Marcellin Guiaro Ndoe | University Of Ngaoundere (original) (raw)

Papers by Marcellin Guiaro Ndoe

WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2024

The increase in fungal resistance to classic drugs and the fact that most antifungal drugs only h... more The increase in fungal resistance to classic drugs and the fact that most antifungal drugs only have fungistatic activity justify the search for new strategies to combat fungal infections. For this purpose, the antifungal and antioxidant potentials of the Spermacoce ocymoides (Rubiaceae) plant, collected in the KALA village, found in the Mbankomo subdivision, and Mefou & Akono division, Center region (Cameroon), were evaluated by antioxidant assays (DPPH radical and ABTS cation trapping assay and Ferric Reducing Antioxidant Power assay) and antifungal assay (Microdilution in liquid medium). The results obtained from the hydro-ethanolic extract of the Spermacoce ocymoides plant, showed that it had fungicidal and fungistatic activity on all the fungal strains of Candida tested with minimum inhibitory and fungicidal concentrations (MIC and MFC), between 1.25 mg/mL and 10 mg/mL. This antifungal activity appeared to be weaker than the one of fluconazole, used as the reference antifungal. We also found that the hydro-ethanolic extract of this plant possessed an antioxidant activity which appeared slowly at low concentration (less than 62.5µg/mL), but increased in a dose-dependent manner with the concentration of the extract in the reaction medium. The antioxidant activity of the hydro-ethanolic extract from this plant, thus seemed to be effective over time and long-lasting, compared to the one of vitamin

EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH, 2024

The pursuit of safe and effective therapeutic alternatives for treating impetigo in infants remai... more The pursuit of safe and effective therapeutic alternatives for treating impetigo in infants remains a persistent focus in pharmaceutical research. This study explores the in-vitro antibacterial activity of Spermacoce ocymoides Burm (Rubiaceae) against microbial strains associated with infantile impetigo. The methodology encompassed phytochemical screening to identify secondary metabolites, solid medium diffusion sensitivity tests, and determination of inhibition parameters through macro dilution in a liquid medium, along with subculture on solid agar. Oxacillin served as the reference antibiotic. Phytochemical screening revealed the presence of phenolic compounds (flavonoids, coumarins, tannins, and phlobatannins), sterols, anthocyanins, saponins, and terpenoids, while alkaloids were absent. Staphylococcus aureus was the sole identified pathogen in our isolates. Antibacterial assays demonstrated the efficacy of our extract against Staphylococcus aureus. Gradual concentration sensitivity assays at 500 mg/mL, 250 mg/mL, 125 mg/mL, and 62.5 mg/mL produced average inhibition zone diameters of 15 ± 0.71 mm, 7 ± 0.71 mm, 4 ± 0.71 mm, and 3 ± 0.71 mm, respectively. These values were lower than the 20 mm diameter of oxacillin at 5 µg/mL. Inhibition parameter determination yielded a Minimum Inhibitory Concentration (MIC) of 1.95 mg/mL and a Minimum Bactericidal Concentration (MBC) of 3.9 mg/mL, with an MBC/MIC ratio of 2, affirming the bactericidal effect of Spermacoce ocymoides Burm on Staphylococcus aureus isolates from impetigo pustules in infants. This research highlights the potential of Spermacoce ocymoides Burm as a promising antibacterial agent for impetigo treatment, laying the groundwork for further exploration and pharmaceutical development.

Current Therapeutic Research, 2016

Background: Malnutrition, nutritional deficiency, or undernutrition is an imbalanced nutritional ... more Background: Malnutrition, nutritional deficiency, or undernutrition is an imbalanced nutritional status resulting from insufficient intake of nutrients to meet normal physiologic requirements. 1 Malnutrition in childhood has both short-term consequences and long-term consequences on mental and physical health as well as the overall health development of children. 2 Of all regions in the world, the Asia and the Pacific region has achieved the fastest rate of economic growth. 3 There is no evidence that this rapid economic growth translates into a decline in malnutrition of children in Asian countries such as India. 4 It has long been recognized that socioeconomic factors, such as income, education, and occupation of parents, are important determinants of health outcomes in children. 5 Objectives: The present study explored the possible relation between parental socioeconomic parameters and nutritional status of children in India and Germany.

Indian Journal of Public Health, 2022

Brief Research Article Nutritionally balanced diet is essential to ensure normal growth and devel... more Brief Research Article Nutritionally balanced diet is essential to ensure normal growth and development in children. Children from households with low-socioeconomic status were more likely to be underweight than children from households with medium to higher socioeconomic status. [1] Low level of nutrition interferes with the physical and mental growth of children. Malnutrition is one of the most important global health problems, affecting large numbers of children in developing countries. [2] Malnutrition and undernutrition significantly address physical, physiological, and mental suffering and constitute a clear violation of the human rights of children. It greatly increases the risk of infant mortality and vulnerability to various diseases later in the long run. [3] In South Africa, a study found that malnutrition of children is the result of low household income. [4] In Africa, globally, the prevalence of malnutrition fell from 24.5% in 2000 to 18.2% in 2014. [5] The prevalence of malnutrition in the three regions of the North part of Cameroon is 40.2% and impacts the performance of these population, especially pupils. [6] These regions count among the four poor and vulnerable regions of Cameroon, and the Adamawa is where poverty is estimated around 79% in the population. [7] These guided the present research to analyze some socioeconomic factors and their impact on the nutritional status of pupils. Malnutrition greatly increases the risk of infant mortality and vulnerability to various diseases later in the long run. It has been shown that children's malnutrition is the result of low household income. Rural areas in Cameroon are mainly made up of poor families. This guided the present research to analyze some socioeconomic factors and their impact on the nutritional status of pupils. Using a simple random sampling technique, 300 pupils were recruited. About 66.33% of pupils were from poor families. Obesity was more prevalent in the category of rich pupils (09.52%) compared to poor (06.53%). The height and weight of pupils studied were lower than the reference (P < 0.001). This study carried out in a single council is proven to be limited for a better understanding of the epidemiology of malnutrition among students, and large-scale studies would be adequate to better prevent and control malnutrition in rural areas.

Background: On the 05th April 2020, the first confirmed case of covid-19 infection was registered... more Background: On the 05th April 2020, the first confirmed case of covid-19 infection was registered in the Lom & Djerem division, more precisely in the city of Bertoua (East Region of Cameroon). This alert confirming the presence of covid-19 infection in the region, also stepped up the search for suspected and confirmed cases of covid-19 infection by the rapid intervention and investigation teams (RIIT) set up by the East Regional Delegation of public health, in order to prevent the spread of covid-19 infection in the region and also to ensure the effective care for people already infected. In turn, this situation prompted us to conduct this study with the general objective of highlighting the epidemiological profile of covid-19 infection by determining its prevalence in the East Region of Cameroon and also to assess the knowledges and practices of its barrier measures by the population. Methods: We conducted a cross-sectional study with prospective data collection from the 05th April...

Estimation of Glomerular Filtration Rate (GFR) can be done using different methods. The cheaper a... more Estimation of Glomerular Filtration Rate (GFR) can be done using different methods. The cheaper and most available are those with formulas to determine the estimated GFR. The majority of these formulas have been developed among extra- African populations. In Sub-Saharan Africa, 3 formulas are almost used to estimate GFR which are MDRD, CG and CKD-EPI. This present study was conducted to assess the importance of these formulas as estimators of GFR for diabetic among African Populations. The study was conducted at the Ngaoundere Regional Hospital. Only diabetics from 30 to 78 years attending the regional hospital were enrolled in the study. After enrolment, diabetics with very high values of urea and/or creatinine were excluded. We evaluated CG, MDRD and CKD–EPI as estimators of GFR. Creatinine clearance of 24 hours has been considered as gold standard method. 60 participants were included for sex ratio (M/F) 1.5. The average eGFR of diabetics with high Blood Pressure was lower (91.2 ...

Medicinal plants have been reported as high risk of kidney failure among consumers. Around 80% in... more Medicinal plants have been reported as high risk of kidney failure among consumers. Around 80% in sub-Saharan population consume medicinal plants. This present study aimed to evaluate the influence of everyday life consumption of anti-diabetic plants among diabetic patients. We performed an analytical study in 54 participants. In diabetic population, we included 27 consumers of anti-diabetic plants and 27 non-consumers. We made the kidney screening with the measurement of the serum creatinine, urine creatinine, serum urea and fasting blood glucose. We estimated the GFR with the creatinine clearance of 24h. We used questionnaire to collect socio-demographic and personal history data. We identified 4 anti-diabetic plants used by our participants which are Leptadenie hastata, Detarium microcarpum, Boswellia dalzielii and Moringa oleifera. The average value of fasting blood glucose was low in patient consumers of plants (166 ± 43 mg/dl) than in non-consumers (229±53 mg/dl). We noted tha...

Introduction: Chronic Kidney Disease (CKD) is a major complication of diabetes worldwide. Diabeti... more Introduction: Chronic Kidney Disease (CKD) is a major complication of diabetes worldwide. Diabetic condition can be also complicated by diabetic dyslipidemia. The prevalence of CKD Cameroon, Africa or in other parts of the world of diabetics is not clearly estimated but, some studies tried to estimate prevalences in local areas or isolated zones. In addition, assessment of both prevelances of CKD and diabetic dyslipidaemia are not well documented. The present study is aimed at estimating the prevalence of CKD and diabetic dyslipidaemia in diabetic patients in Buea, Cameroon. Methodology: This was a cross-section study conducted at the diabetic clinic of Buea Regional Hospital and the Lambe Foundation for diabetes and hypertension in Buea, South-West Region of Cameroon. Result and discussion: Out of 120 diabetics enrolled, 63.33% were females. 53.33% were hypertensive, 74.16% overweight and obese and, 32.50% presented real obesity. The mean of eGFR was 92.76 ml/min/1.73m2 and, woman ...

Journal of Analytical & Pharmaceutical Research, 2016

Journal of Analytical & Pharmaceutical Research, 2016

Journal of Diseases and Medicinal Plants, 2015

Science Journal of Public Health, 2015

The present study was aimed at optimizing the transfusion security of the patients, we determined... more The present study was aimed at optimizing the transfusion security of the patients, we determined the seroprevalence of transferable infections by the blood transfusion notably the HIV, hepatitis B, hepatitis C and the syphilis among the blood donors at the blood bank of regional hospital of Bertoua to reduce meaningfully their impact in hospitable environment. We performed a prospective transversal survey on 429 Blood donors from the 1 st January 2013 to 1 st January 2014. We included 371 men (86.48%) and 38 women (13.52%). During this survey, we noted that, the most large part of blood donation was given by family members of patients with a seroprevalence of 58.04% compared to volunteers donors (23.78%) and remunerated donors (18.18%). The infections seroprevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Syphilis has been estimated to 5.13%, 6.76%, 4.2% and 0.46% respectively. These results showed that it was necessary to put an accent on the pre-donation stages; cross-examination of the blood donor (research of information able to annul the blood donation), verification of the biological parameters (blood type rhesus, the hemoglobin rate and research of the infectious makers) to reduce the residual risks of these infections by the blood transfusion.

Microbiology Research International, 2018

Journal of Analytical & Pharmaceutical Research, 2017

Journal of Analytical & Pharmaceutical Research, 2018

Journal of Analytical & Pharmaceutical Research, 2017

Abstract: The present study was aimed at optimizing the transfusion security of the patients, we ... more Abstract: The present study was aimed at optimizing the transfusion security of the patients, we determined the seroprevalence of transferable infections by the blood transfusion notably the HIV, hepatitis B, hepatitis C and the syphilis among the blood donors at the blood bank of regional hospital of Bertoua to reduce meaningfully their impact in hospitable environment. We performed a prospective transversal survey on 429 Blood donors from the 1 st January 2013 to 1 st January 2014. We included 371 men (86.48%) and 38 women (13.52%). During this survey, we noted that, the most large part of blood donation was given by family members of patients with a seroprevalence of 58.04 % compared to volunteers donors (23.78%) and remunerated donors (18.18%). The infections seroprevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Syphilis has been estimated to 5.13%, 6.76%, 4.2 % and 0.46 % respectively. These results showed that it was necessa...

The present study was aimed at optimizing the biomedical handling of the hepatotoxicity caused by... more The present study was aimed at optimizing the biomedical handling of the hepatotoxicity caused by the HAART accentuated in case of coinfection with the hepatitis viruses among the patients infected with the human immunodeficiency virus (HIV). We performed a prospective transversal survey from 18 th March 2014 to 30 th October 2014, on patients infected with HIV followed at the Bertoua day hospital with the general objective to evaluate the impact of the viral coinfection (HIV-Hepatitis Virus) on the incidence of hepatotoxicity cases caused by the HAART. We included in our survey, all HIV positive patients, eligible to the antiretroviral treatment, registered in our survey place for the follow-up of this treatment and having accepted to participate in the survey. We excluded in our survey, all patients who were not registered at the Bertoua day hospital for the follow-up of the antiretroviral treatment, all patients presenting a hepatic affection other that the infection with hepatit...

International Journal of Health and Biological Sciences , 2019

Estimation of Glomerular Filtration Rate (GFR) can be done using different methods. The cheaper a... more Estimation of Glomerular Filtration Rate (GFR) can be done using different methods. The cheaper and most available are those with formulas to determine the estimated GFR. The majority of these formulas have been developed among extra- African populations. In Sub-Saharan Africa, 3 formulas are almost used to estimate GFR which are MDRD, CG and CKD-EPI. This present study was conducted to assess the importance of these formulas as estimators of GFR for diabetic among African Populations. The study was conducted at the Ngaoundere Regional Hospital. Only diabetics from 30 to 78 years attending the regional hospital were enrolled in the study. After enrolment, diabetics with very high values of urea and/or creatinine were excluded. We evaluated CG, MDRD and CKD–EPI as estimators of GFR. Creatinine clearance of 24 hours has been considered as gold standard method. 60 participants were included for sex ratio (M/F) 1.5. The average eGFR of diabetics with high Blood Pressure was lower (91.2 ml / min) than diabetics with lower Blood Pressure (102 ml / min) according to ClCr24. A significant correlation (0.975) between MDRD and CKD-EPI was found when measuring eGFR. It was less significant between CG and MDRD (0.663) and; between CG and CKD-EPI (0.729). A strong similarity was noticed between MDRD and CKD-EPI (92%) while it was smaller between MDRD and CG (55%) and between CKD-EPI and CG (63%) when estimating the stage of kidney diseases. Compared to ClCr24, similarity in half results was found with MDRD (50%) and less than half with CKD-EPI (48%) and CG (38%). The study shown higher value of fasting blood glucose of diabetics attending the Ngaoundere Regional Hospital (212.1 ± 83.0 mg / dl) than the normal recommandation (127-144 mg / dl) for diabetic patients. The average value of the eGFR with MDRD (76.6 ± 20.0 mL / min) was closer to CKD-EPI (78.8 ± 20.4 ml / min) (P<0,001 ; X2=0,976). eGFR was lower in diabetics with high Blood Pressure compared to diabetics with low Blood Pressure. Estimation of CKD stages using MDRD and CKD shown significant similarity. In conclusion, CKD-EPI and MDRD estimated better the GFR. MDRD presented values that were closer to the Creatinine clearance of 24 hours. Further studies are needed with more participants to evaluate the best formula between MDRD and CKD-EPI for the estimation of GFR in Sub-Saharan diabetic population.

Key words: CG, MDRD, CKD-EPI, CrCl24, diabetes, eGFR.

WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2024

The increase in fungal resistance to classic drugs and the fact that most antifungal drugs only h... more The increase in fungal resistance to classic drugs and the fact that most antifungal drugs only have fungistatic activity justify the search for new strategies to combat fungal infections. For this purpose, the antifungal and antioxidant potentials of the Spermacoce ocymoides (Rubiaceae) plant, collected in the KALA village, found in the Mbankomo subdivision, and Mefou & Akono division, Center region (Cameroon), were evaluated by antioxidant assays (DPPH radical and ABTS cation trapping assay and Ferric Reducing Antioxidant Power assay) and antifungal assay (Microdilution in liquid medium). The results obtained from the hydro-ethanolic extract of the Spermacoce ocymoides plant, showed that it had fungicidal and fungistatic activity on all the fungal strains of Candida tested with minimum inhibitory and fungicidal concentrations (MIC and MFC), between 1.25 mg/mL and 10 mg/mL. This antifungal activity appeared to be weaker than the one of fluconazole, used as the reference antifungal. We also found that the hydro-ethanolic extract of this plant possessed an antioxidant activity which appeared slowly at low concentration (less than 62.5µg/mL), but increased in a dose-dependent manner with the concentration of the extract in the reaction medium. The antioxidant activity of the hydro-ethanolic extract from this plant, thus seemed to be effective over time and long-lasting, compared to the one of vitamin

EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH, 2024

The pursuit of safe and effective therapeutic alternatives for treating impetigo in infants remai... more The pursuit of safe and effective therapeutic alternatives for treating impetigo in infants remains a persistent focus in pharmaceutical research. This study explores the in-vitro antibacterial activity of Spermacoce ocymoides Burm (Rubiaceae) against microbial strains associated with infantile impetigo. The methodology encompassed phytochemical screening to identify secondary metabolites, solid medium diffusion sensitivity tests, and determination of inhibition parameters through macro dilution in a liquid medium, along with subculture on solid agar. Oxacillin served as the reference antibiotic. Phytochemical screening revealed the presence of phenolic compounds (flavonoids, coumarins, tannins, and phlobatannins), sterols, anthocyanins, saponins, and terpenoids, while alkaloids were absent. Staphylococcus aureus was the sole identified pathogen in our isolates. Antibacterial assays demonstrated the efficacy of our extract against Staphylococcus aureus. Gradual concentration sensitivity assays at 500 mg/mL, 250 mg/mL, 125 mg/mL, and 62.5 mg/mL produced average inhibition zone diameters of 15 ± 0.71 mm, 7 ± 0.71 mm, 4 ± 0.71 mm, and 3 ± 0.71 mm, respectively. These values were lower than the 20 mm diameter of oxacillin at 5 µg/mL. Inhibition parameter determination yielded a Minimum Inhibitory Concentration (MIC) of 1.95 mg/mL and a Minimum Bactericidal Concentration (MBC) of 3.9 mg/mL, with an MBC/MIC ratio of 2, affirming the bactericidal effect of Spermacoce ocymoides Burm on Staphylococcus aureus isolates from impetigo pustules in infants. This research highlights the potential of Spermacoce ocymoides Burm as a promising antibacterial agent for impetigo treatment, laying the groundwork for further exploration and pharmaceutical development.

Current Therapeutic Research, 2016

Background: Malnutrition, nutritional deficiency, or undernutrition is an imbalanced nutritional ... more Background: Malnutrition, nutritional deficiency, or undernutrition is an imbalanced nutritional status resulting from insufficient intake of nutrients to meet normal physiologic requirements. 1 Malnutrition in childhood has both short-term consequences and long-term consequences on mental and physical health as well as the overall health development of children. 2 Of all regions in the world, the Asia and the Pacific region has achieved the fastest rate of economic growth. 3 There is no evidence that this rapid economic growth translates into a decline in malnutrition of children in Asian countries such as India. 4 It has long been recognized that socioeconomic factors, such as income, education, and occupation of parents, are important determinants of health outcomes in children. 5 Objectives: The present study explored the possible relation between parental socioeconomic parameters and nutritional status of children in India and Germany.

Indian Journal of Public Health, 2022

Brief Research Article Nutritionally balanced diet is essential to ensure normal growth and devel... more Brief Research Article Nutritionally balanced diet is essential to ensure normal growth and development in children. Children from households with low-socioeconomic status were more likely to be underweight than children from households with medium to higher socioeconomic status. [1] Low level of nutrition interferes with the physical and mental growth of children. Malnutrition is one of the most important global health problems, affecting large numbers of children in developing countries. [2] Malnutrition and undernutrition significantly address physical, physiological, and mental suffering and constitute a clear violation of the human rights of children. It greatly increases the risk of infant mortality and vulnerability to various diseases later in the long run. [3] In South Africa, a study found that malnutrition of children is the result of low household income. [4] In Africa, globally, the prevalence of malnutrition fell from 24.5% in 2000 to 18.2% in 2014. [5] The prevalence of malnutrition in the three regions of the North part of Cameroon is 40.2% and impacts the performance of these population, especially pupils. [6] These regions count among the four poor and vulnerable regions of Cameroon, and the Adamawa is where poverty is estimated around 79% in the population. [7] These guided the present research to analyze some socioeconomic factors and their impact on the nutritional status of pupils. Malnutrition greatly increases the risk of infant mortality and vulnerability to various diseases later in the long run. It has been shown that children's malnutrition is the result of low household income. Rural areas in Cameroon are mainly made up of poor families. This guided the present research to analyze some socioeconomic factors and their impact on the nutritional status of pupils. Using a simple random sampling technique, 300 pupils were recruited. About 66.33% of pupils were from poor families. Obesity was more prevalent in the category of rich pupils (09.52%) compared to poor (06.53%). The height and weight of pupils studied were lower than the reference (P < 0.001). This study carried out in a single council is proven to be limited for a better understanding of the epidemiology of malnutrition among students, and large-scale studies would be adequate to better prevent and control malnutrition in rural areas.

Background: On the 05th April 2020, the first confirmed case of covid-19 infection was registered... more Background: On the 05th April 2020, the first confirmed case of covid-19 infection was registered in the Lom & Djerem division, more precisely in the city of Bertoua (East Region of Cameroon). This alert confirming the presence of covid-19 infection in the region, also stepped up the search for suspected and confirmed cases of covid-19 infection by the rapid intervention and investigation teams (RIIT) set up by the East Regional Delegation of public health, in order to prevent the spread of covid-19 infection in the region and also to ensure the effective care for people already infected. In turn, this situation prompted us to conduct this study with the general objective of highlighting the epidemiological profile of covid-19 infection by determining its prevalence in the East Region of Cameroon and also to assess the knowledges and practices of its barrier measures by the population. Methods: We conducted a cross-sectional study with prospective data collection from the 05th April...

Estimation of Glomerular Filtration Rate (GFR) can be done using different methods. The cheaper a... more Estimation of Glomerular Filtration Rate (GFR) can be done using different methods. The cheaper and most available are those with formulas to determine the estimated GFR. The majority of these formulas have been developed among extra- African populations. In Sub-Saharan Africa, 3 formulas are almost used to estimate GFR which are MDRD, CG and CKD-EPI. This present study was conducted to assess the importance of these formulas as estimators of GFR for diabetic among African Populations. The study was conducted at the Ngaoundere Regional Hospital. Only diabetics from 30 to 78 years attending the regional hospital were enrolled in the study. After enrolment, diabetics with very high values of urea and/or creatinine were excluded. We evaluated CG, MDRD and CKD–EPI as estimators of GFR. Creatinine clearance of 24 hours has been considered as gold standard method. 60 participants were included for sex ratio (M/F) 1.5. The average eGFR of diabetics with high Blood Pressure was lower (91.2 ...

Medicinal plants have been reported as high risk of kidney failure among consumers. Around 80% in... more Medicinal plants have been reported as high risk of kidney failure among consumers. Around 80% in sub-Saharan population consume medicinal plants. This present study aimed to evaluate the influence of everyday life consumption of anti-diabetic plants among diabetic patients. We performed an analytical study in 54 participants. In diabetic population, we included 27 consumers of anti-diabetic plants and 27 non-consumers. We made the kidney screening with the measurement of the serum creatinine, urine creatinine, serum urea and fasting blood glucose. We estimated the GFR with the creatinine clearance of 24h. We used questionnaire to collect socio-demographic and personal history data. We identified 4 anti-diabetic plants used by our participants which are Leptadenie hastata, Detarium microcarpum, Boswellia dalzielii and Moringa oleifera. The average value of fasting blood glucose was low in patient consumers of plants (166 ± 43 mg/dl) than in non-consumers (229±53 mg/dl). We noted tha...

Introduction: Chronic Kidney Disease (CKD) is a major complication of diabetes worldwide. Diabeti... more Introduction: Chronic Kidney Disease (CKD) is a major complication of diabetes worldwide. Diabetic condition can be also complicated by diabetic dyslipidemia. The prevalence of CKD Cameroon, Africa or in other parts of the world of diabetics is not clearly estimated but, some studies tried to estimate prevalences in local areas or isolated zones. In addition, assessment of both prevelances of CKD and diabetic dyslipidaemia are not well documented. The present study is aimed at estimating the prevalence of CKD and diabetic dyslipidaemia in diabetic patients in Buea, Cameroon. Methodology: This was a cross-section study conducted at the diabetic clinic of Buea Regional Hospital and the Lambe Foundation for diabetes and hypertension in Buea, South-West Region of Cameroon. Result and discussion: Out of 120 diabetics enrolled, 63.33% were females. 53.33% were hypertensive, 74.16% overweight and obese and, 32.50% presented real obesity. The mean of eGFR was 92.76 ml/min/1.73m2 and, woman ...

Journal of Analytical & Pharmaceutical Research, 2016

Journal of Analytical & Pharmaceutical Research, 2016

Journal of Diseases and Medicinal Plants, 2015

Science Journal of Public Health, 2015

The present study was aimed at optimizing the transfusion security of the patients, we determined... more The present study was aimed at optimizing the transfusion security of the patients, we determined the seroprevalence of transferable infections by the blood transfusion notably the HIV, hepatitis B, hepatitis C and the syphilis among the blood donors at the blood bank of regional hospital of Bertoua to reduce meaningfully their impact in hospitable environment. We performed a prospective transversal survey on 429 Blood donors from the 1 st January 2013 to 1 st January 2014. We included 371 men (86.48%) and 38 women (13.52%). During this survey, we noted that, the most large part of blood donation was given by family members of patients with a seroprevalence of 58.04% compared to volunteers donors (23.78%) and remunerated donors (18.18%). The infections seroprevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Syphilis has been estimated to 5.13%, 6.76%, 4.2% and 0.46% respectively. These results showed that it was necessary to put an accent on the pre-donation stages; cross-examination of the blood donor (research of information able to annul the blood donation), verification of the biological parameters (blood type rhesus, the hemoglobin rate and research of the infectious makers) to reduce the residual risks of these infections by the blood transfusion.

Microbiology Research International, 2018

Journal of Analytical & Pharmaceutical Research, 2017

Journal of Analytical & Pharmaceutical Research, 2018

Journal of Analytical & Pharmaceutical Research, 2017

Abstract: The present study was aimed at optimizing the transfusion security of the patients, we ... more Abstract: The present study was aimed at optimizing the transfusion security of the patients, we determined the seroprevalence of transferable infections by the blood transfusion notably the HIV, hepatitis B, hepatitis C and the syphilis among the blood donors at the blood bank of regional hospital of Bertoua to reduce meaningfully their impact in hospitable environment. We performed a prospective transversal survey on 429 Blood donors from the 1 st January 2013 to 1 st January 2014. We included 371 men (86.48%) and 38 women (13.52%). During this survey, we noted that, the most large part of blood donation was given by family members of patients with a seroprevalence of 58.04 % compared to volunteers donors (23.78%) and remunerated donors (18.18%). The infections seroprevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Syphilis has been estimated to 5.13%, 6.76%, 4.2 % and 0.46 % respectively. These results showed that it was necessa...

The present study was aimed at optimizing the biomedical handling of the hepatotoxicity caused by... more The present study was aimed at optimizing the biomedical handling of the hepatotoxicity caused by the HAART accentuated in case of coinfection with the hepatitis viruses among the patients infected with the human immunodeficiency virus (HIV). We performed a prospective transversal survey from 18 th March 2014 to 30 th October 2014, on patients infected with HIV followed at the Bertoua day hospital with the general objective to evaluate the impact of the viral coinfection (HIV-Hepatitis Virus) on the incidence of hepatotoxicity cases caused by the HAART. We included in our survey, all HIV positive patients, eligible to the antiretroviral treatment, registered in our survey place for the follow-up of this treatment and having accepted to participate in the survey. We excluded in our survey, all patients who were not registered at the Bertoua day hospital for the follow-up of the antiretroviral treatment, all patients presenting a hepatic affection other that the infection with hepatit...

International Journal of Health and Biological Sciences , 2019

Estimation of Glomerular Filtration Rate (GFR) can be done using different methods. The cheaper a... more Estimation of Glomerular Filtration Rate (GFR) can be done using different methods. The cheaper and most available are those with formulas to determine the estimated GFR. The majority of these formulas have been developed among extra- African populations. In Sub-Saharan Africa, 3 formulas are almost used to estimate GFR which are MDRD, CG and CKD-EPI. This present study was conducted to assess the importance of these formulas as estimators of GFR for diabetic among African Populations. The study was conducted at the Ngaoundere Regional Hospital. Only diabetics from 30 to 78 years attending the regional hospital were enrolled in the study. After enrolment, diabetics with very high values of urea and/or creatinine were excluded. We evaluated CG, MDRD and CKD–EPI as estimators of GFR. Creatinine clearance of 24 hours has been considered as gold standard method. 60 participants were included for sex ratio (M/F) 1.5. The average eGFR of diabetics with high Blood Pressure was lower (91.2 ml / min) than diabetics with lower Blood Pressure (102 ml / min) according to ClCr24. A significant correlation (0.975) between MDRD and CKD-EPI was found when measuring eGFR. It was less significant between CG and MDRD (0.663) and; between CG and CKD-EPI (0.729). A strong similarity was noticed between MDRD and CKD-EPI (92%) while it was smaller between MDRD and CG (55%) and between CKD-EPI and CG (63%) when estimating the stage of kidney diseases. Compared to ClCr24, similarity in half results was found with MDRD (50%) and less than half with CKD-EPI (48%) and CG (38%). The study shown higher value of fasting blood glucose of diabetics attending the Ngaoundere Regional Hospital (212.1 ± 83.0 mg / dl) than the normal recommandation (127-144 mg / dl) for diabetic patients. The average value of the eGFR with MDRD (76.6 ± 20.0 mL / min) was closer to CKD-EPI (78.8 ± 20.4 ml / min) (P<0,001 ; X2=0,976). eGFR was lower in diabetics with high Blood Pressure compared to diabetics with low Blood Pressure. Estimation of CKD stages using MDRD and CKD shown significant similarity. In conclusion, CKD-EPI and MDRD estimated better the GFR. MDRD presented values that were closer to the Creatinine clearance of 24 hours. Further studies are needed with more participants to evaluate the best formula between MDRD and CKD-EPI for the estimation of GFR in Sub-Saharan diabetic population.

Key words: CG, MDRD, CKD-EPI, CrCl24, diabetes, eGFR.