Indah Raya | Hasanuddin University (original) (raw)

Papers by Indah Raya

Asian Pacific Journal of Cancer Prevention, Nov 30, 2023

Objective: Cervical cancer is a malignancy originating from the cervix and often caused by oncoge... more Objective: Cervical cancer is a malignancy originating from the cervix and often caused by oncogenic Human Papilloma Virus (HPV), specifically subtypes 16 and 18. Anticancer drugs are chemotherapeutic compounds used for cancer treatment. Therefore, this research aims to synthesize and characterize Zinc (II) dichloroethylenediamine (Zn(en)Cl 2) complex, as well as determine its antiproliferative activity against HeLa cells. The Zn(en)Cl 2 complex was successfully synthesized, and the antiproliferative activity was tested. Methods: The synthesis involved reacting ethylenediamine and KCl with Zn metal. The complex formed was characterized using a conductometer, UV-Vis spectroscopy, FT-IR spectroscopy, and XRD, while the activity was measured against HeLa cells. Result: The synthesis yielded a 56.12% conversion with a melting point of 198-200 o C and a conductivity value of 2.02 mS/cm. The Zn(en)Cl 2 complex showed potential activity against HeLa cells with an IC 50 value of 898.35 µg/mL, which was evidenced by changes in the morphological structure of HeLa cells. Its interaction with DNA targets was investigated by employing molecular docking. Conclusion: The observed data indicated that the Zn(en)Cl 2 complex bound to DNA at the nitrogenous base Guanine (DG) by coordinate covalent bonds. Interestingly, DG maintained interaction with the complex until the end of the docking simulation. Additionally, molecular dynamics (MD) simulation was conducted, and the results showed that Zn(en)Cl 2 remained bound to the DNA binding pocket all through the process.

Asian Pacific journal of cancer prevention, Apr 1, 2024

Research Square (Research Square), May 17, 2023

In this research, a facile and e cient protocol for the synthesis of rizatriptan analogues using ... more In this research, a facile and e cient protocol for the synthesis of rizatriptan analogues using natural deep eutectic solvents as an inexpensive, easily available, and environmentally friendly catalyst is developed. The reaction of various phenyl hydrazines (a-j) and 3,3-dimethoxy-N,N-dimethylpropan-1amine (2) using natural deep eutectic solvents affords fused indole heterocyclic compounds under optimised conditions at 70°C to produce the desired products with excellent to good yields (77-89%) at short reaction times (1 h). This new facile methodology Compared with previous reactions, has the advantages of a reusable catalyst, short reaction times and simplicity of the product isolation.

Nucleation and Atmospheric Aerosols, 2023

Indonesian Journal of Chemistry, May 22, 2023

This study was conducted to determine the role of thermal treatment on the crystallinity and pore... more This study was conducted to determine the role of thermal treatment on the crystallinity and pore characteristics of porous ceramic, which was prepared from natural clay (NC) and chitosan (CS) biopolymer using the gel casting method. CS was used as an environmentally friendly pore-forming agent. The applied temperature treatment was based on thermal analysis (TGA/DTA) results and followed a sintering temperature of 900 to 1100 °C. The results showed that at sintering temperatures from 900 to 1000 °C, the crystallinities of the ceramic decrease (from 76.06 to 74.06%) and the crystallite size decreases (from 35.71 to 34.47 nm) while the lattice strain increases (calculated from the Full Width at Half Maximum (β) of the diffraction peak). The highest porosity of ceramic occurred at a sintering temperature of 1000 °C of 37.82 ± 0.19, but the formation of heterogeneous microstructure was observed. The resulting pore size for all temperature treatments was almost mesoporous (19.1 Å). Based on the results obtained, it is emphasized that the sintering temperature can be used to adjust the porosity and microstructure of porous ceramics.

Molecular Diversity, Mar 13, 2023

A new series of 2-(4-((5-(4-bromophenyl)-1, 3, 4-oxadiazol-2-yl)methoxy)phenyl)-1H-benzo[de] isoq... more A new series of 2-(4-((5-(4-bromophenyl)-1, 3, 4-oxadiazol-2-yl)methoxy)phenyl)-1H-benzo[de] isoquinoline-1,3(2H)-dione derivatives (6a-l) have been synthesized by using conventional method. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activity four bacterial strains S. aureus, E. coli, B. subtilis, and P. aeruginosa. Ciprofloxacin used standard drug. The antifungal activity screened against two pathogenic fungal strains A.niger and C. albicans and Voriconazole used as standard drug. The antibacterial results shows that compounds 6i more than 6f are as potent against S. aureus with compare to standard drug. In the case of B. subtilis the compounds 6f more than 6i are more active. In the case of E.coli the compounds 6i more than 6f are more active. The compounds 6f and 6i are more active against P. aeruginosa. The anti-fungal activity result shows that the compounds 6f and 6i are as active as standard drug Voriconazole against A.niger. In the case of C. albicans the compounds 6f and 6i are showing the same activity with compare to standard drug. All the synthesized novel compounds were characterized by FTIR, 1 H-NMR, 13 C-NMR, HRMS spectroscopic methods and the elemental analysis (C, H and N).

Jurnal Rekayasa Kimia & Lingkungan, Jun 21, 2019

Limbah zat warna methylene blue (MB) merupakan polutan organik dari industri kimia. Parameter kan... more Limbah zat warna methylene blue (MB) merupakan polutan organik dari industri kimia. Parameter kandungan zat warna MB yang diizinkan dalam bentuk methylene blue active substance (MBAS) tidak melebihi 200 µg/L. Sistem pengolahan limbah zat warna MB dapat dilakukan melalui proses adsorpsi menggunakan nanopartikel TiO2. Penelitian ini bertujuan untuk mensintesis nanopartikel TiO2 menggunakan surfaktan polivinil alkohol (PVA) dan titanium tetraisopropoksida (TTIP) sebagai prekursor melalui proses sol-gel yang diikuti proses hidrotermal pada suhu kalsinasi 400 dan 600 o C. Hasil karakteristik spektrum X-ray diffraction (XRD) menunjukkan bentuk kristal tetragonal, fase anatase, dan ukuran partikel sekitar 1,66-3,15 nm. Spektroskopi infrared membuktikan adanya ikatan gugus Ti-O pada spektrum 467 cm-1 dan adanya gugus hidroksil pada permukaan TiO2. Analisis differential scanning calorimeter (DSC) menunjukkan kestabilan termal TiO2 pada suhu 250 o C. Aplikasi nanopartikel TiO2 sebagai adsorben MB dilakukan melalui proses fotodegradasi menggunakan lampu Hg 150 watt selama 60 menit. Kapasitas adsorpsi terbesar diperoleh pada sampel TiO2 yang dikalsinasi pada suhu 600 o C sebesar 217 mg/g dan daya adsorpsi 81%. Proses adsorpsi MB menggunakan nanopartikel TiO2 dapat mengikuti persamaan isoterm Langmuir dan Freundlich dengan nilai koefisien determinasi, R 2 mendekati nilai 1.

Asian Pacific Journal of Cancer Prevention, Sep 1, 2022

Cancer is one of the leading causes of death worldwide (Momenimovahed, 2017). Approximately 7.5 m... more Cancer is one of the leading causes of death worldwide (Momenimovahed, 2017). Approximately 7.5 million people who have died from cancer generally lived in poor and developing countries (WHO, 2020). The major causes of cancer are unhealthy living habits (e.g. smoking and wrong diet) and air pollution (WHO, 2020). Breast cancer is a neoplasm that is the main cause of death in women, especially those over the age of 40 years (Seidler and Huber, 2020). Various therapies, such as surgery, partial irradiation, endocrine therapy and modern medicine, have been applied to treat cancer (Schneeweiss, et al., 2020). Metal-organic complex-based chemotherapeutic

Journal of Molecular Structure, Mar 1, 2022

International research journal of pharmacy, May 16, 2019

To synthesize and characterize complex compound of Zn(II) with cysteine dithiocarbamate ligands a... more To synthesize and characterize complex compound of Zn(II) with cysteine dithiocarbamate ligands and studies its cytotoxic activity in breast cancer (MCF-7). The complex of Zn(II) cysteine dithiocarbamate was prepared by "in situ method" and characterized by using Ultraviolet-Visible (UV-Vis) and Infra-Red (IR) spectroscopy, melting point and conductivity. The results of UV-Vis maximum spectrums of Zn(II)cysteine dithiocarbamate at 282 nm and 374 nm indicated that electronic transition π→π* dan n→π* of CS2 and N=C=S. While the presence of IR spectra at the wavelength in the region of 397-534 cm-1 indicated that has been coordination occurred between Zn(II) with Sulphur (S), Nitrogen (N) and Oxygen(O) atoms from cysteine dithiocarbamate ligands. Complex characterization using UV-Vis and IR showed that complex Zn(II) cysteine dithiocarbamate compounds were successfully synthesized by the in-situ method. The results of the cytotoxicity assay of Zn(II) cysteine dithiocarbamate complex compounds in MCF-7 cells obtained IC50 values of Zn(II) complex = 98.60 μg/mL and cisplatin (IC50 = 200 μg/mL. These result can be seen that IC50 value of Zn(II) complex is lower than cisplatin so that Zn(II) complex has very good inhibitory activity against MCF-7 cancer cells compared to cisplatin and it can even cause apoptosis in cancer cells.

Acta Chimica Slovenica

Corrosion and scaling are among the problems that may arise when storing water in tanks. Several ... more Corrosion and scaling are among the problems that may arise when storing water in tanks. Several factors affect the corrosion and scaling of water, which include pH, temperature, alkalinity, Ca2+ hardness, TDS, concentrations of Cl–, SO42–, CO32–, and HCO3–. Also, several indices can be measured using these properties such as the Langelier saturation index, Ryznar index, Aggressive index, Larson, Scold index, water quality index, and Puckorius index. These indicators determine the degree of corrosiveness and sedimentation of water. The purpose of this review article was to study the impact of various factors on the corrosiveness and sedimentation of water. To this end, different sources of water in different countries were studied and the impact of physical and chemical parameters on their corrosiveness was investigated. Also, the reaction mechanism of water corrosion inside the pipe was studied. Finally, practical and constructive suggestions were presented to solve the problems of...

Breast Disease

OBJECTIVE: The new Mg(II) cysteindithiocarbamate complex drug has been synthesized by the in-situ... more OBJECTIVE: The new Mg(II) cysteindithiocarbamate complex drug has been synthesized by the in-situ method and tested for its anticancer activity in vitro. METHOD: Mg(II) cysteindithiocarbamate complexes were characterized using Ultra Violet Visible, Infra-Red, melting points, and molar conductivity. RESULTS: The UV-Vis data of cysteindithiocarbamate Mg(II), shows that at 296 nm and 385 nm was occurred the electronic transitions π → π* and n → π* for CS2 and N =C =S. Whereas the IR data at wavelengths in the 393–540 cm−1 shows that there has coordinated between Mg(II) with Sulfur (S), Nitrogen (N), and Oxygen (O) atoms from cysteinedithiocarbamate ligands. CONCLUSION: The cytotoxicity test results showed that the Mg complex’s cytotoxicity was higher than that of the cytotoxicity of the Mg metal without ligands, which means that the Mg complex can be developed as a potential new anticancer drug.

Journal of Sulfur Chemistry

Polycyclic Aromatic Compounds, Mar 8, 2023

Journal of Biomolecular Structure and Dynamics

Egyptian Journal of Chemistry

International Journal of Design & Nature and Ecodynamics, Oct 31, 2022

Lake Tempe in the Wajo Regency, South Sulawesi (Indonesia) is highly toxic due to metal pollution... more Lake Tempe in the Wajo Regency, South Sulawesi (Indonesia) is highly toxic due to metal pollution from industrial activities and the activities of residents living around the region. Zinc-contaminated water poses a potential threat to biotic communities. This research aims to develop phytoremediation technology to effectively remove toxic zinc from contaminated lake Tempe. The use of plants as phytoremediation agents to accumulate metals in polluted water is considered adequate because the method is environmentally friendly and presents economic value. This study was therefore designed to assess the phytoremediation potential of water spinach against zinc (Zn), copper (Cu), and lead (Pb). Water spinach was planted in Tempe lake contaminated with zinc (Zn), copper (Cu), and lead (Pb) metals, and the study was conducted for 30 days under natural conditions. Subsequently, the Tempe lake physicochemical properties, including pH, TDS, TSS, total nitrogen, total phosphate as P, and Zn content, were measured, before and after the phytoremediation process. The ability of plants to absorb zinc (Zn), copper (Cu), and lead (Pb) were assessed by the bioconcentration factor (BCF). The results showed that there was a correlation between the BCF value and the phytoremediation time. The longer the phytoremediation time, the higher the BCF value are obtained. Infra-Red (IR) data shows the presence of metal binding in plants with the functional groups C=S, C=N, and OH. Water spinach has the potential as a phytoremediation agent in remediating zinc (Zn), copper (Cu), and lead (Pb) metals in polluted lake Tempe water.

Materials Science Forum, May 26, 2022