Hubert Löwenheim | Carl von Ossietzky University of Oldenburg (original) (raw)
Papers by Hubert Löwenheim
Acta Oto-laryngologica, 2005
The clinical presentation of otogenic dural sinus thrombosis (DST) as a complication of acute oti... more The clinical presentation of otogenic dural sinus thrombosis (DST) as a complication of acute otitis media (AOM) can be masked by antibiotic treatment. Morning episodes of vomiting and/or headache, visual impairment and a history of AOM seem to be indicative of otogenic hydrocephalus. We therefore advocate that the MRI scans of patients with similar symptoms should be carefully studied to facilitate the early diagnosis of a potentially life-threatening complication. To describe the frequency, pathognomonic signs, clinical course and outcome of otogenic hydrocephalus and DST as complications of AOM in pediatric patients. We undertook a retrospective chart review of all pediatric patients (age 1-14 years) treated for otitis media and its complications at an academic medical center between 1999 and 2003. The main outcome measures were otologic and ophthalmologic findings and CT and MRI scans at the beginning of treatment and 3 months later. We report on five cases with otogenic DST following AOM. All but one of them presented initially with diplopia caused by otogenic hydrocephalus. In four cases the otologic complaints had already disappeared by the time of MRI confirmation of the diagnosis. Only one child was referred with severe otologic symptoms. Management included systemic antibiotics, short-term heparin anticoagulation and surgical decompression. In our cases, even after intensive i.v. antibiotic treatment, only surgery led to a significant improvement in the clinical condition.
American Journal of Neuroradiology
Test occlusion of a patent dural sinus requires careful hemodynamic evaluation. We performed ball... more Test occlusion of a patent dural sinus requires careful hemodynamic evaluation. We performed balloon test occlusion of the sigmoid sinus in a patient with an advanced-stage temporal bone malignancy that affected the dominant sigmoid sinus. Before and during the test occlusion, intrasinus pressure was monitored upstream from the balloon via the inner lumen of a double-lumen angioplasty balloon microcatheter. On the basis of the hemodynamic findings, permanent balloon occlusion was carried out without complications.
Scandinavian Audiology, 2001
HNO
Regenerative medicine offers the prospect of causal treatment of sensorineural hearing loss. In h... more Regenerative medicine offers the prospect of causal treatment of sensorineural hearing loss. In humans, the loss of sensory hair cells is irreversible and results in chronic hearing loss. Other vertebrates, particularly birds, have the capability to spontaneously regenerate lost sensory hair cells and restore hearing. In the bird model, regeneration of hair cells is based on the proliferation of supporting cells. In mammals, supporting cells have lost their proliferative capacity and are terminally differentiated. To gain an understanding about regeneration of hair cells in mammals, cell division of supporting cells has to be controlled. Gene disruption of the cell cycle inhibitor p27(Kip1) allows supporting cell proliferation in the organ of Corti in vivo. Furthermore, in vitro studies indicate that newly generated cells may differentiate into hair cells after p27(Kip1) disruption. Other current methods to induce hair cell regeneration include the gene transfer of Math1 and transpl...
Journal of the Association for Research in Otolaryngology
Various studies point to a crucial role of the high-affinity sodium-coupled glutamate aspartate t... more Various studies point to a crucial role of the high-affinity sodium-coupled glutamate aspartate transporter GLAST-1 for modulation of excitatory transmission as shown in the retina and the CNS. While 2-4-month-old GLAST-1 null mice did not show any functional vestibular abnormality, we observed profound circling behavior in older (7 months) animals lacking GLAST-1. An unchanged total number of otoferlin-positive vestibular hair cells (VHCs), similar ribbon numbers in VHCs, and an unchanged VGLUT3 expression in type II VHCs were detected in GLAST-1 null compared to wild-type mice. A partial loss of supporting cells and an apparent decline of a voltage-gated channel potassium subunit (KCNQ4) was observed in postsynaptic calyceal afferents contacting type I VHCs, together with a reduction of neurofilament- (NF200-) and vesicular glutamate transporter 1- (VGLUT1-) positive calyces in GLAST-1 null mice. Taken together, GLAST-1 deletion appeared to preferentially affect the maintenance of...
HNO, 2003
ABSTRACT Mehrere Tausend Menschen erleiden jedes Jahr ein Knall- oder Explosionstrauma durch Feue... more ABSTRACT Mehrere Tausend Menschen erleiden jedes Jahr ein Knall- oder Explosionstrauma durch Feuerwerkskrper. Fr die Einschtzung der gesundheitlichen und gesundheitspolitischen Bedeutung, fr die Beratung von Patienten z.B. in Bezug auf die Prognose und fr den Vergleich verschiedener Therapieformen sind Kenntnisse ber den Verlauf der Erholung bzw. ber bleibende Folgen wichtig. Im Rahmen einer prospektiven und einer retrospektiven Untersuchung von Patienten mit Knalltrauma durch Feuerwerkskrper,welche sich in den Jahren 1995 bis 2002 an einer deutschen Universittsklinik vorstellten, wurde die Erholung der Hrschwelle ber einen Zeitraum von bis zu zwei Jahren beobachtet. Entsprechend der uns vorliegenden vorlufigen Ergebnisse erholte sich bei einigen Patienten die Hrschwelle trotz ausgeprgtem anfnglichem Hrverlust im Reintonaudiogramm rasch innerhalb von wenigen Tagen bis Wochen. Der Erholungsprozess kann jedoch ber mehrere Monate oder sogar bis zu einem Jahr andauern. Sechs Monate bis zwei Jahre nach dem Trauma litt trotz frh einsetzender Therapie noch mindestens ein Drittel aller in die Studie eingeschlossenen Patienten an einer Hrminderung von mehr als 20 dB HL in dem fr ein Knalltrauma typischen Frequenzbereich und/oder an chronischem, Knalltrauma bedingtem Tinnitus.Weitere prospektive, langfristige Beobachtungen in den nchsten Jahren sollen zeigen, ob die Quantifizierung und Parametrisierung der Hrschwellenerholung durch mathematische Kurvenanpassung in Hinblick auf Prognoseformulierung oder fr den Vergleich unterschiedlicher Therapieverfahren genutzt werden kann.
HNO, 2005
A large proportion of older as well as younger patients do not use their hearing aids. Of the you... more A large proportion of older as well as younger patients do not use their hearing aids. Of the younger hearing impaired population, this occurs in the majority of those who do not benefit sufficiently from their hearing aids and, consequently, they face difficulties in their working and social life. Our aim was to evaluate whether a classical hearing aid adjustment is of sufficient predictive value to determine whether adequate rehabilitation in everyday and professional life will occur. A questionnaire was returned by 197 adult hearing impaired patients. Only 108 were using their hearing aids all the time; 57 rarely and 32 never. The main reason for this low rehabilitation rate proved to be inadequate amplification. At the workplace, insufficient speech discrimination came into play. Another important factor was dysacusis induced by specific noise signals. There was an intolerable acoustic feedback in 40% which could not be sufficiently alleviated. Taking these results into account,...
Neuroscience, Jan 22, 2015
Human auditory nerve afferents consist of two separate systems; one is represented by the large t... more Human auditory nerve afferents consist of two separate systems; one is represented by the large type I cells innervating the inner hair cells and the other one by the small type II cells innervating the outer hair cells. Type I spiral ganglion neurons (SGNs) constitute 96% of the afferent nerve population and, in contrast to other mammals, their soma and pre- and post-somatic segments are unmyelinated. Type II nerve soma and fibers are unmyelinated. Histopathology and clinical experience imply that human SGNs can persist electrically excitable without dendrites, thus lacking connection to the organ of Corti. The biological background to this phenomenon remains elusive. We analyzed the pre- and post-somatic segments of the type I human SGNs using immunohistochemistry and transmission electron microscopy (TEM) in normal and pathological conditions. These segments were found surrounded by non-myelinated Schwann cells (NMSCs) showing strong intracellular expression of laminin-β2/collage...
Cell death & disease, 2014
Hereditary retinal degeneration (RD) relates to a heterogeneous group of blinding human diseases ... more Hereditary retinal degeneration (RD) relates to a heterogeneous group of blinding human diseases in which the light sensitive neurons of the retina, the photoreceptors, die. RD is currently untreatable and the underlying cellular mechanisms remain poorly understood. However, the activity of the enzyme poly-ADP-ribose polymerase-1 (PARP1) and excessive generation of poly-ADP-ribose (PAR) polymers in photoreceptor nuclei have been shown to be causally involved in RD. The activity of PARP1 is to a large extent governed by its functional antagonist, poly-ADP-glycohydrolase (PARG), which thus also may have a role in RD. To investigate this, we analyzed PARG expression in the retina of wild-type (wt) mice and in the rd1 mouse model for human RD, and detected increased PARG protein in a subset of degenerating rd1 photoreceptors. Knockout (KO) animals lacking the 110 kDa nuclear PARG isoform were furthermore analyzed, and their retinal morphology and function were indistinguishable from wil...
HNO, 2008
Regenerative medicine offers the prospect of causal treatment of sensorineural hearing loss. In h... more Regenerative medicine offers the prospect of causal treatment of sensorineural hearing loss. In humans, the loss of sensory hair cells is irreversible and results in chronic hearing loss. Other vertebrates, particularly birds, have the capability to spontaneously regenerate lost sensory hair cells and restore hearing. In the bird model, regeneration of hair cells is based on the proliferation of supporting cells. In mammals, supporting cells have lost their proliferative capacity and are terminally differentiated. To gain an understanding about regeneration of hair cells in mammals, cell division of supporting cells has to be controlled. Gene disruption of the cell cycle inhibitor p27(Kip1) allows supporting cell proliferation in the organ of Corti in vivo. Furthermore, in vitro studies indicate that newly generated cells may differentiate into hair cells after p27(Kip1) disruption. Other current methods to induce hair cell regeneration include the gene transfer of Math1 and transpl...
European journal of medical research, Jan 28, 2005
The aim of this study was to perform a realistic visualization of the auditory and vestibular sys... more The aim of this study was to perform a realistic visualization of the auditory and vestibular system using volume data sets from high-resolution computed tomography (HR-CT) and high-resolution magnetic resonance imaging (HR-MRI). - In 10 patients with conductive and/or sensorineural hearing loss, vertigo and tinnitus, HR-CT and HR-MRI of the petrous bone were performed consecutively. CT was performed with a 16-slice computed tomography scanner using a high spatial resolution. MRI was performed with a 3.0 Tesla scanner using a three-dimensional-constructive interference in steady state (3D-CISS) gradient-echo, and T2-weighted, unenhanced and gadolinium (GD)-enhanced T1-weighted turbo spin-echo sequences. The middle ear structures were interactively segmented and visualized with a color-coded shaded-surface rendering method using the HR-CT volume data sets. The inner ear structures were interactively segmented and visualized with a color-coded shaded-surface rendering method using the...
Advances in Experimental Medicine and Biology, 2014
Poly(ADP-ribose) (PAR) turnover is required for many cellular processes, and highly relevant for ... more Poly(ADP-ribose) (PAR) turnover is required for many cellular processes, and highly relevant for cell death and survival. This post-translational protein modification is regulated by the synthesizing enzyme poly(ADP)ribose-polymerase (PARP) and the degrading enzyme poly(ADP-ribose) glycohydrolase (PARG). Previously, PARP activity was found to be involved in photoreceptor degeneration in the rd1 mouse and in rd1-like conditions PARP-1 was the main PARP family member contributing to photoreceptor cell death. Despite the manifest role of PARP and PAR accumulation in photoreceptor cell death, the influence of PAR degradation on photoreceptor viability was still unknown. Here, we investigated the role of PARG in photoreceptor degeneration using the PARG-110 knock out mouse and report for the first time on PARG expression in wild-type and knock-out retina.
Neurosurgery, 2014
The maneuver of transmeatal drilling carries the risk of injuring inner ear structures, which may... more The maneuver of transmeatal drilling carries the risk of injuring inner ear structures, which may cause immediate or delayed hearing loss. To describe the changes in petrous bone anatomy caused by the tumor and to analyze both the incidence and the risk pattern for violation of the endolymphatic system in a surgical series. One hundred patients operated on for vestibular schwannoma were included in this prospective study. Thin-slice computed tomography was performed before and after surgery. We assessed topographic measurements on both the pathological and healthy sides. Postoperatively, we evaluated anatomic and functional values. The diameter of the internal auditory canal was significantly larger (P < .001) in the petrous bones of the affected sides than in the contralateral healthy sides. An average of 5.6 ± 1.8 mm of the internal auditory canal was drilled, and the distance from the medial border of the sigmoid sinus to the drilling line (tangential to the drilled surface of...
Ear, nose, & throat journal, 2005
Despite the wide variety of ossiculoplasty techniques that are available, success rates are limit... more Despite the wide variety of ossiculoplasty techniques that are available, success rates are limited. Current use indicates that surgeons prefer ceramic, autograft bone, and plastic pore prostheses. During the past decade, titanium prostheses have been used with great promise. Although their use is not widespread, satisfaction rates are high. An earlier study of ossiculoplasty showed that titanium prostheses were effective in reducing conductive hearing loss. To date, the surgical-handling attributes of titanium middle ear prostheses have not been assessed. We report the results of our survey of 32 otologic surgeons who used the open Tübingen titanium prosthesis for primary and revision ossiculoplasty during tympanoplasty in 400 patients at 12 academic and nonacademic otolaryngology clinics, most of them in Germany. Because the audiometric efficacy of titanium prostheses has been previously reported, our primary outcomes measures included ease of use with respect to the amount of tim...
HNO, 2007
ABSTRACT Ohne Zusammenfassung
Acta Oto-laryngologica, 2005
The clinical presentation of otogenic dural sinus thrombosis (DST) as a complication of acute oti... more The clinical presentation of otogenic dural sinus thrombosis (DST) as a complication of acute otitis media (AOM) can be masked by antibiotic treatment. Morning episodes of vomiting and/or headache, visual impairment and a history of AOM seem to be indicative of otogenic hydrocephalus. We therefore advocate that the MRI scans of patients with similar symptoms should be carefully studied to facilitate the early diagnosis of a potentially life-threatening complication. To describe the frequency, pathognomonic signs, clinical course and outcome of otogenic hydrocephalus and DST as complications of AOM in pediatric patients. We undertook a retrospective chart review of all pediatric patients (age 1-14 years) treated for otitis media and its complications at an academic medical center between 1999 and 2003. The main outcome measures were otologic and ophthalmologic findings and CT and MRI scans at the beginning of treatment and 3 months later. We report on five cases with otogenic DST following AOM. All but one of them presented initially with diplopia caused by otogenic hydrocephalus. In four cases the otologic complaints had already disappeared by the time of MRI confirmation of the diagnosis. Only one child was referred with severe otologic symptoms. Management included systemic antibiotics, short-term heparin anticoagulation and surgical decompression. In our cases, even after intensive i.v. antibiotic treatment, only surgery led to a significant improvement in the clinical condition.
American Journal of Neuroradiology
Test occlusion of a patent dural sinus requires careful hemodynamic evaluation. We performed ball... more Test occlusion of a patent dural sinus requires careful hemodynamic evaluation. We performed balloon test occlusion of the sigmoid sinus in a patient with an advanced-stage temporal bone malignancy that affected the dominant sigmoid sinus. Before and during the test occlusion, intrasinus pressure was monitored upstream from the balloon via the inner lumen of a double-lumen angioplasty balloon microcatheter. On the basis of the hemodynamic findings, permanent balloon occlusion was carried out without complications.
Scandinavian Audiology, 2001
HNO
Regenerative medicine offers the prospect of causal treatment of sensorineural hearing loss. In h... more Regenerative medicine offers the prospect of causal treatment of sensorineural hearing loss. In humans, the loss of sensory hair cells is irreversible and results in chronic hearing loss. Other vertebrates, particularly birds, have the capability to spontaneously regenerate lost sensory hair cells and restore hearing. In the bird model, regeneration of hair cells is based on the proliferation of supporting cells. In mammals, supporting cells have lost their proliferative capacity and are terminally differentiated. To gain an understanding about regeneration of hair cells in mammals, cell division of supporting cells has to be controlled. Gene disruption of the cell cycle inhibitor p27(Kip1) allows supporting cell proliferation in the organ of Corti in vivo. Furthermore, in vitro studies indicate that newly generated cells may differentiate into hair cells after p27(Kip1) disruption. Other current methods to induce hair cell regeneration include the gene transfer of Math1 and transpl...
Journal of the Association for Research in Otolaryngology
Various studies point to a crucial role of the high-affinity sodium-coupled glutamate aspartate t... more Various studies point to a crucial role of the high-affinity sodium-coupled glutamate aspartate transporter GLAST-1 for modulation of excitatory transmission as shown in the retina and the CNS. While 2-4-month-old GLAST-1 null mice did not show any functional vestibular abnormality, we observed profound circling behavior in older (7 months) animals lacking GLAST-1. An unchanged total number of otoferlin-positive vestibular hair cells (VHCs), similar ribbon numbers in VHCs, and an unchanged VGLUT3 expression in type II VHCs were detected in GLAST-1 null compared to wild-type mice. A partial loss of supporting cells and an apparent decline of a voltage-gated channel potassium subunit (KCNQ4) was observed in postsynaptic calyceal afferents contacting type I VHCs, together with a reduction of neurofilament- (NF200-) and vesicular glutamate transporter 1- (VGLUT1-) positive calyces in GLAST-1 null mice. Taken together, GLAST-1 deletion appeared to preferentially affect the maintenance of...
HNO, 2003
ABSTRACT Mehrere Tausend Menschen erleiden jedes Jahr ein Knall- oder Explosionstrauma durch Feue... more ABSTRACT Mehrere Tausend Menschen erleiden jedes Jahr ein Knall- oder Explosionstrauma durch Feuerwerkskrper. Fr die Einschtzung der gesundheitlichen und gesundheitspolitischen Bedeutung, fr die Beratung von Patienten z.B. in Bezug auf die Prognose und fr den Vergleich verschiedener Therapieformen sind Kenntnisse ber den Verlauf der Erholung bzw. ber bleibende Folgen wichtig. Im Rahmen einer prospektiven und einer retrospektiven Untersuchung von Patienten mit Knalltrauma durch Feuerwerkskrper,welche sich in den Jahren 1995 bis 2002 an einer deutschen Universittsklinik vorstellten, wurde die Erholung der Hrschwelle ber einen Zeitraum von bis zu zwei Jahren beobachtet. Entsprechend der uns vorliegenden vorlufigen Ergebnisse erholte sich bei einigen Patienten die Hrschwelle trotz ausgeprgtem anfnglichem Hrverlust im Reintonaudiogramm rasch innerhalb von wenigen Tagen bis Wochen. Der Erholungsprozess kann jedoch ber mehrere Monate oder sogar bis zu einem Jahr andauern. Sechs Monate bis zwei Jahre nach dem Trauma litt trotz frh einsetzender Therapie noch mindestens ein Drittel aller in die Studie eingeschlossenen Patienten an einer Hrminderung von mehr als 20 dB HL in dem fr ein Knalltrauma typischen Frequenzbereich und/oder an chronischem, Knalltrauma bedingtem Tinnitus.Weitere prospektive, langfristige Beobachtungen in den nchsten Jahren sollen zeigen, ob die Quantifizierung und Parametrisierung der Hrschwellenerholung durch mathematische Kurvenanpassung in Hinblick auf Prognoseformulierung oder fr den Vergleich unterschiedlicher Therapieverfahren genutzt werden kann.
HNO, 2005
A large proportion of older as well as younger patients do not use their hearing aids. Of the you... more A large proportion of older as well as younger patients do not use their hearing aids. Of the younger hearing impaired population, this occurs in the majority of those who do not benefit sufficiently from their hearing aids and, consequently, they face difficulties in their working and social life. Our aim was to evaluate whether a classical hearing aid adjustment is of sufficient predictive value to determine whether adequate rehabilitation in everyday and professional life will occur. A questionnaire was returned by 197 adult hearing impaired patients. Only 108 were using their hearing aids all the time; 57 rarely and 32 never. The main reason for this low rehabilitation rate proved to be inadequate amplification. At the workplace, insufficient speech discrimination came into play. Another important factor was dysacusis induced by specific noise signals. There was an intolerable acoustic feedback in 40% which could not be sufficiently alleviated. Taking these results into account,...
Neuroscience, Jan 22, 2015
Human auditory nerve afferents consist of two separate systems; one is represented by the large t... more Human auditory nerve afferents consist of two separate systems; one is represented by the large type I cells innervating the inner hair cells and the other one by the small type II cells innervating the outer hair cells. Type I spiral ganglion neurons (SGNs) constitute 96% of the afferent nerve population and, in contrast to other mammals, their soma and pre- and post-somatic segments are unmyelinated. Type II nerve soma and fibers are unmyelinated. Histopathology and clinical experience imply that human SGNs can persist electrically excitable without dendrites, thus lacking connection to the organ of Corti. The biological background to this phenomenon remains elusive. We analyzed the pre- and post-somatic segments of the type I human SGNs using immunohistochemistry and transmission electron microscopy (TEM) in normal and pathological conditions. These segments were found surrounded by non-myelinated Schwann cells (NMSCs) showing strong intracellular expression of laminin-β2/collage...
Cell death & disease, 2014
Hereditary retinal degeneration (RD) relates to a heterogeneous group of blinding human diseases ... more Hereditary retinal degeneration (RD) relates to a heterogeneous group of blinding human diseases in which the light sensitive neurons of the retina, the photoreceptors, die. RD is currently untreatable and the underlying cellular mechanisms remain poorly understood. However, the activity of the enzyme poly-ADP-ribose polymerase-1 (PARP1) and excessive generation of poly-ADP-ribose (PAR) polymers in photoreceptor nuclei have been shown to be causally involved in RD. The activity of PARP1 is to a large extent governed by its functional antagonist, poly-ADP-glycohydrolase (PARG), which thus also may have a role in RD. To investigate this, we analyzed PARG expression in the retina of wild-type (wt) mice and in the rd1 mouse model for human RD, and detected increased PARG protein in a subset of degenerating rd1 photoreceptors. Knockout (KO) animals lacking the 110 kDa nuclear PARG isoform were furthermore analyzed, and their retinal morphology and function were indistinguishable from wil...
HNO, 2008
Regenerative medicine offers the prospect of causal treatment of sensorineural hearing loss. In h... more Regenerative medicine offers the prospect of causal treatment of sensorineural hearing loss. In humans, the loss of sensory hair cells is irreversible and results in chronic hearing loss. Other vertebrates, particularly birds, have the capability to spontaneously regenerate lost sensory hair cells and restore hearing. In the bird model, regeneration of hair cells is based on the proliferation of supporting cells. In mammals, supporting cells have lost their proliferative capacity and are terminally differentiated. To gain an understanding about regeneration of hair cells in mammals, cell division of supporting cells has to be controlled. Gene disruption of the cell cycle inhibitor p27(Kip1) allows supporting cell proliferation in the organ of Corti in vivo. Furthermore, in vitro studies indicate that newly generated cells may differentiate into hair cells after p27(Kip1) disruption. Other current methods to induce hair cell regeneration include the gene transfer of Math1 and transpl...
European journal of medical research, Jan 28, 2005
The aim of this study was to perform a realistic visualization of the auditory and vestibular sys... more The aim of this study was to perform a realistic visualization of the auditory and vestibular system using volume data sets from high-resolution computed tomography (HR-CT) and high-resolution magnetic resonance imaging (HR-MRI). - In 10 patients with conductive and/or sensorineural hearing loss, vertigo and tinnitus, HR-CT and HR-MRI of the petrous bone were performed consecutively. CT was performed with a 16-slice computed tomography scanner using a high spatial resolution. MRI was performed with a 3.0 Tesla scanner using a three-dimensional-constructive interference in steady state (3D-CISS) gradient-echo, and T2-weighted, unenhanced and gadolinium (GD)-enhanced T1-weighted turbo spin-echo sequences. The middle ear structures were interactively segmented and visualized with a color-coded shaded-surface rendering method using the HR-CT volume data sets. The inner ear structures were interactively segmented and visualized with a color-coded shaded-surface rendering method using the...
Advances in Experimental Medicine and Biology, 2014
Poly(ADP-ribose) (PAR) turnover is required for many cellular processes, and highly relevant for ... more Poly(ADP-ribose) (PAR) turnover is required for many cellular processes, and highly relevant for cell death and survival. This post-translational protein modification is regulated by the synthesizing enzyme poly(ADP)ribose-polymerase (PARP) and the degrading enzyme poly(ADP-ribose) glycohydrolase (PARG). Previously, PARP activity was found to be involved in photoreceptor degeneration in the rd1 mouse and in rd1-like conditions PARP-1 was the main PARP family member contributing to photoreceptor cell death. Despite the manifest role of PARP and PAR accumulation in photoreceptor cell death, the influence of PAR degradation on photoreceptor viability was still unknown. Here, we investigated the role of PARG in photoreceptor degeneration using the PARG-110 knock out mouse and report for the first time on PARG expression in wild-type and knock-out retina.
Neurosurgery, 2014
The maneuver of transmeatal drilling carries the risk of injuring inner ear structures, which may... more The maneuver of transmeatal drilling carries the risk of injuring inner ear structures, which may cause immediate or delayed hearing loss. To describe the changes in petrous bone anatomy caused by the tumor and to analyze both the incidence and the risk pattern for violation of the endolymphatic system in a surgical series. One hundred patients operated on for vestibular schwannoma were included in this prospective study. Thin-slice computed tomography was performed before and after surgery. We assessed topographic measurements on both the pathological and healthy sides. Postoperatively, we evaluated anatomic and functional values. The diameter of the internal auditory canal was significantly larger (P < .001) in the petrous bones of the affected sides than in the contralateral healthy sides. An average of 5.6 ± 1.8 mm of the internal auditory canal was drilled, and the distance from the medial border of the sigmoid sinus to the drilling line (tangential to the drilled surface of...
Ear, nose, & throat journal, 2005
Despite the wide variety of ossiculoplasty techniques that are available, success rates are limit... more Despite the wide variety of ossiculoplasty techniques that are available, success rates are limited. Current use indicates that surgeons prefer ceramic, autograft bone, and plastic pore prostheses. During the past decade, titanium prostheses have been used with great promise. Although their use is not widespread, satisfaction rates are high. An earlier study of ossiculoplasty showed that titanium prostheses were effective in reducing conductive hearing loss. To date, the surgical-handling attributes of titanium middle ear prostheses have not been assessed. We report the results of our survey of 32 otologic surgeons who used the open Tübingen titanium prosthesis for primary and revision ossiculoplasty during tympanoplasty in 400 patients at 12 academic and nonacademic otolaryngology clinics, most of them in Germany. Because the audiometric efficacy of titanium prostheses has been previously reported, our primary outcomes measures included ease of use with respect to the amount of tim...
HNO, 2007
ABSTRACT Ohne Zusammenfassung