Lema Yousif | University of Münster (original) (raw)
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Papers by Lema Yousif
Cell Adhesion & Migration, 2013
Page 1. ! ! "#$&'%()*0$#).12! 3'+*+&$.*#4+$#%(3+*/%!5.6#7.*8! ! ! By Lema ... more Page 1. ! ! "#$&'%()*0$#).12! 3'+*+&$.*#4+$#%(3+*/%!5.6#7.*8! ! ! By Lema F. Yousif A thesis submitted in conformity with the requirements for the degree of Master of Science Graduate Department of Biochemistry University of Toronto ...
The EMBO journal, Jan 17, 2017
Shear detection and mechanotransduction by arterial endothelium requires junctional complexes con... more Shear detection and mechanotransduction by arterial endothelium requires junctional complexes containing PECAM-1 and VE-cadherin, as well as firm anchorage to the underlying basement membrane. While considerable information is available for junctional complexes in these processes, gained largely from in vitro studies, little is known about the contribution of the endothelial basement membrane. Using resistance artery explants, we show that the integral endothelial basement membrane component, laminin 511 (laminin α5), is central to shear detection and mechanotransduction and its elimination at this site results in ablation of dilation in response to increased shear stress. Loss of endothelial laminin 511 correlates with reduced cortical stiffness of arterial endothelium in vivo, smaller integrin β1-positive/vinculin-positive focal adhesions, and reduced junctional association of actin-myosin II In vitro assays reveal that β1 integrin-mediated interaction with laminin 511 results in ...
Matrix biology : journal of the International Society for Matrix Biology, 2016
Cell Adhesion & Migration, 2013
These authors contributed equally to this work.
Cell Adhesion & Migration, 2013
Page 1. ! ! "#$&'%()*0$#).12! 3'+*+&$.*#4+$#%(3+*/%!5.6#7.*8! ! ! By Lema ... more Page 1. ! ! "#$&'%()*0$#).12! 3'+*+&$.*#4+$#%(3+*/%!5.6#7.*8! ! ! By Lema F. Yousif A thesis submitted in conformity with the requirements for the degree of Master of Science Graduate Department of Biochemistry University of Toronto ...
The EMBO journal, Jan 17, 2017
Shear detection and mechanotransduction by arterial endothelium requires junctional complexes con... more Shear detection and mechanotransduction by arterial endothelium requires junctional complexes containing PECAM-1 and VE-cadherin, as well as firm anchorage to the underlying basement membrane. While considerable information is available for junctional complexes in these processes, gained largely from in vitro studies, little is known about the contribution of the endothelial basement membrane. Using resistance artery explants, we show that the integral endothelial basement membrane component, laminin 511 (laminin α5), is central to shear detection and mechanotransduction and its elimination at this site results in ablation of dilation in response to increased shear stress. Loss of endothelial laminin 511 correlates with reduced cortical stiffness of arterial endothelium in vivo, smaller integrin β1-positive/vinculin-positive focal adhesions, and reduced junctional association of actin-myosin II In vitro assays reveal that β1 integrin-mediated interaction with laminin 511 results in ...
Matrix biology : journal of the International Society for Matrix Biology, 2016
Cell Adhesion & Migration, 2013
These authors contributed equally to this work.