Tilman Hensch | Universität Leipzig (original) (raw)

Papers by Tilman Hensch

Research paper thumbnail of Electrophysiological and behavioral correlates of polymorphisms in the transcription factor AP-2β coding gene

Neuroscience Letters, May 1, 2008

Transcription factor AP-2beta may influence brain monoaminergic systems by regulating target gene... more Transcription factor AP-2beta may influence brain monoaminergic systems by regulating target genes. Several monoaminergic genes, including the serotonin transporter gene, have AP-2beta binding sites. Late auditory-evoked potentials (P1, N1/P2) and impulsiveness-related personality traits are correlated, and both are modulated by monoaminergic neurotransmission. The present study assesses the impact of two AP-2beta polymorphisms (VNTRs within intron 1 and 2) together with the serotonin transporter polymorphism 5-HTTLPR on late auditory-evoked potentials and personality for the first time. EEG was recorded from 91 male subjects at central electrode positions while tones of six intensity levels were presented. Additionally, subjects completed personality questionnaires. Both AP-2beta polymorphisms revealed significant main effects on P1, and haplotype analysis confirmed the contribution of both AP-2beta-polymorphisms. Additionally, AP-2beta and 5-HTTLPR showed interactions with respect to P1. 5-HTTLPR revealed a main effect on N1/P2 but not P1. Impulsiveness showed an association with intron 1 VNTR. The results are discussed with respect to differential impact of AP-2beta polymorphisms and 5-HTTLPR on the monoaminergic systems. The findings promote replication in a larger sample and suggest a potential usefulness of AP-2beta polymorphisms in explaining or predicting central nervous diseases, drug effects and side effects.

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Research paper thumbnail of P 161 Coupling of brain arousal and autonomic regulation in the transition from wakefulness to sleep onset during an auditory oddball task in the resting state

Clinical Neurophysiology, Oct 1, 2017

Background Simultaneous downregulation of the autonomic and central nervous system activity enabl... more Background Simultaneous downregulation of the autonomic and central nervous system activity enables the gradual physiological state change from wakefulness to sleep onset. Dysregulation of central or autonomic arousal has been found in neurological ( Silvani et al., 2016 ) and psychiatric disorders ( Hegerl and Hensch, 2014 , Hegerl et al., 2012 , Schulz et al., 2016 , Schwabedal et al., 2016 ), often associated with dysregulated sleep-wake patterns. Aim We investigated the hypothesis that brain-autonomic co-regulation affects the attentive process in the transition from wakefulness to sleep onset. We propose that the degree to which autonomic and brain dynamics are correlated predicts the level of cortical excitability or inhibition and sleep onset behavior in this transition. To test our hypothesis, we explored electroencephalogram (EEG), electrocardiogram (ECG) and skin conductance data recorded during a 2-h resting state oddball experiment. Methods 39 healthy study participants underwent a 2-h resting EEG with eyes closed including ECG-derived heart rate (HR) and measurement of skin conductance level (SCL). The Vigilance Algorithm Leipzig (VIGALL 2.1) was used to assess brain arousal regulation based on automatic EEG-vigilance stage classification of 1-s EEG segments. These vigilance stages (=vigilance; V) were scored and cross-correlated with HR and SCL over a range of ±100 s, and a mean period of vigilance fluctuations was estimated from the frequency of maxima after low-pass filtering. Mean amplitudes of event-related potentials N100 and P200 to standard and deviant stimuli at Cz were calculated as indices of cortical excitability (N100) and cortical inhibition (P200) ( Cortoos et al., 2014 ). Results In all subjects, higher max cross-correlation coefficients (V-HR mean: r = 0.362, range: −0.069 to 0.762; SD = 0.192; V-SCL mean: r = 0.277, range: −0.299 to 0.629; SD = 0.211) were associated with longer mean periods of cortico-autonomic signals (V-HR: r = 0.462, p = .003; V-SCL: r = 0.516, p = .001). The cross-correlation of V with either HR and SCL partitioned the subjects into two groups (group no lag: n0 = 20, τ = 0; group lag: n1 = 19, τ (range) = −98 to −87) dependent on the time lag of maximal correlation. Subjects in n0, who fell asleep more often (indexed by the frequency of falling asleep: t37 = 2.49, p = .018) during the 2-h EEG compared to subjects in n1, had higher max cross-correlation coefficients (V-HR: t37 = 4.24, p = 1.43E−4; V-SCL: t37 = 5.02, p = 1.35E−5) and displayed an increased standard (t30.235 = 3.19, p = .003) and deviant P200 amplitude (t37 = 3.63, p = .001) compared to subjects in n1. No significant group differences were found for N100 amplitudes and KSS score either before or after the recording. Conclusion Healthy individuals with no time lag between cortical and autonomic signals showed a stronger brain-autonomic coupling and increased P200 amplitudes (indicating a higher level of cortical inhibition) compared to individuals with a temporal misalignment. This may explain differences in sleep-onset behavior between groups. Present results indicate possible diagnostic value in the assessment of brain-autonomic regulation, for example in disorders with sleep-related symptoms such as insomnia, dementia or depression.

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Research paper thumbnail of FV 15. Genome-wide association study of human brain arousal regulation

Clinical Neurophysiology, Sep 1, 2016

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Research paper thumbnail of The Neural Representation of the Heart is Strongly Attenuated in Patients with Atrial Fibrillation

Social Science Research Network, 2022

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Research paper thumbnail of Relationship between regional white matter hyperintensities and alpha oscillations in older adults

Neurobiology of Aging, Apr 1, 2022

Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of a... more Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of alpha oscillations (7–13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N = 907, 60–80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and long-range temporal correlations. Finally, higher age was associated with elevated alpha power via total WMH volume. We suggest that an elevated alpha power is a consequence of WMHs affecting a spatial organization of

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Research paper thumbnail of Fatigue and brain arousal in patients with major depressive disorder

European Archives of Psychiatry and Clinical Neuroscience, Dec 4, 2020

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Research paper thumbnail of Attenuation of the Heartbeat-Evoked Potential in Patients With Atrial Fibrillation

JACC: Clinical Electrophysiology, Oct 1, 2022

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Research paper thumbnail of Author response for "Large‐scale collaboration in ENIGMA‐EEG: A perspective on the meta‐analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity

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Research paper thumbnail of Cohort Profile: The LIFE-Adult-Study

International Journal of Epidemiology, May 28, 2022

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Research paper thumbnail of Event-related modulation of alpha rhythm explains the auditory P300 evoked response in EEG

Evoked responses and ongoing oscillations represent two major electrophysiological phenomena in t... more Evoked responses and ongoing oscillations represent two major electrophysiological phenomena in the human brain yet the link between them remains rather obscure. Here we show how these two types of brain activity can be mechanistically linked within the framework of the baseline-shift mechanism for the generation of evoked responses. We do so for the two most frequently studied EEG signals: the P300-evoked response and alpha oscillations (8–12 Hz). The baseline-shift mechanism states that oscillations may generate evoked responses if oscillations have a non-zero mean and their amplitude is modulated by the stimulus. Therefore, if the alpha amplitude modulation generates P300, the following predictions should hold: 1) the temporal evolution of P300 and alpha amplitude is similar, 2) spatial localisations of the P300 and alpha amplitude modulation overlap, 3) oscillations are non-zero mean with a sign of the mean being congruent to P300 polarity and direction of alpha amplitude change...

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Research paper thumbnail of MOESM5 of Evoked potentials and behavioral performance during different states of brain arousal

Additional file 5. Mean number of epochs in EEG-vigilance stages during 4 time blocks.

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Research paper thumbnail of MOESM1 of Evoked potentials and behavioral performance during different states of brain arousal

Additional file 1. EEG preprocessing and EP parameterization.

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Research paper thumbnail of The relation between regional white matter hyperintensity and parameters of alpha oscillations in older adults

Using an existing dataset (LIFE-Adult Study), we aim to determine the underlying structural mecha... more Using an existing dataset (LIFE-Adult Study), we aim to determine the underlying structural mechanism for attenuation of EEG-alpha oscillations with age.

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Research paper thumbnail of MOESM3 of Impact of brain arousal and time-on-task on autonomic nervous system activity in the wake-sleep transition

Additional file 3. Results of pared sample t tests for ANS parameters between different EEG-vigil... more Additional file 3. Results of pared sample t tests for ANS parameters between different EEG-vigilance stages in the ignored and attended condition.

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Research paper thumbnail of Supplementary Material for: Brain Arousal Regulation in Carriers of Bipolar Disorder Risk Alleles

<br><strong><em>Objectives%3A</em></strong> Recent genome-wide asso... more <br><strong><em>Objectives%3A</em></strong> Recent genome-wide association studies identified a number of chromosomal risk loci for bipolar disorder (BD, 'manic-depressive illness'). According to the vigilance regulation model, the regulation of brain arousal (referred to as 'vigilance') when assessed via EEG is an emerging biomarker linked to the pathogenesis of manic and depressive episodes. On this basis, the present study aimed to assess whether carriers of BD risk alleles differ in brain arousal regulation. <b><i>Methods%3A</i></b> Healthy participants of the population-based Leipzig Health Care Study (LIFE) underwent a 20-min eyes-closed resting EEG paradigm. Brain arousal was assessed applying the computer-based Vigilance Algorithm Leipzig (VIGALL). The primary sample (n = 540) was genotyped for ten of the most reliable BD risk variants, of which two qualified for replication (n = 509). <b><i>Results%3A</i></b> Primary sample analyses revealed Bonferroni-adjusted significance for rs1006737 in CACNA1C (encoding a calcium channel subunit), with risk allele carriers exhibiting relatively steep brain arousal declines. Further, carriers of two risk alleles of rs472913 at 1p32.1 showed generally lower brain arousal levels for the duration of the resting paradigm. However, both associations failed replication. <b><i>Conclusion%3A</i></b> Although our initial findings are in line with the vigilance regulation model and convincing in view of the previously reported notable role of ion channelopathies in BD, our results do not provide consistent evidence for a link between BD risk variants and brain arousal regulation. Several between-sample differences may account for this inconsistency. The molecular genetics of brain arousal regulation remain to be clarified.

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Research paper thumbnail of Author response for "Large‐scale collaboration in ENIGMA‐EEG: A perspective on the meta‐analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity

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Research paper thumbnail of Fatigue and brain arousal in patients with major depressive disorder

European Archives of Psychiatry and Clinical Neuroscience, 2020

Fatigue is considered a key symptom of major depressive disorder (MDD), yet the term lacks specif... more Fatigue is considered a key symptom of major depressive disorder (MDD), yet the term lacks specificity. It can denote a state of increased sleepiness and lack of drive (i.e., downregulated arousal) as well as a state of high inner tension and inhibition of drive with long sleep onset latencies (i.e., upregulated arousal), the latter typically found in depression. It has been proposed to differentiate fatigue along the dimension of brain arousal. We investigated whether such stratification within a group of MDD patients would reveal a subgroup with distinct clinical features. Using an automatic classification of EEG vigilance stages, an arousal stability score was calculated for 15-min resting EEGs of 102 MDD patients with fatigue. 23.5% of the patients showed signs of hypoarousal with EEG patterns indicating drowsiness or sleep; this hypoaroused subgroup was compared with remaining patients (non-hypoaroused subgroup) concerning self-rated measures of depressive symptoms, sleepiness,...

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Research paper thumbnail of Amygdalar nuclei and hippocampal subfields on MRI: Test-retest reliability of automated volumetry across different MRI sites and vendors

NeuroImage, 2020

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Research paper thumbnail of The Big Five personality traits and CNS arousal in the resting state

Based on Eysenck’s pioneering work, CNS arousal has long been considered an encouraging biologica... more Based on Eysenck’s pioneering work, CNS arousal has long been considered an encouraging biological candidate that may explain individual differences in human personality. Yet, results from empirical studies remained inconclusive. Notably, the vast majority of published results have been derived from small samples, and EEG alpha power has usually served as exclusive indicator for CNS arousal. In this study, we selected N = 468 individuals of the LIFE-Adult cohort and investigated the associations between the Big Five personality traits and CNS arousal by using the low-resolution electromagnetic tomography-based analysis tool VIGALL. Our analyses revealed that subjects who reported higher levels of extraversion and openness to experience, respectively, exhibited lower levels of CNS arousal in the resting state. Bayesian and frequentist analysis results were especially convincing for openness to experience. Among the lower-order personality traits, we obtained strongest evidence for ne...

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Research paper thumbnail of CSF cutoffs for MCI due to AD depend on APOEε4 carrier status

Neurobiology of Aging, 2019

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Research paper thumbnail of Electrophysiological and behavioral correlates of polymorphisms in the transcription factor AP-2β coding gene

Neuroscience Letters, May 1, 2008

Transcription factor AP-2beta may influence brain monoaminergic systems by regulating target gene... more Transcription factor AP-2beta may influence brain monoaminergic systems by regulating target genes. Several monoaminergic genes, including the serotonin transporter gene, have AP-2beta binding sites. Late auditory-evoked potentials (P1, N1/P2) and impulsiveness-related personality traits are correlated, and both are modulated by monoaminergic neurotransmission. The present study assesses the impact of two AP-2beta polymorphisms (VNTRs within intron 1 and 2) together with the serotonin transporter polymorphism 5-HTTLPR on late auditory-evoked potentials and personality for the first time. EEG was recorded from 91 male subjects at central electrode positions while tones of six intensity levels were presented. Additionally, subjects completed personality questionnaires. Both AP-2beta polymorphisms revealed significant main effects on P1, and haplotype analysis confirmed the contribution of both AP-2beta-polymorphisms. Additionally, AP-2beta and 5-HTTLPR showed interactions with respect to P1. 5-HTTLPR revealed a main effect on N1/P2 but not P1. Impulsiveness showed an association with intron 1 VNTR. The results are discussed with respect to differential impact of AP-2beta polymorphisms and 5-HTTLPR on the monoaminergic systems. The findings promote replication in a larger sample and suggest a potential usefulness of AP-2beta polymorphisms in explaining or predicting central nervous diseases, drug effects and side effects.

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Research paper thumbnail of P 161 Coupling of brain arousal and autonomic regulation in the transition from wakefulness to sleep onset during an auditory oddball task in the resting state

Clinical Neurophysiology, Oct 1, 2017

Background Simultaneous downregulation of the autonomic and central nervous system activity enabl... more Background Simultaneous downregulation of the autonomic and central nervous system activity enables the gradual physiological state change from wakefulness to sleep onset. Dysregulation of central or autonomic arousal has been found in neurological ( Silvani et al., 2016 ) and psychiatric disorders ( Hegerl and Hensch, 2014 , Hegerl et al., 2012 , Schulz et al., 2016 , Schwabedal et al., 2016 ), often associated with dysregulated sleep-wake patterns. Aim We investigated the hypothesis that brain-autonomic co-regulation affects the attentive process in the transition from wakefulness to sleep onset. We propose that the degree to which autonomic and brain dynamics are correlated predicts the level of cortical excitability or inhibition and sleep onset behavior in this transition. To test our hypothesis, we explored electroencephalogram (EEG), electrocardiogram (ECG) and skin conductance data recorded during a 2-h resting state oddball experiment. Methods 39 healthy study participants underwent a 2-h resting EEG with eyes closed including ECG-derived heart rate (HR) and measurement of skin conductance level (SCL). The Vigilance Algorithm Leipzig (VIGALL 2.1) was used to assess brain arousal regulation based on automatic EEG-vigilance stage classification of 1-s EEG segments. These vigilance stages (=vigilance; V) were scored and cross-correlated with HR and SCL over a range of ±100 s, and a mean period of vigilance fluctuations was estimated from the frequency of maxima after low-pass filtering. Mean amplitudes of event-related potentials N100 and P200 to standard and deviant stimuli at Cz were calculated as indices of cortical excitability (N100) and cortical inhibition (P200) ( Cortoos et al., 2014 ). Results In all subjects, higher max cross-correlation coefficients (V-HR mean: r = 0.362, range: −0.069 to 0.762; SD = 0.192; V-SCL mean: r = 0.277, range: −0.299 to 0.629; SD = 0.211) were associated with longer mean periods of cortico-autonomic signals (V-HR: r = 0.462, p = .003; V-SCL: r = 0.516, p = .001). The cross-correlation of V with either HR and SCL partitioned the subjects into two groups (group no lag: n0 = 20, τ = 0; group lag: n1 = 19, τ (range) = −98 to −87) dependent on the time lag of maximal correlation. Subjects in n0, who fell asleep more often (indexed by the frequency of falling asleep: t37 = 2.49, p = .018) during the 2-h EEG compared to subjects in n1, had higher max cross-correlation coefficients (V-HR: t37 = 4.24, p = 1.43E−4; V-SCL: t37 = 5.02, p = 1.35E−5) and displayed an increased standard (t30.235 = 3.19, p = .003) and deviant P200 amplitude (t37 = 3.63, p = .001) compared to subjects in n1. No significant group differences were found for N100 amplitudes and KSS score either before or after the recording. Conclusion Healthy individuals with no time lag between cortical and autonomic signals showed a stronger brain-autonomic coupling and increased P200 amplitudes (indicating a higher level of cortical inhibition) compared to individuals with a temporal misalignment. This may explain differences in sleep-onset behavior between groups. Present results indicate possible diagnostic value in the assessment of brain-autonomic regulation, for example in disorders with sleep-related symptoms such as insomnia, dementia or depression.

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Research paper thumbnail of FV 15. Genome-wide association study of human brain arousal regulation

Clinical Neurophysiology, Sep 1, 2016

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Research paper thumbnail of The Neural Representation of the Heart is Strongly Attenuated in Patients with Atrial Fibrillation

Social Science Research Network, 2022

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Research paper thumbnail of Relationship between regional white matter hyperintensities and alpha oscillations in older adults

Neurobiology of Aging, Apr 1, 2022

Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of a... more Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of alpha oscillations (7–13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N = 907, 60–80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and long-range temporal correlations. Finally, higher age was associated with elevated alpha power via total WMH volume. We suggest that an elevated alpha power is a consequence of WMHs affecting a spatial organization of

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Research paper thumbnail of Fatigue and brain arousal in patients with major depressive disorder

European Archives of Psychiatry and Clinical Neuroscience, Dec 4, 2020

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Research paper thumbnail of Attenuation of the Heartbeat-Evoked Potential in Patients With Atrial Fibrillation

JACC: Clinical Electrophysiology, Oct 1, 2022

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Research paper thumbnail of Author response for "Large‐scale collaboration in ENIGMA‐EEG: A perspective on the meta‐analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Cohort Profile: The LIFE-Adult-Study

International Journal of Epidemiology, May 28, 2022

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Event-related modulation of alpha rhythm explains the auditory P300 evoked response in EEG

Evoked responses and ongoing oscillations represent two major electrophysiological phenomena in t... more Evoked responses and ongoing oscillations represent two major electrophysiological phenomena in the human brain yet the link between them remains rather obscure. Here we show how these two types of brain activity can be mechanistically linked within the framework of the baseline-shift mechanism for the generation of evoked responses. We do so for the two most frequently studied EEG signals: the P300-evoked response and alpha oscillations (8–12 Hz). The baseline-shift mechanism states that oscillations may generate evoked responses if oscillations have a non-zero mean and their amplitude is modulated by the stimulus. Therefore, if the alpha amplitude modulation generates P300, the following predictions should hold: 1) the temporal evolution of P300 and alpha amplitude is similar, 2) spatial localisations of the P300 and alpha amplitude modulation overlap, 3) oscillations are non-zero mean with a sign of the mean being congruent to P300 polarity and direction of alpha amplitude change...

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Research paper thumbnail of MOESM5 of Evoked potentials and behavioral performance during different states of brain arousal

Additional file 5. Mean number of epochs in EEG-vigilance stages during 4 time blocks.

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Research paper thumbnail of MOESM1 of Evoked potentials and behavioral performance during different states of brain arousal

Additional file 1. EEG preprocessing and EP parameterization.

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Research paper thumbnail of The relation between regional white matter hyperintensity and parameters of alpha oscillations in older adults

Using an existing dataset (LIFE-Adult Study), we aim to determine the underlying structural mecha... more Using an existing dataset (LIFE-Adult Study), we aim to determine the underlying structural mechanism for attenuation of EEG-alpha oscillations with age.

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Research paper thumbnail of MOESM3 of Impact of brain arousal and time-on-task on autonomic nervous system activity in the wake-sleep transition

Additional file 3. Results of pared sample t tests for ANS parameters between different EEG-vigil... more Additional file 3. Results of pared sample t tests for ANS parameters between different EEG-vigilance stages in the ignored and attended condition.

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Research paper thumbnail of Supplementary Material for: Brain Arousal Regulation in Carriers of Bipolar Disorder Risk Alleles

<br><strong><em>Objectives%3A</em></strong> Recent genome-wide asso... more <br><strong><em>Objectives%3A</em></strong> Recent genome-wide association studies identified a number of chromosomal risk loci for bipolar disorder (BD, 'manic-depressive illness'). According to the vigilance regulation model, the regulation of brain arousal (referred to as 'vigilance') when assessed via EEG is an emerging biomarker linked to the pathogenesis of manic and depressive episodes. On this basis, the present study aimed to assess whether carriers of BD risk alleles differ in brain arousal regulation. <b><i>Methods%3A</i></b> Healthy participants of the population-based Leipzig Health Care Study (LIFE) underwent a 20-min eyes-closed resting EEG paradigm. Brain arousal was assessed applying the computer-based Vigilance Algorithm Leipzig (VIGALL). The primary sample (n = 540) was genotyped for ten of the most reliable BD risk variants, of which two qualified for replication (n = 509). <b><i>Results%3A</i></b> Primary sample analyses revealed Bonferroni-adjusted significance for rs1006737 in CACNA1C (encoding a calcium channel subunit), with risk allele carriers exhibiting relatively steep brain arousal declines. Further, carriers of two risk alleles of rs472913 at 1p32.1 showed generally lower brain arousal levels for the duration of the resting paradigm. However, both associations failed replication. <b><i>Conclusion%3A</i></b> Although our initial findings are in line with the vigilance regulation model and convincing in view of the previously reported notable role of ion channelopathies in BD, our results do not provide consistent evidence for a link between BD risk variants and brain arousal regulation. Several between-sample differences may account for this inconsistency. The molecular genetics of brain arousal regulation remain to be clarified.

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Research paper thumbnail of Author response for "Large‐scale collaboration in ENIGMA‐EEG: A perspective on the meta‐analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Fatigue and brain arousal in patients with major depressive disorder

European Archives of Psychiatry and Clinical Neuroscience, 2020

Fatigue is considered a key symptom of major depressive disorder (MDD), yet the term lacks specif... more Fatigue is considered a key symptom of major depressive disorder (MDD), yet the term lacks specificity. It can denote a state of increased sleepiness and lack of drive (i.e., downregulated arousal) as well as a state of high inner tension and inhibition of drive with long sleep onset latencies (i.e., upregulated arousal), the latter typically found in depression. It has been proposed to differentiate fatigue along the dimension of brain arousal. We investigated whether such stratification within a group of MDD patients would reveal a subgroup with distinct clinical features. Using an automatic classification of EEG vigilance stages, an arousal stability score was calculated for 15-min resting EEGs of 102 MDD patients with fatigue. 23.5% of the patients showed signs of hypoarousal with EEG patterns indicating drowsiness or sleep; this hypoaroused subgroup was compared with remaining patients (non-hypoaroused subgroup) concerning self-rated measures of depressive symptoms, sleepiness,...

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Research paper thumbnail of Amygdalar nuclei and hippocampal subfields on MRI: Test-retest reliability of automated volumetry across different MRI sites and vendors

NeuroImage, 2020

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Research paper thumbnail of The Big Five personality traits and CNS arousal in the resting state

Based on Eysenck’s pioneering work, CNS arousal has long been considered an encouraging biologica... more Based on Eysenck’s pioneering work, CNS arousal has long been considered an encouraging biological candidate that may explain individual differences in human personality. Yet, results from empirical studies remained inconclusive. Notably, the vast majority of published results have been derived from small samples, and EEG alpha power has usually served as exclusive indicator for CNS arousal. In this study, we selected N = 468 individuals of the LIFE-Adult cohort and investigated the associations between the Big Five personality traits and CNS arousal by using the low-resolution electromagnetic tomography-based analysis tool VIGALL. Our analyses revealed that subjects who reported higher levels of extraversion and openness to experience, respectively, exhibited lower levels of CNS arousal in the resting state. Bayesian and frequentist analysis results were especially convincing for openness to experience. Among the lower-order personality traits, we obtained strongest evidence for ne...

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Research paper thumbnail of CSF cutoffs for MCI due to AD depend on APOEε4 carrier status

Neurobiology of Aging, 2019

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