Adel Al-marby | Universidad nacional de ingenieria (original) (raw)

Papers by Adel Al-marby

Research paper thumbnail of Isolation and characterisation of bioactive compounds from plant resources

Research paper thumbnail of Biomimetic Drug Design

Research paper thumbnail of Nematicidal and antimicrobial activities of methanol extracts of seventeen plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula

Journal of Intercultural Ethnopharmacology, 2016

Aim/Background: The development of resistance to synthetic drugs by target organisms is a major c... more Aim/Background: The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these "hidden treasures," the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities. Materials and Methods: The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays. Steinernema feltiae, Staphylococcus carnosus, Escherichia coli, and Saccharomyces cerevisiae were used as test organisms. Concentrations of the extracts ranging from 0.5 to 20 mg/ml were tested and appropriate statistical tests performed on the data generated. Results: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations. Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml. Extracts of C. myrrha and C. murale had the most active antibacterial activity with inhibition zones of 12-15 mm and minimum inhibitory concentrations (MICs) of 2.5 mg/ml for both bacteria. Extracts of the leaves of A. biebersteinii were the most active fungicide, giving an MIC of 1.5 mg/ml. Conclusion: The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

Research paper thumbnail of Turning Waste into Value: Nanosized Natural Plant Materials of Solanum incanum L. and Pterocarpus erinaceus Poir with Promising Antimicrobial Activities

Pharmaceutics, 2016

Numerous plants are known to exhibit considerable biological activities in the fields of medicine... more Numerous plants are known to exhibit considerable biological activities in the fields of medicine and agriculture, yet access to their active ingredients is often complicated, cumbersome and expensive. As a consequence, many plants harbouring potential drugs or green phyto-protectants go largely unnoticed, especially in poorer countries which, at the same time, are in desperate need of antimicrobial agents. As in the case of plants such as the Jericho tomato, Solanum incanum, and the common African tree Pterocarpus erinaceus, nanosizing of original plant materials may provide an interesting alternative to extensive extraction and isolation procedures. Indeed, it is straightforward to obtain considerable amounts of such common, often weed-like plants, and to mill the dried material to more or less uniform particles of microscopic and nanoscopic size. These particles exhibit activity against Steinernema feltiae or Escherichia coli, which is comparable to the ones seen for processed extracts of the same, respective plants. As S. feltiae is used as a model nematode indicative of possible phyto-protective uses in the agricultural arena, these findings also showcase the potential of nanosizing of crude "waste" plant materials for specific practical applications, especially-but not exclusively-in developing countries lacking a more sophisticated industrial infrastructure.

Research paper thumbnail of Nematicidal and antimicrobial evaluation of extracts, nanosized materials and fractions of selected plants and the identification of the bioactive phytochemicals

Methanolextrakte von Blättern, oberirdischen Pflanzenteilen, Früchten und Harz von 17 auf der ara... more Methanolextrakte von Blättern, oberirdischen Pflanzenteilen, Früchten und Harz von 17 auf der arabischen Halbinsel genutzten Pflanzen wurden hinsichtlich ihrer antinematodischen und antimikrobiellen Aktivität gescreent. "Solanum incanum" wurde untersucht, um dadurch einen alternativen Weg der Extraktionsund Isolationsmethode zu entwickeln. Diese Pflanze wurde in mehr oder weniger gleichmäßige mikround nanoskopisch kleine Partikel gemahlen. Die Partikel wurden auf ihre Wirkung gegen die Modelorganismen Steinernema feltiae (Nematoden) und Escherichia coli (Bakterien) untersucht. Sie zeigten eine Wirkung gegen Steinernema feltiae, welche vergleichbar mit der des Extraktes derselben Pflanze ist. Dendrosicyos socotranus (Gurkenpflanze) wurde ebenfalls als Teil dieser Doktorarbeit untersucht. Diese Pflanze wurde phytochemisch gescreent und zur Identifizierung von sekundären Pflanzenstoffen, welche die oben genannten Würmer und Mikroorganismen, in Übereinstimmung mit ihrem traditionellem Nutzen, beeinflussen, aufgetrennt. Der Fraktionierungsprozess wurde durchgeführt und die verschiedenen erhaltenen Fraktionen des methanolischen Extraktes von D. socotranus gegen S. feltiae, Staphylococcus carnosus, E. coli und Saccharomyces cerevisiae getestet. Der Fraktionierungsprozess wurde mit verschiedenen Lösungsmitteln durchgeführt und die Verbindungen anschließend mit Hilfe einer preparativen TLC isoliert und unter Verwendung eines Massenspektrometers analysiert. .

Research paper thumbnail of Nematicidal and antimicrobial activities of methanol extracts of seventeen plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula

Journal of Intercultural Ethnopharmacology, 2016

The development of resistance to synthetic drugs by target organisms is a major challenge facing ... more The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these "hidden treasures," the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities. The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays. Steinernema feltiae, Staphylococcus carnosus, Escherichia coli, and Saccharomyces cerevisiae were used as test organisms. Concentrations of the extracts ranging from 0.5 to 20 mg/ml were tested and appropriate statistical tests performed on the data generated. The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations. Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml. Extracts of C. myrrha and C. murale had the most active antibacterial activity with inhibition zones of 12-15 mm and minimum inhibitory concentrations (MICs) of 2.5 mg/ml for both bacteria. Extracts of the leaves of A. biebersteinii were the most active fungicide, giving an MIC of 1.5 mg/ml. The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

Research paper thumbnail of Turning Waste into Value: Nanosized Natural Plant Materials of Solanum incanum L. and Pterocarpus erinaceus Poir with Promising Antimicrobial Activities

Pharmaceutics, 2016

Numerous plants are known to exhibit considerable biological activities in the fields of medicine... more Numerous plants are known to exhibit considerable biological activities in the fields of medicine and agriculture, yet access to their active ingredients is often complicated, cumbersome and expensive. As a consequence, many plants harbouring potential drugs or green phyto-protectants go largely unnoticed, especially in poorer countries which, at the same time, are in desperate need of antimicrobial agents. As in the case of plants such as the Jericho tomato, Solanum incanum, and the common African tree Pterocarpus erinaceus, nanosizing of original plant materials may provide an interesting alternative to extensive extraction and isolation procedures. Indeed, it is straightforward to obtain considerable amounts of such common, often weed-like plants, and to mill the dried material to more or less uniform particles of microscopic and nanoscopic size. These particles exhibit activity against Steinernema feltiae or Escherichia coli, which is comparable to the ones seen for processed extracts of the same, respective plants. As S. feltiae is used as a model nematode indicative of possible phyto-protective uses in the agricultural arena, these findings also showcase the potential of nanosizing of crude "waste" plant materials for specific practical applications, especially-but not exclusively-in developing countries lacking a more sophisticated industrial infrastructure.

Research paper thumbnail of Nematicidal and antimicrobial activities of methanol extracts of 17 plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula

Aim/Background: The development of resistance to synthetic drugs by target organisms is a major c... more Aim/Background: The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these " hidden treasures, " the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities. Materials and Methods: The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays. Steinernema feltiae, Staphylococcus carnosus, Escherichia coli, and Saccharomyces cerevisiae were used as test organisms. Concentrations of the extracts ranging from 0.5 to 20 mg/ml were tested and appropriate statistical tests performed on the data generated. Results: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations. Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml. Extracts of C. myrrha and C. murale had the most active antibacterial activity with inhibition zones of 12‑15 mm and minimum inhibitory concentrations (MICs) of 2.5 mg/ml for both bacteria. Extracts of the leaves of A. biebersteinii were the most active fungicide, giving an MIC of 1.5 mg/ml. Conclusion: The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

Research paper thumbnail of Isolation and characterisation of bioactive compounds from plant resources

Research paper thumbnail of Biomimetic Drug Design

Research paper thumbnail of Nematicidal and antimicrobial activities of methanol extracts of seventeen plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula

Journal of Intercultural Ethnopharmacology, 2016

Aim/Background: The development of resistance to synthetic drugs by target organisms is a major c... more Aim/Background: The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these "hidden treasures," the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities. Materials and Methods: The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays. Steinernema feltiae, Staphylococcus carnosus, Escherichia coli, and Saccharomyces cerevisiae were used as test organisms. Concentrations of the extracts ranging from 0.5 to 20 mg/ml were tested and appropriate statistical tests performed on the data generated. Results: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations. Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml. Extracts of C. myrrha and C. murale had the most active antibacterial activity with inhibition zones of 12-15 mm and minimum inhibitory concentrations (MICs) of 2.5 mg/ml for both bacteria. Extracts of the leaves of A. biebersteinii were the most active fungicide, giving an MIC of 1.5 mg/ml. Conclusion: The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

Research paper thumbnail of Turning Waste into Value: Nanosized Natural Plant Materials of Solanum incanum L. and Pterocarpus erinaceus Poir with Promising Antimicrobial Activities

Pharmaceutics, 2016

Numerous plants are known to exhibit considerable biological activities in the fields of medicine... more Numerous plants are known to exhibit considerable biological activities in the fields of medicine and agriculture, yet access to their active ingredients is often complicated, cumbersome and expensive. As a consequence, many plants harbouring potential drugs or green phyto-protectants go largely unnoticed, especially in poorer countries which, at the same time, are in desperate need of antimicrobial agents. As in the case of plants such as the Jericho tomato, Solanum incanum, and the common African tree Pterocarpus erinaceus, nanosizing of original plant materials may provide an interesting alternative to extensive extraction and isolation procedures. Indeed, it is straightforward to obtain considerable amounts of such common, often weed-like plants, and to mill the dried material to more or less uniform particles of microscopic and nanoscopic size. These particles exhibit activity against Steinernema feltiae or Escherichia coli, which is comparable to the ones seen for processed extracts of the same, respective plants. As S. feltiae is used as a model nematode indicative of possible phyto-protective uses in the agricultural arena, these findings also showcase the potential of nanosizing of crude "waste" plant materials for specific practical applications, especially-but not exclusively-in developing countries lacking a more sophisticated industrial infrastructure.

Research paper thumbnail of Nematicidal and antimicrobial evaluation of extracts, nanosized materials and fractions of selected plants and the identification of the bioactive phytochemicals

Methanolextrakte von Blättern, oberirdischen Pflanzenteilen, Früchten und Harz von 17 auf der ara... more Methanolextrakte von Blättern, oberirdischen Pflanzenteilen, Früchten und Harz von 17 auf der arabischen Halbinsel genutzten Pflanzen wurden hinsichtlich ihrer antinematodischen und antimikrobiellen Aktivität gescreent. "Solanum incanum" wurde untersucht, um dadurch einen alternativen Weg der Extraktionsund Isolationsmethode zu entwickeln. Diese Pflanze wurde in mehr oder weniger gleichmäßige mikround nanoskopisch kleine Partikel gemahlen. Die Partikel wurden auf ihre Wirkung gegen die Modelorganismen Steinernema feltiae (Nematoden) und Escherichia coli (Bakterien) untersucht. Sie zeigten eine Wirkung gegen Steinernema feltiae, welche vergleichbar mit der des Extraktes derselben Pflanze ist. Dendrosicyos socotranus (Gurkenpflanze) wurde ebenfalls als Teil dieser Doktorarbeit untersucht. Diese Pflanze wurde phytochemisch gescreent und zur Identifizierung von sekundären Pflanzenstoffen, welche die oben genannten Würmer und Mikroorganismen, in Übereinstimmung mit ihrem traditionellem Nutzen, beeinflussen, aufgetrennt. Der Fraktionierungsprozess wurde durchgeführt und die verschiedenen erhaltenen Fraktionen des methanolischen Extraktes von D. socotranus gegen S. feltiae, Staphylococcus carnosus, E. coli und Saccharomyces cerevisiae getestet. Der Fraktionierungsprozess wurde mit verschiedenen Lösungsmitteln durchgeführt und die Verbindungen anschließend mit Hilfe einer preparativen TLC isoliert und unter Verwendung eines Massenspektrometers analysiert. .

Research paper thumbnail of Nematicidal and antimicrobial activities of methanol extracts of seventeen plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula

Journal of Intercultural Ethnopharmacology, 2016

The development of resistance to synthetic drugs by target organisms is a major challenge facing ... more The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these "hidden treasures," the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities. The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays. Steinernema feltiae, Staphylococcus carnosus, Escherichia coli, and Saccharomyces cerevisiae were used as test organisms. Concentrations of the extracts ranging from 0.5 to 20 mg/ml were tested and appropriate statistical tests performed on the data generated. The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations. Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml. Extracts of C. myrrha and C. murale had the most active antibacterial activity with inhibition zones of 12-15 mm and minimum inhibitory concentrations (MICs) of 2.5 mg/ml for both bacteria. Extracts of the leaves of A. biebersteinii were the most active fungicide, giving an MIC of 1.5 mg/ml. The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

Research paper thumbnail of Turning Waste into Value: Nanosized Natural Plant Materials of Solanum incanum L. and Pterocarpus erinaceus Poir with Promising Antimicrobial Activities

Pharmaceutics, 2016

Numerous plants are known to exhibit considerable biological activities in the fields of medicine... more Numerous plants are known to exhibit considerable biological activities in the fields of medicine and agriculture, yet access to their active ingredients is often complicated, cumbersome and expensive. As a consequence, many plants harbouring potential drugs or green phyto-protectants go largely unnoticed, especially in poorer countries which, at the same time, are in desperate need of antimicrobial agents. As in the case of plants such as the Jericho tomato, Solanum incanum, and the common African tree Pterocarpus erinaceus, nanosizing of original plant materials may provide an interesting alternative to extensive extraction and isolation procedures. Indeed, it is straightforward to obtain considerable amounts of such common, often weed-like plants, and to mill the dried material to more or less uniform particles of microscopic and nanoscopic size. These particles exhibit activity against Steinernema feltiae or Escherichia coli, which is comparable to the ones seen for processed extracts of the same, respective plants. As S. feltiae is used as a model nematode indicative of possible phyto-protective uses in the agricultural arena, these findings also showcase the potential of nanosizing of crude "waste" plant materials for specific practical applications, especially-but not exclusively-in developing countries lacking a more sophisticated industrial infrastructure.

Research paper thumbnail of Nematicidal and antimicrobial activities of methanol extracts of 17 plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula

Aim/Background: The development of resistance to synthetic drugs by target organisms is a major c... more Aim/Background: The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these " hidden treasures, " the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities. Materials and Methods: The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays. Steinernema feltiae, Staphylococcus carnosus, Escherichia coli, and Saccharomyces cerevisiae were used as test organisms. Concentrations of the extracts ranging from 0.5 to 20 mg/ml were tested and appropriate statistical tests performed on the data generated. Results: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations. Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml. Extracts of C. myrrha and C. murale had the most active antibacterial activity with inhibition zones of 12‑15 mm and minimum inhibitory concentrations (MICs) of 2.5 mg/ml for both bacteria. Extracts of the leaves of A. biebersteinii were the most active fungicide, giving an MIC of 1.5 mg/ml. Conclusion: The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.