Jan-Falco Wilbrand | Universität Trier (original) (raw)

Papers by Jan-Falco Wilbrand

Current Directions in Biomedical Engineering, Aug 1, 2022

Craniofacial deformities such as positional skull deformities are widespread in infants. The earl... more Craniofacial deformities such as positional skull deformities are widespread in infants. The early detection of these deformities is crucial for the effective treatment and the associated minimization or prevention of visual and pathological abnormalities. This paper presents a solution for the early detection of craniofacial deformities using easy available materials in both the domestic and clinical environments. For this purpose, suitable web technologies as well as webserver systems are used in the context of app and server development. Users can use the app to take a bird's eye view of the child's head and use a 50ct coin as scale to then automatically obtain calculated clinical parameters which they can compare with clinical standard values to rule in or out a skull deformity. The concept represents a way to compensate for the lack of specialists in craniofacial surgery as well as knowledge gaps and to digitize care concepts in the healthcare system.

Pediatric Blood & Cancer, Oct 3, 2016

This case of a rare pigmented SCC, which occurs almost exclusively in the elderly, in an adolesce... more This case of a rare pigmented SCC, which occurs almost exclusively in the elderly, in an adolescent following 10 years exposure to voriconazole may be speculated to reflect the magnitude of the acceleration of skin aging induced by this drug, even in patients without transplant history or other associated risk factors. 10 Children and adolescents with prolonged voriconazole treatment should receive regular dermatological cancer screening taking into account that especially adolescents may try to hide visible skin lesions. Appropriate sunlight avoidance and sun protection should be recommended.

Journal of Cranio-Maxillofacial Surgery, 2016

Background: An accurate preoperative assessment of cervical lymph node status is a prerequisite f... more Background: An accurate preoperative assessment of cervical lymph node status is a prerequisite for individually tailored cancer therapies in patients with oral squamous cell carcinoma. The detection of malignant spread and its treatment crucially influence the prognosis. The aim of the present study was to analyze the different staging modalities used among patients with a diagnosis of primary oral squamous cell carcinoma between 2008 and 2015. Material and Methods: An analysis of preoperative staging findings, collected by clinical palpation, ultrasound, and computed tomography (CT), was performed. The results obtained were compared with the results of the final histopathological findings of the neck dissection specimens. A statistical analysis using McNemar's test was performed. Results: The sensitivity of CT for the detection of malignant cervical tumor spread was 74.5%. The ultrasound obtained a sensitivity of 60.8%. Both CT and ultrasound demonstrated significantly enhanced sensitivity compared to the clinical palpation with a sensitivity of 37.1%. No significant difference was observed between CT and ultrasound. A combination of different staging modalities increased the sensitivity significantly compared with ultrasound staging alone. No significant difference in sensitivity was found between the combined use of different staging modalities and CT staging alone. The highest sensitivity, of 80.0%, was obtained by a combination of all three staging modalities: clinical palpation, ultrasound and CT.

International Journal of Oral and Maxillofacial Surgery, 2019

The implant surface must withstand high insertion torque during implant insertion. The aim of thi... more The implant surface must withstand high insertion torque during implant insertion. The aim of this study was to investigate the damage to implant surfaces caused by two different insertion protocols in vitro. Fifteen titanium implants per group were inserted in standardized polyurethane foam models, group 1 according to a non-threaded surgical protocol and group 2 according to a threaded surgical protocol. Before and after insertion, the surfaces were visualized by scanning electron microscopy (SEM) and non-contact laser profilometry. Different surface area parameters were evaluated and maximum torque during insertion was determined. SEM detected topographical changes such as deposition of the test block and smoothening of the surface in the region of the thread crests in both groups. The laser profilometry analysis revealed significant changes in the surface topography of the implants in both groups, but no differences between the groups. Insertion torque was significantly decreased in the threaded group. Both types of surgical intervention resulted in surface damage. Less damage was detected to the thread crests with the use of a thread cutter, and most of the surface was not visibly affected by the surgical protocol at the microscopic level. The surgical protocol seems to have a minor influence on preservation of the implant surface.

Journal of Cranio-Maxillofacial Surgery, 2014

Context: Bisphosphonates are common drugs used in the management of bone metabolic diseases. Beca... more Context: Bisphosphonates are common drugs used in the management of bone metabolic diseases. Because of their recently increased use, their adverse effects, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), are monitored more frequently. BRONJ is a critical challenge in craniofacial surgery and is difficult to treat. Its occurrence is either spontaneous or follows dentoalveolar surgery. Typical complications of BRONJ are painful exposed bone, pathological fractures, extra-oral fistula, and local infections. Objective: The aim of this paper is to report a rare case of bacterial embolism in the internal jugular vein after a BRONJ-induced submandibular abscess resulting in bacterial sepsis, multi-organ failure syndrome, and death. Case illustration: A 59-year-old female patient developed severe BRONJ (stage II) with recurrent abscesses after oral osteoporosis therapy with alendronic acid. A subsequent submandibular abscess led to bacterial embolism of the left internal jugular vein, causing sepsis and death. Discussion: Prevention, early detection and management of BRONJ remain a crucial challenge in craniofacial clinical practice. Despite several therapeutic approaches described in the current literature, none have undergone bedside application. Conclusion: Considering this report of death after recurrent abscesses following BRONJ, the use of bisphosphonates should be carefully monitored in order to prevent such severe complications.

Klinische Pädiatrie, 2012

Pediatric scurvy is a rare condition characterized by perifollicular petechiae and bruising, hemo... more Pediatric scurvy is a rare condition characterized by perifollicular petechiae and bruising, hemorrhagic gingivitis and musculoskeletal symptoms, all assumed to be predominantly related to abnormal collagen structure. We report on a 9-year-old autistic boy with vitamin C deficiency due to a highly limited food range presenting with multiple petechiae, gum bleeding and debilitating bone pain, in whom platelet aggregometry revealed a distinctly reduced thrombocyte aggregation, normalizing after vitamin C supplementation. This observation indicates that platelet dysfunction may additionally contribute to the hemorrhagic diathesis in scurvy, and demonstrates that ascorbic acid deficiency should be considered in children with an otherwise unexplained acquired thrombocytopathy.

Journal of Dental Research, 2012

Micro-gaps and osseous overload in the implant-abutment connection are the most common causes of ... more Micro-gaps and osseous overload in the implant-abutment connection are the most common causes of peri-implant bone resorption and implant failure. These undesirable events can be visualized on standardized three-dimensional finite element models and by radiographic methods. The present study investigated the influence of 7 available implant systems (Ankylos, Astra, Bego, Brånemark, Camlog, Straumann, and Xive) with different implant-abutment connections on bone overload and the appearance of micro-gaps in vitro. The individual geometries of the implants were transferred to three-dimensional finite element models. In a non-linear analysis considering the pre-loading of the occlusion screw, friction between the implant and abutment, the influence of the cone angle on bone strain, and the appearance of micro-gaps were determined. Increased bone strains were correlated with small (< 15°) cone angles. Conical implant-abutment connections efficiently avoided micro-gaps but had a negati...

Journal of Plastic, Reconstructive & Aesthetic Surgery, 2011

Seit der Einführung der Back to Sleep Campaign (1992) wird zur Vermeidung des Plötzlichen Kindsto... more Seit der Einführung der Back to Sleep Campaign (1992) wird zur Vermeidung des Plötzlichen Kindstods die Rückenlagerung von Säuglingen zum Schlafen empfohlen. Die dadurch veränderte Druckbelastung auf den kindlichen Schädel führte zu einem Inzidenzanstieg von lagebedingten Schädeldeformitäten, deren Vermessung international unterschiedlich erfolgt. Dies erschwert die Vergleichbarkeit international erhobener Daten erheblich. Ziel der Arbeit war es, die in den Niederlanden etablierte und in multiplen hochrangig publizierten Artikeln zu diesem Thema verwendete Plagiocephalometrie auf ihre Untersucherabhängigkeit und klinische Anwendbarkeit hin zu untersuchen und mit den an der Universitätsklinik Gießen etablierten Verfahren der anthropometrischen Zirkelmessung und 3D-Photogrammetrie zu vergleichen. Insgesamt wurden 51 Kinder, die sich von Juni bis August 2017 im Alter von drei bis zwölf Monaten in der "Helmsprechstunde" in der Poliklinik für Mund-, Kiefer- und Gesichtschirurgi...

Einleitung: Die Rekonstruktion von Gewebedefekten im Gesichtsbereich nach Trauma oder Tumorablati... more Einleitung: Die Rekonstruktion von Gewebedefekten im Gesichtsbereich nach Trauma oder Tumorablation gehören zu den komplexesten Eingriffen im gesichtschirurgischen Bereich. Defektgröße, -lokalisation und Art des zu ersetzenden Gewebes sowie das Alter der Patienten bestimmen die Planung[for full text, please go to the a.m. URL]

Einleitung: Abladierende operative Eingriffe bei Nasenhauttumoren stellen je nach Ausdehnung der ... more Einleitung: Abladierende operative Eingriffe bei Nasenhauttumoren stellen je nach Ausdehnung der Resektion einen hohen Anspruch an die rekonstruierenden Chirurgen. Anhand verschiedener Patientenfälle sollen unterschiedliche chirurgische Techniken zur nasalen Rekonstruktion verdeutlicht werden. [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Einleitung: Die kaufunktionelle und ästhetische Rehabilitation mit enossalen Implantaten ist ein ... more Einleitung: Die kaufunktionelle und ästhetische Rehabilitation mit enossalen Implantaten ist ein wichtiger Bestandteil der plastisch-ästhetischen Gesichtschirurgie. Um ein optimales Ergebnis erzielen zu können, müssen häufig knöcherne Strukturen wiederhergesellt werden.[for full text, please go to the a.m. URL]

Einleitung: Kindliche Schädeldeformitäten können synostotischer und nicht-synostostischer Genese ... more Einleitung: Kindliche Schädeldeformitäten können synostotischer und nicht-synostostischer Genese sein. Die klinische Evaluation solcher Schädeldeformitäten ist für den erfahrenen kraniofazialen Behandler in der Regel mittels Blickdiagnose möglich, in Zweifelsfällen[for full text, please go to the a.m. URL]

Einleitung: Entzündungen im Kopf-Hals Bereich stellt ein wichtiges Kapitel in der mund-, kiefer- ... more Einleitung: Entzündungen im Kopf-Hals Bereich stellt ein wichtiges Kapitel in der mund-, kiefer- und gesichtschirurgischen Operationslehre dar. Trotz Weiterentwicklung konservativ-medikamentöser Behandlungsmaßnahmen ist die chirurgische Behandlung mit Inzision und Drainage bei entzündlichen[for full text, please go to the a.m. URL]

Einleitung: Kindliche Schädeldeformitäten können synostotischer oder nicht-synostotischer Genese ... more Einleitung: Kindliche Schädeldeformitäten können synostotischer oder nicht-synostotischer Genese sein. Die differentialdiagnostische Unterscheidung wird in der Regel anhand des klinischen Bildes getroffen. Während prämature Kraniosynostosen meist der chirurgischen Korrektur [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Pathogens, 2022

Necrotizing fasciitis of the head and neck is a rare, very severe disease, which, in most cases, ... more Necrotizing fasciitis of the head and neck is a rare, very severe disease, which, in most cases, originates from odontogenic infections and frequently ends with the death of the patient. Rapid surgical intervention in combination with a preferably pathogen-specific antibiotic therapy can ensure patients’ survival. The question arises concerning which pathogens are causative for the necrotizing course of odontogenic inflammations. Experimental 16S-rRNA gene analysis with next-generation sequencing and bioinformatics was used to identify the microbiome of patients treated with an odontogenic necrotizing infection and compared to the result of the routine culture. Three of four patients survived the severe infection, and one patient died due to septic multiorgan failure. Microbiome determination revealed findings comparable to typical odontogenic abscesses. A specific pathogen which could be causative for the necrotizing course could not be identified. Early diagnosis and rapid surgica...

The Cleft Palate-Craniofacial Journal, 2014

ObjectiveTo photogrammetrically objectify changes in nonsynostotic craniofacial deformity in orth... more ObjectiveTo photogrammetrically objectify changes in nonsynostotic craniofacial deformity in orthotically treated versus untreated infants.DesignA statistical retrospective pairwise comparison of two respective three-dimensional (3D) photo scans of 80 children performed in a 6-month time lag.PatientsTwo comparable samples of children (40 treated, 40 untreated) with nonsynostotic cranial deformity.InterventionsRespective 3D photo scans were matched using Cranioform Analytics 4.0 software.Main Outcome MeasuresMedian change of 30° Cranial Vault Asymmetry Index (CVAI), modified CVAI (CVAImod), Cranial Index (CI), and posterior symmetry ratio (PSR).ResultsWe found an improvement in Δ30° CVAI by 3.3% (treated) and by 1.31% (untreated), respectively. CVAImodimproved by 3.46% in the treated group and by 1.55% in the untreated group. CI improved by 4.41% in the treated group and by 3.68% in the untreated group, and PSR improved by 0.71 in the treated group and 0.49 in the untreated group. Al...

The Journal of Pediatrics, 2013

Objective To evaluate the impact of stretching exercises versus available bedding pillows on posi... more Objective To evaluate the impact of stretching exercises versus available bedding pillows on positional head deformities. Study design Fifty children aged 5 months or younger with positional head deformity were included in this prospective clinical trial (n = 20 plagiocephaly, n = 10 brachycephaly, n = 20 combination). A random distribution was performed for treatment with the bedding pillow alone (n = 25) or with stretching exercises (n = 25) for 6 weeks. Anthropometric caliper measurements were done before and after that interval. Cranial vault asymmetry index (CVAI) and cranial index (CI) were calculated and analyzed using a descriptive statistical general linear model. Results DCVAI in the stretching group was 2.09% for plagiocephaly and 2.34% for combined head deformities. Using the bedding pillow, DCVAI was 3.01% in plagiocephal children and 2.86% for combined head deformity. The DCI in the stretching group was 0.94% for isolated brachycephal children and 2.24% for combined head deformity. DCI in the pillow group was 3.63% for brachycephaly and 3.23% in children with combined head deformities, respectively. Conclusions Bedding pillows and stretching exercises both resulted in improvements in positional cranial deformation. For children with combined plagiocephaly and brachycephaly, improvement in cranial asymmetry was slightly greater when using bedding pillows versus stretching.

Einleitung: Das Stirnlappentransplantat zur Rekonstruktion der Nase, welches auf den indischen Ar... more Einleitung: Das Stirnlappentransplantat zur Rekonstruktion der Nase, welches auf den indischen Arzt Sushruta zurückgeht, ist seit 2500 Jahren bekannt und wird vielfältig zur Nasenrekonstruktion eingesetzt. Verfeinerungen der Operationstechnik mit dem Ziel der Wiederherstellung auch nach mehrschichtigen[for full text, please go to the a.m. URL]

Einleitung: Die Erfassung kindlicher Schädeldeformitäten wird an unterschiedlichen Kliniken unter... more Einleitung: Die Erfassung kindlicher Schädeldeformitäten wird an unterschiedlichen Kliniken unterschiedlich gehandhabt. Dies führt dazu, dass jedes Zentrum lediglich die eigenen Daten auswerten kann und die Vergleichbarkeit der Parameter mit anderen Kliniken, die Kinder mit Schädeldeformitäten[zum vollständigen Text gelangen Sie über die oben angegebene URL]