Carsten H Meyer | Philipps University Marburg (original) (raw)

Papers by Carsten H Meyer

Introduction: The choice of surgical treatment for chronic, persistent and large full-thickness m... more Introduction: The choice of surgical treatment for chronic, persistent and large full-thickness macular holes (FTMH) continues to be undefined and challenging, as some of these cases remain refractory to the treatment. We report the efficacy of combination of inverted internal limiting membrane flap technique (IILMFT) and subretinal application of the fluid (SR fluid application) technique for treatment of refractory FTMHs. Methods: Nine patients (nine eyes) were enrolled into this retrospective non-randomized exploratory consecutive case series study. All patients were diagnosed with chronic, persistent or large FTMH and were treated with a combination of IILMFT and SR fluid application technique. The following outcome parameters were analysed during 1-and 6-month follow-up visits: anatomical FTMH closure rate on spectral domain optical coherence tomography (SD-OCT), best-corrected visual acuity (BCVA), Lyubomyr M. Lytvynchuk and Andrii Ruban contributed equally to this work.

It is with great pleasure that Professor Robert Machemer, one of the most impressive leaders in o... more It is with great pleasure that Professor Robert Machemer, one of the most impressive leaders in ophthalmology, can be congratulated on his 70 th birthday this year (Fig. 1). Born in Münster, Germany, Robert Machemer had a childhood dream of becoming an engineer. This changed, and he studied medicine at the universities of Münster, Vienna and Freiburg, where he graduated with honors in 1959. During this time he met his wife, Christel Machemer MD. After 1 year of internship in general pathology he decided to specialize in ophthalmology, a choice influenced by his father, who was also an ophthalmologist [4].

Adhäsionen zwischen retinalem Pigmentepithel (RPE) und der angrenzenden Netzhaut können den Versc... more Adhäsionen zwischen retinalem Pigmentepithel (RPE) und der angrenzenden Netzhaut können den Verschluss von Makulalöchern behindern. Die Gabe von subretinaler Flüssigkeit kann diese Adhäsionen lösen und den Verschluss unterstützen. Hierbei wird die Retina abgehoben und an ihren ursprünglichen Ort verlagert, indem intraoperativ eine Blase schwerer Flüssigkeit über dem Makulaloch appliziert und der Infusionsdruck auf <20 mmHg reduziert wird. Dr.

Intravitreal injections have become the most commonly performed intraocular treatments worldwide.... more Intravitreal injections have become the most commonly performed intraocular treatments worldwide. Because intravitreal injections may induce severe adverse events, such as infectious and noninfectious endophthalmitis, cataract, ocular hypertension, vitreous hemorrhage, or retinal detachment, appropriate awareness of the materials and techniques used are essential to reduce these sight-threatening complications. This review provides insights into the needles, syringes, silicone oil coating, sterilization methods, devices to assist intravitreal injections, scleral piercing techniques using needles, syringe handling, anesthesia, and safety issues related to materials and techniques. It is paramount that physicians be aware of every step involved in intravitreal injections and consider the roles and implications of all materials and techniques used. The ability to understand the theoretical and practical circumstances may definitely lead to state-of-the-art treatments delivered to patients. The most important practical recommendations are: choosing syringes with as little silicone oil as possible, or, preferably, none; avoiding agitation of syringes; awareness that most biologics (e.g., antiangiogenic proteins) are susceptible to changes in molecular properties under some conditions, such as agitation and temperature variation; understanding that improper materials and techniques may lead to complications after intravitreal injections, e.g., inflammation; and recognizing that some devices may contribute to an enhanced, safer, and faster intravitreal injection technique.

Purpose: To describe the visual, tomographic, and electroretinographic findings in a patient with... more Purpose: To describe the visual, tomographic, and electroretinographic findings in a patient with macular edema secondary to branch retinal vein occlusion who was submitted to three consecutive intravitreal injections of ziv-aflibercept. Methods: The patient underwent a complete ophthalmic examination, as well as optical coherence tomography and full-field electroretinography at baseline and 90 days after the first injection. Results: The best-corrected visual acuity improved from 20/400 to 20/40, and the central retinal thickness decreased from 791 mm to 198 mm after three consecutive intravitreal injections of ziv-aflibercept. Full-field electroretinography showed an increase in cone amplitude and decrease in rod amplitude. No adverse side effects were observed after injections. Conclusion: Intravitreal injections of ziv-aflibercept showed both effectiveness and safety in the treatment of a patient with macular edema secondary to branch retinal vein occlusion. The observed anatomic (by ophthalmic examination, optical coherence tomography) and functional (best-corrected visual acuity, full-field electroretinography) improvements and lack of serious adverse side effects demonstrates the potential of intravitreal injections of ziv-aflibercept for the treatment of macular edema secondary to branch retinal vein occlusion. RETINAL CASES & BRIEF REPORTS 0:1–4, 2016

Subretinal fluid application to close a refractory full thickness macular hole --Manuscript Draft... more Subretinal fluid application to close a refractory full thickness macular hole --Manuscript Draft--Manuscript Number: Full Title: Subretinal fluid application to close a refractory full thickness macular hole Article Type: Case report Funding Information: Abstract: Goal: To close a refractory full thickness macular hole (FTMH) by adjacent subretinal fluid application to release the elastic retinal from the retinal pigment epithelium (RPE). Methods: A 72 year old patient presented an old FTMH with a diameter of 1444um. After confirming intraoperatively the complete release of the epiretinal membrane around the FTMH, we installed 3 small subretinal blebs around the hole, to release the adjacent retinal from the RPE. The mobilized retina was gently moved towards the macular center. A silicone oil tamponade was installed to secure a proper healing and observation of the FTMH. Results: The closure of the 1444 um FTMH was seen on indirect opthalmoscopy and confirmed by OCT 5 days after surgery by restoring the retinal architecture. A late reopening was not apparent at the postoperative observations. Visual acuity improved from hand motion to 20/400 at 4 weeks postoperative. Conclusion: Although FTMH develop by epiretinal tangential traction, large FTMH may per persist even after complete release of its epiretinal traction. Subretinal fluid application may release the flexible retinal from the RPE to achieve a relocation at the central fovea facilitating an anatomical closure of the macular hole.

Ophthalmic Surg Lasers Imaging Retina, 2018

BACKGROUND AND OBJECTIVE: To study the safety and ef cacy of intravitreal injections of ziv-a ibe... more BACKGROUND AND OBJECTIVE: To study the safety and ef cacy of intravitreal injections of ziv-a iber- cept (IVI-ZA) (Zaltrap; Sano -Aventis and Regen- eron Pharmaceuticals, Tarrytown, NY) during a pe- riod of 48 weeks in patients with diabetic macular edema (DME).
PATIENTS AND METHODS: Seven consecutive pa- tients with DME were enrolled and submitted to 12 consecutive IVI-ZA with a 4-week interval. The safety parameters included changes in full- eld electroretinogram (ERG) and systemic or ocular complications, and the ef cacy parameters were the mean change from baseline in best-corrected visual acuity (BCVA) and central retinal thickness (CRT).
RESULTS: No signi cant differences were found in any ERG component after IVI-ZA, and no systemic or ocular complication was observed. The improve- ment of BCVA was most signi cant after the rst IVI-ZA and remained until week 48 (P < .05). The CRT signi cantly decreased during the course of 48 weeks.
CONCLUSION: The 48-week results are consistent with our previous 24-week ndings, supporting IVI-ZA as a safe, ef cient, and well-tolerated thera- py for patients with DME.

British Journal of Ophthalmology, 2003

Acta Ophthalmologica, 2015

Journal of ophthalmology, 2009

Purpose. To demonstrate keratoconus-like hydrops after laser in situ keratomileusis (LASIK) by op... more Purpose. To demonstrate keratoconus-like hydrops after laser in situ keratomileusis (LASIK) by optical coherence tomography (OCT). Patient and Methods. A 21-year-old man received uneventful bilateral LASIK. On slit lamp examination or corneal topography there were no signs of fruste keratoconus. The preoperative corneal thickness was 587-mum OD and the calculated ablation for two treatments was 114-mum. Uneventful LASIK with an optical zone of 7 mm and an ablation of 89-mum OD, and an ablation of 73-mum OS was performed. Three years postoperatively, he complained about progressive myopia and impaired vision OD. His VA was hand motion OD and 20/20 OS. Results. OCT and light microscopy revealed an anterior corneal steepening and acute keratoconus-like excessive edematous swelling. Conclusion. The cornea is mechanically weakened after LASIK by the lamellar cut and tissue subtraction. Although the advocated minimal residual stromal bed thickness is 250-mum, it may not be adequate to pre...

Survey of Ophthalmology, 1999

Ophthalmologist Maximilian Linde (1862-1940) had a passion for contemporary art and owned one of ... more Ophthalmologist Maximilian Linde (1862-1940) had a passion for contemporary art and owned one of the most important private collections in Europe. He first met little-known Norwegian expressionist Edvard Munch in 1903, recognized his special talent, and welcomed him into his family. With Linde's encouragement, patronage, and friendship, Munch became one of the most important artists of his time. Many of Munch's works were commissioned by Linde and many featured Linde and his family as subjects. ( Surv Ophthalmol 43 :525-534, 1999.

American journal of ophthalmology, 2002

To document, in vivo, the foveal morphology and thickness in a patient with oculocutaneous albini... more To document, in vivo, the foveal morphology and thickness in a patient with oculocutaneous albinism. Observational case report. In a 10-year-old female with oculocutaneous albinism, multiple cross-sectional scans of the fovea were performed using optical coherence tomography. Optical coherence tomography scans were unable to detect the foveal pit. A widespread thickening of the retina occurred throughout the entire fovea with no difference from the surrounding macula. The foveal thickness was greater than 300 microm in the eyes of this patient with oculocutaneous albinism, compared with 150 microm in the normal eye. The inner retina had a highly reflective signal on optical coherence tomography. Optical coherence tomography demonstrated in the anatomical location of the fovea a highly reflective inner retinal signal, possibly consistent with multiple layers of ganglion cells, and it confirmed foveal hypoplasia in a patient with oculocutaneous albinism.

$Research paper thumbnail of Patient expectations and recollection of information about photorefractive keratectomy$

Journal of Cataract & Refractive Surgery, 1997

To assess the expectations of surgical result and recollection of a standardized information brie... more To assess the expectations of surgical result and recollection of a standardized information briefing by patients having photorefractive keratectomy (PRK).

Investigative ophthalmology & visual science, 2002

To evaluate the effects of subretinal and intravitreal delivery of INS37217, a P2Y(2) receptor ag... more To evaluate the effects of subretinal and intravitreal delivery of INS37217, a P2Y(2) receptor agonist, on subretinal fluid reabsorption in experimentally induced retinal detachments in rabbits, and to characterize the effects of INS37217 on electroretinograms (ERG) in rabbits. A single retinal detachment was produced in New Zealand White rabbits by injecting approximately 50 micro L of modified phosphate-buffered saline (MPBS) solution into the subretinal space (SRS). In all experiments, one eye served as the INS37217-treated eye and the contralateral eye served as the vehicle control. In the first series of experiments, each rabbit received a SRS injection of MPBS solution, with or without INS37217 (1 mM). In the second series of experiments, each eye received an SRS injection of MPBS solution, followed by an intravitreal injection of MPBS solution, with or without INS37217 (12, 1.4, and 0.15 mM). A masked observer determined the size of blebs by indirect ophthalmoscopy at 30-minu...

Objective: To determine the prevalence and visual sig- nificance of cystoid macular edema (CME) i... more Objective: To determine the prevalence and visual sig- nificance of cystoid macular edema (CME) in eyes with subfoveal neovascular age-related macular degenera- tion using optical coherence tomography (OCT). Materials and Methods: The medical records of 61 consecutive patients initially seen with nondisciform sub- foveal neovascular age-related macular degeneration were retrospectively reviewed. All patients underwent fluo- rescein angiography and OCT imaging.