Jan Koolman | Philipps University Marburg (original) (raw)

Papers by Jan Koolman

Archives of Insect Biochemistry and Physiology, 1998

Delfi, 2005

Trotz offensichtlicher Vorteile und zahlreicher Multimedia-Projekte ist das elektronische Prüfen ... more Trotz offensichtlicher Vorteile und zahlreicher Multimedia-Projekte ist das elektronische Prüfen bislang an wenigen deutschen Universitäten erprobt. Das Hauptaugenmerk bei der Einführung elektronischer Medien liegt häufig auf der Unterstützungd er traditionellen Lehre. Nur s elten w ird das Ziel v erfolgt, elektronische Prüfungssysteme einzusetzen. Durch die neue Approbationsordnung in der Medizin müssen die Studierenden deutlich mehr Prüfungen absolvieren, wobei gleichzeitig den Universitäten mehr Verantwortung bei Gestaltung und Durchführung gegeben wird. Dies führt zu einem erhöhten Bedarf effizienter Prüfungsszenarien. Im Projekt k-MED haben wir bereits mehrmals erfolgreich computerbasierte Prüfungen durchgeführt und positive Erfahrungen hinsichtlich der Akzeptanz unter den Lehrenden und Studierenden gemacht.

Progress in clinical and biological research

Under the new revision of the German licensing regulations for physicians ("Approbationsordn... more Under the new revision of the German licensing regulations for physicians ("Approbationsordnung") the rules for the first national examinations (i.e. "Physikum", equivalent to medical school entrance exams) have been changed. In addition to the written exam a novel "oral-practical" part is required. Here we describe the implications of this oral-practical exam on the examination procedures in the field of biochemistry/molecular biology. A strategy for its realization is proposed.

Fachtagung "e-Learning" der Gesellschaft für Informatik, 2005

Insect Biochemistry, 1980

... and 2-deoxy-20-hydroxyecdysone (94%) were gifts from Dr HORN (Melbourne ... by the Deutsche F... more ... and 2-deoxy-20-hydroxyecdysone (94%) were gifts from Dr HORN (Melbourne ... by the Deutsche Forschungsgememschaft Note added in proof Recently PROFESSOR KARLSON drew ... acid gave a blue fluorescence in uv light JAN KOOLMAN REFERENCES BOLLENBACHER ...

Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1978

The occurrence of the enzyme ecdysone oxidase was demonstrated in several insect species. In blow... more The occurrence of the enzyme ecdysone oxidase was demonstrated in several insect species. In blowflies it was detected mainly in eggs and pupae. The enzyme activity in blowflies varies during development parallel to the ecdysteroid content. This suggests a specific but presently unknown function of the enzyme. Ecdysone oxidase was located mainly in the fat body and gut of blowflies. It is a cytosolic enzyme.

Insect Biochemistry, 1979

ABSTRACT Three antisera obtained with different ecdysteroid protein conjugates as antigens were s... more ABSTRACT Three antisera obtained with different ecdysteroid protein conjugates as antigens were studied. Antiserum DLW has the highest antibody concentration and antiserum H-21B is most sensitive for ecdysone. Antisera H-21B and ICT-1 show a high specificity for the ecdysteroid nucleus, whereas antiserum DLW is more specific for the side chain of ecdysteroids. This can be derived from cross reaction factors of ten different ecdysteroids.No antiserum is specific enough to detect ecdysone exclusively in extracts from biological material. Ecdysterone and other ecdysone metabolites are detected likewise depending on their concentration and affinity to the antibodies. It is shown that the radioimmunoassay of biological samples can lead to an overestimation of the ecdysone concentration.

Insect Biochemistry, 1982

Ecdysone: Structures and Functions, 2009

... des Protéines, CNRS FRE 2852, F-75252 Paris cedex 05, France e-mail: rene.lafont@snv ... Isaa... more ... des Protéines, CNRS FRE 2852, F-75252 Paris cedex 05, France e-mail: rene.lafont@snv ... Isaac and Slinger, 1989; Sonobe and Yamada, 2004; but see also Connat et al ... of immunoreactive material can be investigated with individual organs (gonads), but this cannot provide a ...

Naturwissenschaften, 1981

Molecular and Cellular Endocrinology, 1981

Biochemical Education - BIOCHEM EDUC, 1983

Insect Biochemistry and Molecular Biology, 1993

... DEL BRADBROOK,* GERD KAUSER,* JAN KOOLMAN*$ The biological potency of an ecdysteroid is assum... more ... DEL BRADBROOK,* GERD KAUSER,* JAN KOOLMAN*$ The biological potency of an ecdysteroid is assumed to indicate ... Unlabelled ponasterone A (PoA) was a gift of Professor DHS Horn (Melbourne, Australia ... 3H]ponasterone A was produced in collaboration with Dr L. Sobek ...

General and Comparative Endocrinology, 1979

... 1. Manfred Gersch a , Hermann Eibisch a , Gustav-Adolf Böhm a and Jan Koolman b. ... pupation... more ... 1. Manfred Gersch a , Hermann Eibisch a , Gustav-Adolf Böhm a and Jan Koolman b. ... pupation. Radioimmunoassay The radioimmunoassay (RIA) was performed in triplicate and followed the method of Borst and O'Connor (1974). ...

Chemico-Biological Interactions, 1998

Carbonyl reduction to the respective alcohol metabolites of the anti-insect agent imidazole analo... more Carbonyl reduction to the respective alcohol metabolites of the anti-insect agent imidazole analogue of metyrapone, NKI 42255 (2-(1-imidazolyl)-1-(4-methoxyphenyl)-2-methyl-1propanone) and its parent compound metyrapone was characterized in subcellular fractions previously described bacterial and mammalian hydroxysteroid dehydrogenases/carbonyl from soil bacteria, as well as insect, invertebrate and teleost species. The enzymes involved in this metabolic step were characterized with respect to their cosubstrate specificities, inhibitor susceptibilities, and immunological crossreactivities with antibodies directed against Abbre6iations: MDR, medium-chain dehydrogenases/reductases; SDR, short-chain dehydrogenases/reductases; AKR, aldo-keto reductases; HSD, hydroxysteroid dehydrogenase; NKI, Nö venyvedelmi Kutatointezet (Plant Protection Research Institute). (98)00057-X U.C.T. Oppermann et al. / Chemico-Biological Interactions 114 (1998) 211-224 212

Experientia, 1970

Zusammenfassung An enzymatisch aktiven Leberzellkernen aus Ratten wurde die Reaktivität von Hg2+,... more Zusammenfassung An enzymatisch aktiven Leberzellkernen aus Ratten wurde die Reaktivität von Hg2+, Mn2+, Fe3+ und Cr3+ auf die nukleare Proteinbiosynthese geprüft. Hg2+-Ionen hemmen den14C-Aminosäure-Einbau vollständig, während Mn2+ und Fe3+ eine schwache Stimulierung verursachen. Die14C-Einbaurate ist nach Cr3+-Zusätzen stark erhöht. Es konnte gezeigt werden, dass die Cr3+-Stimulierung nicht durch Adsorption zu erklären ist.