Adarki Pongri | University of Benin (original) (raw)

Papers by Adarki Pongri

Research paper thumbnail of Acute and sub-chronic toxicity evaluations of aqueous extract from stem bark of Grewia mollis (Malvaceae) in rats

Herba Polonica, Sep 26, 2017

Introduction: Different parts of Grewia mollis Juss. (Malvaceae) are commonly used in folk medici... more Introduction: Different parts of Grewia mollis Juss. (Malvaceae) are commonly used in folk medicine to treat several ailments, including diarrhea, ulcers, rickets, cough and fever. Although several studies have proved its therapeutic effectiveness, there are very few toxicological studies on the plant. Objectives: This study was carried out to evaluate the acute and sub-chronic toxicity of the aqueous extract of G. mollis stem bark (GM) in animals. Methods: In the acute study, rats were orally administrated with GM at doses of 150, 300, 600, 1200, 2400, 4800 and 9600 mg/kg to determine the oral medial lethal dose (LD 50). In the chronic study, rats received three doses of GM (150, 300 and 600 mg/kg) for 28 days. After the treatments, food intake, body weights, biochemical, hematological and histopathological parameters were analyzed. Results: The LD 50 was estimated to be >9600 mg/kg. No significant alterations in the animal's body weight gain, relative organs weight, serum biochemical analysis, hematological or histopathological analyses of liver, kidneys, lungs, heart and spleen were observed. Conclusions: The results of this study provided evidence that oral administration of GM at dose of 600 mg/kg is relatively safe in rats and may not exert severe toxic effects.

Research paper thumbnail of Review of two year prescription patterns of antimalarial drug regimen at NIPRD Health Center, Abuja

Background: The World Health Organization (WHO) has recommended the use of artemisinin based comb... more Background: The World Health Organization (WHO) has recommended the use of artemisinin based combination therapy (ACT) for the treatment of malaria to reduce the incidence of treatment failure. Objectives: This study was conducted to describe prescription pattern of antimalarial drugs and evaluates compliance with WHO recommendation. Methods: Healthcare professionals including doctors were trained on the management of malaria and coevent monitoring of ACT antimalarials. An audit of all antimalarial prescriptions received by the Pharmacy unit between 2010 and 2011 was then conducted to assess level of compliance with WHO recommendation on use of ACTs. Results: A total of 3010 and 5269 prescription encounters were received by the pharmacy unit in 2010 and 2011 respectively. There were 495 antimalarial prescriptions (42.6%; N=1161) complying with WHO recommendations in 2010; whereas 665 prescriptions (55.0%; N=1210) complied with WHO recommendation in 2011. Artemisinin derivatives were...

Research paper thumbnail of Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents

Herba Polonica, Sep 1, 2019

Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber... more Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber moth Cussonia barteri is a small tree that grows in the sub-Saharan part of Africa. Various parts of the plant are used for the treatment of a variety of ailments in ethno-medicine. Objective: To evaluate the anti-inflammatory and analgesic effect of the methanol leaf extract of Cussonia barteri. Material and methods: The leaves were air-dried, powdered and repeatedly extracted with methanol using a Soxhlet apparatus. The resulting methanol extract (100, 200 and 400 mg/kg) was evaluated for antiinflammatory activity using carrageenan-induced paw oedema, xylene-induced ear oedema and formalininduced arthritis tests. Analgesic effect was evaluated using acetic acid-induced mouse writhing, hot plate and tail flick tests. Results: All doses of the extract significantly (p<0.05) reduced carrageenan-induced paw oedema, however the 400 mg/kg dose gave a sustained effect. The extract significantly inhibited xylene induced ear oedema at all doses. There were no significant (p>0.05) reductions in paw swellings due to formalin. In the acetic acid induced writhing test, the extract significantly (p<0.05) decreased writhing at 400 mg/kg only. Reaction times were not significantly different from the control in the hot plate and tail flick tests. Conclusion: This study has shown that the methanol extract possesses acute anti-inflammatory and peripherally mediated analgesic effects.

Research paper thumbnail of Co-processing of Microcrystalline Cellulose and Antimalarial prescription pattern

The aim of this study was to evaluate the effect of co-processing of microcrystalline cellulose (... more The aim of this study was to evaluate the effect of co-processing of microcrystalline cellulose (MCC) with Eudragit L100 (R) , cellulose acetate phthalate and ethyl cellulose respectively on the compaction, flow and disintegration properties of MCC. Co-processing MCC with the different polymers enhanced the flow and disintegration properties of MCC as a direct compression excipient for tablets production. When evaluated with the Heckle model, there was no remarkable change in the packing characteristics of the modified motifs in relation to the unmodified; however there was a slight but variable decrease in dilution capacity. This study shows the potential attribute of co-processing MCC with other polymers.

Research paper thumbnail of Acute and sub-chronic toxicity evaluations of aqueous extract from stem bark of Grewia mollis (Malvaceae) in rats

Herba Polonica, Sep 26, 2017

Introduction: Different parts of Grewia mollis Juss. (Malvaceae) are commonly used in folk medici... more Introduction: Different parts of Grewia mollis Juss. (Malvaceae) are commonly used in folk medicine to treat several ailments, including diarrhea, ulcers, rickets, cough and fever. Although several studies have proved its therapeutic effectiveness, there are very few toxicological studies on the plant. Objectives: This study was carried out to evaluate the acute and sub-chronic toxicity of the aqueous extract of G. mollis stem bark (GM) in animals. Methods: In the acute study, rats were orally administrated with GM at doses of 150, 300, 600, 1200, 2400, 4800 and 9600 mg/kg to determine the oral medial lethal dose (LD 50). In the chronic study, rats received three doses of GM (150, 300 and 600 mg/kg) for 28 days. After the treatments, food intake, body weights, biochemical, hematological and histopathological parameters were analyzed. Results: The LD 50 was estimated to be >9600 mg/kg. No significant alterations in the animal's body weight gain, relative organs weight, serum biochemical analysis, hematological or histopathological analyses of liver, kidneys, lungs, heart and spleen were observed. Conclusions: The results of this study provided evidence that oral administration of GM at dose of 600 mg/kg is relatively safe in rats and may not exert severe toxic effects.

Research paper thumbnail of Review of two year prescription patterns of antimalarial drug regimen at NIPRD Health Center, Abuja

Background: The World Health Organization (WHO) has recommended the use of artemisinin based comb... more Background: The World Health Organization (WHO) has recommended the use of artemisinin based combination therapy (ACT) for the treatment of malaria to reduce the incidence of treatment failure. Objectives: This study was conducted to describe prescription pattern of antimalarial drugs and evaluates compliance with WHO recommendation. Methods: Healthcare professionals including doctors were trained on the management of malaria and coevent monitoring of ACT antimalarials. An audit of all antimalarial prescriptions received by the Pharmacy unit between 2010 and 2011 was then conducted to assess level of compliance with WHO recommendation on use of ACTs. Results: A total of 3010 and 5269 prescription encounters were received by the pharmacy unit in 2010 and 2011 respectively. There were 495 antimalarial prescriptions (42.6%; N=1161) complying with WHO recommendations in 2010; whereas 665 prescriptions (55.0%; N=1210) complied with WHO recommendation in 2011. Artemisinin derivatives were...

Research paper thumbnail of Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents

Herba Polonica, Sep 1, 2019

Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber... more Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber moth Cussonia barteri is a small tree that grows in the sub-Saharan part of Africa. Various parts of the plant are used for the treatment of a variety of ailments in ethno-medicine. Objective: To evaluate the anti-inflammatory and analgesic effect of the methanol leaf extract of Cussonia barteri. Material and methods: The leaves were air-dried, powdered and repeatedly extracted with methanol using a Soxhlet apparatus. The resulting methanol extract (100, 200 and 400 mg/kg) was evaluated for antiinflammatory activity using carrageenan-induced paw oedema, xylene-induced ear oedema and formalininduced arthritis tests. Analgesic effect was evaluated using acetic acid-induced mouse writhing, hot plate and tail flick tests. Results: All doses of the extract significantly (p<0.05) reduced carrageenan-induced paw oedema, however the 400 mg/kg dose gave a sustained effect. The extract significantly inhibited xylene induced ear oedema at all doses. There were no significant (p>0.05) reductions in paw swellings due to formalin. In the acetic acid induced writhing test, the extract significantly (p<0.05) decreased writhing at 400 mg/kg only. Reaction times were not significantly different from the control in the hot plate and tail flick tests. Conclusion: This study has shown that the methanol extract possesses acute anti-inflammatory and peripherally mediated analgesic effects.

Research paper thumbnail of Co-processing of Microcrystalline Cellulose and Antimalarial prescription pattern

The aim of this study was to evaluate the effect of co-processing of microcrystalline cellulose (... more The aim of this study was to evaluate the effect of co-processing of microcrystalline cellulose (MCC) with Eudragit L100 (R) , cellulose acetate phthalate and ethyl cellulose respectively on the compaction, flow and disintegration properties of MCC. Co-processing MCC with the different polymers enhanced the flow and disintegration properties of MCC as a direct compression excipient for tablets production. When evaluated with the Heckle model, there was no remarkable change in the packing characteristics of the modified motifs in relation to the unmodified; however there was a slight but variable decrease in dilution capacity. This study shows the potential attribute of co-processing MCC with other polymers.