshfeld surface analysis was conducted to aid in the visualization of these various influences on the packing. research communications

Research paper thumbnail of Fulleride Ionic Liquids

ECS Meeting Abstracts, 2006

not Available.

Research paper thumbnail of Characterization of a stable leuprolide formulation for one year in an implantable device

Kluwer Academic Publishers eBooks, Dec 2, 2005

Research paper thumbnail of Recycling of 1,2-Dimethyl-3-propylimidazolium bis(trifluoromethylsulfonyl)imide Ionic Liquid by Stacked Cation and Anion Exchange Adsorption-Desorption

Research paper thumbnail of Decontamination Reactions of Chemical Warfare Agent Simulants with Alcohols in the Basic Ionic Liquid Tetramethylammonium Hydroxide/1,2-Dimethyl-3-propylimidazolium Bis(trifluoromethylsulfonyl)amide

Industrial & Engineering Chemistry Research, Apr 15, 2008

Research paper thumbnail of Reactions of Chemical Warfare Agent Simulants in the Common Ion Binary Ionic Liquid 1,2-Dimethyl-3-propylimidazolium/Copper(II) Bis(trifluoromethylsulfonyl)amide

Industrial & Engineering Chemistry Research, May 26, 2009

Ionic liquids have the potential for being ideal alternatives for organic solvents in chemical wa... more Ionic liquids have the potential for being ideal alternatives for organic solvents in chemical warfare agent reactions and demilitarization processes. They are considered to be an excellent substitute, because of their extraordinarily wide liquid range, low melting points, chemical ...

Research paper thumbnail of Total Synthesis of Tailorable Fluorinated Pyridine-Based Polymers for High Performance Applications

University of Colorado Colorado Springs. Kraemer Family Library, May 1, 2018

Research paper thumbnail of Pyridine-functionalized linear and network step-growth fluoropolymers

Journal of Fluorine Chemistry, 2020

Research paper thumbnail of Perfluoropyridine as a Scaffold for Semifluorinated Thiol‐ene Networks with Readily Tunable Thermal Properties

Macromolecular Chemistry and Physics, 2020

Two new trifunctional alkene monomers based on the highly modular perfluoropyridine scaffold are ... more Two new trifunctional alkene monomers based on the highly modular perfluoropyridine scaffold are synthesized with an aliphatic and an aromatic moiety, 4‐penten‐1‐ol and eugenol, respectively. The monomers are the basis for thiol‐ene thermoset materials, formulated against a difunctional or trifunctional thiol. Systems based on these novel monomers have a wide range of thermal properties, with glass transition temperatures (Tgs) spanning from −42 to 21 °C. Mixed systems obey the Fox equation, and Tgs of the mixtures can be tuned to specific values in that range. Thermal degradation temperatures follow a similar trend, with decomposition temperatures ranging from 274 to 348 °C in nitrogen with varying compositions having tailorability therein. This new class of semifluorinated thermoset materials with tunable thermal properties has several potential applications within the aerospace industry, such as sealants and coatings, where stability and survivability at high temperatures in hars...

Research paper thumbnail of CCDC 1854635: Experimental Crystal Structure Determination

Research paper thumbnail of CCDC 1996450: Experimental Crystal Structure Determination

Research paper thumbnail of 4. TITLE AND SUBTITLE Di(cyanate Ester) Networks Based on Alternative Fluorinated Bisphenols with Extremely Low Water Uptake

Public reporting burden for this collection of information is estimated to average 1 hour per res... more Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this

Research paper thumbnail of Macromolecular Networks Containing Fluorinated Cyclic Moieties

Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information is est... more Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 12 December 2015 2. RE...

Research paper thumbnail of Density Functional Theory Investigation of Fulvene-Derivatized Fullerenes as Candidates for Organic Solar Cells

Research paper thumbnail of Single-crystal X-ray diffraction dataset for 3,5-difluoro-2,6-bis(4-iodophenoxy)-4-phenoxypyridine

Research paper thumbnail of Utilizing the regioselectivity of perfluoropyridine towards the preparation of phenyoxyacetylene precursors for partially fluorinated polymers of diverse architecture

Journal of Fluorine Chemistry, 2019

Research paper thumbnail of Theoretical Explanation of Reaction Site Selectivity in the Addition of a Phenoxy Group to Perfluoropyridine

The Journal of Physical Chemistry A, 2019

Research paper thumbnail of Crystal structures and Hirshfeld surface analysis of a series of 4-O-arylperfluoropyridines

Research paper thumbnail of Recycling of 1,2-Dimethyl-3-propylimidazolium bis(trifluoromethylsulfonyl)imide Ionic Liquid by Stacked Cation and Anion Exchange Adsorption-Desorption

Separations, 2019

There are many advantages to using ionic liquids as solvents or catalysts in chemical processes. ... more There are many advantages to using ionic liquids as solvents or catalysts in chemical processes. Their non-volatile characteristic and high cost, however, can pose economic, environmental, and long-term health concerns. As such, the recovery and recycling of ionic liquids have become essential to mitigate their environmental impact and to reduce costs. Numerous recovery and recycling methods have been reported, including distillation, extraction, membrane separation (a.k.a. filtration), adsorption, crystallization, gravity, and electrochemical separation. Whereas most of these methods recover both cations and anions of the ionic liquid as ion pairs, recycling methods such as single-phase ion exchange or mixed-ion exchange/non-ionic adsorption methods recover only one of the ionic liquid ions, typically the cation. These methods are frequently used for the recycling of ionic liquids having simple anions such as chloride or acetate, but are seldom employed for ionic liquids consisting...